ROLANDO RUMBAUT

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H1671-9. 2006
  2. ncbi request reprint Magnetic therapy for edema in inflammation: a physiological assessment
    Rolando E Rumbaut
    Baylor College of Medicine, Children s Nutrition Research Center, 1100 Bates Avenue, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 294:H19-20. 2008
  3. ncbi request reprint Mouse cremaster venules are predisposed to light/dye-induced thrombosis independent of wall shear rate, CD18, ICAM-1, or P-selectin
    Rolando E Rumbaut
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Microcirculation 11:239-47. 2004
  4. ncbi request reprint Platelet-microvessel interactions
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey V A Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Microcirculation 12:233-4. 2005
  5. ncbi request reprint Microvascular thrombosis models in venules and arterioles in vivo
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey V A Medical Center, Houston, Texas, USA
    Microcirculation 12:259-74. 2005
  6. pmc Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1
    Fong W Lam
    Department of Pediatrics, Baylor College of Medicine, 1100 Bates, Rm 6014, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 300:H468-75. 2011
  7. ncbi request reprint Neutrophils, nitric oxide, and microvascular permeability in severe sepsis
    Samjot S Dhillon
    Department of Medicine, Baylor College of Medicine, CNRC Building, Room 6014, 1100 Bates St, Houston, TX 77030, USA
    Chest 128:1706-12. 2005
  8. doi request reprint Effect of an anti-sulfatide single-chain antibody probe on platelet function
    Prasenjit Guchhait
    Thrombosis Research Section, Dept of Medicine, One Baylor Plaza, BCM286, N1319, Houston, Texas 77030, USA
    Thromb Haemost 99:552-7. 2008
  9. ncbi request reprint Transendothelial flow inhibits neutrophil transmigration through a nitric oxide-dependent mechanism: potential role for cleft shear stress
    Alan R Burns
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 293:H2904-10. 2007
  10. pmc gamma delta T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion
    Zhijie Li
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 171:838-45. 2007

Research Grants

Detail Information

Publications17

  1. ncbi request reprint Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H1671-9. 2006
    ..These findings support the notion that endotoxemia promotes platelet thrombus formation independent of neutrophils and without enhancement of platelet aggregation, via a TLR4-dependent mechanism...
  2. ncbi request reprint Magnetic therapy for edema in inflammation: a physiological assessment
    Rolando E Rumbaut
    Baylor College of Medicine, Children s Nutrition Research Center, 1100 Bates Avenue, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 294:H19-20. 2008
  3. ncbi request reprint Mouse cremaster venules are predisposed to light/dye-induced thrombosis independent of wall shear rate, CD18, ICAM-1, or P-selectin
    Rolando E Rumbaut
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Microcirculation 11:239-47. 2004
    ..The authors sought to determine whether lower wall shear rates or leukocyte-endothelial interactions accounted for preferential platelet thrombi formation in venules relative to arterioles...
  4. ncbi request reprint Platelet-microvessel interactions
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey V A Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Microcirculation 12:233-4. 2005
  5. ncbi request reprint Microvascular thrombosis models in venules and arterioles in vivo
    Rolando E Rumbaut
    Medical Care Line, Michael E DeBakey V A Medical Center, Houston, Texas, USA
    Microcirculation 12:259-74. 2005
    ..Recognizing these characteristics should help investigators select an appropriate model for studying microvascular thrombosis in vivo...
  6. pmc Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1
    Fong W Lam
    Department of Pediatrics, Baylor College of Medicine, 1100 Bates, Rm 6014, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 300:H468-75. 2011
    ..These data support the notion that platelets enhance neutrophil transmigration across the inflamed endothelium both in vivo and in vitro, via a PSGL-1-dependent mechanism...
  7. ncbi request reprint Neutrophils, nitric oxide, and microvascular permeability in severe sepsis
    Samjot S Dhillon
    Department of Medicine, Baylor College of Medicine, CNRC Building, Room 6014, 1100 Bates St, Houston, TX 77030, USA
    Chest 128:1706-12. 2005
    ..We aimed to determine whether patients with severe sepsis had increased Kf, and whether the magnitude of Kf correlated with indexes of nitric oxide activity and neutrophil activation...
  8. doi request reprint Effect of an anti-sulfatide single-chain antibody probe on platelet function
    Prasenjit Guchhait
    Thrombosis Research Section, Dept of Medicine, One Baylor Plaza, BCM286, N1319, Houston, Texas 77030, USA
    Thromb Haemost 99:552-7. 2008
    ..05), though in-vivo haemostasis did not differ significantly. Thus, this study provides new evidence for a role for membrane sulfatide in platelet function...
  9. ncbi request reprint Transendothelial flow inhibits neutrophil transmigration through a nitric oxide-dependent mechanism: potential role for cleft shear stress
    Alan R Burns
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 293:H2904-10. 2007
    ..These data are consistent with the hypothesis that endothelial cleft shear stress inhibits neutrophil transmigration via a NO-dependent mechanism...
  10. pmc gamma delta T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion
    Zhijie Li
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 171:838-45. 2007
    ..These results are consistent with the conclusion that gammadelta T cells are necessary for efficient inflammation, platelet localization in the limbus, and epithelial wound healing after corneal abrasion...
  11. ncbi request reprint Similar permeability responses to nitric oxide synthase inhibitors of venules from three animal species
    Rolando E Rumbaut
    Department of Medicine and Department of Pediatrics, Baylor College of Medicine, Houston V A Medical Center, 2002 Holcombe Blvd, Building 109, Room 114, Houston, Texas 77030, USA
    Microvasc Res 64:21-31. 2002
    ..These data support a role of nitric oxide release on venular permeability to albumin that is conserved among the three animal species...
  12. ncbi request reprint Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization
    Zhijie Li
    Section of Leukocyte Biology, Department of Pediatrics, Children s Nutrition Research Center, 1100 Bates, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 47:4794-802. 2006
    ..In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated...
  13. ncbi request reprint Mitochondria are fast Ca2+ sinks in rat extraocular muscles: a novel regulatory influence on contractile function and metabolism
    Francisco H Andrade
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Invest Ophthalmol Vis Sci 46:4541-7. 2005
    ....
  14. ncbi request reprint Fluorescent dyes modify properties of proteins used in microvascular research
    Susan Bingaman
    Department of Physiology, University of Missouri Columbia, Columbia, MO, USA
    Microcirculation 10:221-31. 2003
    ..We tested the validity of that assumption for two probes, bovine serum albumin (BSA) and alpha-lactalbumin...
  15. ncbi request reprint Extravascular transport of fluorescently labeled albumins in the rat mesentery
    Norman R Harris
    Department of Bioengineering, Pennsylvania State University, University Park, PA 16802 6804, USA
    Microcirculation 9:177-87. 2002
    ....
  16. ncbi request reprint Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation
    Xiaohua Jiang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 25:2515-21. 2005
    ..A risk factor for cardiovascular disease, hyperhomocystinemia (HHcy), is associated with endothelial dysfunction. In this study, we examined the mechanistic role of HHcy in endothelial dysfunction...
  17. ncbi request reprint Efficacy of antithrombin in the prevention of microvascular thrombosis during endotoxemia: an intravital microscopic study
    Heiko Sorg
    Institute for Experimental Surgery, University of Rostock, Schillingallee 69a, 18055 Rostock, Germany
    Thromb Res 121:241-8. 2007
    ..Therefore, this study investigated the antithrombotic property of AT as potential monotherapy in an experimental endotoxemia model in order to omit concomitant heparin...

Research Grants8

  1. REGULATION OF MICROVASCULAR PERMEABILITY BY NITRIC OXIDE
    ROLANDO RUMBAUT; Fiscal Year: 2004
    ..The long-term goal is to apply the knowledge gained from these studies to allow optimal management of patients with these important clinical entities and their associated microvascular alterations. ..
  2. MECHANISMS OF MICROVASCULAR THROMBOSIS IN ENDOTOXEMIA
    ROLANDO RUMBAUT; Fiscal Year: 2007
    ..S. Our goal is to understand the causes of a severe complication of this illness, clots in tiny blood vessels. This information would help develop new treatments for patients with this devastating illness. ..
  3. MECHANISMS OF MICROVASCULAR THROMBOSIS IN ENDOTOXEMIA
    ROLANDO RUMBAUT; Fiscal Year: 2009
    ..S. Our goal is to understand the causes of a severe complication of this illness, clots in tiny blood vessels. This information would help develop new treatments for patients with this devastating illness. ..