Susan Rosenberg

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins
    Daniel B Magner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 26:273-86. 2007
  2. ncbi request reprint Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy
    Jesse D McCool
    Department of Microbiology, Morrill Science Center IV N203, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Mol Microbiol 53:1343-57. 2004
  3. ncbi request reprint Microbiology and evolution. Modulating mutation rates in the wild
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1382-3. 2003
  4. ncbi request reprint Genomes: worming into genetic instability
    Susan M Rosenberg
    Nature 430:625-6. 2004
  5. pmc Physical analyses of E. coli heteroduplex recombination products in vivo: on the prevalence of 5' and 3' patches
    Laura M Gumbiner-Russo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 2:e1242. 2007
  6. ncbi request reprint Mutation for survival
    S M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Genet Dev 7:829-34. 1997
  7. pmc Rebuttal: adaptive mutation in Escherichia coli (Foster)
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3411, USA
    J Bacteriol 186:4853. 2004
  8. pmc Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson)
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM S809A, Mail Stop BCM225, Houston, TX 77030 3411, USA
    J Bacteriol 186:4862-3. 2004
  9. pmc Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM S809A Mail Stop BCM225, Houston, TX 77030 3411, USA
    J Bacteriol 186:4838-43. 2004
  10. ncbi request reprint Evolving responsively: adaptive mutation
    S M Rosenberg
    Departments of Molecular and Human Genetics, Biochemistry, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    Nat Rev Genet 2:504-15. 2001

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins
    Daniel B Magner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 26:273-86. 2007
    ..The data imply that RecQ promotes the net accumulation of BRIs in vivo, indicating a second paradigm for the in vivo effect of RecQ-like proteins. The E. coli RecQ paradigm may provide a useful model for some human RecQ homologs...
  2. ncbi request reprint Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy
    Jesse D McCool
    Department of Microbiology, Morrill Science Center IV N203, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Mol Microbiol 53:1343-57. 2004
    ..These results are discussed in a context of how the processes of DNA replication and recombination may affect cells in a population differentially...
  3. ncbi request reprint Microbiology and evolution. Modulating mutation rates in the wild
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1382-3. 2003
  4. ncbi request reprint Genomes: worming into genetic instability
    Susan M Rosenberg
    Nature 430:625-6. 2004
  5. pmc Physical analyses of E. coli heteroduplex recombination products in vivo: on the prevalence of 5' and 3' patches
    Laura M Gumbiner-Russo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 2:e1242. 2007
    ..There is, however, in vivo evidence that patches are found in both strands...
  6. ncbi request reprint Mutation for survival
    S M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Genet Dev 7:829-34. 1997
    ..Genomic 'hot' and 'cold' regions may explain previous failures to detect similar mutations in other systems and at other sites. Stationary phase specific limitation of mismatch repair has also been discovered...
  7. pmc Rebuttal: adaptive mutation in Escherichia coli (Foster)
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3411, USA
    J Bacteriol 186:4853. 2004
  8. pmc Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson)
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM S809A, Mail Stop BCM225, Houston, TX 77030 3411, USA
    J Bacteriol 186:4862-3. 2004
  9. pmc Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change
    Susan M Rosenberg
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM S809A Mail Stop BCM225, Houston, TX 77030 3411, USA
    J Bacteriol 186:4838-43. 2004
  10. ncbi request reprint Evolving responsively: adaptive mutation
    S M Rosenberg
    Departments of Molecular and Human Genetics, Biochemistry, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    Nat Rev Genet 2:504-15. 2001
    ..The emerging mechanisms of adaptive genetic change cast evolution, development and heredity into a new perspective, indicating new models for the genetic changes that fuel these processes...
  11. pmc Transient and heritable mutators in adaptive evolution in the lab and in nature
    S M Rosenberg
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Genetics 148:1559-66. 1998
    ....
  12. ncbi request reprint A role for topoisomerase III in a recombination pathway alternative to RuvABC
    Christopher R Lopez
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Microbiol 58:80-101. 2005
    ..These data are consistent with a role for topoisomerase III in disentangling recombination intermediates as an alternative to RuvABC to maintain the stability of the genome...
  13. ncbi request reprint A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation
    Rebecca G Ponder
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell 19:791-804. 2005
    ..Our findings reveal an RpoS-controlled switch from high-fidelity to mutagenic DSBR under stress. This limits genetic instability both in time and to localized genome regions, potentially important evolutionary strategies...
  14. pmc Roles of E. coli double-strand-break-repair proteins in stress-induced mutation
    Albert S He
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 5:258-73. 2006
    ....
  15. pmc Single-strand-specific exonucleases prevent frameshift mutagenesis by suppressing SOS induction and the action of DinB/DNA polymerase IV in growing cells
    Megan N Hersh
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3411, USA
    J Bacteriol 188:2336-42. 2006
    ..Previous results implicated PolIV in E. coli mutagenesis specifically during starvation or antibiotic stresses. Our data imply that PolIV can also promote mutation in growing cells under genome stress due to excess single-stranded DNA...
  16. pmc On the mechanism of gene amplification induced under stress in Escherichia coli
    Andrew Slack
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 2:e48. 2006
    ..We outline its possible applicability to amplification in humans and other organisms and circumstances...
  17. pmc Spontaneous DNA breakage in single living Escherichia coli cells
    Jeanine M Pennington
    Interdepartmental Program in Cell and Molecular Biology and Department of Molecular and Human Genetics, Houston, Texas 77030 3411, USA
    Nat Genet 39:797-802. 2007
    ..Finally, FACS demonstrated two main cell fates after spontaneous DNA damage: viability with or without resumption of proliferation...
  18. pmc Mutation as a stress response and the regulation of evolvability
    Rodrigo S Galhardo
    Department of Molecular and Human Genetics, Baylor College, Houston, Texas 77030 3411, USA
    Crit Rev Biochem Mol Biol 42:399-435. 2007
    ..The emerging commonalities in stress-induced-mutation mechanisms provide hope for new therapeutic interventions for all of these processes...
  19. pmc Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Biol 2:e399. 2004
    ..We suggest that the availability of alternative pathways for genetic/evolutionary adaptation and clonal expansion under stress may be exploited during processes ranging from the evolution of drug resistance to cancer progression...
  20. pmc Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coli
    Joseph F Petrosino
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    Antimicrob Agents Chemother 46:1535-9. 2002
    ..coli chromosome. These cells acquire spontaneous recombination- and SOS response-independent beta-lactam resistance mutations in ampD. This chromosomal system is useful for studying mutation mechanisms that promote antibiotic resistance...
  21. ncbi request reprint In pursuit of a molecular mechanism for adaptive gene amplification
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room T809 Mail Stop 225, Houston, TX 77030 3411, USA
    DNA Repair (Amst) 1:111-23. 2002
    ..We explore possible molecular mechanisms of adaptive amplification in the bacterial system and note parallels to chromosomal instability in other systems...
  22. pmc The dinB operon and spontaneous mutation in Escherichia coli
    Gregory J McKenzie
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    J Bacteriol 185:3972-7. 2003
    ..We demonstrate the existence of a dinB operon that contains four genes, dinB-yafN-yafO-yafP. The results imply a role for yafN, yafO, and/or yafP in spontaneous mutation...
  23. ncbi request reprint xni-deficient Escherichia coli are proficient for recombination and multiple pathways of repair
    Mary Jane Lombardo
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S809A Mail Stop BCM225, Houston, TX 77030 3411, USA
    DNA Repair (Amst) 2:1175-83. 2003
    ..We conclude that the xni gene product does not belong to this group of nucleases that play redundant roles in DNA recombination and repair...
  24. pmc General stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli
    Mary Jane Lombardo
    Department of Molecular Genetics, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Genetics 166:669-80. 2004
    ....
  25. ncbi request reprint Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress
    Megan N Hersh
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S809, Mail Stop 225, Houston, TX 77030 3411, USA
    Res Microbiol 155:352-9. 2004
    ..Stress-induced genetic changes may underlie much of microbial evolution, pathogenesis and antibiotic resistance, and also cancer formation, progression and drug resistance...
  26. pmc Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli
    Caleb Gonzalez
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 4:e1000208. 2008
    ..e., it is important. We consider a model in which HMS differentiation is controlled by stress responses. Differentiation of an HMS potentially limits the risks of mutagenesis in cell clones...
  27. ncbi request reprint Antibiotic-induced lateral transfer of antibiotic resistance
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 3411, USA
    Trends Microbiol 12:401-4. 2004
    ..Several commonly used antibiotics induce the SOS response, potentially hastening genetic change and the evolution to resistance of pathogenic populations. The use of such antibiotics should be reconsidered...
  28. ncbi request reprint Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity
    Xuan Chi
    Graduate Program in Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genesis 35:220-6. 2003
    ..Nkx2-5 BAC-GFP expression was copy number-dependent and locus site-independent. BAC transgenics using the GFP reporter offers an efficient model system to study gene expression and regulation...

Research Grants32

  1. MOLECULAR MECHANISM OF ADAPTIVE MUTATION IN E.COLI
    Susan Rosenberg; Fiscal Year: 2004
    ..This model may apply to many systems previously assumed to follow the rules of Luria/Delbruck growth-dependent mutation, occurring randomly before selective environments are encountered. ..
  2. DNA Repair and Replication Re-start in vivo
    Susan M Rosenberg; Fiscal Year: 2010
    ..coli model. This work will provide a foundation for understanding, and so for diagnosis, treatment, and prevention, of human cancers caused by malfunction of these proteins. ..
  3. Molecular mechanisms of stress-induced mutation in E. coli
    Susan Rosenberg; Fiscal Year: 2009
    ..coli model. Because the mechanism studied has common components with several other (less understood) mechanisms of stress-induced mutation, the results should provide an important general model. ..
  4. DNA REPAIR AND REPLICATION RE START IN VIVO
    Susan Rosenberg; Fiscal Year: 2005
    ....
  5. MOLECULAR MECHANISM OF ADAPTIVE MUTATION IN E COLI
    Susan Rosenberg; Fiscal Year: 2000
    ....
  6. Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes
    Susan Rosenberg; Fiscal Year: 2009
    ..coli, identify their counterparts in human, then id ..
  7. Molecular mechanism of DNA-polymerase choice in vivo
    Susan Rosenberg; Fiscal Year: 2007
    ..coli DNA polymerases, and functions in DNA polymerase choice in vivo: a critical regulatory decision for cell survival of environmental damage, and genomic health. ..
  8. DNA REPAIR IN DRUG RESISTANCE MUTATION
    Susan Rosenberg; Fiscal Year: 2003
    ....
  9. Molecular mechanisms of stress-induced mutation in E. coli
    Susan Rosenberg; Fiscal Year: 2009
    ..coli model. Because the mechanism studied has common components with several other (less understood) mechanisms of stress-induced mutation, the results should provide an important general model. ..