Jeffrey Rosen

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Regulation of milk protein gene expression
    J M Rosen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Annu Rev Nutr 19:407-36. 1999
  2. ncbi request reprint Transcription factors
    Jeffrey M Rosen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:143-4. 2003
  3. ncbi request reprint The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204. 2003
  4. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
  5. pmc The epigenetic landscape of mammary gland development and functional differentiation
    Monique Rijnkels
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    J Mammary Gland Biol Neoplasia 15:85-100. 2010
  6. pmc Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland
    Bryan E Welm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:703-14. 2002
  7. ncbi request reprint Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins
    Monique Rijnkels
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genomics 82:417-32. 2003
  8. pmc Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    Mei Zhang
    Department of Molecular and Cellular Biology, Graduate program in Translational Biology and Molecular Medicine, and Lester and Sue Smith Breast Center of Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:4674-82. 2008
  9. pmc Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
  10. pmc Pregnancy-induced changes in cell-fate in the mammary gland
    Melanie R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 5:192-7. 2003

Research Grants

  1. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007
  2. TRAINING PROGRAM IN MOLECULAR ENDOCRINOLOGY
    Jeffrey Rosen; Fiscal Year: 2007
  3. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Regulation of milk protein gene expression
    J M Rosen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Annu Rev Nutr 19:407-36. 1999
    ..The functional importance of some of these factors in mammary gland development and milk protein gene expression has been elucidated by studying mice in which some of these factors have been deleted...
  2. ncbi request reprint Transcription factors
    Jeffrey M Rosen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:143-4. 2003
  3. ncbi request reprint The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204. 2003
    ..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
  4. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
    ..Additionally, the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients...
  5. pmc The epigenetic landscape of mammary gland development and functional differentiation
    Monique Rijnkels
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    J Mammary Gland Biol Neoplasia 15:85-100. 2010
    ..With the new tools for epigenomics developed in recent years, we now can begin to establish a framework for the role of epigenetics in mammary gland development and disease...
  6. pmc Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland
    Bryan E Welm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:703-14. 2002
    ..These data indicate that acute iFGFR1 signaling results in increased lateral budding of the mammary ductal epithelium, and that sustained activation induces alveolar hyperplasia and invasive lesions...
  7. ncbi request reprint Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins
    Monique Rijnkels
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Genomics 82:417-32. 2003
    ..The conserved regions might have biological importance for the regulation of genes in this genomic "neighborhood."..
  8. pmc Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    Mei Zhang
    Department of Molecular and Cellular Biology, Graduate program in Translational Biology and Molecular Medicine, and Lester and Sue Smith Breast Center of Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:4674-82. 2008
    ..Furthermore, this p53-null mouse mammary tumor model may allow us to identify new CSC markers and to test the functional importance of these markers...
  9. pmc Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
    ..Thus, the developmental heterogeneity of different breast cancers is in part a consequence of differential effects of oncogenes on distinct cell types in the breast...
  10. pmc Pregnancy-induced changes in cell-fate in the mammary gland
    Melanie R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 5:192-7. 2003
    ..Recent studies signify a dramatic advance in our understanding of this phenomenon, and indicate a 'cell fate' model for parity-related changes that lead to protection against breast cancer...
  11. pmc Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
    Adam C Pond
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:4868-79. 2010
    ..Further, they reveal protein translation initiation factors as potential therapeutic targets for human breast cancers with alterations in FGF signaling...
  12. ncbi request reprint Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers
    Elena B Kabotyanski
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 20:2355-68. 2006
    ..Collectively, these data suggest a model for the assembly of a multiprotein complex that helps to define how the signaling pathways controlled by these lactogenic hormones are integrated to regulate beta-casein gene expression...
  13. pmc WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    Wendy A Woodward
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:618-23. 2007
    ..These data demonstrate that, compared with differentiated cells, progenitor cells have different cell survival properties that may facilitate the development of targeted antiprogenitor cell therapies...
  14. ncbi request reprint On mammary stem cells
    Wendy A Woodward
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 3498, USA
    J Cell Sci 118:3585-94. 2005
    ....
  15. pmc A putative role for microRNA-205 in mammary epithelial cell progenitors
    Stephanie B Greene
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 123:606-18. 2010
    ..Additionally, in normal mouse MECs, high expression of miR-205 was observed in stem-cell-enriched cell populations isolated by FACS using established cell-surface markers...
  16. ncbi request reprint A critical role for the inflammatory response in a mouse model of preneoplastic progression
    Kathryn L Schwertfeger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:5676-85. 2006
    ..These findings show that inflammatory cells, specifically macrophages, are critical for mediating early events in an inducible transgenic mouse model of preneoplastic progression...
  17. pmc CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland
    Heather L LaMarca
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Stem Cells 28:535-44. 2010
    ..These findings have critical implications for understanding both stem cell biology and the etiology of different breast cancer subtypes...
  18. ncbi request reprint A beta-catenin survival signal is required for normal lobular development in the mammary gland
    Stacey B Tepera
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 116:1137-49. 2003
    ..This study illustrates the importance of beta-catenin signalling in mammary lobuloalveolar development...
  19. ncbi request reprint Stem/progenitor cells in mouse mammary gland development and breast cancer
    Yi Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 10:17-24. 2005
    ..Thus, the heterogeneity of different breast cancers may reflect the activation of different oncogenic pathways, different cellular targets in which these genetic changes occur, or both...
  20. pmc Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:106. 2006
    ....
  21. ncbi request reprint Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition
    Wa Xian
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:987-1000. 2007
    ..These studies demonstrate, for the first time, that the duration of downstream signaling determines the distinct phenotypes mediated by very homologous RTKs in three-dimensional cultures...
  22. ncbi request reprint Modelling breast cancer: one size does not fit all
    Tracy Vargo-Gogola
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Rev Cancer 7:659-72. 2007
    ..the models commonly used to investigate breast cancer including cell lines, xenografts and genetically engineered mice, are discussed to help address the question: what is the most powerful way to investigate this heterogeneous disease?..
  23. pmc Minireview: hormones and mammary cell fate--what will I become when I grow up?
    Heather L LaMarca
    Department of Molecular and Cellular Biology, DeBakey Building M638a, Houston, Texas 77030, USA
    Endocrinology 149:4317-21. 2008
    ..Here we review recent studies on the involvement of hormone receptors and several transcription factors in mammary stem/progenitor cell differentiation and lineage commitment...
  24. pmc Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation
    Jay P Reddy
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:3728-33. 2010
    ....
  25. doi request reprint Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival
    Wa Xian
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 69:2244-51. 2009
    ....
  26. pmc Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements
    Elena B Kabotyanski
    Departments of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Mail Box BCM 130, Houston, TX 77030, USA
    J Biol Chem 284:22815-24. 2009
    ..Collectively, these data suggest that the communication between these regulatory regions with intervening DNA looping is a crucial step required to both create and maintain active chromatin domains and regulate transcription...
  27. pmc Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    Chad J Creighton
    Department of Molecular and Cellular Biology, Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:13820-5. 2009
    ..Targeting proteins involved in EMT may provide a therapeutic strategy for eliminating surviving cells to prevent recurrence and improve long-term survival in breast cancer patients...
  28. ncbi request reprint P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland
    Tracy Vargo-Gogola
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 20:1391-405. 2006
    ..These data demonstrate that precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development...
  29. ncbi request reprint Striking it rich by data mining
    Jeffrey M Rosen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Cell 114:271-2. 2003
  30. ncbi request reprint Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival
    Inmaculada Hernandez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Mol Cancer Res 1:1036-47. 2003
    ..This suggests that additional tumor-related events specifically influence the ability of the variant p53(R172L) molecule to inhibit tumor growth. These studies support gene therapy strategies employing specific p53 variants...
  31. ncbi request reprint Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:36301-9. 2005
    ..Collectively, these changes prevent C/EBPbeta-null mammary epithelial cells from responding to hormone-induced proliferative signals...
  32. ncbi request reprint Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population
    Bryan E Welm
    Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77035, USA
    Dev Biol 245:42-56. 2002
    ..Finally, the Sca-1(pos) population is enriched for functional stem/progenitor cells, as demonstrated by its increased regenerative potential compared with Sca-1(neg) cells when transplanted into the cleared mammary fat pads of host mice...
  33. ncbi request reprint Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 16:2675-91. 2002
    ..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation...
  34. pmc Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model
    Wa Xian
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 171:663-73. 2005
    ..The addition of a pan MMP inhibitor abolished these phenotypes but did not prevent the effects of iFGFR1 on cell proliferation or survival...
  35. pmc Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression
    Brandy M Heckman-Stoddard
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 11:R61. 2009
    ..P190B is required for mammary gland morphogenesis, and overexpression of p190B in the mammary gland induces hyperplastic lesions. Hence, we hypothesized that p190B may play a pivotal role in mammary tumorigenesis...
  36. ncbi request reprint Hormone dependence in premalignant mammary progression
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:1067-72. 2003
    ..This model would appear an excellent one to test the effects of chemopreventive agents on the development of both ER-negative and ER-positive mammary tumors...
  37. ncbi request reprint Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation
    Kevin W Freeman
    Department of Immunology, Baylor College of Medicine, One Baylor Plaza M929, Houston, TX 77030, USA
    Cancer Res 63:6237-43. 2003
    ..These studies support the hypothesis that observed changes in the FGFR axis in mammals during CaP progression are causally important...
  38. ncbi request reprint The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
    Michelle Kingsley-Kallesen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 16:2008-18. 2002
    ..These studies suggest that MR may compensate for the absence of GR at some, but not at all stages of mammary gland development...
  39. doi request reprint Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    J Mammary Gland Biol Neoplasia 15:253-60. 2010
    ..Here, we review recent evidence of the involvement of EMT in breast cancer TICs, focusing on clinical studies...
  40. pmc Keratin 6 is not essential for mammary gland development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:R29. 2006
    ....
  41. pmc A noncoding RNA is a potential marker of cell fate during mammary gland development
    Melanie R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:5781-6. 2006
    ..This is one of the first reports describing the functional properties of a large, developmentally regulated, mammalian, noncoding RNA...
  42. pmc Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones
    Jie Dong
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 346:196-203. 2010
    ....
  43. ncbi request reprint Transcriptional profiling of mammary gland side population cells
    Fariba Behbod
    Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Stem Cells 24:1065-74. 2006
    ..In conclusion, microarray gene profiling suggests that MG-SPs are a lineage-deficient mammary gland subpopulation expressing key genes involved in cell cycle regulation, development, and angiogenesis...
  44. ncbi request reprint Chking and executing cell division to prevent genomic instability
    Sirisha Peddibhotla
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Cycle 8:2339-42. 2009
    ..Therefore, inappropriate regulation of Chk1 levels during cell cycle progression will result in failed cell division and enhanced genomic instability...
  45. ncbi request reprint p190-B RhoGAP regulates mammary ductal morphogenesis
    Geetika Chakravarty
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:1054-65. 2003
    ..Together, these results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis...
  46. ncbi request reprint Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b
    Elena B Kabotyanski
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 278:17218-27. 2003
    ..Thus, depending on the signal transduction pathway responsible for activation, different conformations of activated Stat5 may result in selective biological responses...
  47. pmc Selective targeting of radiation-resistant tumor-initiating cells
    Mei Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Proc Natl Acad Sci U S A 107:3522-7. 2010
    ..Thus, these results suggest that pretreatment with Akt inhibitors before ionizing radiation treatment may be of potential therapeutic benefit to patients...
  48. pmc The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation
    Alejandro Contreras
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:8626-36. 2003
    ..These data suggest that CDK2 phosphorylates histone H1 in vivo, resulting in a more open chromatin structure by destabilizing H1-chromatin interactions...
  49. ncbi request reprint Chk1 versus Cdc25: chking one's levels of cellular proliferation
    Michael H Lam
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Interdepartmental Program in Cellular and Molecular Biology, Houston, Texas 77030, USA
    Cell Cycle 3:1355-7. 2004
    ..Surprisingly, these effects appear to be specific for Chk1, but not Chk2, which may explain the recently reported in vivo haploinsufficiency phenotype observed in the mammary gland using a Chk1 conditional mouse model...
  50. ncbi request reprint Will cancer stem cells provide new therapeutic targets?
    Fariba Behbod
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Carcinogenesis 26:703-11. 2005
    ....
  51. ncbi request reprint Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells
    Nathalie Cella
    Baylor College of Medicine, Department of Molecular and Cellular Biology, ALKEK Bldg, Rm N630, One Baylor Plaza, Houston, Texas 77030, USA
    FASEB J 20:1510-2. 2006
    ..Collectively, these results suggest that maspin is part of the supramolecular structure of the adhesion plaque and it modulates cell adhesion via a beta1 integrin-dependent mechanism...
  52. ncbi request reprint Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
    Mercy S Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, M638a Houston, TX 77030 3498, USA
    J Cell Sci 120:468-77. 2007
    ..The COMMA-Dbeta-geo cell line may provide a useful model to study the signaling pathways that control mammary progenitor cell regulation...
  53. ncbi request reprint Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    Michael H Lam
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Interdepartmental Program in Cellular and Molecular Biology, Houston, Texas 77030, USA
    Cancer Cell 6:45-59. 2004
    ..Thus, Chk1 heterozygosity results in three distinct haploinsufficient phenotypes that can contribute to tumorigenesis: inappropriate S phase entry, accumulation of DNA damage during replication, and failure to restrain mitotic entry...
  54. pmc The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells
    Sudit S Mukhopadhyay
    Department of Molecular and Cancer Genetics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem Biophys Res Commun 358:770-6. 2007
    ....
  55. pmc Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage
    Heather L LaMarca
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 9:304. 2007
    ..These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression...
  56. ncbi request reprint Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development
    Brandy M Heckman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 309:137-49. 2007
    ..These results indicate that IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis...
  57. ncbi request reprint Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice
    Kevin W Freeman
    Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:8256-63. 2003
    ....
  58. ncbi request reprint Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells
    Adam C Buser
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Mol Endocrinol 21:106-25. 2007
    ..These results define a negative cross talk between PR and Stat5a/GR that may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene in the mammary gland during pregnancy...
  59. ncbi request reprint Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium
    Jonathan M Shillingford
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 16:563-70. 2002
    ..Taken together, our results demonstrate that Jak2 is a critical tyrosine kinase that conveys intracellular signals necessary for proliferation and differentiation of mammary epithelium during pregnancy...
  60. ncbi request reprint Mammary gland macrophages: pleiotropic functions in mammary development
    Kathryn L Schwertfeger
    Department of Lab Medicine and Pathology, University of Minnesota Cancer Center, 420 Delaware St SE, MMC 609, Minneapolis, MN 55455, USA
    J Mammary Gland Biol Neoplasia 11:229-38. 2006
    ..Therefore, the purpose of this review is to describe the interactions between MØs and these various cell types and use this knowledge to identify potential functions of MØs in the mammary gland...

Research Grants3

  1. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007
    ..5. To elucidate the role of Chk1 in normal mitosis and genomic instability in breast cancer. ..
  2. TRAINING PROGRAM IN MOLECULAR ENDOCRINOLOGY
    Jeffrey Rosen; Fiscal Year: 2007
    ..The proximity of two medical schools, Rice University and M.D. Anderson Cancer Center, and the presence of 60,000 professionals make this a unique environment in which to perform medical research ..
  3. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007
    ..4) To develop a human xenograft model from unfolded Iobules to study early breast cancer progression for comparison with the progression models in the mouse. ..