BRUCE RILEY

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1
    B B Riley
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 126:5669-78. 1999
  2. ncbi request reprint Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish
    B B Riley
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Neurobiol 43:329-37. 2000
  3. ncbi request reprint Ringing in the new ear: resolution of cell interactions in otic development
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 261:289-312. 2003
  4. ncbi request reprint Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, Texas 77843 3258, USA
    Dev Dyn 231:278-91. 2004
  5. ncbi request reprint Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch
    Bonny B Millimaki
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 134:295-305. 2007
  6. ncbi request reprint Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 294:376-90. 2006
  7. ncbi request reprint Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
    Melinda D Mackereth
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 132:371-82. 2005
  8. ncbi request reprint An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 129:5279-87. 2002
  9. ncbi request reprint A direct role for Fgf but not Wnt in otic placode induction
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 131:923-31. 2004
  10. pmc Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division
    Bruce B Riley
    Department of Biology, Texas A and M University, College Station, Texas, USA
    Dev Dyn 239:828-43. 2010

Collaborators

  • Tanya T Whitfield
  • Arne C Lekven
  • R M Warga
  • Donald A Kane
  • Bonny B Millimaki
  • Bryan T Phillips
  • Su Jin Kwak
  • Elly M Sweet
  • Hye Joo Kwon
  • Murli Manohar
  • Jessica A Petko
  • Andreas Fritz
  • Melinda D Mackereth
  • Toshiro Shigaki
  • Hui Mei
  • Andrew J Franklin
  • Kendal Hirschi
  • Colin W MacDiarmid
  • Victor A Canfield
  • Robert Levenson
  • Mary S Dhason
  • Paul Houghtaling
  • David Zeddies
  • Colt Melton
  • Stephen J Moorman
  • Shruti Vemaraju
  • Arthur N Popper
  • Elly M Storch
  • Rebecca Heck

Detail Information

Publications17

  1. ncbi request reprint The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1
    B B Riley
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 126:5669-78. 1999
    ..These data indicate that deltaA expressed by hair cells normally prevents adjacent cells from adopting the same cell fate, and that pax2.1 is required for normal levels of Delta-mediated lateral inhibition...
  2. ncbi request reprint Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish
    B B Riley
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Neurobiol 43:329-37. 2000
    ..The presence of a utricular otolith in at least one inner ear is necessary and sufficient for vestibular function and survival. In contrast, saccular otoliths are dispensable for these functions...
  3. ncbi request reprint Ringing in the new ear: resolution of cell interactions in otic development
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 261:289-312. 2003
    ....
  4. ncbi request reprint Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, Texas 77843 3258, USA
    Dev Dyn 231:278-91. 2004
    ..Similar feedback mechanisms operate in the Drosophila wing disc and vertebrate limb bud, suggesting coaptation of a conserved signaling module that spatially organizes cells in complex organ systems...
  5. ncbi request reprint Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch
    Bonny B Millimaki
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 134:295-305. 2007
    ..A model is presented in which zebrafish atoh1 genes operate in a complex network leading to hair cell development...
  6. ncbi request reprint Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 294:376-90. 2006
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border...
  7. ncbi request reprint Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
    Melinda D Mackereth
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 132:371-82. 2005
    ..These data show that pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate...
  8. ncbi request reprint An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 129:5279-87. 2002
    ..This is in sharp contrast to the mouse, in which fgf3 is normally expressed in r5 and r6 because of positive regulation by kreisler, the mouse ortholog of val. Implications for co-evolution of the hindbrain and inner ear are discussed...
  9. ncbi request reprint A direct role for Fgf but not Wnt in otic placode induction
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 131:923-31. 2004
    ..We propose that Wnt8 serves to regulate timely expression of Fgf3 and Fgf8 in the hindbrain, and that Fgf from the hindbrain then acts directly on preplacodal cells to induce otic differentiation...
  10. pmc Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division
    Bruce B Riley
    Department of Biology, Texas A and M University, College Station, Texas, USA
    Dev Dyn 239:828-43. 2010
    ..Despite relatively normal gross patterning, harpy mutants show several defects in morphogenesis, cell migration and differentiation resulting directly or indirectly from the arrest of cell division...
  11. pmc Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 238:1582-94. 2009
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc...
  12. ncbi request reprint Genes controlling the development of the zebrafish inner ear and hair cells
    Bruce B Riley
    Biology Department, Texas A and M University, College Station, Texas 77843, USA
    Curr Top Dev Biol 57:357-88. 2003
  13. ncbi request reprint Zebrafish pax5 regulates development of the utricular macula and vestibular function
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 235:3026-38. 2006
    ..Thus, pax5 works in conjunction with fgf3 and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function...
  14. pmc Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear
    Bonny B Millimaki
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 338:262-9. 2010
    ..In contrast, regeneration does not occur in sox2-depleted embryos. These data show that zebrafish sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration...
  15. doi request reprint Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development
    Murli Manohar
    Vegetable and Fruit Improvement Center, Texas A and M University, College Station, Texas 77845, USA
    Biochemistry 49:6557-66. 2010
    ..Collectively, our findings provide insights into Vnx1 function and support an unexpected role of CAX transporters in animal growth and development...
  16. ncbi request reprint Development of the zebrafish inner ear
    Tanya T Whitfield
    Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Firth Court, Western Bank, Sheffield, United Kingdom
    Dev Dyn 223:427-58. 2002
    ....
  17. pmc Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish
    Jessica A Petko
    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Dev Neurobiol 68:209-22. 2008
    ..Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths...

Research Grants13

  1. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    BRUCE RILEY; Fiscal Year: 2007
    ..Therefore, achieving a fuller understanding of how the inner ear develops could eventually lead to effective medical interventions for human deafness or other disorders of the inner ear. ..
  2. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    BRUCE RILEY; Fiscal Year: 2002
    ..This in turn could lead to effective medical interventions to prevent, treat, or cure disorders of the inner ear. ..
  3. GENETIC ANALYSIS OF INNER EAR DEVELOPMENT IN ZEBRAFISH
    Bruce B Riley; Fiscal Year: 2010
    ..Using zebrafish as a model, we are investigating the functions of genes believed to regulate these processes in all vertebrates. ..