Affiliation: Texas Medical Center
- How is the Drosophila research community making use of the genome sequence?Stephen Richards
Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77006, USA
Genome Biol 4:319. 2003..A report on the 44th Annual Drosophila Research Conference, Chicago, USA, 5-9 March, 2003...
- Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolutionStephen Richards
Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston Texas 77030, USA
Genome Res 15:1-18. 2005..Overall, a pattern of repeat-mediated chromosomal rearrangement, and high coadaptation of both male genes and cis-regulatory sequences emerges as important themes of genome divergence between these species of Drosophila...
- Mind the gap: upgrading genomes with Pacific Biosciences RS long-read sequencing technologyAdam C English
Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
PLoS ONE 7:e47768. 2012..The accuracy of gap closure was validated by comparison to Sanger sequencing on gaps from the original D. pseudoobscura draft assembly and shown to be dependent on initial reference quality...
- A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genomeOliver A Hampton
Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 19:167-77. 2009..We show that knock-down of SULF2 in cell lines causes tumorigenic phenotypes, including increased proliferation, enhanced survival, and increased anchorage-independent growth...
- The genome of the model beetle and pest Tribolium castaneumStephen Richards
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 452:949-55. 2008..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...
- The maternal-effect, selfish genetic element Medea is associated with a composite Tc1 transposonMarcé D Lorenzen
United States Department of Agriculture, Grain Marketing and Production Research Center, Agricultural Research Service, Manhattan, KS 66502, USA
Proc Natl Acad Sci U S A 105:10085-9. 2008..The Medea system in Tribolium represents an unusual type of intragenomic conflict and could provide a useful vehicle for driving desirable genes into populations...
- Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotesJulie C Dunning Hotopp
Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 317:1753-6. 2007..Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions...
- Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomesAdam Siepel
Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA
Genome Res 15:1034-50. 2005..Noncoding HCEs also show strong statistical evidence of an enrichment for RNA secondary structure...
- The DNA sequence of the human X chromosomeMark T Ross
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nature 434:325-37. 2005..Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence...
- Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequenceSusan E Celniker
Berkeley Drosophila Genome Project, Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Genome Biol 3:RESEARCH0079. 2002....
- Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical mapsStephen W Schaeffer
Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 179:1601-55. 2008..Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events...
- Systematic determination of patterns of gene expression during Drosophila embryogenesisPavel Tomancak
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 539 Life Sciences Addition, Berkeley, CA 94720 3200, USA
Genome Biol 3:RESEARCH0088. 2002..Cell-fate specification and tissue differentiation during development are largely achieved by the regulation of gene transcription...
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesRobert L Strausberg
National Cancer Institute, Bethessda, MD 20892 2580, USA
Proc Natl Acad Sci U S A 99:16899-903. 2002..All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov)...