Andrew Rice

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 5:e1000263. 2009
  2. pmc Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors
    Wendong Yu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e3146. 2008
  3. pmc Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes
    Karen Chiang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:3244-52. 2012
  4. pmc Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs
    Wendong Yu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 3:32. 2006
  5. pmc Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 3:66. 2006
  6. ncbi request reprint Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages
    Andrew P Rice
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr HIV Res 1:395-404. 2003
  7. pmc The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions
    Lisa Golebiewski
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:10639-48. 2011
  8. pmc Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 78:8114-9. 2004
  9. pmc Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:10579-87. 2002
  10. ncbi request reprint Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysis
    Yan Wang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030, USA
    Virology 352:485-92. 2006

Research Grants

  1. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2006
  2. Regulation of Cyclin T1 Protein Expression- Macrophages
    Andrew Rice; Fiscal Year: 2006
  3. Regulation of Cyclin T1 Protein Expression- Macrophages
    Andrew Rice; Fiscal Year: 2005
  4. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2005
  5. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2004
  6. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2002
  7. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2001
  8. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 1999
  9. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2000
  10. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2003

Collaborators

Detail Information

Publications16

  1. pmc miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 5:e1000263. 2009
    ..Our data indicate that miR-198 functions to restrict HIV-1 replication in monocytes, and its mechanism of action appears to involve repression of Cyclin T1 expression...
  2. pmc Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors
    Wendong Yu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e3146. 2008
    ..The presence of CTDGs in the protein space that was available for HIV-1 to sample during its evolution and acquisition of Tat function may provide an explanation for why CTDGs are enriched in viral co-factors...
  3. pmc Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes
    Karen Chiang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:3244-52. 2012
    ..These results implicate miR-27b as a novel regulator of cyclin T1 protein levels and HIV-1 replication, while miR-29b, miR-223, and miR-150 may regulate cyclin T1 indirectly...
  4. pmc Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs
    Wendong Yu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 3:32. 2006
    ..To study the functional significance of cyclin T1 induction during differentiation, we utilized the human Mono Mac 6 (MM6) monocytic cell line...
  5. pmc Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 3:66. 2006
    ..We also examined effects of prostratin on Cyclin T2a, an alternative regulatory subunit for CDK9, and 7SK snRNA and the HEXIM1 protein, two factors that associate with P-TEFb and repress its kinase activity...
  6. ncbi request reprint Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages
    Andrew P Rice
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr HIV Res 1:395-404. 2003
    ..These findings suggest that changes in cyclin T1 expression can influence HIV-1 replication levels in monocytes and macrophages. Important areas for future research on Tat and TAK/P-TEFb function are discussed...
  7. pmc The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions
    Lisa Golebiewski
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 85:10639-48. 2011
    ....
  8. pmc Human immunodeficiency virus type 1 infection induces cyclin T1 expression in macrophages
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 78:8114-9. 2004
    ..These findings suggest that HIV-1 infection hijacks a component of the innate immune response in macrophages that results in enhancement rather than inhibition of viral replication...
  9. pmc Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:10579-87. 2002
    ..These results raise the possibility that regulation of CycT1 expression may be involved in establishing latent infection in macrophages and that opportunistic infection may reactivate the virus by inducing CycT1 expression...
  10. ncbi request reprint Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysis
    Yan Wang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030, USA
    Virology 352:485-92. 2006
    ..Together, these results suggest that the down-regulation of cyclin T1, and consequently Tat function, contributes to the suppressive effect of IL-10 on HIV-1 replication in human macrophages...
  11. ncbi request reprint HIV-1 infection and regulation of Tat function in macrophages
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Int J Biochem Cell Biol 36:1767-75. 2004
    ..Future studies of cyclin T1 regulation in macrophages may suggest means of manipulating expression of this crucial cellular co-factor for therapeutic benefit in HIV-1 infected individuals...
  12. ncbi request reprint Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophages
    Li Ying Liou
    Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
    J Leukoc Biol 79:388-96. 2006
    ..It is therefore likely that cyclin T1 induction by PAMPs is the result of a reduction in proteasome-mediated proteolysis...
  13. ncbi request reprint siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes
    Richard E Haaland
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Physiol 205:463-70. 2005
    ..Importantly, depletion of 7SK was found to cause apoptosis by 72 h post-transfection in HeLa cells. These results suggest that 7SK may provide an essential cellular function whose relation to P-TEFb function is unclear...
  14. ncbi request reprint Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes
    Richard E Haaland
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Immunol 42:627-41. 2005
    ..We found however that LKLF-induced quiescence is not sufficient to repress expression of HIV-1 proviruses in Jurkat T cells, suggesting that the HIV-1 provirus is resistant to LKLF-regulated quiescence...
  15. ncbi request reprint Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytes
    Richard E Haaland
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    AIDS 17:2429-36. 2003
    ..This study was undertaken to determine whether 7SK small nuclear RNA (snRNA), which has been proposed to function as an inhibitor of Tat cofactor P-TEFb, plays a role in transcriptional latency in T cells...
  16. pmc Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes
    Hongbing Liu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 80:7765-8. 2006
    ..Taken together, our data indicate that HIV-1 preferentially integrates within genes during untreated infection...

Research Grants20

  1. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2006
    ..This information may serve as the basis for developing novel strategies to reduce viral reservoirs. The reduction of viral reservoirs is likely to have therapeutic benefit in HIV-infected individuals. ..
  2. Regulation of Cyclin T1 Protein Expression- Macrophages
    Andrew Rice; Fiscal Year: 2006
    ..Completion of the proposed studies will provide new knowledge about HIV-1 replication in this important cell type and may suggest strategies for therapeutic intervention. ..
  3. Regulation of Cyclin T1 Protein Expression- Macrophages
    Andrew Rice; Fiscal Year: 2005
    ..Completion of the proposed studies will provide new knowledge about HIV-1 replication in this important cell type and may suggest strategies for therapeutic intervention. ..
  4. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2005
    ..This information may serve as the basis for developing novel strategies to reduce viral reservoirs. The reduction of viral reservoirs is likely to have therapeutic benefit in HIV-infected individuals. ..
  5. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2004
    ..This information may serve as the basis for developing novel strategies to reduce viral reservoirs. The reduction of viral reservoirs is likely to have therapeutic benefit in HIV-infected individuals. ..
  6. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2002
    ..The completion of the proposed research should provide insight into Tat and TAK and will be important background for future development of therapeutic strategies directed against Tat function. ..
  7. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2001
    ..The completion of the proposed research should provide insight into Tat and TAK and will be important background for future development of therapeutic strategies directed against Tat function. ..
  8. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 1999
    ..The completion of the proposed research should provide insight into Tat and TAK and will be important background for future development of therapeutic strategies directed against Tat function. ..
  9. HIV TAT ASSOCIATED KINASE
    Andrew Rice; Fiscal Year: 2000
    ..The completion of the proposed research should provide insight into Tat and TAK and will be important background for future development of therapeutic strategies directed against Tat function. ..
  10. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2003
    ..This information may serve as the basis for developing novel strategies to reduce viral reservoirs. The reduction of viral reservoirs is likely to have therapeutic benefit in HIV-infected individuals. ..
  11. Regulation of Cyclin T1 Protein Expression- Macrophages
    Andrew Rice; Fiscal Year: 2007
    ..Completion of the proposed studies will provide new knowledge about HIV-1 replication in this important cell type and may suggest strategies for therapeutic intervention. ..
  12. Mechanisms of HIV-1 latency in CD4+ T lymphocytes
    Andrew Rice; Fiscal Year: 2007
    ..This information may serve as the basis for developing novel strategies to reduce viral reservoirs. The reduction of viral reservoirs is likely to have therapeutic benefit in HIV-infected individuals. ..