DOODIPALA REDDY

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. pmc Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center College Station, TX, USA
    Front Endocrinol (Lausanne) 2:38. 2011
  2. doi Current pharmacotherapy of attention deficit hyperactivity disorder
    D S Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, Bryan, Texas, USA
    Drugs Today (Barc) 49:647-65. 2013
  3. pmc Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, MREB Building, Bryan, TX 77807, USA
    Int J Mol Sci 14:18284-318. 2013
  4. pmc Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis
    Xin Wu
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, Bryan, Texas 77807 3260, USA
    J Pharmacol Exp Ther 346:146-60. 2013
  5. doi The pathophysiological and pharmacological basis of current drug treatment of migraine headache
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, Medical Research and Education Building, Bryan, TX 77807, USA
    Expert Rev Clin Pharmacol 6:271-88. 2013
  6. pmc Neuroendocrine aspects of catamenial epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, 8447 State Highway 47, MREB Building, Bryan, TX 77807, USA
    Horm Behav 63:254-66. 2013
  7. pmc Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, Bryan, TX 77807, USA
    Epilepsy Behav 25:92-7. 2012
  8. pmc A mouse kindling model of perimenstrual catamenial epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, MREB Building Room 1005, Bryan, TX 77807 3260, USA
    J Pharmacol Exp Ther 341:784-93. 2012
  9. doi Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, Texas 77843, USA
    J Neurosci 31:650-8. 2011
  10. pmc Neurosteroids: endogenous role in the human brain and therapeutic potentials
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, TX, USA
    Prog Brain Res 186:113-37. 2010

Research Grants

  1. Progesterone Receptors and Seizure Susceptibility
    DOODIPALA REDDY; Fiscal Year: 2009
  2. Progesterone Receptors and Seizure Susceptibility
    Doodipala Samba Reddy; Fiscal Year: 2010

Collaborators

  • Michael A Rogawski
  • Omkaram Gangisetty
  • Xin Wu
  • Doodipala Samba Reddy
  • Chase Matthew Carver
  • G Ramanathan

Detail Information

Publications17

  1. pmc Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center College Station, TX, USA
    Front Endocrinol (Lausanne) 2:38. 2011
    ..Agents that stimulate endogenous production of neurosteroids may also be useful for treatment of epilepsy...
  2. doi Current pharmacotherapy of attention deficit hyperactivity disorder
    D S Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, Bryan, Texas, USA
    Drugs Today (Barc) 49:647-65. 2013
    ..Stimulants have a high potential for abuse and dependence, and should be handled safely to prevent misuse and abuse. ..
  3. pmc Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, MREB Building, Bryan, TX 77807, USA
    Int J Mol Sci 14:18284-318. 2013
    ..Novel mechanism-based or clinically relevant models are essential to identify new therapies for SE and neuroprotective interventions...
  4. pmc Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis
    Xin Wu
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, Bryan, Texas 77807 3260, USA
    J Pharmacol Exp Ther 346:146-60. 2013
    ..These findings may provide novel insight on molecular cascades of menstrual disorders like catamenial epilepsy, premenstrual syndrome, and migraine...
  5. doi The pathophysiological and pharmacological basis of current drug treatment of migraine headache
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, Medical Research and Education Building, Bryan, TX 77807, USA
    Expert Rev Clin Pharmacol 6:271-88. 2013
    ..New drugs with improved efficacy and reduced side effects are needed for effective treatment and prevention of migraine...
  6. pmc Neuroendocrine aspects of catamenial epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, 8447 State Highway 47, MREB Building, Bryan, TX 77807, USA
    Horm Behav 63:254-66. 2013
    ..Neurosteroid analogs with favorable profile may be useful in the treatment of catamenial epilepsy...
  7. pmc Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, Bryan, TX 77807, USA
    Epilepsy Behav 25:92-7. 2012
    ....
  8. pmc A mouse kindling model of perimenstrual catamenial epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, MREB Building Room 1005, Bryan, TX 77807 3260, USA
    J Pharmacol Exp Ther 341:784-93. 2012
    ....
  9. doi Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, Texas 77843, USA
    J Neurosci 31:650-8. 2011
    ..The PR pathway may represent a unique target for preventing or retarding epileptogenesis in females...
  10. pmc Neurosteroids: endogenous role in the human brain and therapeutic potentials
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, TX, USA
    Prog Brain Res 186:113-37. 2010
    ..Neurosteroidogenic agents that lack benzodiazepine-like side effects show promise in the treatment of anxiety and depression...
  11. pmc Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Neuropharmacology 59:573-81. 2010
    ....
  12. pmc The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, 228 Reynolds Medical Bldg, College Station, TX 77843 1114, USA
    J Pharmacol Exp Ther 334:1031-41. 2010
    ....
  13. pmc Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model
    Doodipala S Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M System Health Science Center, College Station, TX 77843 1114, USA
    Epilepsy Res 89:254-60. 2010
    ..1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, this study supports the utility of ganaxolone in the treatment of patients with temporal lobe seizures...
  14. pmc The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Epilepsy Res 85:1-30. 2009
    ..Synthetic neurosteroids, which enhance the tonic GABA-A receptor function, might provide an effective approach for the catamenial epilepsy therapy without producing hormonal side effects...
  15. pmc Neurosteroid replacement therapy for catamenial epilepsy
    Doodipala S Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M System Health Science Center, College Station, Texas 77843, USA
    Neurotherapeutics 6:392-401. 2009
    ..Positive allosteric modulatory neurosteroids and synthetic analogs such as ganaxolone may be administered to prevent catamenial seizure exacerbations, in what we call neurosteroid replacement therapy...
  16. pmc The optimization of TaqMan real-time RT-PCR assay for transcriptional profiling of GABA-A receptor subunit plasticity
    Omkaram Gangisetty
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M System Health Science Center, College Station, TX 77843 1114, USA
    J Neurosci Methods 181:58-66. 2009
    ....

Research Grants3

  1. Progesterone Receptors and Seizure Susceptibility
    DOODIPALA REDDY; Fiscal Year: 2009
    ....
  2. Progesterone Receptors and Seizure Susceptibility
    Doodipala Samba Reddy; Fiscal Year: 2010
    ....