A Rajkovic

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Plasma homocyst(e)ine concentrations in eclamptic and preeclamptic African women postpartum
    A Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 94:355-60. 1999
  2. ncbi request reprint Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe
    A Rajkovic
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA
    Mol Genet Metab 69:33-9. 2000
  3. ncbi request reprint NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:1157-9. 2004
  4. pmc Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival
    Youngsok Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 79:442-9. 2008
  5. ncbi request reprint Sohlh2 is a germ cell-specific bHLH transcription factor
    Daniel J Ballow
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 6:1014-8. 2006
  6. pmc Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:8090-5. 2006
  7. doi request reprint Expression and localization of the novel and highly conserved gametocyte-specific factor 1 during oogenesis and spermatogenesis
    Stephan P Krotz
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Fertil Steril 91:2020-4. 2009
  8. ncbi request reprint Transcriptional regulation of early oogenesis: in search of masters
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Hum Reprod Update 12:65-76. 2006
  9. ncbi request reprint Discovery of germ cell-specific transcripts by expressed sequence tag database analysis
    A Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 76:550-4. 2001
  10. ncbi request reprint Genetics of early mammalian folliculogenesis
    Y Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Faculty Center, 1709 Dryden Street, Suite 1100, Houston 77030, USA
    Cell Mol Life Sci 63:579-90. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Plasma homocyst(e)ine concentrations in eclamptic and preeclamptic African women postpartum
    A Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 94:355-60. 1999
    ..To examine the relationship between plasma homocyst(e)ine and risk of eclampsia and preeclampsia among sub-Saharan African women who delivered at Harare Maternity Hospital in Zimbabwe...
  2. ncbi request reprint Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe
    A Rajkovic
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA
    Mol Genet Metab 69:33-9. 2000
    ..Women with plasma folate concentrations less than 5.7 nmol/L experienced a 10. 4-fold increase in risk of preeclampsia. There was no clear pattern of preeclampsia risk and vitamin B(12) concentrations...
  3. ncbi request reprint NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:1157-9. 2004
    ..Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development...
  4. pmc Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival
    Youngsok Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 79:442-9. 2008
    ..Our findings show that Lhx8 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis, and it acts in part by downregulating the Nobox pathway...
  5. ncbi request reprint Sohlh2 is a germ cell-specific bHLH transcription factor
    Daniel J Ballow
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 6:1014-8. 2006
    ..SOHLH2 expression in testes is confined to spermatogonia. The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development...
  6. pmc Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:8090-5. 2006
    ..In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis...
  7. doi request reprint Expression and localization of the novel and highly conserved gametocyte-specific factor 1 during oogenesis and spermatogenesis
    Stephan P Krotz
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Fertil Steril 91:2020-4. 2009
    ..To determine the onset of gametocyte-specific factor 1 (Gtsf1) expression in embryogenesis and its relation to Nobox; and to determine its localization during gonadal development and gametocyte maturation...
  8. ncbi request reprint Transcriptional regulation of early oogenesis: in search of masters
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Hum Reprod Update 12:65-76. 2006
    ..Therefore, oocyte-specific transcription factors, and oocyte-specific genes regulated by such factors, are attractive tissue-specific pharmacological targets to regulate human fertility...
  9. ncbi request reprint Discovery of germ cell-specific transcripts by expressed sequence tag database analysis
    A Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 76:550-4. 2001
    ..CONCLUSION: We have shown that utilization of publicly available ESTs from murine EST libraries is a simple and rapid in silico approach to the identification of transcripts preferentially expressed in germ cells...
  10. ncbi request reprint Genetics of early mammalian folliculogenesis
    Y Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Faculty Center, 1709 Dryden Street, Suite 1100, Houston 77030, USA
    Cell Mol Life Sci 63:579-90. 2006
    ..Genes critical in early folliculogenesis are important determinants of reproductive life span and represent candidate genes for human ovarian failure...
  11. doi request reprint Placenta percreta at 7th week of pregnancy in a woman with previous caesarean section
    Janos L Tanyi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Obstet Gynaecol 28:338-40. 2008
  12. ncbi request reprint Microarray analyses of newborn mouse ovaries lacking Nobox
    Youngsok Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 77:312-9. 2007
    ..Our findings indicate that Nobox is likely an activator of oocyte-specific gene expression and suggest that the oocyte plays an important role in suppressing expression of male-determining genes, such as Dmrt1...
  13. ncbi request reprint Ovarian differentiation and gonadal failure
    J L Simpson
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Med Genet 89:186-200. 1999
    ..Identification, functional analysis, and mapping of novel genes specifically expressed in the ovary of mice and women eventually should lead to fruitful dissection of essential genes in mammalian ovarian development and maintenance...
  14. ncbi request reprint Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters
    Youngsok Choi
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:35747-56. 2006
    ..These results suggest that NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis...
  15. ncbi request reprint Obox, a family of homeobox genes preferentially expressed in germ cells
    Aleksandar Rajkovic
    Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 79:711-7. 2002
    ..The Obox1 and Obox2 genomic structures revealed the presence of six exons each. The Obox genes represent a new family of tissue-specific homeobox genes preferentially expressed in gonads...
  16. ncbi request reprint Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes
    Nobuhiro Suzumori
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 111:137-41. 2002
    ..In situ hybridization analysis demonstrates that Nobox mRNA is present in primordial and growing oocytes. Nobox is one of the first homeobox-encoding genes preferentially expressed during mammalian folliculogenesis...
  17. ncbi request reprint Sohlh1 is essential for spermatogonial differentiation
    D Ballow
    Faculty Center, Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Street, Suite 1100, Houston, TX 77030, USA
    Dev Biol 294:161-7. 2006
    ..Sohlh1 represents the first testis-specific bHLH transcription factor that is essential for spermatogonial differentiation...
  18. doi request reprint Recent developments in identifying genetic determinants of premature ovarian failure
    A Skillern
    Baylor College of Medicine, Department of Obstetrics and Gynecology, Houston, TX 77030, USA
    Sex Dev 2:228-43. 2008
    ..Here, we review recent developments in identifying genetic determinants of POF...
  19. ncbi request reprint Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 5:257-63. 2004
    ..The mouse Nohma gene is comprised of 15 exons and maps to chromosome 3. A human ortholog was also identified. The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis...
  20. ncbi request reprint Genetics of ovarian failure and development
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Semin Reprod Med 25:223-4. 2007
  21. doi request reprint MicroRNAs and mammalian ovarian development
    Han Zhao
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Semin Reprod Med 26:461-8. 2008
    ..The role of individual miRNAs in mammalian ovarian development is currently unknown and will remain an important focus for future investigations...
  22. ncbi request reprint The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 112:173-7. 2002
    ..We have identified the human ortholog, which maps to 19q13.4. These studies suggest that RFPL4 mediates protein degradation pathways important for gametogenesis or early embryonic development...
  23. pmc TEX14 is essential for intercellular bridges and fertility in male mice
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:4982-7. 2006
    ..Thus, TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility...
  24. ncbi request reprint Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 16:1168-84. 2002
    ....
  25. ncbi request reprint Expression of Drosophila neoplastic tumor suppressor genes discslarge, scribble, and lethal giant larvae in the mammalian ovary
    Julie H Y Huang
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Gene Expr Patterns 3:3-11. 2003
    ..Our data suggests that as in Drosophila, these tumor suppressors may cooperate during mammalian folliculogenesis, but also have distinct functions...
  26. ncbi request reprint Functional analysis of oocyte-expressed genes using transgenic models
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 187:5-9. 2002
    ..The combination of these identification approaches, coupled with the use of knockout mice, will lead to many future functional studies of genes uniquely devoted to oogenesis and folliculogenesis...
  27. ncbi request reprint Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development
    Emese Gazdag
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, CNRS, INSERM, ULP, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
    Reproduction 134:51-62. 2007
    ..Moreover, our results obtained with oocytes lacking the oocyte-specific nuclear chaperone nucleoplasmin 2 suggest that TBP2 function may be related to non-condensed chromatin conformation...
  28. pmc Analysis of LHX8 mutation in premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
    Fertil Steril 89:1012-4. 2008
    ..1787A>G) of the LHX8 gene. These polymorphisms also were found in controls (n = 94), at frequencies that were not statistically different from those in POF women. Mutations in the LHX8 exons are uncommon in Caucasian women with POF...
  29. ncbi request reprint Candidate genes for premature ovarian failure
    Nobuhiro Suzumori
    Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, 1 Kawasumi, Nagoya 467 8601, Japan
    Curr Med Chem 14:353-7. 2007
    ..Studies in animal models provide new candidate genes for ovarian failure in humans...
  30. pmc NOBOX homeobox mutation causes premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Shandong Provincial Hospital of Shandong University, Jinan, China
    Am J Hum Genet 81:576-81. 2007
    ..Arg355His, disrupted NOBOX homeodomain binding to NOBOX DNA-binding element (NBE) and had a dominant negative effect on the binding of wild-type NOBOX to DNA. Our findings demonstrate that NOBOX mutations can cause POF...