Hui-Qi Qu

Summary

Affiliation: University of Texas School of Public Health

Publications

  1. doi A cis-acting regulatory variant in the IL2RA locus
    Hui Qi Qu
    Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
    J Immunol 183:5158-62. 2009
  2. pmc Adiponectin/leptin ratio and metabolic syndrome in a Mexican American population
    Shaper Mirza
    University of Texas Health Science Center atHouston, School of Public Health, Brownsville Campus, USA
    Clin Invest Med 34:E290. 2011
  3. doi Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
  4. pmc The effect of the MHC locus on autoantibodies in type 1 diabetes
    H Q Qu
    J Med Genet 46:469-71. 2009
  5. pmc Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies
    H Q Qu
    J Med Genet 46:553-4. 2009
  6. pmc From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes
    Zhi Wei
    Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS Genet 5:e1000678. 2009
  7. pmc Remapping the type I diabetes association of the CTLA4 locus
    H Q Qu
    Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    Genes Immun 10:S27-32. 2009
  8. pmc The type I diabetes association of the IL2RA locus
    H Q Qu
    Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, 2300 Tupper, Montreal, Quebec, Canada
    Genes Immun 10:S42-8. 2009
  9. pmc Reassessment of the type I diabetes association of the OAS1 locus
    H Q Qu
    Department of Pediatrics, McGill University, 23 Tupper, Montreal, Quebec, Canada
    Genes Immun 10:S69-73. 2009
  10. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010

Collaborators

Detail Information

Publications45

  1. doi A cis-acting regulatory variant in the IL2RA locus
    Hui Qi Qu
    Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
    J Immunol 183:5158-62. 2009
    ....
  2. pmc Adiponectin/leptin ratio and metabolic syndrome in a Mexican American population
    Shaper Mirza
    University of Texas Health Science Center atHouston, School of Public Health, Brownsville Campus, USA
    Clin Invest Med 34:E290. 2011
    ..Adiponectin and leptin play critical roles in the development of Metabolic Syndrome (MetS). This study was designed to assess the feasibility of using circulating levels of adiponectin and leptin for the early diagnosis of MetS...
  3. doi Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
    ..The low cost associated with a pooling-based GWAS clearly justifies its use in screening for genetic determinants of complex diseases...
  4. pmc The effect of the MHC locus on autoantibodies in type 1 diabetes
    H Q Qu
    J Med Genet 46:469-71. 2009
    ..To investigate whether the presence of autoantibodies specific for type 1 diabetes (T1D) is determined by the major genetic susceptibility locus for the disease at the HLA genes, using the T1D Genetics Consortium data...
  5. pmc Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies
    H Q Qu
    J Med Genet 46:553-4. 2009
    ....
  6. pmc From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes
    Zhi Wei
    Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS Genet 5:e1000678. 2009
    ..We are optimistic that genotype-based disease risk assessment may be feasible for diseases where a notable proportion of the risk has already been captured by SNP arrays...
  7. pmc Remapping the type I diabetes association of the CTLA4 locus
    H Q Qu
    Department of Pediatrics, McGill University, Montreal, Quebec, Canada
    Genes Immun 10:S27-32. 2009
    ..Comprehensive resequencing and fine mapping of the CTLA4 region are still needed to clarify the causal variants...
  8. pmc The type I diabetes association of the IL2RA locus
    H Q Qu
    Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, 2300 Tupper, Montreal, Quebec, Canada
    Genes Immun 10:S42-8. 2009
    ..Instead, the most significant independent effect was detected from the 5' flanking IL2RA SNP rs4749955, which remained significant after regression for H5. Thus, we confirm independent effects at the IL2RA locus...
  9. pmc Reassessment of the type I diabetes association of the OAS1 locus
    H Q Qu
    Department of Pediatrics, McGill University, 23 Tupper, Montreal, Quebec, Canada
    Genes Immun 10:S69-73. 2009
    ..Extended LD in populations earlier examined may account for the prior observation of an association of T1D with OAS1 variants. This possibility needs to be addressed further by fine mapping of the T1D association represented in 12q24...
  10. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
    ..These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes...
  11. pmc Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas
    Hui Qi Qu
    Montreal Children s Hospital, 2300 Tupper, Montreal, Que, Canada, H3H 1P3
    Neuro Oncol 12:153-63. 2010
    ..It further shows that, despite commonalities in a few CNAs, pGBM and aGBMs are two different diseases...
  12. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ....
  13. ncbi In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium
    Hui Qi Qu
    Department of Pediatrics, McGill University, Montreal, QC, Canada H4H 2P4
    Hum Mol Genet 19:2534-8. 2010
    ..This study replicated T1D association with at least as many of these novel loci as expected from the power of our sample size, thus supporting the validity of the new discoveries...
  14. pmc Statistical significance in genetic association studies
    Hui Qi Qu
    Clin Invest Med 33:E266-70. 2010
  15. pmc Knowledge gaining by human genetic studies on tuberculosis susceptibility
    Hui Qi Qu
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Brownsville, Texas 78520, USA
    J Hum Genet 56:177-82. 2011
    ....
  16. pmc Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases
    Hui Qi Qu
    University of Texas Health Science Center at Houston, School of Public Health, Brownsville Campus, 80 Fort Brown, SPH Bldg, Brownsville, Texas 78520, USA
    Int J Infect Dis 15:e305-13. 2011
    ..Mutations in the interleukin-12 (IL-12) signaling genes have phenotypes with non-specificity. Current studies highlight a complex molecular network in antimycobacterial immunity, centered on IFN-γ signaling...
  17. pmc Prevalence of metabolic syndrome and risks of abnormal serum alanine aminotransferase in Hispanics: a population-based study
    Jen Jung Pan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e21515. 2011
    ..Study the prevalence of metabolic syndrome (MS) and risk factors for and association with elevated alanine aminotransferase (ALT) as markers of hepatic injury in a large Hispanic health disparity cohort with high rates of obesity...
  18. pmc Decreased expression of ATP6V1H in type 2 diabetes: a pilot report on the diabetes risk study in Mexican Americans
    Melanie F Molina
    Division of Epidemiology, Human Genetics and Environmental Sciences, Brownsville Regional Campus, The University of Texas School of Public Health, Brownsville, TX, USA
    Biochem Biophys Res Commun 412:728-31. 2011
    ..Previous studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes...
  19. pmc Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:290-5. 2009
    ....
  20. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    ..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L...
  21. pmc Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms
    Hui Qi Qu
    Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
    BMC Genomics 7:213. 2006
    ..Here we studied asymmetry of human synonymous SNPs (sSNPs) in the fourfold degenerate (FFD) sites as compared to intronic SNPs (iSNPs)...
  22. ncbi Lack of association of type 1 diabetes with the IL4R gene
    H Q Qu
    Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
    Diabetologia 49:958-61. 2006
    ..The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background...
  23. pmc Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?
    M C Tessier
    Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
    J Med Genet 43:129-32. 2006
    ..Recently, the minor allele of an OAS1 single nucleotide polymorphism (SNP) that alters splicing (rs10774671) was found to be associated with increased enzymatic activity and, in a case-sibling control study, with type 1 diabetes (T1D)...
  24. pmc Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study
    H Qu
    J Med Genet 42:266-70. 2005
  25. ncbi Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
    Huiqi Qu
    Nat Genet 37:111-2; author reply 112-3. 2005
  26. ncbi Allele A in intron 4 of ecNOS gene will not increase the risk of diabetic nephropathy in type 2 diabetes of Chinese population
    Shan Lin
    Nephron 91:768. 2002
  27. ncbi [Meta-analysis on the association of ACE/ID polymorphism and essential hypertension in Chinese population]
    H Qu
    Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China
    Zhonghua Yu Fang Yi Xue Za Zhi 35:408-11. 2001
    ..To study on the association of the insertion(I)/deletion(D) polymorphism of the angiotensin-converting enzyme gene intron 16 (ACE/ID) and essential hypertension(EH) in Chinese population by the means of meta-analysis...
  28. ncbi Restless legs syndrome (RLS) in uremic patients is related to the frequency of hemodialysis sessions
    Q Huiqi
    Nephron 86:540. 2000
  29. ncbi No association of type 1 diabetes with a functional polymorphism of the LRAP gene
    Hui Qi Qu
    Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, 2300 Tupper, Montreal, Que H3H 1P3, Canada
    Mol Immunol 44:2135-8. 2007
    ..This study was designed to confirm that LRAP expression in B-cell derived lines is controlled by a haplotype marked by rs2762 and to see whether this would be the basis of an association with type 1 diabetes (T1D)...
  30. ncbi Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, QC, Canada
    Diabetes 56:270-5. 2007
    ....
  31. doi The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II
    H Q Qu
    Endocrine Genetics Lab, The McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
    Genes Immun 9:264-6. 2008
    ..Conditional regression showed that all of the ITPR3 SNP T1D association could be accounted for by the DQB1 effect. Therefore, our findings do not support an obvious role of genetic variation of the ITPR3 gene in T1D risk...
  32. doi A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Diabetes 57:1143-6. 2008
    ..03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results of testing, in these additional cohorts, 23 loci that were next in rank of statistical significance...
  33. ncbi The association between the IFIH1 locus and type 1 diabetes
    H Q Qu
    Endocrine Genetics Lab, The McGill University Health Center Montreal Children s Hospital, 2300 Tupper, Montreal, QC, Canada, H3H 1P3
    Diabetologia 51:473-5. 2008
    ..We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent...
  34. pmc The TCF7L2 locus and type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Lab, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
    BMC Med Genet 8:51. 2007
    ..This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D)...
  35. ncbi A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 448:591-4. 2007
    ..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
  36. pmc The IRF5 polymorphism in type 1 diabetes
    Hui Qi Qu
    J Med Genet 44:670-2. 2007
    ..Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D...
  37. ncbi A common variant of the PAX2 gene is associated with reduced newborn kidney size
    Jacklyn Quinlan
    Montreal Children s Hospital Research Institute, 4060 Saint Catherine West, PT 413, Montreal, Quebec, Canada
    J Am Soc Nephrol 18:1915-21. 2007
    ..Subtle renal hypoplasia in normal newborns may be partially due to a common variant of the PAX2 gene that reduces mRNA expression during kidney development...
  38. ncbi Toward further mapping of the association between the IL2RA locus and type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Laboratory, McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
    Diabetes 56:1174-6. 2007
    ....
  39. pmc A case report of syndrome of inappropriate antidiuretic hormone secretion with Castleman's disease and lymphoma
    Chong Gui Zhu
    Department of Endocrinology, Tianjin Medical University General Hospital, No 154 Anshan Road, Heping District, Tianjin, 300052, China
    BMC Endocr Disord 13:19. 2013
    ..In this report, we described both Castleman's disease and lymphoma coexisting in one patient with SIADH...
  40. pmc Human coding synonymous single nucleotide polymorphisms at ramp regions of mRNA translation
    Quan Li
    Endocrine Genetics Lab, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
    PLoS ONE 8:e59706. 2013
    ..The distribution bias of sSNPs in human genome, i.e. frequent SCs to less frequent SCs is favored in the 3(rd) ~50(th) codons, indicates translational selection on sSNPs in the ramp regions of mRNA templates...
  41. pmc Ancestral effect on HOMA-IR levels quantitated in an American population of Mexican origin
    Hui Qi Qu
    The University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA
    Diabetes Care 35:2591-3. 2012
    ..We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR...
  42. pmc Population-based risk factors for elevated alanine aminotransferase in a South Texas Mexican-American population
    Hui Qi Qu
    University of Texas School of Public Health, Brownsville, Texas, USA
    Arch Med Res 43:482-8. 2012
    ..We aimed to identify and stratify risk factors associated with elevated ALT in a randomly selected population with a high prevalence of elevated ALT (39%), obesity (49%) and diabetes (30%)...
  43. pmc PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population
    Quan Li
    The University of Texas School of Public Health, Brownsville, TX 78520, USA
    Clin Invest Med 35:E237-45. 2012
    ....
  44. pmc Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetes
    H Q Qu
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA
    Int J Tuberc Lung Dis 16:370-2. 2012
    ..To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility...