DARWIN JOHNSON PROCKOP

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. pmc Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms
    Darwin J Prockop
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine, Scott and White Hospital, Temple, Texas 76502 6954, USA
    Mol Ther 17:939-46. 2009
  2. pmc Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)
    Darwin J Prockop
    Texas A and M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    J Cell Mol Med 14:2190-9. 2010
  3. pmc Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease
    Brooke R Snyder
    Yerkes National Primate Research Center, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9347. 2010
  4. pmc Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells
    Gregory J Block
    Institute for Regenerative Medicine at Scott and White Hospital, Texas A and M Health Sciences Center, Temple, Texas, United States of America
    PLoS ONE 5:e10237. 2010
  5. pmc Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea
    Joo Youn Oh
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, TX, USA
    EMBO Mol Med 4:435-48. 2012
  6. pmc Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs
    Andrea M Foskett
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, 5701 Airport Rd, Module C, Temple, TX 76502
    Am J Physiol Lung Cell Mol Physiol 306:L120-31. 2014
  7. pmc Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Neuroinflammation 9:59. 2012
  8. doi request reprint Mitochondria to the rescue
    Darwin J Prockop
    Texas A and M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott and White, Temple, USA
    Nat Med 18:653-4. 2012
  9. pmc Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations
    Darwin J Prockop
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, Texas 76502, USA
    J Cell Biochem 113:1460-9. 2012
  10. pmc Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation
    Darwin J Prockop
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, Texas 76502, USA
    Mol Ther 20:14-20. 2012

Research Grants

  1. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2001
  2. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2005
  3. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2006
  4. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2006
  5. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2007
  6. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2006
  7. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2006
  8. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2006
  9. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2005
  10. Adult Stem Cells for Repair of Cardiac Damage
    DARWIN JOHNSON PROCKOP; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. pmc Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms
    Darwin J Prockop
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine, Scott and White Hospital, Temple, Texas 76502 6954, USA
    Mol Ther 17:939-46. 2009
    ..Some of these issues will be reviewed in this study with special emphasis on how they can be applied to the adult stem/progenitor cells from bone marrow, referred to as MSCs...
  2. pmc Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)
    Darwin J Prockop
    Texas A and M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    J Cell Mol Med 14:2190-9. 2010
    ....
  3. pmc Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease
    Brooke R Snyder
    Yerkes National Primate Research Center, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9347. 2010
    ..We hypothesized that hMSCs would be beneficial in a mouse model of Huntington disease (HD) due to these neurogenic effects...
  4. pmc Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells
    Gregory J Block
    Institute for Regenerative Medicine at Scott and White Hospital, Texas A and M Health Sciences Center, Temple, Texas, United States of America
    PLoS ONE 5:e10237. 2010
    ..In particular, extracellular ATP has been reported to be critical for the epithelial cell response to stress and has recently been shown to be upregulated in tumors in vivo...
  5. pmc Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea
    Joo Youn Oh
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, TX, USA
    EMBO Mol Med 4:435-48. 2012
    ..Therefore, our data identified the HSPB4/TLR2/NF-κB axis in macrophages as an effective target for therapy of corneal inflammation...
  6. pmc Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs
    Andrea M Foskett
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, 5701 Airport Rd, Module C, Temple, TX 76502
    Am J Physiol Lung Cell Mol Physiol 306:L120-31. 2014
    ..Similar phase-directed strategy with TSG-6 or other therapeutic factors that MSCs produce may be useful for other lung diseases and diseases of other organs. ..
  7. pmc Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    Jingsheng Tuo
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Neuroinflammation 9:59. 2012
    ..In this study, we evaluated the effect of an intravitreous injection of recombinant TSG-6 on the retinal lesions of Ccl2-/-/Cx3cr1-/- mice...
  8. doi request reprint Mitochondria to the rescue
    Darwin J Prockop
    Texas A and M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott and White, Temple, USA
    Nat Med 18:653-4. 2012
    ..This suggests that rescue of injured cells through mitochondrial transfer may be an important process in many diseases...
  9. pmc Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations
    Darwin J Prockop
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, Texas 76502, USA
    J Cell Biochem 113:1460-9. 2012
    ..This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs...
  10. pmc Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation
    Darwin J Prockop
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, Texas 76502, USA
    Mol Ther 20:14-20. 2012
    ..There are also suggestions that MSCs may produce anti-inflammatory effects through additional modes of action including activation to express the antireactive oxygen species protein stanniocalcin-1...
  11. pmc Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6
    Svitlana Danchuk
    Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Stem Cell Res Ther 2:27. 2011
    ..Recent studies have demonstrated the ability of MSCs to attenuate inflammation in rodent models of acute lung injury (ALI) suggesting that MSCs may also be beneficial in treating ALI...
  12. pmc Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs)
    Suzanne Zeitouni
    Center for Gene Therapy, Tulane University Medical School, New Orleans, LA, 70115, USA
    BMC Biotechnol 8:75. 2008
    ..Therefore human MSCs (hMSCs) are a promising vector for the administration of ApoE epsilon3 in humans...
  13. doi request reprint Defining the risks of mesenchymal stromal cell therapy
    Darwin J Prockop
    Texas A and M Health Science College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Cytotherapy 12:576-8. 2010
    ....
  14. pmc Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties
    Thomas J Bartosh
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Proc Natl Acad Sci U S A 107:13724-9. 2010
    ....

Research Grants28

  1. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2001
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  2. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2005
    ..3) Develop an in vivo assay for engraftment and differentiation of hMSCs to sites of tissue injury in lung. (4) Identify the properties of hMSCs that enhance their engraftment to specific sites of tissue injury in lung. ..
  3. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2006
    ..abstract_text> ..
  4. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2006
    ..abstract_text> ..
  5. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2007
    ..abstract_text> ..
  6. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2006
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  7. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2006
    ..3) Develop an in vivo assay for engraftment and differentiation of hMSCs to sites of tissue injury in lung. (4) Identify the properties of hMSCs that enhance their engraftment to specific sites of tissue injury in lung. ..
  8. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2006
    ..abstract_text> ..
  9. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2005
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  10. Adult Stem Cells for Repair of Cardiac Damage
    DARWIN JOHNSON PROCKOP; Fiscal Year: 2010
    ..The present application is to extend this work and to capitalize an unexpected discovery that it may justify infusing therapeutic intravenously, a much more attractive route for therapy than injection into the heart. ..
  11. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2004
    ..abstract_text> ..
  12. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2003
    ..abstract_text> ..
  13. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2002
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  14. Adult Stem Cells for Repair of Cardiac Damage
    Darwin Prockop; Fiscal Year: 2003
    ..abstract_text> ..
  15. Preparation and Distribution of Adult Stem Cells
    DARWIN JOHNSON PROCKOP; Fiscal Year: 2010
    ..The need for experiments with fully characterized MSCs has become critical with the current efforts by us and others to initiate Phase I and Phase II clinical trials with MSCs. ..
  16. Preparation and Distribution of Adult Stem Cells
    Darwin Prockop; Fiscal Year: 2009
    ..The need for experiments with fully characterized MSCs has become critical with the current efforts by us and others to initiate Phase I and Phase II clinical trials with MSCs. ..
  17. Adult Stem Cells for Repair of Cardiac Damage
    Darwin Prockop; Fiscal Year: 2009
    ..The present application is to extend this work and to capitalize an unexpected discovery that it may justify infusing therapeutic intravenously, a much more attractive route for therapy than injection into the heart. ..
  18. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2003
    ..3) Develop an in vivo assay for engraftment and differentiation of hMSCs to sites of tissue injury in lung. (4) Identify the properties of hMSCs that enhance their engraftment to specific sites of tissue injury in lung. ..
  19. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2006
    ..abstract_text> ..
  20. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2003
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  21. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2006
    ..3) Develop an in vivo assay for engraftment and differentiation of hMSCs to sites of tissue injury in lung. (4) Identify the properties of hMSCs that enhance their engraftment to specific sites of tissue injury in lung. ..
  22. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2004
    ..abstract_text> ..
  23. Osteoprogenitors for Potential Therapy of OI
    Darwin Prockop; Fiscal Year: 2004
    ..4) Determine the feasibility of correcting the gene defect in a patients own RS cells, (a) by overexpression of a cDNA for the wildtype COL I A I gene, or (b) by replacing a mutated COLlAl gene by homologous recombination. ..
  24. Culture and Lung Engraftment of Mesenchymal Stem Cells
    Darwin Prockop; Fiscal Year: 2004
    ..3) Develop an in vivo assay for engraftment and differentiation of hMSCs to sites of tissue injury in lung. (4) Identify the properties of hMSCs that enhance their engraftment to specific sites of tissue injury in lung. ..
  25. PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS
    Darwin Prockop; Fiscal Year: 2005
    ..abstract_text> ..
  26. Adult Stem Cells for Repair Cardiac Damage
    Darwin Prockop; Fiscal Year: 2005
    ..abstract_text> ..