Research Topics
| V N PotamanSummaryAffiliation: Texas A and M University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Stabilization of intramolecular triple/single-strand structure by cationic peptidesV N Potaman
Institute of Biosciences and Technology, Texas A and M University, Houston 77030 3303, USA
Biochemistry 37:12952-61. 1998..It is possible that Arg-rich peptides interact with the unpaired single strand in H-DNA and stabilize its unpaired conformation...
Overcoming a barrier for DNA polymerization in triplex-forming sequencesV N Potaman
Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
Nucleic Acids Res 27:e5. 1999..The described approach is potentially useful for sequencing and analysis of chemical adducts and point mutations in a variety of sequences prone to the formation of folded structures, such as long hairpins and quadruplexes...- Applications of triple-stranded nucleic acid structures to DNA purification, detection and analysisVladimir N Potaman
Institute of Biosciences and Technology, Texas A and M University Health Sciences Center, Houston 77030 3303, USA
Expert Rev Mol Diagn 3:481-96. 2003..Adaptations of triplex methodology to molecular diagnostics (DNA purification, detection and analysis) are reviewed in greater detail... - Site-specific labeling of supercoiled DNA at the A+T rich sequencesVladimir N Potaman
Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston, Texas 77030 3303, USA
Biochemistry 41:13198-206. 2002..Site-specific oligonucleotide reactions with DNA may also have application in biotechnology and gene therapy... - Involvement of the nucleotide excision repair protein UvrA in instability of CAG*CTG repeat sequences in Escherichia coliE A Oussatcheva
Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
J Biol Chem 276:30878-84. 2001..These results imply a more comprehensive role for UvrA, in addition to the recognition of DNA damage, in maintaining the integrity of the genome... - Length-dependent structure formation in Friedreich ataxia (GAA)n*(TTC)n repeats at neutral pHV N Potaman
Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston, TX 77030, USA
Nucleic Acids Res 32:1224-31. 2004..At the premutation repeat length (n = 42) and higher negative supercoiling, the formation of a single H-DNA structure becomes less favorable and the data are consistent with the formation of a bi-triplex structure... - Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeatsVladimir N Potaman
Laboratory of DNA Structure and Function, Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, Houston, TX 77030-3303, USA
J Mol Biol 326:1095-111. 2003..A model is proposed in which unscheduled or aberrant DNA replication is a critical step in the expansion mutation... - Site-specific labeling of supercoiled DNAAlexander Y Lushnikov
Department of Pharmaceutical Sciences, College of Pharmacy University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA
Nucleic Acids Res 34:e111. 2006..The complex is relatively stable at low and high pH (pH 5 and 9) making the developed approach attractive for use at conditions requiring the pH change... - DNA strand arrangement within the SfiI-DNA complex: atomic force microscopy analysisAlexander Y Lushnikov
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, USA
Biochemistry 45:152-8. 2006..This suggests no preferential orientation of the DNA cognate site within the complex, suggesting that the central part of the DNA binding site does not form strong sequence specific contacts with the protein... - Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpinsVladimir N Potaman
Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
J Mol Biol 348:609-15. 2005..Furthermore, our data indicate that PARP-1 can interact with the gene regulatory sequences by binding to the promoter-localized cruciforms... - Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific bindingIrina Lonskaya
Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D C 20057, USA
J Biol Chem 280:17076-83. 2005..These data suggest a link between PARP-1 binding to non-B DNA structures in genome and its function in the dynamics of local modulation of chromatin structure in the normal physiology of the cell... - Interaction of the Zalpha domain of human ADAR1 with a negatively supercoiled plasmid visualized by atomic force microscopyAlexander Y Lushnikov
School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
Nucleic Acids Res 32:4704-12. 2004..These results indicate that Zalpha(ADAR1) binding facilities the B-to-Z transition and provides additional support to the model that Z-DNA binding proteins may regulate biological processes through structure-specific recognition... - Supercoiling-induced DNA bendingJeffrey W Pavlicek
School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA
Biochemistry 43:10664-8. 2004..This is consistent with increased helical distortion at an apical bend... - Influence of global DNA topology on cruciform formation in supercoiled DNAElena A Oussatcheva
Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA
J Mol Biol 338:735-43. 2004..As structural transitions can be involved in biological processes, localization of alternative conformation-forming sequences to specific locations within a domain provides an additional means for gene regulation... - Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNARichard R Sinden
Laboratory of DNA Structure and Mutagenesis, Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Sciences Center, 2121 West Holcombe Blvd, Houston, TX 77030 3303, USA
J Biosci 27:53-65. 2002..The remarkable stability of slipped strand DNA may, in part, be due to loop-loop interactions facilitated by the sequence complementarity of the loops and the dynamic structure of three-way junctions formed at the loop-outs... - Intersegmental interactions in supercoiled DNA: atomic force microscope studyLuda S Shlyakhtenko
Department of Microbiology, Arizona State University, Tempe, AZ 85287, USA
Ultramicroscopy 97:263-70. 2003..Implications of the observed effect for understanding DNA compaction in the cell and for regulation DNA transactions via interaction of distantly separated DNA regions are discussed... - Slipped strand DNA structuresRichard R Sinden
Laboratory of DNA Structure and Mutagenesis, Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901 6975, USA
Front Biosci 12:4788-99. 2007..This alternative DNA structure, or a similar slipped intermediate DNA that may form during DNA replication or repair, may be a causative factor in the instability of the DNA sequences that can form these structures... - Transcriptional repression by binding of poly(ADP-ribose) polymerase to promoter sequencesViatcheslav A Soldatenkov
Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
J Biol Chem 277:665-70. 2002..These data provide support for PARP protein as a potent regulator of transcription including down-regulation of its own promoter...