Research Topics
| PEDRO PIEDRASummaryAffiliation: Texas Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in childrenPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX 77030, USA
Vaccine 23:1540-8. 2005..Vaccination of approximately 20-25% of children, 1.5-18 years of age in the intervention communities resulted in an indirect protection of 8-18% against MAARI in adults > or =35 years of age...
Live attenuated influenza vaccine, trivalent, is safe in healthy children 18 months to 4 years, 5 to 9 years, and 10 to 18 years of age in a community-based, nonrandomized, open-label trialPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatrics 116:e397-407. 2005....- Immunopathogenesis of respiratory syncytial virus bronchiolitisBerkeley L Bennett
Department of Pediatrics, Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Infect Dis 195:1532-40. 2007..The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis... - Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in childrenPedro A Piedra
Baylor College of Medicine, Department of Molecular Virology and Microbiology, Room 248E, One Baylor Plaza, Houston, TX 77030, USA
Pediatrics 120:e553-64. 2007..The objective of this study was to determine the effectiveness of influenza vaccines for healthy school-aged children when administered during the influenza outbreak... - Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodiesPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
Vaccine 21:3479-82. 2003..To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages... - Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosisPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Vaccine 21:2448-60. 2003..After 28 days post-vaccination, Nt Ab and Bd Ab to F protein titers declined slowly at rates of 0.23 and 0.37 log2 per month, respectively. The PFP-3 vaccine-induced a robust immune response that lasted throughout the RSV season... 
Effects of oseltamivir on influenza-related complications in children with chronic medical conditionsPedro A Piedra
Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatrics 124:170-8. 2009..This study investigated the influence of oseltamivir on influenza-related complications and hospitalizations for children and adolescents, 1 to 17 years of age, with chronic medical conditions or neurologic or neuromuscular disease...- Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged childrenPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatrics 110:662-72. 2002..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children... - Future directions in vaccine prevention of respiratory syncytial virusPedro A Piedra
Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
Pediatr Infect Dis J 21:482-7. 2002 - Safety of the trivalent, cold-adapted influenza vaccine (CAIV-T) in childrenPedro A Piedra
Department of Molecular Virology and Microbiology, Rm 248E, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Semin Pediatr Infect Dis 13:90-6. 2002..CAIV-T did not cause an increase in healthcare utilization. Thus CAIV-T is safe in healthy children and should complement the use of inactivated influenza vaccine, trivalent (IIV-T) in children with underlying chronic conditions... - T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infectionDeepthi Kolli
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
J Virol 82:8560-9. 2008..Whether these findings have implications for naturally acquired human infections remains to be determined... - Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy childrenManjusha J Gaglani
Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
Arch Pediatr Adolesc Med 158:65-73. 2004.... - Human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosisDaniel F Garcia
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Pediatr Pulmonol 42:66-74. 2007..Its epidemiology remains to be defined in children with cystic fibrosis (CF). We describe the epidemiology and clinical impact of hMPV in CF children and compared it to respiratory syncytial virus (RSV)... - LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severityFederico R Laham
Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
Pediatrics 125:e225-33. 2010.... - Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccinesPhilip R Wyde
Department of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Antiviral Res 66:57-66. 2005.... - Direct and indirect effectiveness of influenza vaccination delivered to children at school preceding an epidemic caused by 3 new influenza virus variantsW Paul Glezen
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Infect Dis 202:1626-33. 2010..This field trial examines the effectiveness of school-based clinics for vaccine delivery before an epidemic caused by 3 new influenza virus variants not contained in the vaccine... - Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responsesPatricia Yotnda
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Ther 5:233-41. 2002.... - Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assaysPhilip R Wyde
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Antiviral Res 63:51-9. 2004..Interestingly, NMSO3, but not heparin, was able to limit secondary infection and spread of both viruses... - Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitroPhilip R Wyde
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Antiviral Res 60:51-9. 2003..v.IG utilized were found to have equivalent antiviral activity against hMPV and hRSV. In contrast, except for antisera specifically raised against hMPV, all of the other materials tested had marked activity only against hRSV... - Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant womenFlor M Munoz
Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Influenza Reseach Center, One Baylor Plaza Suite 221 D, MS BCM 280, Houston, TX 77030, USA
Vaccine 21:3465-7. 2003..infants of placebo recipients. Vaccine specific anti-F IgA and IgG concentrations in breast milk were higher in mothers who received RSV-PFP-2... - Clinical experience with respiratory syncytial virus vaccinesPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Pediatr Infect Dis J 22:S94-9. 2003.... - The search for adenovirus 14 in children in Houston, TexasFederico R Laham
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
Pediatr Infect Dis J 27:653-4. 2008..None were Ad14; Ad1, Ad2, and Ad3 were the most common identified serotypes... - Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboonsNuria Morral
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 13:143-54. 2002..Extensive histological studies provide a detailed picture of the pathology associated with a lethal dose of first-generation adenoviral vector in a primate... - Respiratory viral infections in patients with chronic, obstructive pulmonary diseaseJ David Beckham
Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, One Baylor Plaza, Houston, TX 77030, USA
J Infect 50:322-30. 2005..CONCLUSIONS: Respiratory viral infections are commonly associated with acute respiratory illness in COPD patients, and the use of RT-PCR assays significantly increases the ability to diagnose these infections... - Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with intermittent wheezing in an open-label field trialManjusha J Gaglani
Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center College of Medicine, Temple, TX 76508, USA
Pediatr Infect Dis J 27:444-52. 2008..Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with asthma is unknown. A previous report showed an "asthma signal" in children aged 18-35 months... - Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applicationsAnn M Leen
Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin S, MC 3-3320, Houston, TX 77030, USA
Blood 103:1011-9. 2004..This is the first report of a simple and reproducible method to activate and expand Ad-specific cytotoxic T lymphocytes (CTLs), which should be protective against the range of different Ad subtypes that affect transplant recipients... - Societal and economic consequences of influenzaPedro A Piedra
Department of Molecular Virology, Microbiology, and Pediatrics, Baylor College of Medicine, USA
Manag Care 17:8-14. 2008..More focused and effective influenza prevention strategies are necessary to improve quality of life and to limit the burden of flu complications... 
Rotavirus antigenemia in children is associated with viremiaSarah E Blutt
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Med 4:e121. 2007..We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia...- Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cellsAnn M Leen
Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin St, MC 3-3320, Houston, TX, USA
Blood 104:2432-40. 2004..Thus, by exploiting these peptide targets, it is possible to prepare a T-cell population capable of reacting with most adenoviruses that cause disease in immunocompromised patients... - Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004M Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Vaccine 25:4038-45. 2007..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza... - Safety of cold-adapted live influenza vaccineW Paul Glezen
Pediatr Infect Dis J 23:593-4; author reply 594. 2004 - Immunization against viral respiratory disease: a reviewHarry B Greenberg
Department of Medicine and Microbiology and Immunology, Stanford University School of Medicine, CA, USA
Pediatr Infect Dis J 23:S254-61. 2004..Research should continue into safe and effective vaccines for all childhood viral illnesses... - Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance culturesM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 158:305-11. 2003..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies... - Cost-effectiveness of live-attenuated influenza vaccine, trivalent in preventing influenza in young children attending day-care centresClare L Hibbert
RTI Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, United Kingdom
Vaccine 25:8010-20. 2007..2%; placebo, 13.4%), vaccination saved US$ 5.47 per child in societal costs. In the high attack-rate season (vaccinated, 4.7%; placebo, 32.1%), vaccination led to a societal costs savings of US$ 144.44 per child... - Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in childrenYae-Jean Kim
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
J Clin Microbiol 41:4594-9. 2003..In conclusion, the data confirm that Ad3 genome types are more diverse than those of Ad7 and suggest that shifts of genome types may occur during successive outbreaks of Ad3 and Ad7... - Adenovirus in the neonatal intensive care unit: formidable, forgotten foePedro A Piedra
J Pediatr 146:447-8. 2005
Research Grants
- CONTROL OF EPIDEMIC INFLUENZAPEDRO PIEDRA; Fiscal Year: 2007..abstract_text> ..