PEDRO PIEDRA

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
    Vaccine 21:3479-82. 2003
  2. ncbi request reprint Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX 77030, USA
    Vaccine 23:1540-8. 2005
  3. pmc Live attenuated influenza vaccine, trivalent, is safe in healthy children 18 months to 4 years, 5 to 9 years, and 10 to 18 years of age in a community-based, nonrandomized, open-label trial
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 116:e397-407. 2005
  4. ncbi request reprint Immunopathogenesis of respiratory syncytial virus bronchiolitis
    Berkeley L Bennett
    Department of Pediatrics, Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 195:1532-40. 2007
  5. ncbi request reprint Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in children
    Pedro A Piedra
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, Room 248E, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 120:e553-64. 2007
  6. ncbi request reprint Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosis
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Vaccine 21:2448-60. 2003
  7. doi request reprint Effects of oseltamivir on influenza-related complications in children with chronic medical conditions
    Pedro A Piedra
    Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 124:170-8. 2009
  8. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 110:662-72. 2002
  9. ncbi request reprint Future directions in vaccine prevention of respiratory syncytial virus
    Pedro A Piedra
    Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 21:482-7. 2002
  10. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine (CAIV-T) in children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Rm 248E, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Semin Pediatr Infect Dis 13:90-6. 2002

Research Grants

  1. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
    Vaccine 21:3479-82. 2003
    ..To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages...
  2. ncbi request reprint Herd immunity in adults against influenza-related illnesses with use of the trivalent-live attenuated influenza vaccine (CAIV-T) in children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX 77030, USA
    Vaccine 23:1540-8. 2005
    ..Vaccination of approximately 20-25% of children, 1.5-18 years of age in the intervention communities resulted in an indirect protection of 8-18% against MAARI in adults > or =35 years of age...
  3. pmc Live attenuated influenza vaccine, trivalent, is safe in healthy children 18 months to 4 years, 5 to 9 years, and 10 to 18 years of age in a community-based, nonrandomized, open-label trial
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 116:e397-407. 2005
    ....
  4. ncbi request reprint Immunopathogenesis of respiratory syncytial virus bronchiolitis
    Berkeley L Bennett
    Department of Pediatrics, Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 195:1532-40. 2007
    ..The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis...
  5. ncbi request reprint Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in children
    Pedro A Piedra
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, Room 248E, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 120:e553-64. 2007
    ..The objective of this study was to determine the effectiveness of influenza vaccines for healthy school-aged children when administered during the influenza outbreak...
  6. ncbi request reprint Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosis
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Vaccine 21:2448-60. 2003
    ..After 28 days post-vaccination, Nt Ab and Bd Ab to F protein titers declined slowly at rates of 0.23 and 0.37 log2 per month, respectively. The PFP-3 vaccine-induced a robust immune response that lasted throughout the RSV season...
  7. doi request reprint Effects of oseltamivir on influenza-related complications in children with chronic medical conditions
    Pedro A Piedra
    Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 124:170-8. 2009
    ..This study investigated the influence of oseltamivir on influenza-related complications and hospitalizations for children and adolescents, 1 to 17 years of age, with chronic medical conditions or neurologic or neuromuscular disease...
  8. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 110:662-72. 2002
    ..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children...
  9. ncbi request reprint Future directions in vaccine prevention of respiratory syncytial virus
    Pedro A Piedra
    Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 21:482-7. 2002
  10. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine (CAIV-T) in children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Rm 248E, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Semin Pediatr Infect Dis 13:90-6. 2002
    ..CAIV-T did not cause an increase in healthcare utilization. Thus CAIV-T is safe in healthy children and should complement the use of inactivated influenza vaccine, trivalent (IIV-T) in children with underlying chronic conditions...
  11. pmc T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infection
    Deepthi Kolli
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 82:8560-9. 2008
    ..Whether these findings have implications for naturally acquired human infections remains to be determined...
  12. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  13. ncbi request reprint Human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosis
    Daniel F Garcia
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Pulmonol 42:66-74. 2007
    ..Its epidemiology remains to be defined in children with cystic fibrosis (CF). We describe the epidemiology and clinical impact of hMPV in CF children and compared it to respiratory syncytial virus (RSV)...
  14. pmc LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity
    Federico R Laham
    Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
    Pediatrics 125:e225-33. 2010
    ....
  15. ncbi request reprint Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines
    Philip R Wyde
    Department of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 66:57-66. 2005
    ....
  16. pmc Direct and indirect effectiveness of influenza vaccination delivered to children at school preceding an epidemic caused by 3 new influenza virus variants
    W Paul Glezen
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1626-33. 2010
    ..This field trial examines the effectiveness of school-based clinics for vaccine delivery before an epidemic caused by 3 new influenza virus variants not contained in the vaccine...
  17. ncbi request reprint Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses
    Patricia Yotnda
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 5:233-41. 2002
    ....
  18. ncbi request reprint Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays
    Philip R Wyde
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 63:51-9. 2004
    ..Interestingly, NMSO3, but not heparin, was able to limit secondary infection and spread of both viruses...
  19. ncbi request reprint Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro
    Philip R Wyde
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 60:51-9. 2003
    ..v.IG utilized were found to have equivalent antiviral activity against hMPV and hRSV. In contrast, except for antisera specifically raised against hMPV, all of the other materials tested had marked activity only against hRSV...
  20. ncbi request reprint Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant women
    Flor M Munoz
    Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Influenza Reseach Center, One Baylor Plaza Suite 221 D, MS BCM 280, Houston, TX 77030, USA
    Vaccine 21:3465-7. 2003
    ..infants of placebo recipients. Vaccine specific anti-F IgA and IgG concentrations in breast milk were higher in mothers who received RSV-PFP-2...
  21. ncbi request reprint Clinical experience with respiratory syncytial virus vaccines
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Infect Dis J 22:S94-9. 2003
    ....
  22. doi request reprint The search for adenovirus 14 in children in Houston, Texas
    Federico R Laham
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 27:653-4. 2008
    ..None were Ad14; Ad1, Ad2, and Ad3 were the most common identified serotypes...
  23. ncbi request reprint Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons
    Nuria Morral
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 13:143-54. 2002
    ..Extensive histological studies provide a detailed picture of the pathology associated with a lethal dose of first-generation adenoviral vector in a primate...
  24. ncbi request reprint Respiratory viral infections in patients with chronic, obstructive pulmonary disease
    J David Beckham
    Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, One Baylor Plaza, Houston, TX 77030, USA
    J Infect 50:322-30. 2005
    ..The purpose of the present study was to apply reverse transcription-PCR (RT-PCR) assays to clinical specimens collected from patients with acute respiratory illness and chronic obstructive pulmonary disease (COPD)...
  25. doi request reprint Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with intermittent wheezing in an open-label field trial
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center College of Medicine, Temple, TX 76508, USA
    Pediatr Infect Dis J 27:444-52. 2008
    ..Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with asthma is unknown. A previous report showed an "asthma signal" in children aged 18-35 months...
  26. ncbi request reprint Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications
    Ann M Leen
    Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin S, MC 3 3320, Houston, TX 77030, USA
    Blood 103:1011-9. 2004
    ..This is the first report of a simple and reproducible method to activate and expand Ad-specific cytotoxic T lymphocytes (CTLs), which should be protective against the range of different Ad subtypes that affect transplant recipients...
  27. ncbi request reprint Societal and economic consequences of influenza
    Pedro A Piedra
    Department of Molecular Virology, Microbiology, and Pediatrics, Baylor College of Medicine, USA
    Manag Care 17:8-14. 2008
    ..More focused and effective influenza prevention strategies are necessary to improve quality of life and to limit the burden of flu complications...
  28. pmc Rotavirus antigenemia in children is associated with viremia
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Med 4:e121. 2007
    ..We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia...
  29. ncbi request reprint Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells
    Ann M Leen
    Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin St, MC 3 3320, Houston, TX, USA
    Blood 104:2432-40. 2004
    ..Thus, by exploiting these peptide targets, it is possible to prepare a T-cell population capable of reacting with most adenoviruses that cause disease in immunocompromised patients...
  30. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
    ..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza...
  31. ncbi request reprint Safety of cold-adapted live influenza vaccine
    W Paul Glezen
    Pediatr Infect Dis J 23:593-4; author reply 594. 2004
  32. ncbi request reprint Immunization against viral respiratory disease: a review
    Harry B Greenberg
    Department of Medicine and Microbiology and Immunology, Stanford University School of Medicine, CA, USA
    Pediatr Infect Dis J 23:S254-61. 2004
    ..The World Health Organization is attempting to develop and distribute effective vaccines to prevent/reduce key viral respiratory diseases...
  33. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  34. ncbi request reprint Cost-effectiveness of live-attenuated influenza vaccine, trivalent in preventing influenza in young children attending day-care centres
    Clare L Hibbert
    RTI Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, United Kingdom
    Vaccine 25:8010-20. 2007
    ..2%; placebo, 13.4%), vaccination saved US$ 5.47 per child in societal costs. In the high attack-rate season (vaccinated, 4.7%; placebo, 32.1%), vaccination led to a societal costs savings of US$ 144.44 per child...
  35. pmc Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children
    Yae Jean Kim
    Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
    J Clin Microbiol 41:4594-9. 2003
    ..In conclusion, the data confirm that Ad3 genome types are more diverse than those of Ad7 and suggest that shifts of genome types may occur during successive outbreaks of Ad3 and Ad7...
  36. ncbi request reprint Adenovirus in the neonatal intensive care unit: formidable, forgotten foe
    Pedro A Piedra
    J Pediatr 146:447-8. 2005

Research Grants4

  1. CONTROL OF EPIDEMIC INFLUENZA
    PEDRO PIEDRA; Fiscal Year: 2007
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