Emerson C Perin

Summary

Affiliation: Texas Heart Institute at St. Luke's Episcopal Hospital
Country: USA

Publications

  1. ncbi request reprint Assessing myocardial viability and infarct transmurality with left ventricular electromechanical mapping in patients with stable coronary artery disease: validation by delayed-enhancement magnetic resonance imaging
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute St Luke s Episcopal Hospital and Baylor College of Medicine, Houston, Tex, USA
    Circulation 106:957-61. 2002
  2. pmc The use of stem cell therapy for cardiovascular disease
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 32:390-2. 2005
  3. ncbi request reprint Methods of stem cell delivery in cardiac diseases
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Nat Clin Pract Cardiovasc Med 3:S110-3. 2006
  4. ncbi request reprint Stem cell therapy for cardiac diseases
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Curr Opin Hematol 11:399-403. 2004
  5. ncbi request reprint Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circulation 110:II213-8. 2004
  6. pmc Stem cell therapy for cardiovascular disease
    Emerson C Perin
    The Texas Heart Institute, USA
    Tex Heart Inst J 33:204-8. 2006
  7. ncbi request reprint Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circulation 107:2294-302. 2003
  8. ncbi request reprint Adult stem cell therapy in perspective
    Emerson C Perin
    Department of Cardiology, Texas Heart Institute, and the University of Texas Health Science Center, Houston, USA
    Circulation 107:935-8. 2003
  9. ncbi request reprint Left ventricular electromechanical mapping: preliminary evidence of electromechanical changes after successful coronary intervention
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute St Luke s Episcopal Hospital, and Baylor College of Medicine, Houston, Tex, USA
    Am Heart J 144:693-701. 2002
  10. pmc Validation of QwikStar Catheter for left ventricular electromechanical mapping with NOGA XP system
    Marlos R Fernandes
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 35:240-4. 2008

Detail Information

Publications47

  1. ncbi request reprint Assessing myocardial viability and infarct transmurality with left ventricular electromechanical mapping in patients with stable coronary artery disease: validation by delayed-enhancement magnetic resonance imaging
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute St Luke s Episcopal Hospital and Baylor College of Medicine, Houston, Tex, USA
    Circulation 106:957-61. 2002
    ..We validated our results by delayed-enhancement cardiac MRI (DE-MRI)...
  2. pmc The use of stem cell therapy for cardiovascular disease
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 32:390-2. 2005
    ..We still have a lot to learn about the biology, but everything that we are learning just makes this field more exciting...
  3. ncbi request reprint Methods of stem cell delivery in cardiac diseases
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Nat Clin Pract Cardiovasc Med 3:S110-3. 2006
    ..In this article, we describe the most important conceptual aspects and the evidence for the use of these techniques, with emphasis on intramyocardial injections...
  4. ncbi request reprint Stem cell therapy for cardiac diseases
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Curr Opin Hematol 11:399-403. 2004
    ..These questions concern patient selection and safety, the optimal type of stem cells, the best route for their delivery, the fate of the transplanted cells, and the mechanism by which this therapy works...
  5. ncbi request reprint Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circulation 110:II213-8. 2004
    ..The present study evaluated the safety and efficacy of this therapy at 6- and 12-month follow-up...
  6. pmc Stem cell therapy for cardiovascular disease
    Emerson C Perin
    The Texas Heart Institute, USA
    Tex Heart Inst J 33:204-8. 2006
  7. ncbi request reprint Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circulation 107:2294-302. 2003
    ....
  8. ncbi request reprint Adult stem cell therapy in perspective
    Emerson C Perin
    Department of Cardiology, Texas Heart Institute, and the University of Texas Health Science Center, Houston, USA
    Circulation 107:935-8. 2003
  9. ncbi request reprint Left ventricular electromechanical mapping: preliminary evidence of electromechanical changes after successful coronary intervention
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute St Luke s Episcopal Hospital, and Baylor College of Medicine, Houston, Tex, USA
    Am Heart J 144:693-701. 2002
    ..Postinterventional ischemic myocardial dysfunction and its sequelae are still not well understood...
  10. pmc Validation of QwikStar Catheter for left ventricular electromechanical mapping with NOGA XP system
    Marlos R Fernandes
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 35:240-4. 2008
    ....
  11. pmc A dosing study of bone marrow mononuclear cells for transendocardial injection in a pig model of chronic ischemic heart disease
    Guilherme V Silva
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 38:219-24. 2011
    ..05 vs controls).In conclusion, transendocardial injections (up to 200 × 10(6) bone marrow mononuclear cells) were safe. Analyses of individual injected segments suggest potential benefit from higher cell concentrations per segment...
  12. pmc Catheter-based transendocardial delivery of autologous bone-marrow-derived mononuclear cells in patients listed for heart transplantation
    Guilherme V Silva
    the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Tex Heart Inst J 31:214-9. 2004
    ..This technique may hold promise as an alternative to medical management in patients with severe ischemic heart failure who are ineligible for conventional revascularization...
  13. pmc Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model
    Emerson C Perin
    the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, United States of America
    PLoS ONE 6:e22949. 2011
    ..Intramyocardially transplanted MSCs appear to integrate into the lymphatic endothelium and may help improve myocardial lymphatic system function after MI...
  14. doi request reprint Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure
    Emerson C Perin
    Stem Cell Center at the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    Am Heart J 163:415-21, 421.e1. 2012
    ....
  15. pmc Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial
    Emerson C Perin
    Texas Heart Institute, St Luke s Episcopal Hospital, Houston, USA
    JAMA 307:1717-26. 2012
    ..Previous studies using autologous bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy...
  16. ncbi request reprint Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction
    Emerson C Perin
    the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    J Mol Cell Cardiol 44:486-95. 2008
    ..The higher local cell density in the TE group may be important for therapeutic effectiveness...
  17. doi request reprint Xenotransplantation of human unrestricted somatic stem cells in a pig model of acute myocardial infarction
    Amir Gahremanpour
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, 77030 TX, USA
    Xenotransplantation 20:110-22. 2013
    ..Stem cell therapy may help restore cardiac function after acute myocardial infarction (AMI), but the optimal therapeutic cell type has not been identified...
  18. pmc Histopathological study of healing after allogenic mesenchymal stem cell delivery in myocardial infarction in dogs
    Deborah C Vela
    Cardiovascular Pathology Research Department, Texas Heart Institute, Houston, TX 77030, USA
    J Histochem Cytochem 57:167-76. 2009
    ..MSCs delivered during the subacute phase of acute myocardial infarction positively affect healing, apparently by mechanisms other than differentiation into mature native cardiac cells...
  19. doi request reprint Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    J Card Fail 17:601-11. 2011
    ..Hepatocyte growth factor (HGF) may stimulate angiogenesis. We examined the safety and therapeutic potential of the HGF plasmid (VM202) in pigs with chronic myocardial ischemia...
  20. doi request reprint A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute, St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Catheter Cardiovasc Interv 78:1060-7. 2011
    ....
  21. pmc Safety and feasibility of mapping and stem cell delivery in the presence of an implanted left ventricular assist device: a preclinical investigation in sheep
    Yi Zheng
    The Stem Cell Center and Cardiovascular Pathology Research Department, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 40:229-34. 2013
    ..Surgically implanted metal devices, including the LVAD, steel chest-closure wire, and skin staples, were compatible with the electromechanical mapping system. ..
  22. pmc The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty
    Lesa A Tran
    Department of Chemistry and the Smalley Institute for Nanoscale Science and Technology, Rice University, MS 60, P O Box 1892, Houston, TX 77251 1892, USA
    Biomaterials 35:720-6. 2014
    ..These proof-of-concept studies support the feasibility and value of using GNTs as a magnetic nanoparticle facilitator to improve cell retention during cellular cardiomyoplasty...
  23. pmc Restoration of microcirculatory patency after myocardial infarction: results of current coronary interventional strategies and techniques
    Marlos R Fernandes
    Departments of Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 39:342-50. 2012
    ..Restoration of the microvasculature was associated with smaller infarcts. Procedure-related variables associated with suboptimal perfusion were unlikely to be causative...
  24. doi request reprint Comparative healing response after sirolimus- and paclitaxel-eluting stent implantation in a pig model of restenosis
    Guilherme V Silva
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Catheter Cardiovasc Interv 73:801-8. 2009
    ..We compared local vessel healing and inflammatory responses associated with nonoverlapping sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES)...
  25. doi request reprint Diabetic and nondiabetic patients respond differently to transendocardial injection of bone marrow mononuclear cells: findings from prospective clinical trials in "no-option" patients
    Pilar Jimenez-Quevedo
    The Stem Cell Center at the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    Rev Esp Cardiol (Engl Ed) 61:635-9. 2008
    ..04) from 16.4 (13.1-21.5) to 24.5 (17.3-29.2) mL/kg/min. These changes were not observed in diabetic patients. This is the first clinical study to show that BMMNC injection could have a smaller effect in diabetics. ..
  26. ncbi request reprint Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    Guilherme V Silva
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Circulation 111:150-6. 2005
    ..Bone marrow-derived stem cells are under investigation as a treatment for ischemic heart disease. Mesenchymal stem cells (MSCs) have been used preferentially in the acute ischemia model; data in the chronic ischemia model are lacking...
  27. doi request reprint A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF)
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute, St Luke s Episcopal Hospital, Houston, TX, USA
    Am Heart J 161:1078-87.e3. 2011
    ..Autologous bone marrow mononuclear cell (ABMMNC) therapy has shown promise in patients with heart failure (HF). Cell function analysis may be important in interpreting trial results...
  28. pmc Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design
    James T Willerson
    Coordinating Center for Clinical Trials, The University of Texas, Health Science Center, Houston, TX 77030, USA
    Am Heart J 160:215-23. 2010
    ..Despite advances in these methods, CAD is a leading cause of recurrent ischemia and heart failure, posing significant morbidity and mortality risks along with increasing health costs in a large patient population worldwide...
  29. ncbi request reprint [Diabetic and nondiabetic patients respond differently to transendocardial injection of bone marrow mononuclear cells: findings from prospective clinical trials in "no-option" patients]
    Pilar Jimenez-Quevedo
    Centro de Terapia Celular, Texas Heart Institute, St Luke s Episcopal Hospital, Houston, Texas, Estados Unidos
    Rev Esp Cardiol 61:635-9. 2008
    ..04) from 16.4 (13.1-21.5) to 24.5 (17.3-29.2) ml/kg/min. These changes were not observed in diabetic patients. This is the first clinical study to show that BMMNC injection could have a smaller effect in diabetics...
  30. pmc Carotid artery stenting versus endarterectomy: a systematic review
    Amir Gahremanpour
    Division of Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 39:474-87. 2012
    ..We conclude that carotid artery stenting is an equivalent alternative to carotid endarterectomy when patient age and anatomy, surgical risk, and operator experience are considered in the choice of treatment approach...
  31. doi request reprint Autologous cell-based therapy for ischemic heart disease: clinical evidence, proposed mechanisms of action, and current limitations
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Catheter Cardiovasc Interv 73:281-8. 2009
    ..Cardiac stem cell therapy promises to become an important option for treating patients with coronary artery disease...
  32. doi request reprint Cell-based therapy for chronic ischemic heart disease--a clinical perspective
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    Cardiovasc Ther 29:211-7. 2011
    ..Initial data have shown that cell therapy with autologous bone marrow cells is associated with modest functional improvements. This finding needs to be confirmed in subsequent phase 2 and 3 trials...
  33. pmc Gadonanotubes as magnetic nanolabels for stem cell detection
    Lesa A Tran
    Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, MS 60, P O Box 1892, Rice University, Houston, TX 77251 1892, USA
    Biomaterials 31:9482-91. 2010
    ..It is anticipated that GNTs will allow in vivo tracking of GNT-labeled MSCs, as well as other mammalian cell types, by T₁-weighted imaging with greater efficacy than other current technologies now allow...
  34. ncbi request reprint One-year results of percutaneous myocardial revascularization for refractory angina pectoris
    Patrick L Whitlow
    Department of Cardiology, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Cardiol 91:1342-6. 2003
  35. pmc Comparison of left ventricular electromechanical mapping and left ventricular angiography: defining practical standards for analysis of NOGA maps
    Rogerio Sarmento-Leite
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Tex Heart Inst J 30:19-26. 2003
    ....
  36. pmc Histopathological validation of electromechanical mapping in assessing myocardial viability in a porcine model of chronic ischemia
    Yi Zheng
    Stem Cell Center, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Exp Clin Cardiol 13:198-203. 2008
    ..The aim of the present study was to validate EMM in differentiating infarcted myocardium from viable myocardium by histopathological analysis...
  37. ncbi request reprint First experience with remote left ventricular mapping and transendocardial cell injection with a novel integrated magnetic navigation-guided electromechanical mapping system
    Emerson C Perin
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX, USA
    EuroIntervention 3:142-8. 2007
    ..This system also allows transendocardial cell injections to be performed with a high success rate. Further studies are needed to define the safety profile of this system for clinical use...
  38. ncbi request reprint Choosing a drug-eluting stent: a comparison between CYPHER and TAXUS
    Emerson C Perin
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Rev Cardiovasc Med 6:S13-21. 2005
    ..Both stents offer excellent short-term safety. To improve our understanding of these stents, a head-to-head comparison is needed...
  39. ncbi request reprint Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial
    Emerson C Perin
    Stem Cell Center, Texas Heart Institute, Houston, TX
    Am Heart J 168:88-95.e2. 2014
    ..We performed the first randomized, placebo-controlled, double-blind trial to examine the safety and feasibility of the transendocardial injections of ADRCs in no-option patients with ischemic cardiomyopathy...
  40. ncbi request reprint Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings
    Hans F R Dohmann
    Hospital Procardiaco, Rio de Janeiro, Brazil
    Circulation 112:521-6. 2005
    ..The current report focuses on postmortem cardiac findings from one of the treated patients, who died 11 months after cell therapy...
  41. ncbi request reprint [Sustained improvement in symptoms and exercise capacity up to six months after autologous transendocardial transplantation of bone marrow mononuclear cells in patients with severe ischemic heart disease]
    Hans Fernando R Dohmann
    Hospital Pró Cardíatico, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Arq Bras Cardiol 84:360-6. 2005
    ....
  42. ncbi request reprint Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis
    Ahmed Abdel-Latif
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Arch Intern Med 167:989-97. 2007
    ..However, the effects of BMC transplantation in patients with ischemic heart disease remains unclear...
  43. pmc Hyperexpansion of coronary stents and clinical outcomes
    Alexandre Schaan de Quadros
    Catheterization Laboratory, Cardiology Institute of Rio Grande do Sul University Foundation of Cardiology, Porto Alegre 90620 001, Brazil
    Tex Heart Inst J 33:437-44. 2006
    ..Hyperexpansion was not associated with lower rates of MACE...
  44. pmc Effects of carvedilol therapy on QT-interval dispersion in congestive heart failure: is there a difference in the elderly?
    Ricardo Mourilhe Rocha
    The State University of Rio de Janeiro, Brazil
    Tex Heart Inst J 30:176-9. 2003
    ....
  45. ncbi request reprint Power thrombectomy in acute ischemic coronary syndromes
    On Topaz
    Cardiac Catheterization Laboratories, Division of Cardiology, Medical College of Virginia Hospital, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23249, USA
    Angiology 54:457-68. 2003
    ..In acute coronary syndromes the strategy of power thrombectomy aims to achieve the clinical advantages of more nearly complete vessel patency, improved antegrade flow, and enhanced preservation of myocardial tissue...
  46. ncbi request reprint Assessing intermediate coronary lesions: angiographic prediction of lesion severity on intravascular ultrasound
    Marlos R Fernandes
    Rede D or Hospitais, Rio de Janeiro, Brazil
    J Invasive Cardiol 19:412-6. 2007
    ..We compared the detection of stenosis by IVUS and angiography and identified angiographic predictors of severe luminal stenosis on IVUS in patients with angiographically-intermediate coronary lesions...
  47. ncbi request reprint Blood-derived progenitor cells after recanalization of chronic coronary artery occlusions in humans
    James T Willerson
    Circ Res 97:735-6. 2005