Sudhir Paul

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc CD4 binding determinant mimicry for HIV vaccine design
    Yasuhiro Nishiyama
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School Houston, TX, USA
    Front Immunol 3:383. 2012
  2. doi request reprint Nature and nurture of catalytic antibodies
    Sudhir Paul
    Chemical Immunology Research Center, Department of Pathology, University of Texas Houston Medical School, Texas, USA
    Adv Exp Med Biol 750:56-75. 2012
  3. ncbi request reprint Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:39611-9. 2004
  4. ncbi request reprint Antibodies as defensive enzymes
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, MSB 2 250, 6431 Fannin, Houston, TX 77030, USA
    Springer Semin Immunopathol 26:485-503. 2005
  5. ncbi request reprint Theory of proteolytic antibody occurrence
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, 77030, USA
    Immunol Lett 103:8-16. 2006
  6. pmc Immunological origin and functional properties of catalytic autoantibodies to amyloid beta peptide
    Sudhir Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Clin Immunol 30:S43-9. 2010
  7. ncbi request reprint Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120
    Sudhir Paul
    Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, 77030, USA
    J Biol Chem 278:20429-35. 2003
  8. pmc Back to the future: covalent epitope-based HIV vaccine development
    Sudhir Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, 6431 Fannin, MSB 2 230A, Houston, TX 77030, USA
    Expert Rev Vaccines 9:1027-43. 2010
  9. pmc Beneficial catalytic immunity to abeta peptide
    Sudhir Paul
    Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Rejuvenation Res 13:179-87. 2010
  10. ncbi request reprint Phosphonate ester probes for proteolytic antibodies
    S Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology and Therapeutics Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 276:28314-20. 2001

Collaborators

Detail Information

Publications53

  1. pmc CD4 binding determinant mimicry for HIV vaccine design
    Yasuhiro Nishiyama
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School Houston, TX, USA
    Front Immunol 3:383. 2012
    ..Successful vaccine targeting of the CD4BD will require a sufficiently rigid immunogen that mimics the native epitope conformation and bypasses B cell checkpoints restricting synthesis of the neutralizing antibodies...
  2. doi request reprint Nature and nurture of catalytic antibodies
    Sudhir Paul
    Chemical Immunology Research Center, Department of Pathology, University of Texas Houston Medical School, Texas, USA
    Adv Exp Med Biol 750:56-75. 2012
    ..These concepts may be useful for developing novel vaccines that capitalize and improve on constitutive antibody functions for protection against microbes...
  3. ncbi request reprint Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:39611-9. 2004
    ..These observations suggest that IgMs can selectively cleave gp120 by a nucleophilic mechanism and raise the possibility of their role as defense enzymes...
  4. ncbi request reprint Antibodies as defensive enzymes
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, MSB 2 250, 6431 Fannin, Houston, TX 77030, USA
    Springer Semin Immunopathol 26:485-503. 2005
    ....
  5. ncbi request reprint Theory of proteolytic antibody occurrence
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, 77030, USA
    Immunol Lett 103:8-16. 2006
    ..This article attempts to provide a rational basis for natural Ab catalysis, in the hope that understanding this phenomenon will stimulate medical and basic science advances in the field...
  6. pmc Immunological origin and functional properties of catalytic autoantibodies to amyloid beta peptide
    Sudhir Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Clin Immunol 30:S43-9. 2010
    ....
  7. ncbi request reprint Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120
    Sudhir Paul
    Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, 77030, USA
    J Biol Chem 278:20429-35. 2003
    ..These findings suggest the feasibility of raising antigen-specific proteolytic antibodies on demand by covalent immunization...
  8. pmc Back to the future: covalent epitope-based HIV vaccine development
    Sudhir Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, 6431 Fannin, MSB 2 230A, Houston, TX 77030, USA
    Expert Rev Vaccines 9:1027-43. 2010
    ..We summarize evidence supporting development of covalent immunization as the first vaccine strategy with the potential to induce an antibody response to a conserved HIV epitope that neutralizes genetically divergent HIV strains...
  9. pmc Beneficial catalytic immunity to abeta peptide
    Sudhir Paul
    Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Rejuvenation Res 13:179-87. 2010
    ..We present our view that catalytic antibodies are likely to emerge as more efficacious and safer immunotherapy reagents compared to traditional Abeta-binding antibodies...
  10. ncbi request reprint Phosphonate ester probes for proteolytic antibodies
    S Paul
    Department of Pathology and Laboratory Medicine, Chemical Immunology and Therapeutics Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 276:28314-20. 2001
    ..The covalent reactivity of Abs with phosphonate esters suggests their ability to recapitulate the catalytic mechanism utilized by classical serine proteases...
  11. ncbi request reprint VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease
    Yogesh Bangale
    Chemical Immunology Research Center, Department of Pathology, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
    FASEB J 17:628-35. 2003
    ..These observations show that VIP is a target for specific catalytic autoantibodies in autoimmune disease...
  12. ncbi request reprint Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infection
    Stephanie Planque
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine and Hemophilia and Thrombophilia Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    AIDS Res Hum Retroviruses 23:1541-54. 2007
    ..The neutralizing activity was specifically inhibited by an electrophilic inhibitor of the catalytic activity. The existence of catalytic IgAs to gp120 in uninfected humans suggests their role in resistance to HIV...
  13. pmc Antibodies to a superantigenic glycoprotein 120 epitope as the basis for developing an HIV vaccine
    Stephanie A Planque
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Medical School at Houston, Houston, TX 77030, USA
    J Immunol 189:5367-81. 2012
    ..The studies indicate broad and potent HIV neutralization by constitutive Abs as an innate, germline-encoded activity directed to the superantigenic CD4BD(core) epitope that is available for amplification for vaccination against HIV...
  14. pmc Exceptional amyloid beta peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds
    Hiroaki Taguchi
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 283:36724-33. 2008
    ..In view of their superior catalytic activity, the VL domain IgVs may help attain clearance of medically important antigens more efficiently than natural Igs...
  15. ncbi request reprint Toward selective covalent inactivation of pathogenic antibodies: a phosphate diester analog of vasoactive intestinal peptide that inactivates catalytic autoantibodies
    Yasuhiro Nishiyama
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:7877-83. 2004
    ..These results suggest a novel route to antigen-specific covalent targeting of pathogenic Abs...
  16. ncbi request reprint A mechanism-based probe for gp120-Hydrolyzing antibodies
    Hiroaki Taguchi
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Bioorg Med Chem Lett 12:3167-70. 2002
    ..These results reveal that the peptidyl phosphonate ester can serve as a probe for the antigen recognition and catalytic subsites of proteolytic antibodies...
  17. pmc Toward effective HIV vaccination: induction of binary epitope reactive antibodies with broad HIV neutralizing activity
    Yasuhiro Nishiyama
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 284:30627-42. 2009
    ..We present models accounting for improved CD4-binding site recognition and broad HIV neutralizing activity of the mAbs, long sought goals in HIV vaccine development...
  18. pmc Catalytic antibodies to amyloid beta peptide in defense against Alzheimer disease
    Hiroaki Taguchi
    Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
    Autoimmun Rev 7:391-7. 2008
    ..Reduced Abeta aggregation and neurotoxicity attributable to the catalytic function were evident. These findings provide a foundation for development of catalytic Igs for AD immunotherapy...
  19. ncbi request reprint Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodies
    Yukie Mitsuda
    Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Mol Biotechnol 36:113-22. 2007
    ..These observations suggest that mechanisms underlying B cell clonal selection favor the retention and improvement of catalytic activity in the IgA, but not the IgG compartment of the immune response...
  20. ncbi request reprint Towards irreversible HIV inactivation: stable gp120 binding by nucleophilic antibodies
    Yasuhiro Nishiyama
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Mol Recognit 19:423-31. 2006
    ..These findings suggest the feasibility of raising antibodies capable of long-lasting inactivation of antigens by electrophilic immunization...
  21. ncbi request reprint Autoantibody-catalyzed hydrolysis of amyloid beta peptide
    Hiroaki Taguchi
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 283:4714-22. 2008
    ..Our results suggest that catalytic IgM autoantibodies can help clear Abeta, and they open the possibility of using catalytic Abs for AD immunotherapy...
  22. pmc Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120-CD4-binding site from long-term survivors of HIV infection
    Stephanie Planque
    Chemical Immunology Research Center and Gulf States Hemophilia and Thrombophilia Center, Departments of Pathology and Pediatrics, University of Texas Houston Medical School, Houston, Texas, USA
    AIDS 24:875-84. 2010
    ..To identify an HIV epitope suitable for vaccine development...
  23. ncbi request reprint Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library
    Sangeeta Karle
    Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, USA
    AIDS 18:329-31. 2004
    ..The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C, and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV...
  24. ncbi request reprint Towards covalent vaccination: improved polyclonal HIV neutralizing antibody response induced by an electrophilic gp120 V3 peptide analog
    Yasuhiro Nishiyama
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 282:31250-6. 2007
    ..These results suggest that electrophilic immunization induces a sufficiently robust nucleophilic Ab response to enhance the anti-microbial efficacy of candidate polypeptide vaccines...
  25. ncbi request reprint Ontogeny of proteolytic immunity: IgM serine proteases
    Stephanie Planque
    Department of Pathology and Laboratory Medicine, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:14024-32. 2004
    ..These observations indicate the existence of serine protease-like BCRs and secreted IgM Abs as innate immunity components with potential roles in B cell development and Ab effector functions...
  26. ncbi request reprint Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide
    Hiroaki Taguchi
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, 77030, USA
    Bioorg Med Chem Lett 14:4529-32. 2004
    ..One of the 39 light chains studied hydrolyzed the Val197-Ser198 bond of the peptide with Km and kcat values of 223 +/- 7 microM and 0.087 +/- 0.001 min(-1)...
  27. ncbi request reprint Antibodies to the superantigenic site of HIV-1 gp120: hydrolytic and binding activities of the light chain subunit
    Yasuhiro Nishiyama
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Mol Immunol 44:2707-18. 2007
    ..The pairing of such light chains with heavy chains capable of gp120(SAg) recognition represents a potential mechanism for generating protective Abs with enhanced HIV binding strength and anti-viral proteolytic activity...
  28. pmc Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain
    Gopal Sapparapu
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 284:24622-33. 2009
    ..These studies provide proof-of-principle that the catalytic activity of a light chain can be rendered antigen-specific by pairing with a noncovalently binding heavy chain subunit...
  29. ncbi request reprint Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity
    Stephanie Planque
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 77030, USA
    J Biol Chem 278:20436-43. 2003
    ....
  30. pmc Catalytic antibodies to HIV: physiological role and potential clinical utility
    Stephanie Planque
    Department of Pathology, University of Texas Houston Medical School, Houston, TX, USA
    Autoimmun Rev 7:473-9. 2008
    ..Further study of the properties of the naturally occurring anti-SAg catalytic Igs should provide valuable guidance in designing a prophylactic vaccine that amplifies protective catalytic immunity to HIV...
  31. ncbi request reprint Broadly distributed nucleophilic reactivity of proteins coordinated with specific ligand binding activity
    Yasuhiro Nishiyama
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    J Mol Recognit 18:295-306. 2005
    ..These observations suggest the potential of EPs for specific and covalent targeting of proteins, and raise the possibility of nucleophile-electrophile pairing as a novel mechanism stabilizing protein-protein complexes...
  32. ncbi request reprint Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus, and autoimmune mice
    Stephanie Planque
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Internal Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    FASEB J 17:136-43. 2003
    ..Short-lived but strong inhibition of cellular DNA synthesis was observed in the presence of the autoantibodies. We concluded that autoantibody responses to EGFR hold the potential of fulfilling a pathogenic role in autoimmune disease...
  33. ncbi request reprint Prospects for immunotherapeutic proteolytic antibodies
    Yong Xin Zhou
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    J Immunol Methods 269:257-68. 2002
    ..In reference to therapy of HIV infection, assurance is required that the Abs recognize the native conformation of gp120 expressed as a trimer on the virus surface...
  34. ncbi request reprint Physiological IgM class catalytic antibodies selective for transthyretin amyloid
    Stephanie A Planque
    From the Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030
    J Biol Chem 289:13243-58. 2014
    ..Excess misTTR was dissolved by a hydrolytic mIgM. The studies reveal a novel antibody property, the innate ability of IgMs to selectively degrade and dissolve toxic misTTR species as a first line immune function. ..
  35. ncbi request reprint Lupus-derived antiprothrombin autoantibodies from a V gene phage display library are specific for the kringle 2 domain of prothrombin
    Anhquyen Le
    Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Biochemistry 43:4047-54. 2004
    ..Analysis of the cDNA sequences of these antibodies show clustered mutational patterns in the complementarity determining region, suggesting that variable domains are the products of antigen-driven B cell clonal maturation...
  36. pmc Covalent inactivation of factor VIII antibodies from hemophilia A patients by an electrophilic FVIII Analog
    Stephanie Planque
    Chemical Immunology Research Center, Department of Pathology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 283:11876-86. 2008
    ..E-FVIII is a prototype reagent able to attain irreversible and specific inactivation of pathogenic Abs...
  37. ncbi request reprint Covalent reactivity of phosphonate monophenyl esters with serine proteinases: an overlooked feature of presumed transition state analogs
    Yasuhiro Nishiyama
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Arch Biochem Biophys 402:281-8. 2002
    ..47 vs 2.0 min(-1)). These observations suggest that the covalent reactivity of phosphonate monoesters contributes to their interactions with serine proteinases, including certain proteolytic antibodies...
  38. pmc Constant domain-regulated antibody catalysis
    Gopal Sapparapu
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 287:36096-104. 2012
    ....
  39. ncbi request reprint Vasoactive intestinal peptide binding autoantibodies in autoimmune humans and mice
    Yogesh Bangale
    Department of Pathology and Medicine, Chemical Immunology Research Center, University of Texas Medical School, Houston, TX, USA
    Peptides 23:2251-7. 2002
    ..The depletion of VIP by specific antibodies in autoimmune disease may interfere with VIP regulation of T cells and inflammatory cells and result in further amplification of autoreactive immunological responses...
  40. ncbi request reprint Metal-dependent amyloid β-degrading catalytic antibody construct
    Yasuhiro Nishiyama
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Biotechnol 180:17-22. 2014
    ..The studies reveal the absolute catabody dependence on a metal cofactor. ..
  41. ncbi request reprint Monoclonal antibody light chain with prothrombinase activity
    P Thiagarajan
    Departments of Internal Medicine and Pathology and Laboratory Medicine, Center for Chemical Immunology, University of Texas Houston Medical School, 77030, USA
    Biochemistry 39:6459-65. 2000
    ..These finding suggest a novel mechanism whereby antibodies can induce a procoagulant state, i.e., prothrombin activation via cleavage of the molecule...
  42. ncbi request reprint Nucleophilic proteolytic antibodies
    G Gololobov
    University of Texas Houston Medical School, Department of Pathology and Laboratory Medicine, 77030, USA
    Appl Biochem Biotechnol 83:221-31; discussion 231-2, 297-313. 2000
    ....
  43. pmc Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infection
    Eric L Brown
    Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas 77030, USA
    J Biol Chem 287:9940-51. 2012
    ..These data suggest a potential defense function for constitutively produced catalytic antibodies to a putative superantigenic site of Efb, but an adaptive catalytic response appears to be proscribed...
  44. pmc Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity
    Zhen Yong Keck
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Virol 78:7257-63. 2004
    ..Finally, H-111 blocks HCV-like particle binding to and HCV virion infection of target cells, suggesting the involvement of this epitope in virus binding and entry...
  45. ncbi request reprint Mechanism and functional role of antibody catalysis
    S Paul
    Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston 77030, USA
    Appl Biochem Biotechnol 75:13-24. 1998
    ....
  46. ncbi request reprint Autoantibody catalysis: no longer hostage to Occam's razor
    S Paul
    Department of Pathology, University of Texas Medical School, Houston, Texas 77030, USA
    Ann N Y Acad Sci 865:238-46. 1998
    ..Scientific theories are changeable entities, dependent on empirical data and interpretations of the data, and their growth is better served by keeping an open mind...
  47. ncbi request reprint Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120
    S Karle
    Department of Pathology and Internal Medicine, Chemical Immunology and Therapeutics Research Center, University of Texas, Houston Medical School, Houston, TX 77030, USA
    Vaccine 21:1213-8. 2003
    ....
  48. ncbi request reprint Catalytic hydrolysis of VIP in pregnant women with asthma
    Christopher O Olopade
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    J Asthma 43:429-32. 2006
    ..We hypothesized that hydrolysis of VIP by circulating catalytic VIP antibodies will be increased in pregnancy in patients with asthma...
  49. ncbi request reprint Degradation of beta-amyloid by proteolytic antibody light chains
    Srinath Kasturi Rangan
    Department of Chemical and Materials Engineering, Arizona State University, Tempe, Arizona 85287, USA
    Biochemistry 42:14328-34. 2003
    ..These antibody light chains provide a novel route toward engineering efficient therapeutic antibodies capable of cleaving Abeta in vivo...
  50. ncbi request reprint Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice
    Julia K Voice
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    J Immunol 170:308-14. 2003
    ..The level of VIP recognized by CD4 T cells thus is a major determinant of the relative contributions of Th subsets to the immune effector phenotype...
  51. ncbi request reprint Catalytic antibodies and their applications
    Carl Veith Hanson
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, 94804, USA
    Curr Opin Biotechnol 16:631-6. 2005
    ..Artificial CAbs are likely to find increasing applications in research, clinical medicine, diagnostics and manufacturing...
  52. pmc Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2)
    Mei Chuan Huang
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 176:6640-6. 2006
    ..Thus the ratio of two forms of T cell VPAC2 determines the net effect of VIP on IL-4 generation by activated Th2 cells...
  53. ncbi request reprint c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide
    Julia Voice
    Departments of Medicine and Microbiology Immunology, Medical Center, University of California San Francisco, 533 Parnassus at 4th, San Francisco, CA 94143, USA
    J Immunol 172:7289-96. 2004
    ....

Research Grants24

  1. beta-Amyloid Antibodies w/ Specific Proteolytic Activity
    Sudhir Paul; Fiscal Year: 2005
    ..Proteolytic anti-Abeta Abs capable of preventing the deposition of Abeta and cognitive decline would be candidates for passive immunotherapy of humans with AD. ..
  2. RECOMBINANT SINGLE DOMAIN & HYBRID PEPTIDASE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2001
    ....
  3. Nucleophilic Antibodies: Characterization and Induction
    Sudhir Paul; Fiscal Year: 2009
    ..From these studies, we hope to identify the strengths and weaknesses of the Abs and immunogens relevant to HIV vaccination and therapy. ..
  4. CATALYTIC ANTIBODIES FOR TUMOR IMMUNOTHERAPY
    Sudhir Paul; Fiscal Year: 1999
    ..The investigators expect the proposed studies to generate catalytic Fv constructs capable of permanent and efficient inactivation of EGFR, and to establish the validity of using catalytic Abs for tumor immunotherapy. ..
  5. Nucleophilic Antibodies: Characterization and Induction
    Sudhir Paul; Fiscal Year: 2007
    ..From these studies, we hope to identify the strengths and weaknesses of the Abs and immunogens relevant to HIV vaccination and therapy. ..
  6. gp120 covalent analogs as candidate HIV vaccines
    Sudhir Paul; Fiscal Year: 2006
    ..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. ..
  7. Proteolytic Antibody HIVcides
    Sudhir Paul; Fiscal Year: 2007
    ..These studies may identify proteolytic antibodies suitable for further development as a topical HIVcide. ..
  8. beta-Amyloid Antibodies with Specific Proteolytic Activity
    Sudhir Paul; Fiscal Year: 2007
    ..Proteolytic anti-Abeta Abs capable of preventing the deposition of Abeta and cognitive decline would be candidates for passive immunotherapy of humans with AD. ..
  9. gp120 covalent analogs as candidate HIV vaccines
    Sudhir Paul; Fiscal Year: 2007
    ..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. ..
  10. gp120 covalent analogs as candidate HIV vaccines
    Sudhir Paul; Fiscal Year: 2005
    ..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. ..
  11. RECOMBINANT SINGLE DOMAIN & HYBRID PEPTIDASE ANTIBODIES
    Sudhir Paul; Fiscal Year: 1999
    ....
  12. RECOMBINANT SINGLE DOMAIN & HYBRID PEPTIDASE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2000
    ....
  13. Nucleophilic Antibodies: Characterization and Induction
    Sudhir Paul; Fiscal Year: 2010
    ..From these studies, we hope to identify the strengths and weaknesses of the Abs and immunogens relevant to HIV vaccination and therapy. ..
  14. RECOMBINANT SINGLE DOMAIN & HYBRID PEPTIDASE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2002
    ....
  15. INNATE AND Ag-ADAPTED CHEMICALLY REACTIVE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2003
    ..Successful execution of this project will provide insight to the genesis of chemically reactive Abs and potentially validate the use CRAs for inhibition and induction of antigen-specific catalytic Abs. ..
  16. CATALYTIC ANTIBODIES FOR TUMOR IMMUNOTHERAPY
    Sudhir Paul; Fiscal Year: 2000
    ..The investigators expect the proposed studies to generate catalytic Fv constructs capable of permanent and efficient inactivation of EGFR, and to establish the validity of using catalytic Abs for tumor immunotherapy. ..
  17. gp120 covalent analogs as candidate HIV vaccines
    Sudhir Paul; Fiscal Year: 2004
    ..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. ..
  18. beta-Amyloid Antibodies with Specific Proteolytic Activity
    Sudhir Paul; Fiscal Year: 2006
    ..Proteolytic anti-Abeta Abs capable of preventing the deposition of Abeta and cognitive decline would be candidates for passive immunotherapy of humans with AD. ..
  19. CATALYTIC ANTIBODIES FOR TUMOR IMMUNOTHERAPY
    Sudhir Paul; Fiscal Year: 2001
    ..The investigators expect the proposed studies to generate catalytic Fv constructs capable of permanent and efficient inactivation of EGFR, and to establish the validity of using catalytic Abs for tumor immunotherapy. ..