Debananda Pati

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice
    Malini Mukherjee
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22167. 2011
  2. pmc Calpain-1 cleaves Rad21 to promote sister chromatid separation
    Anil K Panigrahi
    Department of Pediatric Hematology Oncology, Baylor College of Medicine, 1102 Bates Avenue, Suite 1220, Houston, TX 77030
    Mol Cell Biol 31:4335-47. 2011
  3. pmc Linking sister chromatid cohesion and apoptosis: role of Rad21
    Debananda Pati
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:8267-77. 2002
  4. pmc Characterization of the interaction between the cohesin subunits Rad21 and SA1/2
    Nenggang Zhang
    Texas Children Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e69458. 2013
  5. pmc Overexpression of Separase induces aneuploidy and mammary tumorigenesis
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:13033-8. 2008
  6. pmc Development and validation of a fluorogenic assay to measure separase enzyme activity
    Dipanjan Basu
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Anal Biochem 392:133-8. 2009
  7. pmc Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
    Rene Meyer
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Cancer Res 15:2703-10. 2009
  8. pmc A handcuff model for the cohesin complex
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 183:1019-31. 2008
  9. pmc Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion
    Nenggang Zhang
    Texas Children s Cancer and Hematology Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 286:41826-37. 2011
  10. pmc Sororin is a master regulator of sister chromatid cohesion and separation
    Nenggang Zhang
    Texas Children s Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, TX, USA
    Cell Cycle 11:2073-83. 2012

Collaborators

Detail Information

Publications22

  1. pmc Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice
    Malini Mukherjee
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22167. 2011
    ..However, the effect of Separase haploinsufficiency has not been thoroughly investigated...
  2. pmc Calpain-1 cleaves Rad21 to promote sister chromatid separation
    Anil K Panigrahi
    Department of Pediatric Hematology Oncology, Baylor College of Medicine, 1102 Bates Avenue, Suite 1220, Houston, TX 77030
    Mol Cell Biol 31:4335-47. 2011
    ..Collectively, our work reveals a novel function of calpain-1 and describes an additional pathway for sister chromatid separation in humans...
  3. pmc Linking sister chromatid cohesion and apoptosis: role of Rad21
    Debananda Pati
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:8267-77. 2002
    ....
  4. pmc Characterization of the interaction between the cohesin subunits Rad21 and SA1/2
    Nenggang Zhang
    Texas Children Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e69458. 2013
    ....
  5. pmc Overexpression of Separase induces aneuploidy and mammary tumorigenesis
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:13033-8. 2008
    ..These results collectively suggest that Separase is an oncogene, whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 mutant background...
  6. pmc Development and validation of a fluorogenic assay to measure separase enzyme activity
    Dipanjan Basu
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Anal Biochem 392:133-8. 2009
    ..We used this assay to quantify separase activity during cell cycle progression and in a panel of human tumor cell lines as well as leukemia patient samples...
  7. pmc Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
    Rene Meyer
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Cancer Res 15:2703-10. 2009
    ..Proc Natl Acad Sci 2008;105:13033). In the present study, we have investigated the expression level of Separase across a wide range of human tumors...
  8. pmc A handcuff model for the cohesin complex
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 183:1019-31. 2008
    ..These data support a two-ring handcuff model for the cohesin complex, which is flexible enough to establish and maintain sister chromatid cohesion as well as ensure the fidelity of chromosome segregation in higher eukaryotes...
  9. pmc Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion
    Nenggang Zhang
    Texas Children s Cancer and Hematology Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 286:41826-37. 2011
    ....
  10. pmc Sororin is a master regulator of sister chromatid cohesion and separation
    Nenggang Zhang
    Texas Children s Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, TX, USA
    Cell Cycle 11:2073-83. 2012
    ....
  11. doi request reprint A cohesin-RAD21 interactome
    Anil K Panigrahi
    Texas Children s Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, 77030, USA
    Biochem J 442:661-70. 2012
    ..Identification of cohesin interactors provides a framework for explaining the various non-canonical functions of the cohesin complex...
  12. pmc Handcuff for sisters: a new model for sister chromatid cohesion
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Cycle 8:399-402. 2009
    ..in the Journal of Cell Biology describes a two-ring handcuff model for the cohesin complex, and provides new information regarding how sister chromatid cohesion and separation are achieved in vertebrate cell systems...
  13. ncbi request reprint Hormone-induced chromosomal instability in p53-null mammary epithelium
    Debananda Pati
    Department of Pediatrics, Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:5608-16. 2004
    ....
  14. pmc Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity
    Terzah M Horton
    Texas Children s Cancer Center Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cancer Ther 8:2232-42. 2009
    ..In conclusion, although ABT-888 potentiation of TMZ was most pronounced in MMR-deficient cells with low MGMT activity, neither MMR proficiency nor MGMT overexpression completely abrogated ABT-888 potentiation of TMZ...
  15. pmc Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer
    Anil K Panigrahi
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin St, MC3 3320, Houston, TX 77030, USA
    Crit Rev Oncol Hematol 72:181-93. 2009
    ....
  16. pmc Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
    Malini Mukherjee
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA
    J Neurooncol 119:27-35. 2014
    ....
  17. ncbi request reprint A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study
    Terzah M Horton
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 13:1516-22. 2007
    ..A phase 1 study to determine the maximum-tolerated dose, dose-limiting toxicity, pharmacokinetics, and biological effects of bortezomib in children with recurrent/refractory leukemia...
  18. pmc Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    Xin Yan Lu
    Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Mol Cancer Res 6:937-46. 2008
    ..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma...
  19. pmc Higher-order orchestration of hematopoiesis: is cohesin a new player?
    Anil K Panigrahi
    Texas Children s Cancer Center, Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Hematol 40:967-73. 2012
    ..Here, we suggest that cohesin, which is known to mediate chromosomal cohesion between sister chromatids, may have a central role in the orchestration of hematopoiesis and serve as a master transcriptional regulator...
  20. pmc Spatial quantitation of FISH signals in diploid versus aneuploid nuclei
    Amol Shete
    Department of Computer Science, University of Houston, Houston, Texas
    Cytometry A 85:339-52. 2014
    ..These studies underscore the unique utility of our modeling algorithms in quantifying FISH signals in three dimensions...
  21. pmc RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females
    Sergey Kuznetsov
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Cell Biol 176:581-92. 2007
    ..Based on the marked reduction in Holliday junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, we propose that this late function may be associated with HJ resolution...
  22. ncbi request reprint Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary
    Debananda Pati
    Department of Biological Sciences and Endocrine Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biol Reprod 66:813-22. 2002
    ....