S Pathak

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi Telomere dynamics, aneuploidy, stem cells, and cancer (review)
    Sen Pathak
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 20:637-41. 2002
  2. ncbi Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells
    S Pathak
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Anticancer Drugs 11:455-63. 2000
  3. ncbi Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion
    S Pathak
    Cellular Genetics Laboratory, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 17:1219-24. 2000
  4. pmc Can cancer cells transform normal host cells into malignant cells?
    S Pathak
    Department of Cell Biology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Br J Cancer 76:1134-8. 1997
  5. ncbi Heterochromatin and interstitial telomeric DNA homology
    A S Multani
    Department of Cancer Biology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
    Chromosoma 110:214-20. 2001
  6. ncbi Integrin-mediated entry into S phase of human gastric adenocarcinoma cells
    T Udagawa
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 13:427-38. 1995
  7. ncbi Human bone marrow transplant rejection is associated with telomere cleavage
    A S Multani
    Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Int J Mol Med 8:607-10. 2001
  8. ncbi Loss of chromosomal integrity drives rat mammary tumorigenesis
    Thea M Goepfert
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Cancer 120:985-94. 2007
  9. ncbi Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer
    Sen Pathak
    Department of Molecular Genetics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 23:975-82. 2003
  10. pmc Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    Purnima R Laud
    Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 19:2560-70. 2005

Collaborators

Detail Information

Publications30

  1. ncbi Telomere dynamics, aneuploidy, stem cells, and cancer (review)
    Sen Pathak
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 20:637-41. 2002
    ....
  2. ncbi Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells
    S Pathak
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Anticancer Drugs 11:455-63. 2000
    ....
  3. ncbi Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion
    S Pathak
    Cellular Genetics Laboratory, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 17:1219-24. 2000
    ..Such abnormal chromosome configurations are lost, following the breakage-fusion-bridge-cycles, and result in extensive DNA fragmentation, as shown by laddering experiments, and, finally, cell death...
  4. pmc Can cancer cells transform normal host cells into malignant cells?
    S Pathak
    Department of Cell Biology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Br J Cancer 76:1134-8. 1997
    ..These results suggest that cancer cells are capable of inducing neoplastic transformation in stromal cells of the host organ by some, as yet unknown, epigenetic mechanism(s)...
  5. ncbi Heterochromatin and interstitial telomeric DNA homology
    A S Multani
    Department of Cancer Biology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
    Chromosoma 110:214-20. 2001
    ....
  6. ncbi Integrin-mediated entry into S phase of human gastric adenocarcinoma cells
    T Udagawa
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Exp Metastasis 13:427-38. 1995
    ..These studies suggest that during the metastatic process, integrin receptor interaction with the insoluble matrix may be an important step leading to proliferation of some tumors...
  7. ncbi Human bone marrow transplant rejection is associated with telomere cleavage
    A S Multani
    Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Int J Mol Med 8:607-10. 2001
    ..We, therefore, conclude that BM rejection could be directly associated with the cleavage, clustering, and extrusion of telomeric DNA in the donor cells...
  8. ncbi Loss of chromosomal integrity drives rat mammary tumorigenesis
    Thea M Goepfert
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Cancer 120:985-94. 2007
    ..Collectively, these data suggest that the carcinogen MNU induces changes resulting in genetic instability detectable before hyperplasia and tumors develop in the rat mammary gland...
  9. ncbi Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer
    Sen Pathak
    Department of Molecular Genetics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 23:975-82. 2003
    ..Cancer cell death was initiated by telomere erosion and completed through mitotic catastrophe events. We propose that Ruta in combination with Ca3(PO4)2 could be used for effective treatment of brain cancers, particularly glioma...
  10. pmc Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    Purnima R Laud
    Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 19:2560-70. 2005
    ....
  11. ncbi Telomere erosion-induced mitotic catastrophe in continuously grown chinese hamster don cells
    Sea H Sohn
    Department of Animal Science and Biotechnology, Chinju National University, Chinju, 660 758, Republic of Korea
    Exp Cell Res 279:271-6. 2002
    ....
  12. ncbi Pleotropic effects of genistein on MCF-7 breast cancer cells
    Sreenivasa R Chinni
    Department of Urology and Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Mol Med 12:29-34. 2003
    ..From these results, we conclude that genistein-induced inhibition of cell division is partly mediated by decreased telomere length, reduced mitosis and inhibition of Akt activation, leading to induction of apoptosis...
  13. ncbi Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    Sandy Chang
    Department of Molecular Genetics, M D Anderson Cancer Center, Box 11, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Nat Genet 36:877-82. 2004
    ..These genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomere shortening...
  14. ncbi Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
    Ling Wu
    Department of Molecular Genetics, Box 1006, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 126:49-62. 2006
    ..Telomeric HR following Pot1a loss requires NBS1. Pot1a deletion also results in chromosomal instability. Our results suggest that POT1a is crucial for the maintenance of both telomere integrity and overall genomic stability...
  15. ncbi Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis
    Jianchun Xu
    Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 66:1664-73. 2006
    ..This study characterized the host microenvironmental role in cancer progression, epithelial to mesenchymal transition (EMT), and bone and adrenal metastasis in parental ARCaP and its derived cell subclones...
  16. ncbi Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma
    Michael E Kupferman
    Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
    Oral Oncol 43:440-54. 2007
    ..Therapies targeting these potential mediators of anoikis resistance may prove to be beneficial in the treatment of metastatic squamous cell carcinoma...
  17. pmc POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination
    Hua He
    Department of Molecular Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 25:5180-90. 2006
    ..Our results indicate that POT1b plays important protective functions at telomeres and that proper maintenance of chromosomal stability requires both POT proteins...
  18. pmc Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    Wilfredo Cosme-Blanco
    Department of Cancer Genetics, The MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    EMBO Rep 8:497-503. 2007
    ..These results indicate that suppression of spontaneous tumorigenesis by dysfunctional telomeres requires the activation of the p53-dependent cellular senescence pathway...
  19. ncbi Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis
    Jack S K Chen
    Department of Bioimmunotherapy, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Cell Physiol 200:223-34. 2004
    ....
  20. ncbi Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer
    Said Akli
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:3198-208. 2004
    ....
  21. pmc N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
    Aruna S Jaiswal
    UF Shands Cancer Center and Anatomy and Cell Biology, College of Medicine, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
    Mol Cancer 3:3. 2004
    ..In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line...
  22. ncbi Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
    Jiang Shou
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Road, Houston, TX 77030, USA
    Oncogene 21:878-89. 2002
    ..These results show that hDkk-1 is a pro-apoptotic gene and suggest that it may play important roles in linking the oncogenic Wnt and p53 tumor suppressor pathways...
  23. ncbi Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features
    Eswaran Devarajan
    Department of Bioimmunotherapy, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 20:913-20. 2002
    ..These results suggest that drug resistance is an inherent property of some cancer cells that are present in the initial tumor burden and exhibit distinct phenotypic/genotypic alterations...
  24. ncbi Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model
    Kristy L Weber
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Urol 168:774-9. 2002
    ..A relevant renal cell carcinoma cell line developed from a human bone metastasis is described and an experimental model in the nude mouse was established...
  25. ncbi Organ- and tissue-specific stem cells and carcinogenesis
    Sen Pathak
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Anticancer Res 22:1353-6. 2002
    ..I, therefore, suggest that drug development for cancer treatment be directed towards tissue-specific stem cells...
  26. ncbi Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin
    Dominic Fan
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 1:595-600. 2002
    ..Our data indicate that mesothelin-producing squamous cell carcinoma of the lung may be a good target for this immunotoxin...
  27. ncbi Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells
    Xinqiao Zhang
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:760-5. 2003
    ..The lack of cytotoxicity to normal cells should also provide a high therapeutic index when used in gene therapy protocols for the treatment of bladder and other cancers...
  28. ncbi Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiation
    Faith M Strickland
    Department of Immunology 178, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3503-10. 2003
    ..These reagents will provide opportunities to search for new tumor suppressor genes that may contribute to the growth and metastasis of primary melanoma...
  29. ncbi In vivo opossum xenograft model for cancer research
    Zhiqiang Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Cancer Res 63:6121-4. 2003
    ..These results establish Monodelphis as a natural mammalian model to study the cascade of interactions between xenografted cells and the host system...
  30. ncbi Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT
    Bobby Bhatia
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Int J Cancer 122:1483-95. 2008
    ..These results suggest that senescent NHP cells, like senescent fibroblasts, may promote tumor development and that one of the mechanisms underlying the senescent NHP cell-enhanced tumorigenicity could be through cell fusion...