T Patel

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis
    Milan Sheth
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University Health Science Center College of Medicine, Temple, Texas, USA
    BMC Gastroenterol 2:2. 2002
  2. ncbi request reprint Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
  3. pmc Worldwide trends in mortality from biliary tract malignancies
    Tushar Patel
    Division of Gastroenterology Scott and White Memorial Hospital and Clinic Texas A and M University System Health Science Center College of Medicine Temple, TX, USA
    BMC Cancer 2:10. 2002
  4. ncbi request reprint Aberrant local renin-angiotensin II responses in the pathogenesis of primary sclerosing cholangitis
    Tushar Patel
    Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76502, USA
    Med Hypotheses 61:64-7. 2003
  5. ncbi request reprint Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes
    F Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, TX, USA
    Oncogene 27:378-86. 2008
  6. doi request reprint microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
    C Braconi
    College of Medicine, and The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA
    Oncogene 30:4750-6. 2011
  7. ncbi request reprint Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats
    Marco Marzioni
    Medical Physiology, Department of Internal Medicine, R and E, Scott and White Hospital, The Texas A and M University System Health Sciences Center, College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Am J Physiol Gastrointest Liver Physiol 284:G837-52. 2003
  8. ncbi request reprint The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model
    Val M Runge
    Department of Radiology, Scott and White Clinic and Hospital, Texas A and M University Health Science Center, Temple Texas 76508, USA
    Invest Radiol 41:244-8. 2006
  9. ncbi request reprint Current approaches to the diagnosis and treatment of cholangiocarcinoma
    Santosh B Reddy
    Department of Internal Medicine, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA
    Curr Gastroenterol Rep 8:30-7. 2006
  10. ncbi request reprint Advances in the diagnosis, evaluation and management of cholangiocarcinoma
    Pankaj Singh
    Department of Internal Medicine, Central Texas Veterans Health Care System, Temple, 76508, USA
    Curr Opin Gastroenterol 22:294-9. 2006

Collaborators

  • Yoshiyuki Ueno
  • Shannon S Glaser
  • Marco Marzioni
  • GIANFRANCO D ALPINI
  • D Alvaro
  • Jonmenjoy Biswas
  • Samson Jacob
  • Val M Runge
  • C U Herborn
  • B J Wintersperger
  • Silvia Taffetani
  • Fanyin Meng
  • Yoko Yamagiwa
  • Roger Henson
  • Hania Wehbe
  • Carla Marienfeld
  • Laura Tadlock
  • Shail Maheshwari
  • C Braconi
  • F Meng
  • Peter J Naus
  • Hania Wehbe-Janek
  • Luciana McLean
  • Pankaj Singh
  • Molly Lang
  • Santosh B Reddy
  • Giammarco Fava
  • Jeff L Browning
  • Antonio Benedetti
  • Heather Francis
  • Luca Marucci
  • Milan Sheth
  • Gene D Lesage
  • M Negrini
  • E Miotto
  • C M Croce
  • G Nuovo
  • S Costinean
  • N Huang
  • N Valeri
  • T Kogure
  • H Smith
  • H Wehbe-Janek
  • R Henson
  • Parita Patel
  • Heather Smith
  • Kalpana Ghoshal
  • Grant Bleeker
  • Thomas D Schmittgen
  • Janna Mize-Berge
  • Jinmai Jiang
  • Joshua T Mendell
  • Julie Venter
  • Cynthia Meininger
  • Sharon De Morrow
  • Paul C Brandt
  • Paul B Hicks
  • Leigh A Holcomb
  • Ryun Summers
  • Ramona Reichenbach
  • Keith A Young
  • Linda Brooks
  • Valorie Chiasson
  • Martin Holcik
  • Mark Riggs
  • Jo Lynne Phinizy

Detail Information

Publications34

  1. pmc Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis
    Milan Sheth
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University Health Science Center College of Medicine, Temple, Texas, USA
    BMC Gastroenterol 2:2. 2002
    ..Our aims were to assess the utility of the MELD score as a predictor of short-term mortality in persons with alcoholic hepatitis...
  2. ncbi request reprint Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
    ..8%, respectively. In conclusion, there has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years. This tumor continues to be associated with a poor prognosis...
  3. pmc Worldwide trends in mortality from biliary tract malignancies
    Tushar Patel
    Division of Gastroenterology Scott and White Memorial Hospital and Clinic Texas A and M University System Health Science Center College of Medicine Temple, TX, USA
    BMC Cancer 2:10. 2002
    ..As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies...
  4. ncbi request reprint Aberrant local renin-angiotensin II responses in the pathogenesis of primary sclerosing cholangitis
    Tushar Patel
    Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76502, USA
    Med Hypotheses 61:64-7. 2003
    ..Proof of this hypothesis will have implications for future therapeutic approaches given that current treatments for PSC aimed at reducing inflammation or the effects of cholestasis have proven ineffective...
  5. ncbi request reprint Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes
    F Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, TX, USA
    Oncogene 27:378-86. 2008
    ..These studies define a mechanism by which inflammation-associated cytokines can epigenetically modulate gene expression and directly contribute to tumor biology...
  6. doi request reprint microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
    C Braconi
    College of Medicine, and The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA
    Oncogene 30:4750-6. 2011
    ....
  7. ncbi request reprint Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats
    Marco Marzioni
    Medical Physiology, Department of Internal Medicine, R and E, Scott and White Hospital, The Texas A and M University System Health Sciences Center, College of Medicine, and Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Am J Physiol Gastrointest Liver Physiol 284:G837-52. 2003
    ..Bile acids are important in modulating cholangiocyte proliferation in denervated livers...
  8. ncbi request reprint The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model
    Val M Runge
    Department of Radiology, Scott and White Clinic and Hospital, Texas A and M University Health Science Center, Temple Texas 76508, USA
    Invest Radiol 41:244-8. 2006
    ..5 T and to compare Gd-BOPTA with a standard gadolinium chelate, gadopentetate dimeglumine (Gd-DTPA or Magnevist), at 3 T in a rat glioma model...
  9. ncbi request reprint Current approaches to the diagnosis and treatment of cholangiocarcinoma
    Santosh B Reddy
    Department of Internal Medicine, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA
    Curr Gastroenterol Rep 8:30-7. 2006
    ..Although surgical resection can be curative, many patients with cholangiocarcinoma are diagnosed at an advanced stage when only palliative approaches can be used. Photodynamic therapy is emerging as a useful modality...
  10. ncbi request reprint Advances in the diagnosis, evaluation and management of cholangiocarcinoma
    Pankaj Singh
    Department of Internal Medicine, Central Texas Veterans Health Care System, Temple, 76508, USA
    Curr Opin Gastroenterol 22:294-9. 2006
    ..There has been recent progress in identifying potential risk factors for the tumor, and in the use of emerging technologies for diagnosis and palliative treatment...
  11. ncbi request reprint Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76508, USA
    Gastroenterology 130:2113-29. 2006
    ..Our aims were to identify specific miRNA involved in the regulation of cholangiocarcinoma growth and response to chemotherapy...
  12. ncbi request reprint Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes
    Hania Wehbe
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76508, USA
    J Pharmacol Exp Ther 319:1153-61. 2006
    ..Thus, pifithrin-alpha may prove useful for enhancing chemosensitivity in tumors with mutated p53. Moreover, modulation of eIF-4E is an attractive therapeutic target for intervention in cancer treatment...
  13. ncbi request reprint Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression
    Hania Wehbe
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76508, USA
    Cancer Res 66:10517-24. 2006
    ..These observations have important implications for cancer treatment and provide a mechanism by which persistent cytokine stimulation can promote tumor growth...
  14. ncbi request reprint Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells
    Fanyin Meng
    Dept of Internal Medicine, The Ohio State University, 514A Tzagournis Medical Research Facility, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 293:C749-60. 2007
    ..These studies, showing differences in cellular responses to chemotherapy in tumor-derived ECs, indicate that specific therapies targeting these cells may be therapeutically useful for liver cancers...
  15. ncbi request reprint Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity
    Gene D Lesage
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System HSC COM, Temple, TX, USA
    Hepatology 36:641-51. 2002
    ..In conclusion, insulin counter-regulates cholangiocyte secretory processes in the BDL model, which is characterized by cholangiocyte proliferation...
  16. ncbi request reprint MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  17. pmc Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes
    Fanyin Meng
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA
    J Hepatol 44:1055-65. 2006
    ..Our aims were to assess the mechanisms by which over-expression of IL-6 promotes transformed cell growth in malignant cholangiocytes...
  18. ncbi request reprint Cholangiocarcinoma
    Tushar Patel
    Texas A and M Health Science Center College of Medicine, Scott and White Clinic, Temple, TX 76508, USA
    Nat Clin Pract Gastroenterol Hepatol 3:33-42. 2006
    ....
  19. ncbi request reprint Translational regulation by p38 mitogen-activated protein kinase signaling during human cholangiocarcinoma growth
    Yoko Yamagiwa
    Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, TX 76502, USA
    Hepatology 38:158-66. 2003
    ..As protein synthesis is intimately linked to cell growth, dysregulation of translation initiation is a mechanism by which cellular p38 MAPK signaling participates in growth regulation of malignant cholangiocytes...
  20. ncbi request reprint Inhibition of cholangiocarcinoma growth by tannic acid
    Carla Marienfeld
    Scott and White Clinic, Texas A and M University System Health Sciences Center, Temple, USA
    Hepatology 37:1097-104. 2003
    ..TA warrants evaluation as a candidate for the treatment of human cholangiocarcinoma either by itself or in combination with other chemotherapeutic agents...
  21. pmc Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway
    Silvia Taffetani
    Department of Internal Medicine, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Am J Pathol 166:1671-9. 2005
    ..These data suggest that tannic acid may be useful in limiting excessive cholangiocyte proliferation and modulating secretion during cholestasis...
  22. ncbi request reprint Brain tumor enhancement in magnetic resonance imaging: comparison of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) at 1.5 versus 3 tesla
    Jonmenjoy Biswas
    Department of Radiology, Scott and White Clinic and Hospital, Texas A and M University Health Science Center, Temple, Texas 76508, USA
    Invest Radiol 40:792-7. 2005
    ..The objective of this study was to compare the difference in lesion enhancement between 1.5 and 3 T using an extracellular gadolinium chelate in a rat brain glioma model...
  23. ncbi request reprint gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway
    Giammarco Fava
    Central Texas Veterans Health Care System, Research Service, College of Medicine, Temple, 76504, USA
    Cancer Res 65:11437-46. 2005
    ..GABA decreases biliary cancer proliferation and reduces the metastatic potential of cholangiocarcinoma. GABA may represent a therapeutic agent for patients affected by malignancies of the biliary tract...
  24. ncbi request reprint Screening for colorectal cancer in elderly persons: who should we screen and when can we stop?
    Shail Maheshwari
    Baylor College of Medicine, USA
    J Aging Health 20:126-39. 2008
    ..The aim of this study was to quantify the impact of age on the potential benefits of screening for colorectal cancer...
  25. ncbi request reprint Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation
    Gianfranco Alpini
    Department of Internal Medicine, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76502, USA
    Am J Physiol Cell Physiol 285:C183-94. 2003
    ..Thus TNF-alpha mediates cholangiocyte injury and altered ductal secretion following bile duct ligation. These observations suggest that cholestasis may enhance susceptibility to cytokine-mediated cholangiocyte injury...
  26. ncbi request reprint Cholangiocarcinoma: emerging approaches to a challenging cancer
    Tushar Patel
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University Health Science Center, Temple, TX 76508, USA
    Curr Opin Gastroenterol 23:317-23. 2007
    ..The diagnosis, evaluation and management of these tumors continue to be clinically challenging. In this review, we will discuss recent information that may influence the approach to the diagnosis and management of this devastating tumor...
  27. ncbi request reprint The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes
    Fanyin Meng
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76508, USA
    J Biol Chem 282:8256-64. 2007
    ....
  28. ncbi request reprint Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival
    Yoko Yamagiwa
    Scott and White Clinic, College of Medicine, Texas A and M University System Health Science Center, 2401 South 31st Street, Temple, TX 76502, USA
    Cancer Res 64:1293-8. 2004
    ....
  29. pmc Tannic acid synergizes the cytotoxicity of chemotherapeutic drugs in human cholangiocarcinoma by modulating drug efflux pathways
    Peter J Naus
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine Temple, TX 76508, USA
    J Hepatol 46:222-9. 2007
    ..To determine the potential use of tannic acid as an adjunct therapy, we sought to evaluate the interaction between tannic acid and chemotherapeutic agents...
  30. ncbi request reprint Racial and ethnic variations in the epidemiology of intrahepatic cholangiocarcinoma in the United States
    Luciana McLean
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Liver Int 26:1047-53. 2006
    ..To assess the potential contribution of racial/ethnic factors, we assessed the epidemiology of these cancers in different racial and ethnic groups in the United States...
  31. ncbi request reprint Translational regulation of XIAP expression and cell survival during hypoxia in human cholangiocarcinoma
    Carla Marienfeld
    Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76502, USA
    Gastroenterology 127:1787-97. 2004
    ..Thus, our aims were to assess translational mechanisms involved in cell survival during hypoxia and to identify specific translationally regulated proteins involved in the cellular response to hypoxia...
  32. ncbi request reprint Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions
    Jeff L Browning
    Department of Psychiatry, Scott and White Memorial Hospital, Central Texas Veterans Health Care System, and Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Biol Psychiatry 57:617-23. 2005
    ....
  33. pmc Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes
    Yoko Yamagiwa
    Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76508, USA
    Life Sci 78:2494-502. 2006
    ..Interleukin-6 (IL-6) is an autocrine promoter of cholangiocarcinoma growth. Our aims were to assess the relationship between IL-6 activated p38 mitogen-activated protein kinase (MAPK) pathways and senescence in malignant cholangiocytes...
  34. ncbi request reprint Double-stranded RNA activates a p38 MAPK-dependent cell survival program in biliary epithelia
    Laura Tadlock
    Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76508, USA
    Am J Physiol Gastrointest Liver Physiol 284:G924-32. 2003
    ..Thus dsRNA stimulates a p38 MAPK-dependent cell-survival pathway in biliary epithelial cells that may modulate the response of the biliary epithelia to dsRNA produced during genotoxic injury or virus infection...