Xuewen Pan

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Trivalent arsenic inhibits the functions of chaperonin complex
    Xuewen Pan
    Department of Biology and Integrated Imaging Center, The Johns Hopkins University, Baltimore, MD 21218, USA
    Genetics 186:725-34. 2010
  2. doi Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray
    Pamela B Meluh
    Department of Molecular Biology and Genetics, The High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 416:221-47. 2008
  3. ncbi Global synthetic-lethality analysis and yeast functional profiling
    Siew Loon Ooi
    High Throughput Biology Center, Institute of Genetic Medicine, Department of Biostatistics, Johns Hopkins University School of Medicine, 339 Broadway Research Building, 733 North Broadway, Baltimore, MD 21205, USA
    Trends Genet 22:56-63. 2006
  4. pmc Gene function prediction from congruent synthetic lethal interactions in yeast
    Ping Ye
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
    Mol Syst Biol 1:2005.0026. 2005
  5. pmc dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Methods 41:206-21. 2007
  6. ncbi A DNA integrity network in the yeast Saccharomyces cerevisiae
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Cell 124:1069-81. 2006
  7. pmc A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation
    Yu yi Lin
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 22:2062-74. 2008
  8. ncbi A robust toolkit for functional profiling of the yeast genome
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 16:487-96. 2004
  9. pmc Improved microarray methods for profiling the Yeast Knockout strain collection
    Daniel S Yuan
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 33:e103. 2005
  10. pmc The Saccharomyces cerevisiae Nrd1-Nab3 transcription termination pathway acts in opposition to Ras signaling and mediates response to nutrient depletion
    Miranda M Darby
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:1762-75. 2012

Research Grants

  1. Functional Variomics and Applications
    Xuewen Pan; Fiscal Year: 2010

Collaborators

  • Joel S Bader
  • Ping Ye
  • Yan Qi
  • Jef D Boeke
  • Daniel S Yuan
  • Pamela B Meluh
  • Forrest A Spencer
  • Brian D Peyser
  • Siew Loon Ooi
  • Miranda M Darby
  • Yu yi Lin
  • Rafael A Irizarry
  • Leo Serebreni
  • Jeffry L Corden
  • Xiaoling Wang
  • Ou Chen
  • Jin Ying Lu
  • Carol Tiffany
  • Sharon Sookhai-Mahadeo
  • Yingming Zhao
  • Rafael Irizarry

Detail Information

Publications10

  1. pmc Trivalent arsenic inhibits the functions of chaperonin complex
    Xuewen Pan
    Department of Biology and Integrated Imaging Center, The Johns Hopkins University, Baltimore, MD 21218, USA
    Genetics 186:725-34. 2010
    ..Moreover, arsenic impaired substrate folding by both bovine and archaeal TRiC complexes in vitro. These results together indicate that TRiC is a conserved target of arsenic inhibition in various biological systems...
  2. doi Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray
    Pamela B Meluh
    Department of Molecular Biology and Genetics, The High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 416:221-47. 2008
    ..Analysis of double-mutant strains is of growing importance in defining the spectrum of essential cellular functionalities and in understanding how these functionalities interrelate...
  3. ncbi Global synthetic-lethality analysis and yeast functional profiling
    Siew Loon Ooi
    High Throughput Biology Center, Institute of Genetic Medicine, Department of Biostatistics, Johns Hopkins University School of Medicine, 339 Broadway Research Building, 733 North Broadway, Baltimore, MD 21205, USA
    Trends Genet 22:56-63. 2006
    ....
  4. pmc Gene function prediction from congruent synthetic lethal interactions in yeast
    Ping Ye
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
    Mol Syst Biol 1:2005.0026. 2005
    ..These in silico methods can predict phenotypes and gene functions and are applicable to genomic synthetic lethality screens in yeast and analogous RNA interference screens in metazoans...
  5. pmc dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Methods 41:206-21. 2007
    ..This technology has been effectively adapted to study other types of genome-wide genetic interactions including gene-compound synthetic lethality, secondary mutation suppression, dosage-dependent synthetic lethality and suppression...
  6. ncbi A DNA integrity network in the yeast Saccharomyces cerevisiae
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Cell 124:1069-81. 2006
    ..This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms...
  7. pmc A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation
    Yu yi Lin
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 22:2062-74. 2008
    ..These new characterizations of the HDA and NuA4 complexes demonstrate how systematic analyses of genetic interactions may help illuminate the mechanisms of intricate cellular processes...
  8. ncbi A robust toolkit for functional profiling of the yeast genome
    Xuewen Pan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 16:487-96. 2004
    ..Direct comparison revealed that these techniques are more robust than existing methods in functional profiling of the yeast genome. Widespread application of these tools will elucidate a comprehensive yeast genetic network...
  9. pmc Improved microarray methods for profiling the Yeast Knockout strain collection
    Daniel S Yuan
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 33:e103. 2005
    ..The materials, protocols, data and associated software described here comprise a suite of experimental resources that should facilitate the use of TAG microarrays for a wide variety of genetic screens...
  10. pmc The Saccharomyces cerevisiae Nrd1-Nab3 transcription termination pathway acts in opposition to Ras signaling and mediates response to nutrient depletion
    Miranda M Darby
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:1762-75. 2012
    ..Taken together, these results indicate a role for Nrd1-Nab3 in regulating the cellular response to nutrient availability...

Research Grants2

  1. Functional Variomics and Applications
    Xuewen Pan; Fiscal Year: 2010
    ..The actual mechanisms of drug resistance and drug modes of actions learned from yeast will also provide invaluable hints for rapidly elucidating similar mechanisms in other systems. ..