Lynne A Opperman

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. ncbi request reprint Erk1/2 signaling is required for Tgf-beta 2-induced suture closure
    Lynne A Opperman
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Texas 75266 0677, USA
    Dev Dyn 235:1292-9. 2006
  2. doi request reprint Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis
    Elias Kontogiorgos
    Department of Biomedical Sciences, Center for Craniofacial Research and Diagnosis, Texas A and M University, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Int J Oral Maxillofac Implants 28:677-86. 2013
  3. ncbi request reprint The extracellular matrix environment in suture morphogenesis and growth
    Lynne A Opperman
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex 75266 0677, USA
    Cells Tissues Organs 181:127-35. 2005
  4. doi request reprint Antioxidant combinations protect oral fibroblasts against metal-induced toxicity
    Symone M San Miguel
    Departments of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, United States
    Arch Oral Biol 58:299-310. 2013
  5. doi request reprint Bone generation in the reconstruction of a critical size calvarial defect in an experimental model
    Yong Chen Por
    International Craniofacial Institute, Dallas, Texas, USA
    J Craniofac Surg 19:383-92. 2008
  6. doi request reprint Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts
    Symone M San Miguel
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX, USA
    Arch Oral Biol 56:812-22. 2011
  7. pmc Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible
    Lucy K Nagashima
    Department of Prosthodontics, Baylor College of Dentistry, Texas A and M University System, Dallas, TX, USA
    J Oral Maxillofac Surg 70:429-39. 2012
  8. doi request reprint Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents
    Symone M San Miguel
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, United States
    Arch Oral Biol 57:1657-67. 2012
  9. ncbi request reprint Comparison of the effects of phosphate-coated and sandblasted acid-etched titanium implants on osseointegration: a microcomputed tomographic examination in the canine model
    Stephen S Walker
    Department of Periodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Int J Oral Maxillofac Implants 27:1069-80. 2012
  10. doi request reprint In vitro evaluation of dentinal tubule penetration and biomineralization ability of a new root-end filling material
    David C Bird
    Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
    J Endod 38:1093-6. 2012

Research Grants

  1. Mandibular Bone transport Reconstruction Plate
    LYNNE OPPERMAN; Fiscal Year: 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Erk1/2 signaling is required for Tgf-beta 2-induced suture closure
    Lynne A Opperman
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Texas 75266 0677, USA
    Dev Dyn 235:1292-9. 2006
    ....
  2. doi request reprint Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis
    Elias Kontogiorgos
    Department of Biomedical Sciences, Center for Craniofacial Research and Diagnosis, Texas A and M University, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Int J Oral Maxillofac Implants 28:677-86. 2013
    ..The purpose of this study was to compare the osseointegration of dental implants placed in canine mandibular bone and in regenerated bone produced by bone transport distraction osteogenesis...
  3. ncbi request reprint The extracellular matrix environment in suture morphogenesis and growth
    Lynne A Opperman
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex 75266 0677, USA
    Cells Tissues Organs 181:127-35. 2005
    ..This review elucidates the nature of the sutural extracellular matrix and its role in mediating suture maintenance and growth through the regulation of cellular and biomechanical signaling...
  4. doi request reprint Antioxidant combinations protect oral fibroblasts against metal-induced toxicity
    Symone M San Miguel
    Departments of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, United States
    Arch Oral Biol 58:299-310. 2013
    ..In this study, we investigated specific antioxidant (AO) combinations to determine if they counteract the effects of Cu, Ni and Zn on cultured oral fibroblast proliferation and oxidative damage...
  5. doi request reprint Bone generation in the reconstruction of a critical size calvarial defect in an experimental model
    Yong Chen Por
    International Craniofacial Institute, Dallas, Texas, USA
    J Craniofac Surg 19:383-92. 2008
    ..rhBMP2, but not PRP, accelerated calvarial regeneration in 3 months. The DBMs in the rhBMP2 groups were substituted by new trabecular bone. Shape molding was good with both metal and resorbable plate...
  6. doi request reprint Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts
    Symone M San Miguel
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX, USA
    Arch Oral Biol 56:812-22. 2011
    ..The aim of this study was to provide cytotoxicity, proliferation and migration data on the in vitro effects of bioactive AO mixtures on human oral fibroblasts...
  7. pmc Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible
    Lucy K Nagashima
    Department of Prosthodontics, Baylor College of Dentistry, Texas A and M University System, Dallas, TX, USA
    J Oral Maxillofac Surg 70:429-39. 2012
    ..The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone...
  8. doi request reprint Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents
    Symone M San Miguel
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, United States
    Arch Oral Biol 57:1657-67. 2012
    ..In this study, we investigated specific polyphenols and turmeric derivative antioxidants (AO) in combinations that counteracted the effects of these stressors on cultured oral fibroblast proliferation and ROS production...
  9. ncbi request reprint Comparison of the effects of phosphate-coated and sandblasted acid-etched titanium implants on osseointegration: a microcomputed tomographic examination in the canine model
    Stephen S Walker
    Department of Periodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Int J Oral Maxillofac Implants 27:1069-80. 2012
    ..This study tested the effects of phosphate treatment of titanium on bone volume fraction (BV/TV) at 30 to 60 Μm from the implant surface using microcomputed tomography to analyze the mineralized tissue...
  10. doi request reprint In vitro evaluation of dentinal tubule penetration and biomineralization ability of a new root-end filling material
    David C Bird
    Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
    J Endod 38:1093-6. 2012
    ....
  11. pmc Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-β3 inhibition of posterior interfrontal suture fusion
    Reiko Shibazaki-Yorozuya
    Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, Dallas, USA
    Anat Rec (Hoboken) 295:928-38. 2012
    ..These findings suggest that the continued presence of patent sutures can affect strain patterns, perhaps when higher bite forces are present as in adult animals...
  12. pmc Three-dimensional evaluation of mandibular bone regenerated by bone transport distraction osteogenesis
    Elias Kontogiorgos
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX 75246, USA
    Calcif Tissue Int 89:43-52. 2011
    ..However, the regenerate showed a significantly higher number of thicker trabeculae...
  13. pmc Biomechanical characteristics of regenerated cortical bone in the canine mandible
    Uriel Zapata
    Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, USA
    J Tissue Eng Regen Med 5:551-9. 2011
    ..In addition, the elastic mechanical properties are higher not only on the control side but also in the lingual anatomical position, suggesting a stress shielding effect from the presence of the reconstruction plate...
  14. doi request reprint Ephrin-B stimulation of calvarial bone formation
    M Douglas Benson
    Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 241:1901-10. 2012
    ..Little is known about the role of ephrin-B signaling to EphBs in developmental bone formation...
  15. doi request reprint Biocompatibility and osteogenic potential of new generation endodontic materials established by using primary osteoblasts
    Jelani T Washington
    Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
    J Endod 37:1166-70. 2011
    ..The aim of this study was to evaluate the biocompatibility and osteogenic potential of these new materials by using primary osteoblasts...
  16. pmc Effect of phosphate treatment of Acid-etched implants on mineral apposition rates near implants in a dog model
    Christine Hyon Foley
    Department of Periodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
    Int J Oral Maxillofac Implants 25:278-86. 2010
    ..This study evaluated the effects of phosphate coating of acid-etched titanium on the mineral apposition rate (MAR) and new bone-to-implant contact (BIC) in a canine model...
  17. doi request reprint Effect of recombinant human bone morphogenetic protein-2 on bone regeneration in large defects of the growing canine skull after dura mater replacement with a dura mater substitute
    Dongmei He
    International Craniofacial Institute, Cleft Lip and Palate Treatment Center, Medical City Dallas, Dallas, Texas, USA
    J Neurosurg 112:319-28. 2010
    ....
  18. pmc Osteoblasts responses to three-dimensional nanofibrous gelatin scaffolds
    Ashneet Sachar
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University Health Sciences Center, Dallas, Texas 75246, USA
    J Biomed Mater Res A 100:3029-41. 2012
    ..Taken together, these results give insight into osteoblast-matrix interactions in biomimetic nanofibrous 3D scaffolds and will guide the development of optimal scaffolds for bone tissue engineering...
  19. doi request reprint Timing of Egf treatment differentially affects Tgf-beta2 induced cranial suture closure
    Joseph T Rawlins
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, PO Box 660677, Dallas, TX 75266 0677, USA
    Exp Biol Med (Maywood) 233:1518-26. 2008
    ..Appropriate timing of signal generation by Egf and Tgf-beta 2 is critical for normal suture development and maintenance of suture patency...
  20. doi request reprint Tgf-beta regulation of suture morphogenesis and growth
    Joseph T Rawlins
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas, USA
    Front Oral Biol 12:178-96. 2008
    ..This chapter focuses on the role of Tgf-beta in suture morphogenesis and growth, exploring Tgf-beta biology, receptors, signaling pathways, animal models, and expression in both normal and pathological sutures...
  21. ncbi request reprint Biomechanical strain and morphologic changes with age in rat calvarial bone and sutures
    Reiko Shibazaki
    Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75266 0677, USA
    Plast Reconstr Surg 119:2167-78; 2179-81. 2007
    ..The role of calvarial sutures in transmitting biomechanical forces within the head is unclear...
  22. ncbi request reprint Bone generation in the reconstruction of a critical size calvarial defect in an experimental model
    Yong Chen Por
    International Craniofacial Institute, Dallas, TX, USA
    Ann Acad Med Singapore 36:911-9. 2007
    ..This study was designed to investigate the optimal combination of known osteogenic biomaterials with shape conforming struts to achieve calvarial vault reconstruction, using a canine model...
  23. ncbi request reprint Use of antioxidants in oral healthcare
    Symone M San Miguel
    Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
    Compend Contin Educ Dent 32:E156-9. 2011
    ..This review focuses on relationships between antioxidants and free-radical/reactive-oxygen species in the oral environment...
  24. ncbi request reprint Reactive oxygen species and antioxidant defense mechanisms in the oral cavity: a literature review
    Symone M San Miguel
    Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
    Compend Contin Educ Dent 32:E10-5. 2011
    ..The protective mechanisms of antioxidants and how routine dental procedures may increase ROS is discussed. The final section reviews the effect of tobacco products on gingival health and disease...
  25. ncbi request reprint Use of antioxidants in oral healthcare
    Symone M San Miguel
    Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
    Compend Contin Educ Dent 32:e25-8. 2011
    ..This review focuses on relationships between antioxidants and free-radical/reactive-oxygen species in the oral environment...
  26. doi request reprint Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis
    Jayne S Reuben
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:196-204. 2011
    ..SOCS3 has been shown to regulate cell differentiation and survival; however, its potential role in mediating the effects of BPs has not been explored...
  27. doi request reprint Recombinant human bone morphogenetic protein-2 stimulates bone formation during interfrontal suture expansion in rabbits
    Sean Shih Yao Liu
    Graduate Student, Department of Orthodontics, Texas A and M University, Baylor College of Dentistry, Dallas, Tex currently, Assistant Professor, Department of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, Indianapolis, Ind
    Am J Orthod Dentofacial Orthop 144:210-7. 2013
    ..The objective of this study was to investigate whether there is a dose-dependent relationship between the recombinant human bone morphogenetic protein-2 (rhBMP-2) and bone formation during suture expansion...
  28. ncbi request reprint Inheritance of sutural pattern at the pterion in Rhesus monkey skulls
    Qian Wang
    Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, Texas A and M University Health Science Center, Dallas, TX 75246, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1042-9. 2006
    ..Future work will be focused on defining the inheritance patterns of variation at the pterion, with the ultimate objective of identifying the specific genes involved and their mechanism of action...
  29. doi request reprint Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
    Symone M San Miguel
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
    J Periodontol 81:1675-90. 2010
    ..The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive oxygen species and inhibiting cell migration, and antioxidants (AOs) may counteract nicotine effects...
  30. doi request reprint The effects of bisphosphonates on osteoblasts in vitro
    Aparna Naidu
    Department of Diagnostic Science, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:5-13. 2008
    ..The purpose of this study was to test the effects of bisphosphonates on osteoblast viability and function...
  31. ncbi request reprint Transforming growth factor-beta 3(Tgf-beta3) in a collagen gel delays fusion of the rat posterior interfrontal suture in vivo
    Lynne A Opperman
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, TX 75266 0677, USA
    Anat Rec 267:120-30. 2002
    ..However, Tgf-beta3-treated sutures had altered Tgf-beta2 and Tbetar-I distribution compared to controls...
  32. ncbi request reprint Nasal capsular cartilage is required for rat transpalatal suture morphogenesis
    Katayoun Adab
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center Dallas, TX 75246, USA
    Differentiation 71:496-505. 2003
    ..These studies indicate that tissue interactions likely regulate morphogenesis of all cranial and facial sutures...
  33. ncbi request reprint Lateral functional shift of the mandible: Part I. Effects on condylar cartilage thickness and proliferation
    Maria Angeles Fuentes
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Sciences Center, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Am J Orthod Dentofacial Orthop 123:153-9. 2003
    ..These data suggest that changes in MCC thickness and proliferative activity might accompany a lateral functional shift of the mandible in growing persons...
  34. pmc Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice
    Sunil Wadhwa
    Division of Orthodontics, School of Dental Medicine, Department of Craniofacial Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 40:861-6. 2007
    ..Failure of PFS fusion and hypomineralization of the calvaria in the Bgn/Dcn double deficient mice demonstrates that these extracellular matrix proteoglycans could have a role in controlling the formation and growth of the cranial vault...
  35. ncbi request reprint Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits
    Mark P Mooney
    Department of Oral Medicine and Pathology, the Cleft Palate Craniofacial Center, and the School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Plast Reconstr Surg 119:1200-12; discussion 1213-5. 2007
    ..Interference with TGF-beta2 function with the use of neutralizing antibodies may inhibit resynostosis. The present study was designed to test this hypothesis...
  36. ncbi request reprint Transforming growth factor-beta isoform expression in the perisutural tissues of craniosynostotic rabbits
    Elyane Poisson
    Department of Orthodontics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Cleft Palate Craniofac J 41:392-402. 2004
    ....
  37. ncbi request reprint Rescue of coronal suture fusion using transforming growth factor-beta 3 (Tgf-beta 3) in rabbits with delayed-onset craniosynostosis
    Sherri Lyn Chong
    Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Anat Rec A Discov Mol Cell Evol Biol 274:962-71. 2003
    ..The results suggest that there is a dose-dependent effect of TGF-beta 3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis...

Research Grants1

  1. Mandibular Bone transport Reconstruction Plate
    LYNNE OPPERMAN; Fiscal Year: 2006
    ..abstract_text> ..