Research Topics
Species | Lynne A OppermanSummaryAffiliation: Texas A and M Health Science Center Country: USA Publications
Research Grants
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Detail Information
Publications
Erk1/2 signaling is required for Tgf-beta 2-induced suture closureLynne A Opperman
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Texas 75266 0677, USA
Dev Dyn 235:1292-9. 2006....- The extracellular matrix environment in suture morphogenesis and growthLynne A Opperman
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex 75266 0677, USA
Cells Tissues Organs 181:127-35. 2005..This review elucidates the nature of the sutural extracellular matrix and its role in mediating suture maintenance and growth through the regulation of cellular and biomechanical signaling... 
Bone generation in the reconstruction of a critical size calvarial defect in an experimental modelYong Chen Por
International Craniofacial Institute, Dallas, Texas, USA
J Craniofac Surg 19:383-92. 2008..rhBMP2, but not PRP, accelerated calvarial regeneration in 3 months. The DBMs in the rhBMP2 groups were substituted by new trabecular bone. Shape molding was good with both metal and resorbable plate...- Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblastsSymone M San Miguel
Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX, USA
Arch Oral Biol 56:812-22. 2011..The aim of this study was to provide cytotoxicity, proliferation and migration data on the in vitro effects of bioactive AO mixtures on human oral fibroblasts... 
Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandibleLucy K Nagashima
Department of Prosthodontics, Baylor College of Dentistry, Texas A and M University System, Dallas, TX, USA
J Oral Maxillofac Surg 70:429-39. 2012..The purpose of this research was to test a new device, the mandibular bone transport reconstruction plate, in an animal model with comparable mandible size to humans and to histologically and mechanically examine the regenerate bone...- In vitro evaluation of dentinal tubule penetration and biomineralization ability of a new root-end filling materialDavid C Bird
Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
J Endod 38:1093-6. 2012.... - Biomechanical characteristics of regenerated cortical bone in the canine mandibleUriel Zapata
Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, USA
J Tissue Eng Regen Med 5:551-9. 2011..In addition, the elastic mechanical properties are higher not only on the control side but also in the lingual anatomical position, suggesting a stress shielding effect from the presence of the reconstruction plate... - Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-β3 inhibition of posterior interfrontal suture fusionReiko Shibazaki-Yorozuya
Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, Dallas, USA
Anat Rec (Hoboken) 295:928-38. 2012..These findings suggest that the continued presence of patent sutures can affect strain patterns, perhaps when higher bite forces are present as in adult animals... - Three-dimensional evaluation of mandibular bone regenerated by bone transport distraction osteogenesisElias Kontogiorgos
Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX 75246, USA
Calcif Tissue Int 89:43-52. 2011..However, the regenerate showed a significantly higher number of thicker trabeculae... - Effect of phosphate treatment of Acid-etched implants on mineral apposition rates near implants in a dog modelChristine Hyon Foley
Department of Periodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
Int J Oral Maxillofac Implants 25:278-86. 2010..This study evaluated the effects of phosphate coating of acid-etched titanium on the mineral apposition rate (MAR) and new bone-to-implant contact (BIC) in a canine model... - Effect of recombinant human bone morphogenetic protein-2 on bone regeneration in large defects of the growing canine skull after dura mater replacement with a dura mater substituteDongmei He
International Craniofacial Institute, Cleft Lip and Palate Treatment Center, Medical City Dallas, Dallas, Texas, USA
J Neurosurg 112:319-28. 2010.... - Biocompatibility and osteogenic potential of new generation endodontic materials established by using primary osteoblastsJelani T Washington
Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA
J Endod 37:1166-70. 2011..The aim of this study was to evaluate the biocompatibility and osteogenic potential of these new materials by using primary osteoblasts... - Osteoblasts responses to three-dimensional nanofibrous gelatin scaffoldsAshneet Sachar
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University Health Sciences Center, Dallas, Texas 75246, USA
J Biomed Mater Res A 100:3029-41. 2012..Taken together, these results give insight into osteoblast-matrix interactions in biomimetic nanofibrous 3D scaffolds and will guide the development of optimal scaffolds for bone tissue engineering... - Tgf-beta regulation of suture morphogenesis and growthJoseph T Rawlins
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas, USA
Front Oral Biol 12:178-96. 2008..This chapter focuses on the role of Tgf-beta in suture morphogenesis and growth, exploring Tgf-beta biology, receptors, signaling pathways, animal models, and expression in both normal and pathological sutures... - Timing of Egf treatment differentially affects Tgf-beta2 induced cranial suture closureJoseph T Rawlins
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, PO Box 660677, Dallas, TX 75266 0677, USA
Exp Biol Med (Maywood) 233:1518-26. 2008..Appropriate timing of signal generation by Egf and Tgf-beta 2 is critical for normal suture development and maintenance of suture patency... - Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agentsSymone M San Miguel
Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, United States
Arch Oral Biol 57:1657-67. 2012..In this study, we investigated specific polyphenols and turmeric derivative antioxidants (AO) in combinations that counteracted the effects of these stressors on cultured oral fibroblast proliferation and ROS production... - Inheritance of sutural pattern at the pterion in Rhesus monkey skullsQian Wang
Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, Texas A and M University Health Science Center, Dallas, TX 75246, USA
Anat Rec A Discov Mol Cell Evol Biol 288:1042-9. 2006..Future work will be focused on defining the inheritance patterns of variation at the pterion, with the ultimate objective of identifying the specific genes involved and their mechanism of action... - Antioxidant combinations protect oral fibroblasts against metal-induced toxicitySymone M San Miguel
Departments of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX, United States
Arch Oral Biol 58:299-310. 2013..In this study, we investigated specific antioxidant (AO) combinations to determine if they counteract the effects of Cu, Ni and Zn on cultured oral fibroblast proliferation and oxidative damage... - Comparison of the effects of phosphate-coated and sandblasted acid-etched titanium implants on osseointegration: a microcomputed tomographic examination in the canine modelStephen S Walker
Department of Periodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
Int J Oral Maxillofac Implants 27:1069-80. 2012..This study tested the effects of phosphate treatment of titanium on bone volume fraction (BV/TV) at 30 to 60 Μm from the implant surface using microcomputed tomography to analyze the mineralized tissue... - Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesisJayne S Reuben
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:196-204. 2011..SOCS3 has been shown to regulate cell differentiation and survival; however, its potential role in mediating the effects of BPs has not been explored... - Ephrin-B stimulation of calvarial bone formationM Douglas Benson
Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, Dallas, Texas 75246, USA
Dev Dyn 241:1901-10. 2012..Little is known about the role of ephrin-B signaling to EphBs in developmental bone formation... - Bone generation in the reconstruction of a critical size calvarial defect in an experimental modelYong Chen Por
International Craniofacial Institute, Dallas, TX, USA
Ann Acad Med Singapore 36:911-9. 2007..This study was designed to investigate the optimal combination of known osteogenic biomaterials with shape conforming struts to achieve calvarial vault reconstruction, using a canine model... - Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cellsSymone M San Miguel
Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
J Periodontol 81:1675-90. 2010..The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive oxygen species and inhibiting cell migration, and antioxidants (AOs) may counteract nicotine effects... - The effects of bisphosphonates on osteoblasts in vitroAparna Naidu
Department of Diagnostic Science, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:5-13. 2008..The purpose of this study was to test the effects of bisphosphonates on osteoblast viability and function... - Biomechanical strain and morphologic changes with age in rat calvarial bone and suturesReiko Shibazaki
Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75266 0677, USA
Plast Reconstr Surg 119:2167-78; 2179-81. 2007..The role of calvarial sutures in transmitting biomechanical forces within the head is unclear... - Transforming growth factor-beta 3(Tgf-beta3) in a collagen gel delays fusion of the rat posterior interfrontal suture in vivoLynne A Opperman
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, TX 75266 0677, USA
Anat Rec 267:120-30. 2002..However, Tgf-beta3-treated sutures had altered Tgf-beta2 and Tbetar-I distribution compared to controls... - Nasal capsular cartilage is required for rat transpalatal suture morphogenesisKatayoun Adab
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center Dallas, TX 75246, USA
Differentiation 71:496-505. 2003..These studies indicate that tissue interactions likely regulate morphogenesis of all cranial and facial sutures... - Lateral functional shift of the mandible: Part I. Effects on condylar cartilage thickness and proliferationMaria Angeles Fuentes
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Sciences Center, 3302 Gaston Avenue, Dallas, TX 75246, USA
Am J Orthod Dentofacial Orthop 123:153-9. 2003..These data suggest that changes in MCC thickness and proliferative activity might accompany a lateral functional shift of the mandible in growing persons... - Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient miceSunil Wadhwa
Division of Orthodontics, School of Dental Medicine, Department of Craniofacial Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
Bone 40:861-6. 2007..Failure of PFS fusion and hypomineralization of the calvaria in the Bgn/Dcn double deficient mice demonstrates that these extracellular matrix proteoglycans could have a role in controlling the formation and growth of the cranial vault... - Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbitsMark P Mooney
Department of Oral Medicine and Pathology, the Cleft Palate Craniofacial Center, and the School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Plast Reconstr Surg 119:1200-12; discussion 1213-5. 2007..Interference with TGF-beta2 function with the use of neutralizing antibodies may inhibit resynostosis. The present study was designed to test this hypothesis... - Transforming growth factor-beta isoform expression in the perisutural tissues of craniosynostotic rabbitsElyane Poisson
Department of Orthodontics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Cleft Palate Craniofac J 41:392-402. 2004..These abnormal expression patterns may be involved in premature suture fusion either through increased cell proliferation, decreased apoptosis of the osteoblasts or both at the osteogenic fronts... - Rescue of coronal suture fusion using transforming growth factor-beta 3 (Tgf-beta 3) in rabbits with delayed-onset craniosynostosisSherri Lyn Chong
Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Anat Rec A Discov Mol Cell Evol Biol 274:962-71. 2003..The results suggest that there is a dose-dependent effect of TGF-beta 3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis...
Research Grants
- Mandibular Bone transport Reconstruction PlateLYNNE OPPERMAN; Fiscal Year: 2006..abstract_text> ..