ROGER G O'NEIL

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Generation of hair cells by stepwise differentiation of embryonic stem cells
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 100:13495-500. 2003
  2. ncbi request reprint Stem cells as therapy for hearing loss
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Trends Mol Med 10:309-15. 2004
  3. ncbi request reprint Sound from silence
    Kazuo Oshima
    Nat Med 11:249-50. 2005
  4. pmc Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A
    Min Jin
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 6:e16713. 2011
  5. ncbi request reprint Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells
    ROGER G O'NEIL
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Mol Imaging Biol 7:388-92. 2005
  6. ncbi request reprint The mechanosensitive nature of TRPV channels
    ROGER G O'NEIL
    Department of Integrative Biology and Pharmacology, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    Pflugers Arch 451:193-203. 2005
  7. ncbi request reprint Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells
    Ling Wu
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 293:F1699-713. 2007
  8. pmc Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 288:20306-14. 2013
  9. pmc TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress
    Kali Hicks
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Physiol Cell Physiol 298:C1583-93. 2010
  10. pmc Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e22824. 2011

Collaborators

Detail Information

Publications40

  1. pmc Generation of hair cells by stepwise differentiation of embryonic stem cells
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 100:13495-500. 2003
    ....
  2. ncbi request reprint Stem cells as therapy for hearing loss
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Trends Mol Med 10:309-15. 2004
    ....
  3. ncbi request reprint Sound from silence
    Kazuo Oshima
    Nat Med 11:249-50. 2005
  4. pmc Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A
    Min Jin
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 6:e16713. 2011
    ..TRPV4 subunit assembly appears to occur during trafficking from the ER/Golgi to the plasma membrane and is not altered by agonist stimulation...
  5. ncbi request reprint Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells
    ROGER G O'NEIL
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Mol Imaging Biol 7:388-92. 2005
    ....
  6. ncbi request reprint The mechanosensitive nature of TRPV channels
    ROGER G O'NEIL
    Department of Integrative Biology and Pharmacology, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    Pflugers Arch 451:193-203. 2005
    ..Hence, many TRPV channels, or combinations of TRPV channels, display a mechanosensitive nature that underlies multiple mechanosensitive processes from worms to mammals...
  7. ncbi request reprint Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells
    Ling Wu
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 293:F1699-713. 2007
    ....
  8. pmc Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 288:20306-14. 2013
    ..Although the PKA-dependent cascade promotes TRPV4 trafficking and translocation to the apical membrane, the PKC-dependent pathway increases the activity of the channel on the plasma membrane. ..
  9. pmc TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress
    Kali Hicks
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Physiol Cell Physiol 298:C1583-93. 2010
    ..These data suggest that hypoxic stress triggers alterations to cytoskeletal structure that contribute to BBB disruption and that calcium influx through TRPC channels contributes to these events...
  10. pmc Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e22824. 2011
    ..We conclude that stimulation of purinergic signaling by mechanical stimuli leads to activation of TRPV4 and, to a lesser extent, TRPCs channels, and this is an important component of mechano-sensitive response of the ASDN...
  11. pmc TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease
    Oleg Zaika
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    J Am Soc Nephrol 24:604-16. 2013
    ..In conclusion, the functional status of TRPV4, which underlies mechanosensitive Ca(2+) signaling in CD cells, inversely correlates with renal cystogenesis in ARPKD. Augmenting TRPV4 activity may have therapeutic potential in ARPKD...
  12. doi request reprint Ca2+ Imaging as a tool to assess TRP channel function in murine distal nephrons
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA
    Methods Mol Biol 998:371-84. 2013
    ....
  13. pmc Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system
    Jonathan Berrout
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 287:8782-91. 2012
    ..We concluded that TRPV4 is highly expressed along the entire collecting duct system where it appears to function as a sensor/transducer of flow-induce mechanical stresses...
  14. pmc Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels
    Min Jin
    Dept of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77030, USA
    Cell Calcium 51:131-9. 2012
    ....
  15. doi request reprint Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells
    Jonathan Berrout
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77030, USA
    Brain Res 1436:1-12. 2012
    ..We conclude that mechanical injury of brain endothelial cells induces a rapid influx of calcium, mediated by TRPC1 and TRPP2 channels, which leads to NO synthesis and actin cytoskeletal rearrangement...
  16. doi request reprint Emerging Role of the Calcium-Activated, Small Conductance, SK3 K+ Channel in Distal Tubule Function: Regulation by TRPV4
    Jonathan Berrout
    Department of Integrative Biology, The University of Texas Health Science Center Medical School, Houston, Texas, United States of America
    PLoS ONE 9:e95149. 2014
    ..Further, with sites of expression localized to the apical cell membrane, especially in the CNT and CCD, SK3 is poised to be a key pathway for Ca2+-dependent regulation of membrane potential and K+ secretion. ..
  17. ncbi request reprint Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways
    Xiaochong Gao
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 278:27129-37. 2003
    ..The convergence of multiple signals and transduction pathways on the same channel indicate that the channel functions as a molecular integrator of microenvironmental chemical and physical signals...
  18. ncbi request reprint The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli
    ROGER G O'NEIL
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    News Physiol Sci 18:226-31. 2003
    ..Evidence is presented that TRPV channels function as novel "molecular integrators" of diverse microenvironmental stimuli...
  19. pmc Novel insights into TRPV4 function in the kidney
    Oleh Pochynyuk
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Pflugers Arch 465:177-86. 2013
    ....
  20. pmc Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels
    Rachel C Brown
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Microcirculation 15:359-71. 2008
    ..To identify plasma membrane ion channels mediating calcium influx at the blood-brain barrier in response to disrupting stimuli...
  21. doi request reprint TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury
    Zizhen Wu
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Pain 154:2130-41. 2013
    ....
  22. pmc Long-lasting hyperexcitability induced by depolarization in the absence of detectable Ca2+ signals
    Kumud K Kunjilwar
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, Houston, TX, USA
    J Neurophysiol 101:1351-60. 2009
    ....
  23. ncbi request reprint PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries
    Sean P Marrelli
    Department of Anesthesiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H1390-7. 2007
    ..We conclude that PLA(2) is involved in EC Ca(2+) regulation through its regulation of TRPV4 channels. Furthermore, the PLA(2)-sensitive component of Ca(2+) influx may be polarized to the abluminal face of the endothelium...
  24. doi request reprint Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion
    Zahra Timsah
    Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Nat Struct Mol Biol 21:180-8. 2014
    ..Therefore, metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcγ1 for the phosphorylation-independent binding site on FGFR2. ..
  25. pmc Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron
    Oleg Zaika
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 77030, USA
    Am J Physiol Renal Physiol 300:F1105-15. 2011
    ..Therefore, we concluded that BK acutely inhibits ENaC P(o) in mammalian ASDN via stimulation of B2 receptors and following depletion of PI(4,5)P(2), but not increases in [Ca(2+)](i)...
  26. pmc TRP channels as candidates for hearing and balance abnormalities in vertebrates
    Math P Cuajungco
    Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305, USA
    Biochim Biophys Acta 1772:1022-7. 2007
    ..In summary, only a few TRP channels have been analyzed thus far for a prospective role in the inner ear, and this makes the search for additional TRPs associated with inner ear function quite a tantalizing endeavor...
  27. ncbi request reprint A unified nomenclature for the superfamily of TRP cation channels
    Craig Montell
    Mol Cell 9:229-31. 2002
  28. ncbi request reprint Vertebrate and invertebrate TRPV-like mechanoreceptors
    Hideki Mutai
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Boston, MA 02114, USA
    Cell Calcium 33:471-8. 2003
    ....
  29. pmc The potential role of endogenous stem cells in regeneration of the inner ear
    Rodrigo Martinez-Monedero
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Hear Res 227:48-52. 2007
    ..Future strategies for regeneration must consider the distribution of endogenous stem cells in the inner ear and whether the tissue retains cells with the capacity for regeneration...
  30. ncbi request reprint Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system
    Gabor Keresztes
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Mol Cell Neurosci 24:687-95. 2003
    ..GTPase-activating proteins to specific membranous compartments...
  31. ncbi request reprint Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 468:125-34. 2004
    ....
  32. ncbi request reprint Pluripotent stem cells from the adult mouse inner ear
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nat Med 9:1293-9. 2003
    ..Our observation that these stem cells are capable of differentiating into hair cell-like cells implies a possible use of such cells for the replacement of lost inner-ear sensory cells...
  33. pmc Parvalbumin 3 is an abundant Ca2+ buffer in hair cells
    Stefan Heller
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Assoc Res Otolaryngol 3:488-98. 2002
    ..Parvalbumin 3 is therefore a significant mobile Ca2+ buffer, and perhaps the dominant buffer, in many types of hair cell. Moreover, parvalbumin 3 provides an early marker for developing hair cells in the frog, chicken, and zebrafish...
  34. ncbi request reprint Islet-1 expression in the developing chicken inner ear
    Huawei Li
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 477:1-10. 2004
    ..Our data is consistent with a role for islet-1 in differentiating inner ear neurons and sensory epithelia cells, perhaps in the specification of cellular subtypes in conjunction with other LIM/homeodomain proteins...
  35. pmc BMP4 signaling is involved in the generation of inner ear sensory epithelia
    Huawei Li
    Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    BMC Dev Biol 5:16. 2005
    ..Homozygous BMP4-/- animals die before the inner ear's sensory organs develop, which precludes determining the role of BMP4 in these organs with simple gene knockout experiments...
  36. ncbi request reprint Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro
    Yanling Zhao
    Otology Skull Base Surgery Department, Hearing Research Institute, PR China
    Neuroreport 17:121-4. 2006
    ..When Shh signaling was blocked with cyclopamine, hair cell generation was largely inhibited. Our results suggest that Shh may be a regulator of inner ear progenitor cell growth and hair cell generation...
  37. pmc Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons
    Rodrigo Martinez-Monedero
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurobiol 66:319-31. 2006
    ..These findings suggest that it may be possible to replace degenerated neurons by grafting new cells into the organ of Corti...
  38. pmc Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti
    C Eduardo Corrales
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Neurobiol 66:1489-500. 2006
    ..The regeneration of these neurons shows that neurons differentiated from stem cells have the capacity to grow to a specific target in an animal model of neuronal degeneration...
  39. pmc Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells
    Sang Jun Jeon
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Neurosci 34:59-68. 2007
    ....
  40. pmc Differential distribution of stem cells in the auditory and vestibular organs of the inner ear
    Kazuo Oshima
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305 5739, USA
    J Assoc Res Otolaryngol 8:18-31. 2007
    ..Our findings indicate that the lack of regenerative capacity in the adult mammalian cochlea is either a result of an early postnatal loss of stem cells or diminishment of stem cell features of maturing cochlear cells...