W Ondo

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Tetrabenazine treatment for stereotypies and tics associated with dementia
    William G Ondo
    Baylor College of Medicine, Houston, TX, USA
    J Neuropsychiatry Clin Neurosci 24:208-14. 2012
  2. doi request reprint Apomorphine injections: predictors of initial common adverse events and long term tolerability
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Parkinsonism Relat Disord 18:619-22. 2012
  3. doi request reprint Task-specific writing tremor: clinical phenotypes, progression, treatment outcomes, and proposed nomenclature
    William G Ondo
    Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
    Int J Neurosci 122:88-91. 2012
  4. ncbi request reprint Predictors of battery life for the Activa Soletra 7426 Neurostimulator
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, USA
    Parkinsonism Relat Disord 13:240-2. 2007
  5. ncbi request reprint Computerized posturography balance assessment of patients with bilateral ventralis intermedius nuclei deep brain stimulation
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:2243-7. 2006
  6. ncbi request reprint Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:1614-7. 2006
  7. ncbi request reprint Subthalamic deep brain stimulation in patients with a previous pallidotomy
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:1252-4. 2006
  8. ncbi request reprint VIM deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor
    William Ondo
    Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX77030, USA
    Parkinsonism Relat Disord 12:113-4. 2006
  9. pmc Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial
    W G Ondo
    Baylor College of Medicine, Houston, TX 77030, USA
    J Neurol Neurosurg Psychiatry 76:1636-9. 2005
  10. ncbi request reprint Restless legs syndrome
    William G Ondo
    Baylor College of Medicine, Houston, TX, USA
    Neurol Clin 23:1165-85, viii. 2005

Detail Information

Publications87

  1. doi request reprint Tetrabenazine treatment for stereotypies and tics associated with dementia
    William G Ondo
    Baylor College of Medicine, Houston, TX, USA
    J Neuropsychiatry Clin Neurosci 24:208-14. 2012
    ..Efficacy has not waned over time. Tetrabenazine dramatically improved stereotypies in patients with dementia. This observation could increase understanding of this interesting phenotype...
  2. doi request reprint Apomorphine injections: predictors of initial common adverse events and long term tolerability
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Parkinsonism Relat Disord 18:619-22. 2012
    ..Apomorphine injections effectively abort "off" episodes in Parkinson's disease (PD). However, their use is limited by actual and perceived adverse events (AE). To our knowledge, no study has evaluated for predictors of these problems...
  3. doi request reprint Task-specific writing tremor: clinical phenotypes, progression, treatment outcomes, and proposed nomenclature
    William G Ondo
    Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
    Int J Neurosci 122:88-91. 2012
    ..This supports segregation between task-specific tremor and essential tremor but does not support the specific diagnosis of "writing tremor" because many patients progress to tremor with other tasks...
  4. ncbi request reprint Predictors of battery life for the Activa Soletra 7426 Neurostimulator
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, USA
    Parkinsonism Relat Disord 13:240-2. 2007
    ..002), pulse width (p=0.026), and not using exclusive bipolar settings (p=0.029). The implant location, underlying disease, and sex did not affect battery life. Battery life varied but was generally consistent with published predictors...
  5. ncbi request reprint Computerized posturography balance assessment of patients with bilateral ventralis intermedius nuclei deep brain stimulation
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:2243-7. 2006
    ..Falls lessened with activation in ET patients. Motor control testing was not changed. Bilateral Vim DBS activation mostly improved balance, but may modestly worsen other specific features...
  6. ncbi request reprint Intravenous flumazenil for Parkinson's disease: a single dose, double blind, placebo controlled, cross-over trial
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:1614-7. 2006
    ..The medication was well tolerated. The most common adverse event on drug was a sense of "light-headedness" or "dizziness." GABA antagonists represent a novel potential treatment class for PD...
  7. ncbi request reprint Subthalamic deep brain stimulation in patients with a previous pallidotomy
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:1252-4. 2006
    ..This may be partially due to a selection bias, but it may also indicate that prior pallidotomy is a negative predictor of outcome of STN DBS and should be considered in patient selection...
  8. ncbi request reprint VIM deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor
    William Ondo
    Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX77030, USA
    Parkinsonism Relat Disord 12:113-4. 2006
    ..Although the VIM DBS improved tremor, none of the subjects felt there was any meaningful effect on their RLS symptoms. The VIM thalamus, which is involved in ET and Parkinson's disease, does not seem to be primarily involved in RLS...
  9. pmc Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial
    W G Ondo
    Baylor College of Medicine, Houston, TX 77030, USA
    J Neurol Neurosurg Psychiatry 76:1636-9. 2005
    ..The aetiology of EDS is probably multifactorial but is probably exacerbated by dopaminergic medications. Modafinil is a wake-promoting agent approved for use in narcolepsy, but it is often used to treat a variety of somnolent conditions...
  10. ncbi request reprint Restless legs syndrome
    William G Ondo
    Baylor College of Medicine, Houston, TX, USA
    Neurol Clin 23:1165-85, viii. 2005
    ..Effective treatments include dopaminergics and narcotics. Recent advances in our understanding of RLS clinical presentation, epidemiology, etiology, and treatment will be discussed...
  11. ncbi request reprint The North American survey of placement and adjustment strategies for deep brain stimulation
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Stereotact Funct Neurosurg 83:142-7. 2005
    ..Deep brain stimulation (DBS) is gaining wide acceptance as treatment for Parkinson's disease (PD), essential tremor, and dystonia...
  12. ncbi request reprint Restless legs syndrome
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Curr Neurol Neurosci Rep 5:266-74. 2005
    ..Genetic studies will hopefully soon identify specific abnormalities. Treatment of restless legs syndrome with dopaminergic medications is highly effective, although augmentation may occur eventually and require dosing flexibility...
  13. ncbi request reprint Double-blind, placebo-controlled, unforced titration parallel trial of quetiapine for dopaminergic-induced hallucinations in Parkinson's disease
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 20:958-63. 2005
    ..Larger doses of drug and greater sample sizes might be considered in future studies...
  14. ncbi request reprint Evaluating factors that can influence spirography ratings in patients with essential tremor
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
    Parkinsonism Relat Disord 11:45-8. 2005
    ..Effort' had little effect on ratings. Based on our results, we recommend that assessment of ET include unsupported, freehand spirals...
  15. ncbi request reprint Animal models of restless legs syndrome
    W G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Sleep Med 8:344-8. 2007
    ..More sophisticated animal modeling is needed to facilitate our understanding of RLS...
  16. ncbi request reprint Predictors of impulsivity and reward seeking behavior with dopamine agonists
    William G Ondo
    Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Parkinsonism Relat Disord 14:28-32. 2008
    ..01), larger doses of DA (p<0.001), and PD, as opposed to RLS (p<0.01), but this lost significance after correcting for dose (p=0.09). Increased impulsivity is common but usually not deleterious...
  17. doi request reprint Motor complications in Parkinson's disease
    William G Ondo
    Department of Neurology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Int J Neurosci 121:37-44. 2011
    ..Surgical interventions such as lesioning and deep brain stimulation are considered when pharmacological strategies for motor complications are not satisfactory...
  18. doi request reprint Hyperglycemic nonketotic states and other metabolic imbalances
    William G Ondo
    Baylor College of Medicine, Houston, TX 77030, USA
    Handb Clin Neurol 100:287-91. 2011
    ..Tetrabenazine has worked well when symptomatic treatment is required. Other rare causes of metabolic choreas include hypoparathyroid abnormalities, hypoglycemia, and hypernatremia...
  19. doi request reprint Memantine for non-motor features of Parkinson's disease: a double-blind placebo controlled exploratory pilot trial
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Parkinsonism Relat Disord 17:156-9. 2011
    ..To perform an exploratory study evaluating memantine for several common non-motor problems in Parkinson's disease...
  20. doi request reprint Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease
    William G Ondo
    Dept of Neurology, Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Parkinsonism Relat Disord 17:117-8. 2011
    ..Adverse events were mild. Patients generally preferred the Zydis selegiline preparation but the modest difference is of unclear clinical significance given the open label nature of the trial...
  21. doi request reprint Comparison of orally dissolving carbidopa/levodopa (Parcopa) to conventional oral carbidopa/levodopa: A single-dose, double-blind, double-dummy, placebo-controlled, crossover trial
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 25:2724-7. 2010
    ..However, all trends did favor OD C/L. Adverse events were similar. This small pilot study did not show significant group differences favoring OD C/L; however, larger studies may be justified, and individual patients may benefit...
  22. doi request reprint Intravenous iron dextran for severe refractory restless legs syndrome
    William G Ondo
    Baylor College of Medicine, Houston TX 77030, USA
    Sleep Med 11:494-6. 2010
    ..Although burdened by a higher rate of anaphylactic reactions, iron dextran may be superior to other IV iron preparations...
  23. doi request reprint Sodium oxybate for excessive daytime sleepiness in Parkinson disease: an open-label polysomnographic study
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA
    Arch Neurol 65:1337-40. 2008
    ..Many patients with Parkinson disease (PD) have excessive daytime sleepiness and numerous nocturnal sleep abnormalities...
  24. doi request reprint Comparison of weight gain in treatments for Tourette syndrome: tetrabenazine versus neuroleptic drugs
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    J Child Neurol 23:435-7. 2008
    ..006). Most patients who switched from a neuroleptic drug to tetrabenazine subsequently lost weight. Although the study was not designed to compare efficacy, this tended to be greater with tetrabenazine than with neuroleptic drugs...
  25. ncbi request reprint Zonisamide for essential tremor
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Neuropharmacol 30:345-9. 2007
    ..The pharmacological therapy for essential tremor (ET) is inadequate, and many patients resort to surgical procedures. Zonisamide is an antiepileptic with several potential mechanisms of action...
  26. ncbi request reprint Selegiline orally disintegrating tablets in patients with Parkinson disease and "wearing off" symptoms
    William G Ondo
    Baylor College of Medicine, Department of Neurology, 6550 Fannin, Houston, TX 77030, USA
    Clin Neuropharmacol 30:295-300. 2007
    ..Most patients on long-term LD therapy eventually experience deterioration at the end of the LD dosing interval, with predictable "wearing off" and "on-off" fluctuations...
  27. ncbi request reprint Withdrawal of visual feedback improves micrographia in Parkinson's disease
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030 2744, USA
    Mov Disord 22:2130-1. 2007
    ..Furthermore, some patients have adapted this simple eye closing strategy when writing, especially signatures...
  28. ncbi request reprint An open-label pilot study of levetiracetam for essential tremor
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, Texas 77030, USA
    Clin Neuropharmacol 27:274-7. 2004
    ..Adverse events included dizziness (n=2), sedation (n=1), and nervousness (n=1). Levetiracetam was well tolerated but failed to improve tremor consistently in this small trial...
  29. ncbi request reprint Olfaction testing in patients with tremor-dominant Parkinson's disease: is this a distinct condition?
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 20:471-5. 2005
    ..It additionally suggests phenotypic overlap between PD and ET...
  30. ncbi request reprint Methadone for refractory restless legs syndrome
    William G Ondo
    Baylor College of Medicine, Houston Texas 77030 2744, USA
    Mov Disord 20:345-8. 2005
    ..All patients who remain on methadone report at least a 75% reduction in symptoms, and none have developed augmentation. Methadone should be considered in RLS patients with an unsatisfactory dopaminergic response...
  31. ncbi request reprint Flumazenil, a GABA antagonist, may improve features of Parkinson's disease
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 18:683-5. 2003
    ..05). Total motor Unified Parkinson's Disease Rating Scale scores modestly improved (P < 0.05). There were no adverse events. Mechanisms by which flumazenil could improve PD are discussed...
  32. ncbi request reprint Gait and balance disorders
    William Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA
    Med Clin North Am 87:793-801, viii. 2003
    ..Because treatment is so dependent on the underlying etiology, this article mostly concerns diagnosis and provides descriptive case studies...
  33. ncbi request reprint Daytime sleepiness and other sleep disorders in Parkinson's disease
    W G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Neurology 57:1392-6. 2001
    ..PD is associated with a variety of sleep problems. The dopamine agonists (DA) pramipexole and ropinirole were recently implicated in causing "sleep attacks" and motor vehicle accidents...
  34. ncbi request reprint Physiological assessment of paroxysmal dystonia secondary to subacute sclerosing panencephalitis
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, Texas, USA
    Mov Disord 17:154-7. 2002
    ..The frequency and amplitude of the episodes initially markedly improved after the addition of carbamazepine. We suggest that the movements seen in this case of SSPE may represent basal ganglia ictal activity...
  35. ncbi request reprint Thalamic deep brain stimulation: comparison between unilateral and bilateral placement
    W Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Dr, Suite 1801, Houston, TX 77030, USA
    Arch Neurol 58:218-22. 2001
    ..There are, however, relatively little data concerning bilateral thalamic DBS and no thorough comparisons between the 2 methods...
  36. ncbi request reprint Restless legs syndrome in monozygotic twins: clinical correlates
    W G Ondo
    Parkinson s Disease Center, Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Neurology 55:1404-6. 2000
    ..Despite the high concordance rate, the disease severity, age at onset, and symptom descriptions often varied between twins. Birth order, birth weight, and serum ferritin levels did not predict RLS severity or age at onset...
  37. ncbi request reprint Hearing impairment in essential tremor
    W G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, USA
    Neurology 61:1093-7. 2003
    ..To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls...
  38. ncbi request reprint Exploring the relationship between Parkinson disease and restless legs syndrome
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030
    Arch Neurol 59:421-4. 2002
    ..Restless legs syndrome (RLS) and Parkinson disease (PD) are common neurological conditions that respond to dopaminergic therapy. To our knowledge, the relationship between the two has not been thoroughly explored...
  39. ncbi request reprint Botulinum toxin A for chronic daily headache: a randomized, placebo-controlled, parallel design study
    W G Ondo
    Department of Neurology, Baylor College of Medicine, 6556 Fannin, Suite 1801, Houston, TX 77030, USA
    Cephalalgia 24:60-5. 2004
    ..26 +/- 19 (P < 0.05). BTX may help chronic daily headache and appears to have a cumulative effect with subsequent injections. The treatment was very well tolerated...
  40. ncbi request reprint A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson's disease
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA
    Neurology 62:37-40. 2004
    ..Based on the relatively high rates of dry mouth seen with botulinum toxin B, there is reason to suspect that it may also improve sialorrhea...
  41. ncbi request reprint Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls
    W Ondo
    Department of Neurlogy, Baylor College of Medicine, Houston, Texas, USA
    Arch Neurol 57:1464-9. 2000
    ..Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is frequently mistaken for Parkinson's disease (PD) in its early stages...
  42. ncbi request reprint Tetrabenazine treatment for Huntington's disease-associated chorea
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Neuropharmacol 25:300-2. 2002
    ..TBZ was well tolerated and resulted in a significant improvement in modified AIMS scores in HD patients. These results support the use of TBZ for chorea in patients with HD...
  43. ncbi request reprint Long-term treatment of restless legs syndrome with dopamine agonists
    William Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Houston, TX 77030, USA
    Arch Neurol 61:1393-7. 2004
    ..Augmentation-an increase in the duration, intensity, and anatomy of RLS symptoms-is commonly associated with dopaminergic treatments; however, risk factors for this troubling scenario have not been formally evaluated...
  44. ncbi request reprint Tetrabenazine treatment for tardive dyskinesia: assessment by randomized videotape protocol
    W G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Psychiatry 156:1279-81. 1999
    ..Tetrabenazine, a monoamine depleter and dopamine receptor blocker, is used to treat several hyperkinetic movement disorders. The authors studied the use of tetrabenazine for tardive dyskinesia...
  45. ncbi request reprint Thalamic deep brain stimulation: effects on the nontarget limbs
    W Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 16:1137-42. 2001
    ..We conclude that VIM DBS may mildly improve ipsilateral ET, and that concerns about meaningful ipsilateral tremor augmentation after device deactivation are not warranted...
  46. ncbi request reprint Locomotor response to levodopa in fluctuating Parkinson's disease
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, Box 1135, 1 E 100th St, New York, NY 10029, USA
    Exp Brain Res 184:469-78. 2008
    ..Ambulatory monitoring of gait objectively measures the dynamic locomotor response to levodopa, and this information could be used to improve daily management of motor fluctuations...
  47. doi request reprint Long-term efficacy of rasagiline in early Parkinson's disease
    Mark F Lew
    Department of Neurology, Keck University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Int J Neurosci 120:404-8. 2010
    ..Rasagiline was well tolerated, with 11.3% of patients (45/398) withdrawing because of an adverse event. Rasagiline therapy for PD was effective, well tolerated, and safe in this long-term trial...
  48. ncbi request reprint Olanzapine treatment for dopaminergic-induced hallucinations
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 17:1031-5. 2002
    ..8%) of all patients exposed to drug (including those originally randomly assigned to placebo) remained on olanzapine. In patients with PD, low-dose olanzapine did not significantly improve hallucinations but did worsen motor function...
  49. pmc Re-emergent tremor of Parkinson's disease
    J Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurol Neurosurg Psychiatry 67:646-50. 1999
    ..It is postulated that one type of postural tremor in Parkinson's disease represents a rest tremor that re-emerges after a variable delay while maintaining posture, hence "re-emergent tremor"...
  50. ncbi request reprint Comparison of thalamotomy and pallidotomy for the treatment of dystonia
    D Yoshor
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Neurosurgery 48:818-24; discussion 824-6. 2001
    ..In this study, we compare our results using thalamotomy and pallidotomy to treat patients with different forms of dystonia, and we discuss our results in the context of other published series...
  51. ncbi request reprint Alcohol dehydrogenase polymorphism and Parkinson's disease
    E K Tan
    Department of Neurology, VA Medical Center, Baylor College of Medicine, Houston, TX, USA
    Neurosci Lett 305:70-2. 2001
    ..2%). No strong evidence of an association was found between ADH A1 allele and PD susceptibility in our study patients. There was also no suggestion of linkage disequilibrium between NACP-Rep 1 and ADH A1 alleles...
  52. doi request reprint A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)
    Oraporn Sitburana
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Clin Neurol Neurosurg 112:106-9. 2010
    ..To perform a pilot study to investigate the relationship between the microlesion effect (MLE) seen in deep brain stimulation (DBS) of the ventralis intermedius nucleus (VIM) and subsequent tremor response and DBS parameter settings...
  53. doi request reprint Restless legs syndrome
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Neurol Clin 27:779-99, vii. 2009
    ..Dopamine agonists are clearly the best investigated and probably the most effective treatments for RLS...
  54. doi request reprint Weight change in Parkinson and Alzheimer patients taking atypical antipsychotic drugs
    Oraporn Sitburana
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    J Neurol Sci 272:77-82. 2008
    ..The BMI for 28 AD subjects on AA increased 0.01 kg/m(2)/month (95% CI 0.26-0.83, P<0.0001), comparing PD on AA vs. AD on AA. The weight loss seen in the PD/AA group, compared to AD, suggest uniquely altered weight homeostasis in PD...
  55. doi request reprint Open-label study assessment of safety and adverse effects of subcutaneous apomorphine injections in treating "off" episodes in advanced Parkinson disease
    Peter A LeWitt
    Department of Neurology, Wayne State University School of Medicine and Henry Ford Hospital, Detroit, MI 48034, USA
    Clin Neuropharmacol 32:89-93. 2009
    ..To assess the safety and adverse effect profile of continued use of intermittent subcutaneous apomorphine to treat "off" episodes in subjects with advanced Parkinson disease...
  56. ncbi request reprint Association between restless legs syndrome and essential tremor
    William G Ondo
    Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:515-8. 2006
    ....
  57. doi request reprint Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States
    Wayne A Hening
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Mov Disord 25:1675-83. 2010
    ..Rotigotine transdermal patches releasing 2 to 3 mg/24 hr significantly reduced the severity of RLS symptoms. Treatment efficacy was maintained throughout the 6-month double-blind period...
  58. ncbi request reprint Long-term evaluation of deep brain stimulation of the thalamus
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 104:506-12. 2006
    ..The aim of this study was to evaluate the long-term safety and efficacy of DBS of the ventralis intermedius nucleus (VIM) of the thalamus for PD and ET...
  59. ncbi request reprint Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation
    Hongru Zhao
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 85:1065-76. 2007
    ....
  60. ncbi request reprint Long-term monitoring of gait in Parkinson's disease
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gait Posture 26:200-7. 2007
    ....
  61. doi request reprint Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study
    Arthur S Walters
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
    J Neurol Sci 279:62-5. 2009
    ..In addition, other opioid rich areas need to be explored as well as areas implicated in the pathogenesis of RLS such as the red nucleus and raphe nucleus...
  62. ncbi request reprint Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy
    Manjit K Sanghera
    Department of Neurosurgery, Baylor College of Medicine, 6560 Fannin Street, Houston, TX 77030, USA
    Neurosurgery 52:1358-70; discussion 1370-3. 2003
    ..Basal ganglia neuronal activity in patients undergoing posteroventral pallidotomy (PVP) for the treatment of primary genetic, secondary, or idiopathic dystonia (DYS) was studied to gain a better understanding of the pathophysiology of DYS...
  63. ncbi request reprint Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome
    Shen Qu
    Departments of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neuropathol Exp Neurol 66:383-8. 2007
    ..This model could be consistent with human RLS, attention deficit hyperactivity disorder, or akathisia...
  64. doi request reprint Gabapentin enacarbil in restless legs syndrome: a phase 2b, 2-week, randomized, double-blind, placebo-controlled trial
    Arthur S Walters
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave, Nashville, TN 37232 2551, USA
    Clin Neuropharmacol 32:311-20. 2009
    ..Assess the efficacy and tolerability of gabapentin enacarbil (GEn), a transported prodrug of gabapentin with improved gabapentin exposure, in adults with moderate-to-severe primary restless legs syndrome...
  65. ncbi request reprint Ambulatory monitoring of freezing of gait in Parkinson's disease
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, Box 1135, 1 E 100th Street, New York, NY 10029, USA
    J Neurosci Methods 167:340-8. 2008
    ..Individual calibration of the freeze threshold improved accuracy and sensitivity of the device to 89% for detection of FOG with 10% false positives. Ambulatory monitoring may significantly improve clinical management of FOG...
  66. ncbi request reprint Heterogeneous phenotype in a family with compound heterozygous parkin gene mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Neurol 63:273-7. 2006
    ..Mutations in the parkin gene (PRKN) cause autosomal recessive early-onset Parkinson disease (EOPD)...
  67. ncbi request reprint Tetrabenazine for hyperglycemic-induced hemichorea-hemiballismus
    Oraporn Sitburana
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 21:2023-5. 2006
    ..Subsequent dose reductions lead to a reemergence of symptoms. Tetrabenazine improves a variety of hyperkinetic movement disorders but, to our knowledge, its use has never been reported for HIHH...
  68. ncbi request reprint Vascular parkinsonism: clinical correlates predicting motor improvement after lumbar puncture
    William G Ondo
    Baylor College of Medicine, Department of Neurology, Houston, Texas, USA
    Mov Disord 17:91-7. 2002
    ..These results warrant further investigation and also raise the possibility of testing CSF drainage in patients with idiopathic PD complicated by SCWMC...
  69. ncbi request reprint Basal ganglia neuronal discharge in primary and secondary dystonia
    Manjit K Sanghera
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA
    Adv Neurol 94:29-36. 2004
  70. ncbi request reprint Restless legs syndrome: pathophysiology, diagnosis and treatment
    Pankaj Satija
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    CNS Drugs 22:497-518. 2008
    ..Other treatment options include gabapentin, or similar antiepileptic drugs, and opioids. High-dose intravenous iron is a promising but still experimental approach...
  71. ncbi request reprint A pilot study of botulinum toxin A for headache in cervical dystonia
    William G Ondo
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Headache 45:1073-7. 2005
    ..To evaluate the prevalence of associated headache (HA) pain with craniocervical dystonia and the therapeutic effect of BoNT-A injections on the HA component when injected for cervical dystonia...
  72. ncbi request reprint A pilot study of the clinical efficacy and safety of memantine for Huntington's disease
    William G Ondo
    Parkinsonism Relat Disord 13:453-4. 2007
  73. ncbi request reprint Open-label flexible-dose pilot study to evaluate the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson's disease
    Joseph H Friedman
    Parkinson Disease and Movement Disorders Center, NeuroHealth, Warwick, Rhode Island 02886, USA
    Mov Disord 21:2078-81. 2006
    ..While some patients had a favorable response, aripiprazole was associated with an exacerbation of motor symptoms. In this small study on psychosis in PD, aripiprazole did not appear promising...
  74. ncbi request reprint Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor
    Mark A Stacy
    Division of Neurology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Mov Disord 22:833-8. 2007
    ..It is best when the same rater performs repeated measures of tremor on a patient, particularly when judging tremor in handwriting and drawings. Training of raters on use of the TRS would help standardize judgement...
  75. ncbi request reprint Placebo response in Parkinson trials using patient diaries: sites do matter
    William G Ondo
    Clin Neuropharmacol 30:301-4. 2007
  76. doi request reprint Efficacy and safety of purified botulinum toxin type A (Dysport) for the treatment of benign essential blepharospasm: a randomized, placebo-controlled, phase II trial
    Daniel Truong
    The Parkinson s and Movement Disorder Institute, Orange Coast Memorial Medical Center, 9940 Talbert Ave 204, Fountain Valley, CA 92708, USA
    Parkinsonism Relat Disord 14:407-14. 2008
    ..The best balance of sustained efficacy and favorable safety profile was provided by 80 units of Dysport/eye in this study...
  77. pmc Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p
    Shenghan Chen
    Center for Molecular Genetics, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Hum Genet 74:876-85. 2004
    ..This study establishes RLS as a highly heritable trait, identifies a novel genetic locus for RLS, and will facilitate further cloning and identification of the genes for RLS...
  78. ncbi request reprint Ropinirole is effective in the treatment of restless legs syndrome. TREAT RLS 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled study
    Arthur S Walters
    New Jersey Neuroscience Institute at JFK Medical Center, Edison, New Jersey 08818, USA
    Mov Disord 19:1414-23. 2004
    ..Ropinirole improves symptoms, associated sleep disturbance, and QoL of RLS patients and is generally well tolerated...
  79. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  80. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  81. ncbi request reprint G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy
    Laurie J Ozelius
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
    Mov Disord 22:546-9. 2007
    ..We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA...
  82. doi request reprint Task-specific focal hand dystonia in a professional pistol-shooter
    Oraporn Sitburana
    Clin Neurol Neurosurg 110:423-4. 2008
  83. ncbi request reprint Benefits and risks of pharmacological treatments for essential tremor
    Kelly E Lyons
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Drug Saf 26:461-81. 2003
    ..The use of medication and/or surgery can provide adequate tremor control in the majority of the patients...
  84. ncbi request reprint Potential outcome measures and trial design issues for multiple system atrophy
    Susanne May
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0717, USA
    Mov Disord 22:2371-7. 2007
    ..The UMSARS Motor Examination score exhibited the most favorable characteristics as an outcome measure for a therapeutic trial in MSA with 1 year of follow-up...
  85. ncbi request reprint Animal studies in restless legs syndrome
    Paul Christian Baier
    Department of Psychiatry and Psychotherapy, Christian Albrechts University Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Mov Disord 22:S459-65. 2007
    ..This review discusses the general and specific prerequisites necessary for the establishment of animal models for RLS and summarizes the approaches that have been made...
  86. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...