J R Nation

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Brain and plasma levels of cocaine and benzoylecgonine in lead-expose and cadmium-exposed rats following acute or chronic intraperitoneal administration of cocaine
    J R Nation
    Department of Psychology, Texas A and M University, College Station 77843, USA
    Toxicol Lett 92:47-57. 1997
  2. ncbi request reprint The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs
    J R Nation
    Department of Psychology, Texas A and M University, College Station 77843 4235, USA
    Exp Clin Psychopharmacol 7:90-102. 1999
  3. ncbi request reprint Perinatal lead exposure and relapse to drug-seeking behavior in the rat: a cocaine reinstatement study
    Jack R Nation
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Psychopharmacology (Berl) 168:236-43. 2003
  4. ncbi request reprint Early developmental lead exposure increases sensitivity to cocaine in a self-administration paradigm
    Jack R Nation
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 77:127-35. 2004
  5. ncbi request reprint Enhanced acquisition of cocaine self-administration in rats developmentally exposed to lead
    Angelica Rocha
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Neuropsychopharmacology 30:2058-64. 2005
  6. pmc Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task
    Ian A Mendez
    Department of Psychology, Texas A and M University, USA
    Behav Neurosci 124:470-7. 2010
  7. ncbi request reprint The effects of the GABAA antagonist bicuculline on cocaine self-administration in rats exposed to lead during gestation/lactation
    Rodrigo Valles
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 80:611-9. 2005
  8. ncbi request reprint Exposure to cadmium during gestation and lactation decreases cocaine self-administration in rats
    Aaron L Cardon
    Department of Psychology, Rm 230, Texas A and M University, College Station, TX 77843, USA
    Neurotoxicology 25:869-75. 2004
  9. pmc Prenatal lead exposure enhances methamphetamine sensitization in rats
    P Shane Clifford
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 93:165-9. 2009
  10. pmc Lobeline attenuates progressive ratio breakpoint scores for intracranial self-stimulation in rats
    Paul J Wellman
    Behavioral Neuroscience Program, Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Physiol Behav 93:952-7. 2008

Research Grants

Collaborators

  • PAUL JEFFERSON WELLMAN
  • Barry Setlow
  • Nicholas W Simon
  • Angelica Rocha
  • Rodrigo Valles
  • Gerald R Bratton
  • Aaron L Cardon
  • Nigel Hart
  • Kelly R Smith
  • N Hart
  • Ian A Mendez
  • P Shane Clifford
  • Anna J Diller
  • Marci R Mitchell
  • A Rocha
  • D K Miller
  • Sam Buckman
  • Jeff Thompson
  • Aaron Cardon
  • Heather M Heard

Detail Information

Publications22

  1. ncbi request reprint Brain and plasma levels of cocaine and benzoylecgonine in lead-expose and cadmium-exposed rats following acute or chronic intraperitoneal administration of cocaine
    J R Nation
    Department of Psychology, Texas A and M University, College Station 77843, USA
    Toxicol Lett 92:47-57. 1997
    ..The failure to show that lead or cadmium alters the disposition of cocaine in brain or plasma underscores the need to pursue alternative accounts of metal/cocaine interactions...
  2. ncbi request reprint The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs
    J R Nation
    Department of Psychology, Texas A and M University, College Station 77843 4235, USA
    Exp Clin Psychopharmacol 7:90-102. 1999
    ..Also, cadmium exposure blocked tolerance to cocaine that was evident in control rats following 14 days of exposure to 60 mg/kg/day cocaine...
  3. ncbi request reprint Perinatal lead exposure and relapse to drug-seeking behavior in the rat: a cocaine reinstatement study
    Jack R Nation
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Psychopharmacology (Berl) 168:236-43. 2003
    ..Insofar as drug potency is increased by early lead exposure, it must be considered that cocaine-seeking and relapse after periods of withdrawal similarly may be enhanced by perinatal lead exposure...
  4. ncbi request reprint Early developmental lead exposure increases sensitivity to cocaine in a self-administration paradigm
    Jack R Nation
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 77:127-35. 2004
    ..Collectively, these data suggest that early developmental lead exposure may increase sensitivity to cocaine later in the life cycle...
  5. ncbi request reprint Enhanced acquisition of cocaine self-administration in rats developmentally exposed to lead
    Angelica Rocha
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Neuropsychopharmacology 30:2058-64. 2005
    ..At the higher cocaine dose (Experiment 2), acquisition rates for control and lead-exposed animals were not markedly different, and significantly different infusion rates were not observed...
  6. pmc Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task
    Ian A Mendez
    Department of Psychology, Texas A and M University, USA
    Behav Neurosci 124:470-7. 2010
    ....
  7. ncbi request reprint The effects of the GABAA antagonist bicuculline on cocaine self-administration in rats exposed to lead during gestation/lactation
    Rodrigo Valles
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 80:611-9. 2005
    ..The data suggest that GABA antagonism results in increased reward potency of a low dose of cocaine and further, that this effect is differentially expressed in animals exposed to perinatal lead...
  8. ncbi request reprint Exposure to cadmium during gestation and lactation decreases cocaine self-administration in rats
    Aaron L Cardon
    Department of Psychology, Rm 230, Texas A and M University, College Station, TX 77843, USA
    Neurotoxicology 25:869-75. 2004
    ..030, and 0.060 mg/kg inf cocaine. These data indicate that early-life cadmium exposure, a common exposure vector of which is the use of tobacco products, may affect cocaine sensitivity...
  9. pmc Prenatal lead exposure enhances methamphetamine sensitization in rats
    P Shane Clifford
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 93:165-9. 2009
    ..Hart N., Bratton G.R., Nation J.R. Developmental lead exposure attenuates methamphetamine dose-effect self-administration performance and progressive ratio responding in the male rat. Pharmacol Biochem Behav 2008b;89:508-514]...
  10. pmc Lobeline attenuates progressive ratio breakpoint scores for intracranial self-stimulation in rats
    Paul J Wellman
    Behavioral Neuroscience Program, Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Physiol Behav 93:952-7. 2008
    ..0 mg/kg cocaine, a dose that is sufficient to elevate locomotion in the rat. These results are consistent with the view that lobeline modulates brain reinforcement processes...
  11. doi request reprint Differential impact of cocaine on meal patterns in female and male rats
    Paul J Wellman
    Cellular and Behavioral Neuroscience Program, Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Life Sci 82:359-66. 2008
    ..These results extend the range of behavioral perturbations induced by cocaine that are modulated by sex and by the estrous cycle and are consistent with the notion that estradiol may modulate the neurochemical actions of cocaine...
  12. pmc Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet
    Paul J Wellman
    Behavioral Neuroscience Program, Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Pharmacol Biochem Behav 88:89-93. 2007
    ..The results suggest that prolonged exposure to a high-fat diet diminishes the efficacy of cocaine reinforcement...
  13. ncbi request reprint Augmentation of cocaine hyperactivity in rats by systemic ghrelin
    Paul J Wellman
    Behavioral Neuroscience Program, Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Regul Pept 125:151-4. 2005
    ..These results indicate that acute injection of ghrelin, at a feeding-relevant dose, augments the acute effects of cocaine on locomotion in rats...
  14. ncbi request reprint Self-administration of heroin in rats: effects of low-level lead exposure during gestation and lactation
    Angelica Rocha
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Psychopharmacology (Berl) 174:203-10. 2004
    ..Developmental lead exposure has been found to produce differential patterns of drug self-administration in adult animals...
  15. ncbi request reprint Morphine conditioned place preference is attenuated by perinatal lead exposure
    Rodrigo Valles
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Pharmacol Biochem Behav 75:295-300. 2003
    ..The present data suggest that early lead exposure may have an enduring impact on the reinforcing properties of morphine...
  16. pmc Developmental lead exposure alters methamphetamine self-administration in the male rat: acquisition and reinstatement
    Angelica Rocha
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Drug Alcohol Depend 95:23-9. 2008
    ..These results suggest perinatal lead exposure alters patterns of methamphetamine self-administration during the adult cycle...
  17. pmc Dose-dependent attenuation of heroin self-administration with lobeline
    N Hart
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    J Psychopharmacol 24:51-5. 2010
    ..3, 1.0, or 3.0 mg/kg, 15 min prior to testing sessions). At doses of 1.0 and 3.0 mg/kg, lobeline attenuated self-administration of heroin. The results suggest a potential for lobeline to be used in pharmacotherapy for opioid abuse...
  18. pmc Developmental lead exposure attenuates methamphetamine dose-effect self-administration performance and progressive ratio responding in the male rat
    Angelica Rocha
    Department of Psychology, Texas A and M University, College Station, TX 77843, United States
    Pharmacol Biochem Behav 89:508-14. 2008
    ..The data showed a general attenuation of the reinforcement efficacy of methamphetamine in animals perinatally exposed to lead, as compared to control animals...
  19. ncbi request reprint The effects of acquisition training schedule on extinction and reinstatement of cocaine self-administration in male rats
    Rodrigo Valles
    Department of Psychology, Texas A and M University, College Station, 77843, USA
    Exp Clin Psychopharmacol 14:245-53. 2006
    ..The reinstatement test was conducted following extinction, in which it was observed that overtraining under FR-1-medium dose reward schedules resulted in a decrease in the tendency to return to active drug seeking...
  20. ncbi request reprint Developmental exposure to cadmium alters responsiveness to cocaine in the rat
    Kelly R Smith
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Drug Alcohol Depend 72:1-11. 2003
    ..The implications of these findings with respect to the interactive role of cadmium in the dynamics of cocaine use/abuse remain unclear...
  21. pmc The effects of concurrent administration of +/-3,4-methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat
    Anna J Diller
    Department of Psychology, Texas A and M University, College Station, TX 77843, United States
    Pharmacol Biochem Behav 88:165-70. 2007
    ..These data are instructive insofar as they suggest that the behavioral and neurochemical effects of MDMA and cocaine presented in isolation are dramatically altered when the two drugs are presented in combination...
  22. ncbi request reprint The effects of developmental cadmium exposure on morphine sensitization and challenge with selective D(1) and D(2) antagonists
    Kelly R Smith
    Department of Psychology, Texas A and M University, College Station 77843, USA
    Pharmacol Biochem Behav 72:581-90. 2002
    ..Furthermore, it was found that the suppressive effects of the D(2) antagonist eticlopride were decreased by early cadmium exposure...

Research Grants8

  1. HEAVY METALS AND POLYDRUG SELF-ADMINISTRATION
    Jack Nation; Fiscal Year: 2005
    ....
  2. Heavy Metal and Drug Self-Administration: Mechanisms
    Paul Wellman; Fiscal Year: 2007
    ..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..