W J Murphy

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Supermatrix and species tree methods resolve phylogenetic relationships within the big cats, Panthera (Carnivora: Felidae)
    Brian W Davis
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Mol Phylogenet Evol 56:64-76. 2010
  2. pmc Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Evol Biol 8:54. 2008
  3. ncbi request reprint A rhesus macaque radiation hybrid map and comparative analysis with the human genome
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Genomics 86:383-95. 2005
  4. ncbi request reprint Designing and optimizing comparative anchor primers for comparative gene mapping and phylogenetic inference
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Nat Protoc 2:3022-30. 2007
  5. pmc Using genomic data to unravel the root of the placental mammal phylogeny
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Genome Res 17:413-21. 2007
  6. pmc A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, Mail Stop 4458, College Station, TX 77843, USA
    Genomics 89:189-96. 2007
  7. pmc Novel gene acquisition on carnivore Y chromosomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 2:e43. 2006
  8. ncbi request reprint Mammalian phylogenomics comes of age
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Trends Genet 20:631-9. 2004
  9. ncbi request reprint Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 309:613-7. 2005
  10. doi request reprint The feline genome
    W J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Tex 77843 4458, USA
    Genome Dyn 2:60-8. 2006

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Supermatrix and species tree methods resolve phylogenetic relationships within the big cats, Panthera (Carnivora: Felidae)
    Brian W Davis
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Mol Phylogenet Evol 56:64-76. 2010
    ..These results highlight new avenues for the study of speciation genomics and understanding the historical events surrounding the origin of the members of this lineage...
  2. pmc Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Evol Biol 8:54. 2008
    ..We also discuss the likely sequence of gene duplication events generating multiple CES genes during vertebrate evolution...
  3. ncbi request reprint A rhesus macaque radiation hybrid map and comparative analysis with the human genome
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Genomics 86:383-95. 2005
    ....
  4. ncbi request reprint Designing and optimizing comparative anchor primers for comparative gene mapping and phylogenetic inference
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Nat Protoc 2:3022-30. 2007
    ..We discuss factors that have to be considered for experimental design of broad-scope phylogenetic studies. With this protocol, primers can be designed, optimized and implemented within as little as 1-2 weeks...
  5. pmc Using genomic data to unravel the root of the placental mammal phylogeny
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Genome Res 17:413-21. 2007
    ..We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny...
  6. pmc A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, Mail Stop 4458, College Station, TX 77843, USA
    Genomics 89:189-96. 2007
    ..This improved RH comparative map provides a useful tool to facilitate positional cloning studies in the feline model...
  7. pmc Novel gene acquisition on carnivore Y chromosomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 2:e43. 2006
    ..Specific plans to identify the male-specific genes encoded in the Y chromosome of mammals should be a priority...
  8. ncbi request reprint Mammalian phylogenomics comes of age
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Trends Genet 20:631-9. 2004
    ....
  9. ncbi request reprint Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 309:613-7. 2005
    ..We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement...
  10. doi request reprint The feline genome
    W J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Tex 77843 4458, USA
    Genome Dyn 2:60-8. 2006
    ..The cat gene map also provides a useful tool in multispecies comparative genomic analyses to better understand the causes and consequences of chromosome breakage and evolution...
  11. ncbi request reprint NK cell subsets in the regulation of murine hematopoiesis. I. 5E6+ NK cells promote hematopoietic growth in H-2d strain mice
    W J Murphy
    Biological Response Modifiers Program, Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702, USA
    J Immunol 155:2911-7. 1995
    ..These results demonstrate that physiologically relevant subsets of NK cells exist that are involved in the homeostatic regulation of hematopoiesis and that they can be distinguished on the basis of 5E6 expression...
  12. pmc Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Hum Genomics 1:30-40. 2003
    ....
  13. ncbi request reprint Genomics. A dog's breakfast?
    STEPHEN J O'BRIEN
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Science 301:1854-5. 2003
    ..As they explain, even though the coverage of the dog genome (1.5x) is lower than that of mouse (8x), there are many valuable insights to be gained from comparing the sequence of dog with those of mouse and human...
  14. pmc Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    Genome Res 9:1223-30. 1999
    ....
  15. pmc A radiation hybrid map of the cat genome: implications for comparative mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201 USA
    Genome Res 10:691-702. 2000
    ..These data demonstrate that ordered RH-based gene maps provide the most precise assessment of comparing genomes, short of contig construction or full-sequence determination...
  16. ncbi request reprint Molecular dating and biogeography of the early placental mammal radiation
    E Eizirik
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:212-9. 2001
    ..We propose an integrated genomic, paleontological, and biogeographic hypothesis to account for these earliest splits on the placental mammal family tree and address current discrepancies between fossil and molecular evidence...
  17. ncbi request reprint Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD 21702, USA
    Cytogenet Genome Res 102:272-6. 2003
    ..These resources can also be extended to the remaining 36 species of the cat family for population genetic and evolutionary genomic analyses...
  18. ncbi request reprint Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies
    W J Murphy
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute at Frederick, Maryland 21702, USA
    Immunol Rev 181:279-89. 2001
    ..Understanding their role in BMT provides insights as to their physiological roles and points the way to potential clinical uses...
  19. ncbi request reprint Phylogenetic assessment of introns and SINEs within the Y chromosome using the cat family felidae as a species tree
    J Pecon-Slattery
    National Cancer Institute Frederick, Frederick, Maryland, USA
    Mol Biol Evol 21:2299-309. 2004
    ..Overall, our data suggest X-degenerate genes within the NRY are singularly powerful markers and offer a valuable patrilineal perspective in species evolution...
  20. ncbi request reprint Development of a feline whole genome radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, 21702, USA
    Genomics 57:1-8. 1999
    ..Assessment of concordant and discordant marker order for these loci provides improved resolution into the evolution of subchromosomal genome organizations and the methods to track them in these species...
  21. ncbi request reprint Integration of the feline radiation hybrid and linkage maps
    S Sun
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA
    Mamm Genome 12:436-41. 2001
    ..This integrated map provides the foundation for gene mapping assessments in the domestic cat and in related species of the Felidae family...
  22. ncbi request reprint CD16 cross-linking blocks rearrangement of the TCR beta locus and development of alpha beta T cells and induces development of NK cells from thymic progenitors
    S K Durum
    Laboratory of Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Immunol 161:3325-9. 1998
    ..These results suggest that common lymphoid precursors can respond to environmental signals to commit to the alpha beta T vs NK developmental pathways...
  23. doi request reprint Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome
    Alison J Pearks Wilkerson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Genomics 92:329-38. 2008
    ..We observed no statistical difference in the ages of Stratum 2 and Stratum 3 gene pairs, suggesting that eutherian and marsupial Stratum 2 genes may have been independently retained in each lineage...
  24. ncbi request reprint Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens
    K Tani
    Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Int Immunol 12:691-700. 2000
    ..Thus, defensins appear to function as neutrophil-derived signals that promote adaptive immune responses...
  25. ncbi request reprint New strategies for preventing graft-versus-host disease
    W J Murphy
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Curr Opin Immunol 11:509-15. 1999
    ..Questions about these features need answers to enable us to design successful approaches for intervention...
  26. ncbi request reprint Resolution of the early placental mammal radiation using Bayesian phylogenetics
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Science 294:2348-51. 2001
    ..Crown-group Eutheria may have their most recent common ancestry in the Southern Hemisphere (Gondwana)...
  27. pmc The origin of human chromosome 1 and its homologs in placental mammals
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:1880-8. 2003
    ..Further, historic chromosome exchange appears to have been disproportionately clustered in two breakpoint hotspots on the long arm...
  28. ncbi request reprint Molecular and genomic data identify the closest living relative of primates
    Jan E Janecka
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 318:792-4. 2007
    ..Our data show that colugos are the closest living relatives of primates and indicate that their divergence occurred in the Cretaceous...
  29. ncbi request reprint Molecular phylogenetics and the origins of placental mammals
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Nature 409:614-8. 2001
    ..Our results provide new insight into the pattern of the early placental mammal radiation...
  30. ncbi request reprint A radiation hybrid mapping panel for the rhesus macaque
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:516-9. 2001
    ..Concordant marker order between all three species maps suggests that the current panel represents a powerful mapping resource for generating high-density comparative maps of the rhesus macaque and other species genomes...
  31. pmc Evolution of mammalian genome organization inferred from comparative gene mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Genome Biol 2:REVIEWS0005. 2001
    ....
  32. pmc Initial sequence and comparative analysis of the cat genome
    Joan U Pontius
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Genome Res 17:1675-89. 2007
    ..9-fold) coverage mammal genome sequence...
  33. ncbi request reprint The late Miocene radiation of modern Felidae: a genetic assessment
    Warren E Johnson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 311:73-7. 2006
    ..The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation...
  34. pmc A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae
    Brian W Davis
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, Mail Stop 4458, College Station, TX 77843 4458, USA
    Genomics 93:299-304. 2009
    ..The integrated map constitutes a comprehensive framework for identifying genes controlling feline phenotypes of interest, and to aid in assembly of a higher coverage feline genome sequence...
  35. pmc Insertional polymorphisms of endogenous feline leukemia viruses
    Alfred L Roca
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Maryland, USA
    J Virol 79:3979-86. 2005
    ..Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats...
  36. doi request reprint A conserved segmental duplication within ELA
    C L Brinkmeyer-Langford
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Anim Genet 41:186-95. 2010
    ..Striking sequence conservation throughout Perissodactyl evolution is consistent with a functional role for at least some of the genes included within this segmental duplication...
  37. ncbi request reprint Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization
    Nuria Vazquez-Salat
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Genomics 90:213-24. 2007
    ....
  38. ncbi request reprint CD40 stimulation promotes human secondary immunoglobulin responses in HuPBL-SCID chimeras
    W J Murphy
    Laboratory of Leukocyte Biology, Division of Basic Sciences, Frederick, Maryland, 21702 1201, USA
    Clin Immunol 90:22-7. 1999
    ..Thus, CD40 stimulation promotes human secondary IgG responses in huPBL-SCID mice. These data demonstrate that CD40 stimulation is capable of promoting antigen-specific human B-cell responses in vivo...
  39. ncbi request reprint Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells
    R Salcedo
    Laboratory of Molecular Immunoregulation, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:7571-8. 2001
    ..This suggests that CCL11 may contribute to angiogenesis in conditions characterized by increased CCL11 production and eosinophil infiltration such as Hodgkin's lymphoma, nasal polyposis, endometriosis, and allergic diathesis...
  40. ncbi request reprint Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
    R A Kirken
    IRSP, SAIC Frederick, Frederick Cancer Research and Development Center, Maryland, USA
    J Leukoc Biol 65:891-9. 1999
    ....
  41. ncbi request reprint Thymic emigrants isolated by a new method possess unique phenotypic and functional properties
    C K Lee
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute and Intramural Research Support Program, Science Application International Corporation, Frederick, MD 21702-1201, USA
    Blood 97:1360-9. 2001
    ..This suggests that a mechanism operating in vivo, perhaps tolerance or migration pattern, attenuates the response of emigrants against antigens that did not induce their deletion in the thymus...
  42. ncbi request reprint Second-generation integrated genetic linkage/radiation hybrid maps of the domestic cat (Felis catus)
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 94:95-106. 2003
    ....
  43. ncbi request reprint Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
    C Y Koh
    Laboratory of Leukocyte Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 97:3132-7. 2001
    ..Therefore, strategies to block inhibitory receptors may be of potential use in increasing the efficacy of immunotherapy. (Blood. 2001;97:3132-3137)..
  44. ncbi request reprint Nuclear gene sequences confirm an ancient link between New Zealand's short-tailed bat and South American noctilionoid bats
    Emma C Teeling
    Basic Research Program, Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Inc, Frederick, MD 21702, USA
    Mol Phylogenet Evol 28:308-19. 2003
    ..It is most probable that Mystacina dispersed from Australia to New Zealand while other noctilionoid bats either remained in or dispersed to South America...
  45. ncbi request reprint A molecular phylogeny for bats illuminates biogeography and the fossil record
    Emma C Teeling
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Science 307:580-4. 2005
    ....
  46. ncbi request reprint The Feline Genome Project
    STEPHEN J O'BRIEN
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Annu Rev Genet 36:657-86. 2002
    ..Here we review the advantages, rationale, and present strategy of a feline genome project, and we describe the disease models, comparative genomics, and biological applications posed by the full resolution of the cat's genome...
  47. ncbi request reprint The diverse role of chemokines in tumor progression: prospects for intervention (Review)
    G P Schneider
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick, Frederick, MD 21702, USA
    Int J Mol Med 8:235-44. 2001
    ..The role of chemokines in tumor biology as well as various means of blocking chemokines in cancer models in order to develop successful therapeutic strategies will be discussed...
  48. ncbi request reprint Mesozoic origin for West Indian insectivores
    Alfred L Roca
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
    Nature 429:649-51. 2004
    ..Efforts to prevent extinction of the two surviving solenodon species would conserve an entire lineage as old or older than many mammalian orders...
  49. ncbi request reprint The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region
    Thomas W Beck
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD, 21702 1201, USA
    Immunogenetics 56:702-9. 2005
    ..50 Mb of MHC class I/extended class I region, such that TRIM39 is adjacent to the Chromosome B2 centromere and TRIM26 is adjacent to the B2 telomere in the domestic cat...
  50. pmc Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment
    Jonathan M Weiss
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, NCI Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:19455-60. 2009
    ..These results suggest that the use of anti-CD40 in combination with IL-2 or IL-15 may hold substantially more promise for clinical cancer treatment than anti-CD40 alone...
  51. ncbi request reprint Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
    Thomas J Sayers
    Intramural Research Program, SAIC Frederick, Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702 1201, USA
    Cancer Immunol Immunother 55:76-84. 2006
    ..In addition, we present recent information from our groups concerning the possible therapeutic benefits of combining Apo2L/TRAIL with the proteasome inhibitor bortezomib...
  52. ncbi request reprint In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells
    John R Ortaldo
    Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
    J Immunol 175:693-9. 2005
    ....
  53. ncbi request reprint Mammalian evolution and biomedicine: new views from phylogeny
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Biol Rev Camb Philos Soc 82:375-92. 2007
    ....
  54. pmc 28-way vertebrate alignment and conservation track in the UCSC Genome Browser
    Webb Miller
    Center for Comparative Genomics and Bioinformatics, Penn State University, University Park, Pennsylvania 16802, USA
    Genome Res 17:1797-808. 2007
    ..Each functional class has a distinctive period of stringent constraint, followed by decays that allow (for the case of regulatory regions) or reject (for coding regions and ultraconserved elements) insertions and deletions...
  55. pmc Placental mammal diversification and the Cretaceous-Tertiary boundary
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 100:1056-61. 2003
    ..In these analyses, interordinal splits remained in the Cretaceous...
  56. ncbi request reprint Serum-dependent potentiation of lipopolysaccharide-induced nitric oxide production is mediated by the events after the transcription of inducible type of nitric oxide synthase
    Yue H Zhang
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160 7184, USA
    Cell Immunol 234:16-22. 2005
    ..Rather, FBS was suggested to affect the accumulation and stabilization of iNOS mRNA leading to iNOS protein and NO production by some post-transcriptional regulatory mechanism...
  57. ncbi request reprint Natural killer cells: biology and clinical use in cancer therapy
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA
    Cell Mol Immunol 1:12-21. 2004
    ..This review will attempt to be a synthesis of current knowledge concerning NK cells, their involvement in BMT, and their use as an immunotherapy for cancer and other hematologic malignancies...
  58. ncbi request reprint The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis
    Alan D Brooks
    Basic Research Program, SAIC Frederick Inc, MD 21702 1201, USA
    Ann N Y Acad Sci 1059:160-7. 2005
    ..Although the molecular basis of bortezomib sensitization of tumor cells to Apo2L/TRAIL remains to be determined, this combination can have an enhanced apoptotic effect over either agent alone for certain human cancer cells...
  59. pmc An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival
    John C Fyfe
    Laboratory of Comparative Medical Genetics, Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Genome Res 16:1084-90. 2006
    ..Nonetheless, a LIX1-associated etiology in feline SMA implicates a previously undetected mechanism of motor neuron maintenance and mandates consideration of LIX1 as a candidate gene in human SMA when SMN1 mutations are not found...
  60. doi request reprint Construction of radiation hybrid panels
    John E Page
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD
    Methods Mol Biol 422:51-64. 2008
    ..The described procedure has been used successfully to create RH panels from diverse mammalian species such as macaques, elephants, alpacas, and armadillos, and may be applicable to nonmammalian vertebrates as well...
  61. doi request reprint Morphology and placental mammal phylogeny
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Syst Biol 57:499-503. 2008
  62. ncbi request reprint Genomics and conservation genetics
    Michael H Kohn
    Department of Ecology and Evolutionary Biology, Rice University, MS 170, 6100 Main Street, Houston, TX 77005, USA
    Trends Ecol Evol 21:629-37. 2006
    ..A new conservation genetic agenda would utilize data from enhanced surveys of genomic variation in endangered species to better manage functional genetic variation...
  63. doi request reprint Tracking genome organization in rodents by Zoo-FISH
    Alexander S Graphodatsky
    Institute of Cytology and Genetics, SB RAS 6300090, Novosibirsk, Russia
    Chromosome Res 16:261-74. 2008
    ..These findings provide insights into the likely composition of the ancestral rodent karyotype and an improved understanding of placental genome evolution...
  64. ncbi request reprint Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:163-70. 2008
    ..These results suggest that the combination of proteasome inhibition with immune therapy may result in increased antitumor efficacy...
  65. ncbi request reprint Positive and negative regulation of Natural Killer cells: therapeutic implications
    William H D Hallett
    Department of Microbiology and Immunology, MS 199, University of Nevada School of Medicine, University of Nevada Reno, Reno, NV 89557, USA
    Semin Cancer Biol 16:367-82. 2006
    ....
  66. ncbi request reprint Immunobiology of allogeneic hematopoietic stem cell transplantation
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
    Annu Rev Immunol 25:139-70. 2007
    ..We also review new strategies to optimize the GVT and improve overall immune function while reducing GVHD and graft rejection...
  67. ncbi request reprint Susceptibility to the ototoxic properties of toluene is species specific
    Rickie R Davis
    Hearing Loss Prevention Section, Engineering and Physical Hazards Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Hear Res 166:24-32. 2002
    ..However, chinchillas may provide a valuable model for investigating how ototoxic agents can be detoxified to less damaging compounds...
  68. ncbi request reprint The adequacy of morphology for reconstructing the early history of placental mammals
    Mark S Springer
    Department of Biology, University of California Riverside, Riverside, CA 92521, USA
    Syst Biol 56:673-84. 2007
  69. ncbi request reprint A family matter: conclusive resolution of the taxonomic position of the long-fingered bats, miniopterus
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Biol Evol 24:1553-61. 2007
    ..The Molossidae diverged from these lineages approximately 54-43 MYA and form a sister group to the Miniopteridae-Vespertilionidae clade...