Research Topics
Species | Keith E MurphySummaryAffiliation: Texas A and M University Country: USA Publications
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Detail Information
Publications
Statistical analysis regarding the effects of height and weight on life span of the domestic dogKimberly A Greer
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
Res Vet Sci 82:208-14. 2007..These data form the ground work for investigations of aging utilizing the dog as a model and provide owners with a quantitative method for predicting lifespan of dog breeds, thereby aiding in pet selection...- Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker SpanielAshley G Davidson
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
J Vet Intern Med 21:394-401. 2007..Autosomal recessive hereditary nephropathy (ARHN) in the English Cocker Spaniel is caused by a type IV collagen defect, but the underlying mutation is unknown... 
Understanding hereditary diseases using the dog and human as companion model systemsKate L Tsai
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
Mamm Genome 18:444-51. 2007..Specifically, the canine models discussed herein have played important roles in identification of causative genes and/or have been utilized in novel therapeutic approaches of interest to the dog and human...- Identification, amplification and characterization of miR-17-92 from canine tissueRené M Boggs
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Gene 404:25-30. 2007..The expression levels of miR-17-3p, miR-17-5p, miR-18, miR-19a, miR-19b, miR-20, and miR-92 were evaluated in five canine tissues (heart, lung, brain, kidney, and liver) using the delta-delta Ct (critical threshold) method... 
Analysis of gene transcript profiling and immunobiology in Shetland sheepdogs with dermatomyositisJacquelyn M Wahl
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Vet Dermatol 19:52-8. 2008..While our work suggests that canine DM is a disease that may be immune mediated, it did not detect the production of specific disease-associated autoantibodies...- Gene expression analysis in a canine model of X-linked Alport syndromeKimberly A Greer
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843-4467, USA
Mamm Genome 17:976-90. 2006.... - Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dogLeigh Anne Clark
Departments of Pathobiology and Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Proc Natl Acad Sci U S A 103:1376-81. 2006..Although the mutant phenotype of SILV in the human is unknown, these results make it an intriguing candidate gene for human auditory-pigmentation disorders... - Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd DogLeigh Anne Clark
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843-4467, USA
Mamm Genome 16:955-62. 2005..Sequence data did not reveal a mutation in the coding sequence that segregates with PAA... - Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35Leigh Anne Clark
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A+M University, College Station, TX 77843, USA
Vet Dermatol 16:392-4. 2005..00002). Further studies are necessary to narrow the region harbouring the dermatomyositis locus, identify candidate genes and determine mode of inheritance... - Identification of microsatellite markers linked to progressive retinal atrophy in American Eskimo DogsJessica A Moody
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843-4467, USA
Am J Vet Res 66:1900-2. 2005.... - Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dogLeigh Anne Clark
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Genomics 84:550-4. 2004..Sixty-nine chromosome-specific panels were created by coamplification of a maximum number of markers and subsequent coloading of the remaining markers... - Hereditary evaluation of multiple developmental abnormalities in the Havanese dog breedAlison N Starr
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
J Hered 98:510-7. 2007..A canine-specific microarray was used to identify changes in gene expression in the liver that accompany the aforementioned developmental problems. One hundred and thirteen genes were found to be differentially regulated in the Havanese... - Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9Leigh Anne Clark
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
Gene 418:49-52. 2008..Reported herein is linkage mapping of the H locus to a 3.27 Mb region of chromosome 9 containing approximately 20 genes... - Isolation, culture, and characterization of canine Sertoli cellsAshley G Davidson
Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
In Vitro Cell Dev Biol Anim 43:324-7. 2007.... - Genetic cause of X-linked Alport syndrome in a family of domestic dogsMelissa L Cox
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
Mamm Genome 14:396-403. 2003..Characterization of the causative mutation was followed by development of an allele-specific test for identification of dogs in this kindred that are destined to develop XLAS... - Clinical and genetic assessments of hip joint laxity in the Boykin spanielKate L Tsai
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77845-4467, USA
Can J Vet Res 70:148-50. 2006..Although there was a positive correlation between the incidence of hip dysplasia and increased joint laxity, we did not find significant linkage in the 28 BSs that underwent genotyping, likely owing to the small size of the pedigree... - Evaluation of a rapid single multiplex microsatellite-based assay for use in forensic genetic investigations in dogsLeigh Anne Clark
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843-4467, USA
Am J Vet Res 65:1446-50. 2004.... - Aging-associated loci in Canis familiarisSarah C Canterberry
Texas A and M University, College of Veterinary Medicine, Veterinary Pathobiology, College Station 77843-4467, USA
Growth Dev Aging 69:101-13. 2005..Within the species, naturally diverse life expectancies and highly homogeneous populations create an ideal population structure for studying the genetic components of aging (Patronek et al., 1997)... - MicroRNA expression in canine mammary cancerR Michelle Boggs
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
Mamm Genome 19:561-9. 2008.... - Multiplexing of canine microsatellite markers for whole-genome screensEdward J Cargill
Program in Genetics, Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843-4467, USA
Genomics 80:250-3. 2002..Screening the canine genome for linkage of markers with various hereditary diseases facilitates identification of affected and carrier individuals, thereby providing researchers and clinicians with an additional diagnostic tool... - Sequencing and radiation hybrid mapping of canine uromodulinMelissa L Cox
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
DNA Seq 14:61-9. 2003..Data indicate that umod is linked to the marker CZP2 (canine zona pellucida gene) on an RH group not yet assigned to a canine chromosome. The human umod and CZP2 genes are located on chromosome 16p13... - Linkage and segregation analysis of black and brindle coat color in domestic dogsJulie A Kerns
Department of Genetics, Stanford University, Stanford, California 94035, USA
Genetics 176:1679-89. 2007..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection... - Radiation hybrid mapping of the canine type I and type IV collagen gene subfamiliesJennifer K Lowe
Department of Molecular and Cellular Biology, University of Washington, Seattle, WA 98115, USA
Funct Integr Genomics 3:112-6. 2003..These data provide an insight into the molecular evolution of these subfamilies and increase the number of mapped genes in discrete regions of the canine genome... - Inheritance of pancreatic acinar atrophy in German Shepherd DogsE Michael Moeller
Division of Small Animal Surgery and Orthopedics, Faculty of Veterinary Medicine, University of Bern, Switzerland
Am J Vet Res 63:1429-34. 2002..CONCLUSIONS AND CLINICAL RELEVANCE: Evaluation of data by complex segregation analysis is strongly suggestive of an autosomal recessive mode of inheritance for EPI in GSDs in the United States... - Identification of quantitative trait loci for osteoarthritis of hip joints in dogsRaluca G Mateescu
Department of Animal Science, College of Agricultural Sciences and Natural Resources, Oklahoma State University, Stillwater, OK 74078, USA
Am J Vet Res 69:1294-300. 2008..To identify quantitative trait loci (QTL) associated with osteoarthritis (OA) of hip joints of dogs by use of a whole-genome microsatellite scan...