Keith E Murphy

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Statistical analysis regarding the effects of height and weight on life span of the domestic dog
    Kimberly A Greer
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Res Vet Sci 82:208-14. 2007
  2. ncbi request reprint Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker Spaniel
    Ashley G Davidson
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    J Vet Intern Med 21:394-401. 2007
  3. pmc Understanding hereditary diseases using the dog and human as companion model systems
    Kate L Tsai
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 18:444-51. 2007
  4. ncbi request reprint Identification, amplification and characterization of miR-17-92 from canine tissue
    René M Boggs
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Gene 404:25-30. 2007
  5. doi request reprint Analysis of gene transcript profiling and immunobiology in Shetland sheepdogs with dermatomyositis
    Jacquelyn M Wahl
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Vet Dermatol 19:52-8. 2008
  6. ncbi request reprint Gene expression analysis in a canine model of X-linked Alport syndrome
    Kimberly A Greer
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 17:976-90. 2006
  7. pmc Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog
    Leigh Anne Clark
    Departments of Pathobiology and Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 103:1376-81. 2006
  8. ncbi request reprint Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 16:955-62. 2005
  9. ncbi request reprint Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A M University, College Station, TX 77843, USA
    Vet Dermatol 16:392-4. 2005
  10. ncbi request reprint Identification of microsatellite markers linked to progressive retinal atrophy in American Eskimo Dogs
    Jessica A Moody
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Am J Vet Res 66:1900-2. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Statistical analysis regarding the effects of height and weight on life span of the domestic dog
    Kimberly A Greer
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Res Vet Sci 82:208-14. 2007
    ..These data form the ground work for investigations of aging utilizing the dog as a model and provide owners with a quantitative method for predicting lifespan of dog breeds, thereby aiding in pet selection...
  2. ncbi request reprint Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker Spaniel
    Ashley G Davidson
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    J Vet Intern Med 21:394-401. 2007
    ..Autosomal recessive hereditary nephropathy (ARHN) in the English Cocker Spaniel is caused by a type IV collagen defect, but the underlying mutation is unknown...
  3. pmc Understanding hereditary diseases using the dog and human as companion model systems
    Kate L Tsai
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 18:444-51. 2007
    ..Specifically, the canine models discussed herein have played important roles in identification of causative genes and/or have been utilized in novel therapeutic approaches of interest to the dog and human...
  4. ncbi request reprint Identification, amplification and characterization of miR-17-92 from canine tissue
    René M Boggs
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Gene 404:25-30. 2007
    ..The expression levels of miR-17-3p, miR-17-5p, miR-18, miR-19a, miR-19b, miR-20, and miR-92 were evaluated in five canine tissues (heart, lung, brain, kidney, and liver) using the delta-delta Ct (critical threshold) method...
  5. doi request reprint Analysis of gene transcript profiling and immunobiology in Shetland sheepdogs with dermatomyositis
    Jacquelyn M Wahl
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Vet Dermatol 19:52-8. 2008
    ..While our work suggests that canine DM is a disease that may be immune mediated, it did not detect the production of specific disease-associated autoantibodies...
  6. ncbi request reprint Gene expression analysis in a canine model of X-linked Alport syndrome
    Kimberly A Greer
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 17:976-90. 2006
    ....
  7. pmc Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog
    Leigh Anne Clark
    Departments of Pathobiology and Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 103:1376-81. 2006
    ..Although the mutant phenotype of SILV in the human is unknown, these results make it an intriguing candidate gene for human auditory-pigmentation disorders...
  8. ncbi request reprint Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843 4467, USA
    Mamm Genome 16:955-62. 2005
    ..Sequence data did not reveal a mutation in the coding sequence that segregates with PAA...
  9. ncbi request reprint Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A M University, College Station, TX 77843, USA
    Vet Dermatol 16:392-4. 2005
    ..00002). Further studies are necessary to narrow the region harbouring the dermatomyositis locus, identify candidate genes and determine mode of inheritance...
  10. ncbi request reprint Identification of microsatellite markers linked to progressive retinal atrophy in American Eskimo Dogs
    Jessica A Moody
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Am J Vet Res 66:1900-2. 2005
    ..To identify microsatellite markers linked to progressive retinal atrophy (PRA) in American Eskimo Dogs...
  11. ncbi request reprint Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Genomics 84:550-4. 2004
    ..Sixty-nine chromosome-specific panels were created by coamplification of a maximum number of markers and subsequent coloading of the remaining markers...
  12. ncbi request reprint Hereditary evaluation of multiple developmental abnormalities in the Havanese dog breed
    Alison N Starr
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    J Hered 98:510-7. 2007
    ..A canine-specific microarray was used to identify changes in gene expression in the liver that accompany the aforementioned developmental problems. One hundred and thirteen genes were found to be differentially regulated in the Havanese...
  13. doi request reprint Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Gene 418:49-52. 2008
    ..Reported herein is linkage mapping of the H locus to a 3.27 Mb region of chromosome 9 containing approximately 20 genes...
  14. ncbi request reprint Isolation, culture, and characterization of canine Sertoli cells
    Ashley G Davidson
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    In Vitro Cell Dev Biol Anim 43:324-7. 2007
    ....
  15. ncbi request reprint Genetic cause of X-linked Alport syndrome in a family of domestic dogs
    Melissa L Cox
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Mamm Genome 14:396-403. 2003
    ..Characterization of the causative mutation was followed by development of an allele-specific test for identification of dogs in this kindred that are destined to develop XLAS...
  16. pmc Clinical and genetic assessments of hip joint laxity in the Boykin spaniel
    Kate L Tsai
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77845 4467, USA
    Can J Vet Res 70:148-50. 2006
    ..Although there was a positive correlation between the incidence of hip dysplasia and increased joint laxity, we did not find significant linkage in the 28 BSs that underwent genotyping, likely owing to the small size of the pedigree...
  17. ncbi request reprint Evaluation of a rapid single multiplex microsatellite-based assay for use in forensic genetic investigations in dogs
    Leigh Anne Clark
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Am J Vet Res 65:1446-50. 2004
    ..To develop a set of microsatellite markers, composed of a minimal number of these markers, suitable for use in forensic genetic investigations in dogs...
  18. ncbi request reprint Aging-associated loci in Canis familiaris
    Sarah C Canterberry
    Texas A and M University, College of Veterinary Medicine, Veterinary Pathobiology, College Station 77843 4467, USA
    Growth Dev Aging 69:101-13. 2005
    ..Within the species, naturally diverse life expectancies and highly homogeneous populations create an ideal population structure for studying the genetic components of aging (Patronek et al., 1997)...
  19. doi request reprint MicroRNA expression in canine mammary cancer
    R Michelle Boggs
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4467, USA
    Mamm Genome 19:561-9. 2008
    ....
  20. ncbi request reprint Multiplexing of canine microsatellite markers for whole-genome screens
    Edward J Cargill
    Program in Genetics, Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Genomics 80:250-3. 2002
    ..Screening the canine genome for linkage of markers with various hereditary diseases facilitates identification of affected and carrier individuals, thereby providing researchers and clinicians with an additional diagnostic tool...
  21. ncbi request reprint Sequencing and radiation hybrid mapping of canine uromodulin
    Melissa L Cox
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    DNA Seq 14:61-9. 2003
    ..Data indicate that umod is linked to the marker CZP2 (canine zona pellucida gene) on an RH group not yet assigned to a canine chromosome. The human umod and CZP2 genes are located on chromosome 16p13...
  22. pmc Linkage and segregation analysis of black and brindle coat color in domestic dogs
    Julie A Kerns
    Department of Genetics, Stanford University, Stanford, California 94035, USA
    Genetics 176:1679-89. 2007
    ..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection...
  23. ncbi request reprint Radiation hybrid mapping of the canine type I and type IV collagen gene subfamilies
    Jennifer K Lowe
    Department of Molecular and Cellular Biology, University of Washington, Seattle, WA 98115, USA
    Funct Integr Genomics 3:112-6. 2003
    ..These data provide an insight into the molecular evolution of these subfamilies and increase the number of mapped genes in discrete regions of the canine genome...
  24. ncbi request reprint Inheritance of pancreatic acinar atrophy in German Shepherd Dogs
    E Michael Moeller
    Division of Small Animal Surgery and Orthopedics, Faculty of Veterinary Medicine, University of Bern, Switzerland
    Am J Vet Res 63:1429-34. 2002
    ..To assess the heritability of pancreatic acinar atrophy (PAA) in German Shepherd Dogs (GSDs) in the United States...
  25. doi request reprint Identification of quantitative trait loci for osteoarthritis of hip joints in dogs
    Raluca G Mateescu
    Department of Animal Science, College of Agricultural Sciences and Natural Resources, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 69:1294-300. 2008
    ..To identify quantitative trait loci (QTL) associated with osteoarthritis (OA) of hip joints of dogs by use of a whole-genome microsatellite scan...