L A Moye

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Bayesians in clinical trials: asleep at the switch
    Lemuel A Moye
    School of Public Health, University of Texas, 1200 Herman Pressler E815 Houston, TX 77025, USA
    Stat Med 27:469-82; discussion 483-9. 2008
  2. ncbi request reprint Defending the rationale for the two-tailed test in clinical research
    Lemuel A Moye
    University of Texas Houston Health Science Center, School of Public Health, Houston, Tex, USA
    Circulation 105:3062-5. 2002
  3. ncbi request reprint Random research
    L A Moye
    University of Texas School of Public Health, Houston, Texas, USA
    Circulation 103:3150-3. 2001
  4. ncbi request reprint Alpha calculus in clinical trials: considerations and commentary for the new millennium
    L A Moye
    University of Texas School of Public Health, Ruell A Stallones Building, 1200 Herman Pressler, Houston, Texas 77030, USA
    Stat Med 19:767-79. 2000
  5. ncbi request reprint Transdermal nitroglycerin patch therapy improves left ventricular function and prevents remodeling after acute myocardial infarction: results of a multicenter prospective randomized, double-blind, placebo-controlled trial
    J J Mahmarian
    Baylor College of Medicine, Houston, Tex, USA
    Circulation 97:2017-24. 1998
  6. ncbi request reprint Comparison of stroke hospitalization rates among Mexican-Americans and non-Hispanic whites
    L B Morgenstern
    Stroke Program, Department of Neurology, The University of Texas, Medical School, Houston, TX 77030, USA
    Neurology 54:2000-2. 2000
  7. ncbi request reprint Barriers to acute stroke therapy and stroke prevention in Mexican Americans
    L B Morgenstern
    Stroke Program, Department of Neurology, University of Texas Medical School, Houston, TX, USA
    Stroke 32:1360-4. 2001
  8. ncbi request reprint Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia
    J J Mahmarian
    Section of Cardiology, Baylor College of Medicine, The Methodist Hospital, Houston, Texas, USA
    J Am Coll Cardiol 30:125-30. 1997
  9. ncbi request reprint The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction
    P F Bray
    Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Cardiol 88:347-52. 2001
  10. ncbi request reprint Dependence, hyper-dependence and hypothesis testing in clinical trials
    Lemuel A Moye
    University of Texas School of Public Health, 1200 Herman Pressler E815, Houston, Texas 77025, USA
    Contemp Clin Trials 28:68-78. 2007

Detail Information

Publications24

  1. ncbi request reprint Bayesians in clinical trials: asleep at the switch
    Lemuel A Moye
    School of Public Health, University of Texas, 1200 Herman Pressler E815 Houston, TX 77025, USA
    Stat Med 27:469-82; discussion 483-9. 2008
    ..Seven suggestions are offered to the Bayesians to help them adapt to the rigors of clinical research...
  2. ncbi request reprint Defending the rationale for the two-tailed test in clinical research
    Lemuel A Moye
    University of Texas Houston Health Science Center, School of Public Health, Houston, Tex, USA
    Circulation 105:3062-5. 2002
  3. ncbi request reprint Random research
    L A Moye
    University of Texas School of Public Health, Houston, Texas, USA
    Circulation 103:3150-3. 2001
    ..This article explains in nonmathematical terms the rationale for the tenet "first say what you will do, then do what you said" in sample-based research...
  4. ncbi request reprint Alpha calculus in clinical trials: considerations and commentary for the new millennium
    L A Moye
    University of Texas School of Public Health, Ruell A Stallones Building, 1200 Herman Pressler, Houston, Texas 77030, USA
    Stat Med 19:767-79. 2000
    ....
  5. ncbi request reprint Transdermal nitroglycerin patch therapy improves left ventricular function and prevents remodeling after acute myocardial infarction: results of a multicenter prospective randomized, double-blind, placebo-controlled trial
    J J Mahmarian
    Baylor College of Medicine, Houston, Tex, USA
    Circulation 97:2017-24. 1998
    ..Short-term administration prevents left ventricular (LV) dilation and infarct expansion. However, little information is available regarding their long-term effects on LV remodeling in patients surviving Q-wave AMI...
  6. ncbi request reprint Comparison of stroke hospitalization rates among Mexican-Americans and non-Hispanic whites
    L B Morgenstern
    Stroke Program, Department of Neurology, The University of Texas, Medical School, Houston, TX 77030, USA
    Neurology 54:2000-2. 2000
    ..007) and were less likely to receive neuroimaging (p = 0.001). Additional studies are needed to confirm this finding and to determine the role of stroke risk factors and access to care variables...
  7. ncbi request reprint Barriers to acute stroke therapy and stroke prevention in Mexican Americans
    L B Morgenstern
    Stroke Program, Department of Neurology, University of Texas Medical School, Houston, TX, USA
    Stroke 32:1360-4. 2001
    ..The purpose of this study was to identify specific targets to improve acute stroke treatment and stroke prevention in the Mexican American (MA) community...
  8. ncbi request reprint Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia
    J J Mahmarian
    Section of Cardiology, Baylor College of Medicine, The Methodist Hospital, Houston, Texas, USA
    J Am Coll Cardiol 30:125-30. 1997
    ..We sought to determine the effects of nicotine patch therapy, when used to promote smoking cessation, on myocardial ischemia in patients with coronary artery disease...
  9. ncbi request reprint The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction
    P F Bray
    Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Cardiol 88:347-52. 2001
    ..These data suggest that it would be important to perform a larger study to address the potential role of these genotypes in therapeutic decision making...
  10. ncbi request reprint Dependence, hyper-dependence and hypothesis testing in clinical trials
    Lemuel A Moye
    University of Texas School of Public Health, 1200 Herman Pressler E815, Houston, Texas 77025, USA
    Contemp Clin Trials 28:68-78. 2007
    ..In circumstances in which the endpoint and all members of the family of analyses are selected during the design phase of the trial, this procedure provides confirmatory conclusions as opposed to exploratory findings...
  11. ncbi request reprint Kids Identifying and Defeating Stroke (KIDS): design of a school-based intervention to improve stroke awareness
    Nicole R Gonzales
    Department of Neurology, University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Ethn Dis 17:320-6. 2007
    ..Increasing awareness in this group may increase the number of patients eligible for acute stroke treatment by encouraging emergency medical services (EMS) activation...
  12. ncbi request reprint A multinational study to establish the value of early adenosine technetium-99m sestamibi myocardial perfusion imaging in identifying a low-risk group for early hospital discharge after acute myocardial infarction
    John J Mahmarian
    Methodist DeBakey Heart Center, Department of Cardiology, The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 48:2448-57. 2006
    ....
  13. ncbi request reprint An initial strategy of intensive medical therapy is comparable to that of coronary revascularization for suppression of scintigraphic ischemia in high-risk but stable survivors of acute myocardial infarction
    John J Mahmarian
    Methodist DeBakey Heart Center, Department of Cardiology, The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 48:2458-67. 2006
    ..The purpose of this study was to determine the relative benefit of intensive medical therapy compared with coronary revascularization for suppressing scintigraphic ischemia...
  14. ncbi request reprint Alcohol consumption and prognosis in patients with left ventricular systolic dysfunction after a myocardial infarction
    David Aguilar
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:2015-21. 2004
    ..We assessed the influence of alcohol intake on the development of symptomatic heart failure (HF) in patients with left ventricular (LV) dysfunction after a myocardial infarction (MI)...
  15. ncbi request reprint Perils of the random experiment
    Lemuel A Moye
    University of Texas School of Public Health, RAS Building E815, 1200 Herman Pressler, Houston, TX 77030, USA
    Am J Ther 10:112-21. 2003
    ..Readers of clinical trial results must be vigilant for nonprotocol-driven research and understand that the results from these programs are at best exploratory and cannot be used to answer scientific questions...
  16. ncbi request reprint Disciplined analyses in clinical trials: the dark heart of the matter
    Lemuel A Moye
    Department of Biostatistics, University of Texas School of Public Health, Houston, TX 77025, USA
    Stat Methods Med Res 17:253-64. 2008
    ....
  17. ncbi request reprint The fragility of cardiovascular clinical trial results
    Lemuel A Moye
    University of Texas School of Public Health, Houston, Texas 77030, USA
    J Card Fail 8:247-53. 2002
    ..Clinical trials that have their prospective analysis plan altered are difficult to interpret...
  18. pmc A study to assess the effects of a broad-spectrum immune modulatory therapy on mortality and morbidity in patients with chronic heart failure: the ACCLAIM trial rationale and design
    Guillermo Torre-Amione
    Methodist Hospital, Houston, Texas, USA
    Can J Cardiol 23:369-76. 2007
    ..In a feasibility study of 73 patients with moderate to severe HF, active therapy (versus placebo) had a significant benefit on both mortality and hospitalization, and was not associated with adverse hemodynamic or metabolic effects...
  19. pmc Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design
    James T Willerson
    Coordinating Center for Clinical Trials, The University of Texas, Health Science Center, Houston, TX 77030, USA
    Am Heart J 160:215-23. 2010
    ..Despite advances in these methods, CAD is a leading cause of recurrent ischemia and heart failure, posing significant morbidity and mortality risks along with increasing health costs in a large patient population worldwide...
  20. pmc Evaluation of ethnic minorities and gender effects in clinical trials: opportunities lost and rediscovered
    L A Moye
    University of Texas School of Public Health, Houston 77030, USA
    J Natl Med Assoc 93:29S-34S. 2001
    ....
  21. ncbi request reprint Trials within trials: confirmatory subgroup analyses in controlled clinical experiments
    L A Moye
    University of Texas School of Public Health, RAS Building E815, 1200 Herman Pressler, Houston, TX 77030, USA
    Control Clin Trials 22:605-19. 2001
    ....
  22. ncbi request reprint The Cardiac Arrhythmia Suppression Trial: background, interim results and implications
    C M Pratt
    Department of Internal Medicine, Baylor College of Medicine, Houston, Texas
    Am J Cardiol 65:20B-29B. 1990
    ..The reasons for this discrepancy are discussed. The results of the CAST emphasize the power of a randomized, placebo-controlled clinical trial to uncover previously unsuspected benefits or liabilities of traditional therapies...
  23. ncbi request reprint Argatroban tPA stroke study: study design and results in the first treated cohort
    Rebecca M Sugg
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Arch Neurol 63:1057-62. 2006
    ..Argatroban is a direct thrombin inhibitor that safely augments the benefit of rtPA in animal stroke models. There are no human data on this combination...
  24. ncbi request reprint Sample size for biomarker studies: more subjects or more measurements per subject?
    Dejian Lai
    Program in Biometry, The University of Texas, School of Public Health, Houston 77030, USA
    Ann Epidemiol 13:204-8. 2003
    ..This is particularly true in pilot studies, which often have limited funding and involve small numbers of biological samples too small for assessment of recently developed biomarkers...