Laura E Mitchell

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. doi request reprint Spina Bifida Research Resource: study design and participant characteristics
    Laura E Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 82:684-91. 2008
  2. ncbi request reprint Spina bifida
    Laura E Mitchell
    Institute of BioScience and Technology, The Texas A and M University System Health Science Center, TX 77030 3303, USA
    Lancet 364:1885-95. 2004
  3. ncbi request reprint Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design
    Laura E Mitchell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas AandM University System Health Sciences Center, Houston, TX 77030, USA
    Am J Epidemiol 162:676-85. 2005
  4. ncbi request reprint Epidemiology of neural tube defects
    Laura E Mitchell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Med Genet C Semin Med Genet 135:88-94. 2005
  5. ncbi request reprint Proportion of neural tube defects attributable to known risk factors
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 97:42-6. 2013
  6. doi request reprint Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study
    A J Agopian
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Am J Med Genet A 158:109-15. 2012
  7. doi request reprint Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:875-81. 2012
  8. pmc Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas, Houston, TX, USA
    Am J Epidemiol 176:1101-9. 2012
  9. doi request reprint Polytomous logistic regression as a tool for exploring heterogeneity across birth defect subtypes: an example using anencephaly and spina bifida
    Philip J Lupo
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 88:701-5. 2010
  10. pmc Maternal and infant gene-folate interactions and the risk of neural tube defects
    Analee J Etheredge
    Texas A and M System Health Science Center Institute of Biosciences and Technology, Houston, USA
    Am J Med Genet A 158:2439-46. 2012

Collaborators

Detail Information

Publications50

  1. doi request reprint Spina Bifida Research Resource: study design and participant characteristics
    Laura E Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 82:684-91. 2008
    ..Myelomeningocele is a common serious malformation. In the majority of affected individuals, it is believed to be nonsyndromic and determined by the effects of multiple genetic and nongenetic factors...
  2. ncbi request reprint Spina bifida
    Laura E Mitchell
    Institute of BioScience and Technology, The Texas A and M University System Health Science Center, TX 77030 3303, USA
    Lancet 364:1885-95. 2004
    ..Medical management is a lifelong necessity for individuals with spina bifida, and should be provided by a multidisciplinary team...
  3. ncbi request reprint Evaluation of offspring and maternal genetic effects on disease risk using a family-based approach: the "pent" design
    Laura E Mitchell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas AandM University System Health Sciences Center, Houston, TX 77030, USA
    Am J Epidemiol 162:676-85. 2005
    ..In addition, the power of the pent-1 approach is comparable with that of the approach based on data using all four grandparents...
  4. ncbi request reprint Epidemiology of neural tube defects
    Laura E Mitchell
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Med Genet C Semin Med Genet 135:88-94. 2005
    ..The challenge for the future is to design studies that address these complexities, and are adequately powered to detect the factors or combination of factors that influence the development of NTDs...
  5. ncbi request reprint Proportion of neural tube defects attributable to known risk factors
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 97:42-6. 2013
    ..Recognized risk factors for neural tube defects (NTDs) poorly predict population-level NTD risk. However, the proportion of NTDs that can be attributed to these risk factors is uncertain...
  6. doi request reprint Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study
    A J Agopian
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Am J Med Genet A 158:109-15. 2012
    ..55, 95% confidence interval: 1.23-1.95]. These findings provide evidence that certain spina bifida subtypes and sub-phenotypes may be etiologically distinct...
  7. doi request reprint Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:875-81. 2012
    ..Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring...
  8. pmc Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas, Houston, TX, USA
    Am J Epidemiol 176:1101-9. 2012
    ..These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy...
  9. doi request reprint Polytomous logistic regression as a tool for exploring heterogeneity across birth defect subtypes: an example using anencephaly and spina bifida
    Philip J Lupo
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 88:701-5. 2010
    ..Although the validity of using composite phenotypes has been questioned, formal evaluations of the underlying assumption of effect homogeneity across component phenotypes have not been conducted...
  10. pmc Maternal and infant gene-folate interactions and the risk of neural tube defects
    Analee J Etheredge
    Texas A and M System Health Science Center Institute of Biosciences and Technology, Houston, USA
    Am J Med Genet A 158:2439-46. 2012
    ....
  11. doi request reprint Swimming pool use and birth defect risk
    A J Agopian
    Division of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA
    Am J Obstet Gynecol 209:219.e1-9. 2013
    ..Thus, we evaluated the relationship between maternal swimming pool use during early pregnancy and risk for select birth defects in offspring...
  12. doi request reprint Age of onset and effect size in genome-wide association studies
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:908-11. 2012
    ..g., birth defects) than for traits with onset in adulthood...
  13. doi request reprint Working towards a risk prediction model for neural tube defects
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:141-6. 2012
    ..Several risk factors have been consistently associated with neural tube defects (NTDs). However, the predictive ability of these risk factors in combination has not been evaluated...
  14. doi request reprint Maternal-fetal metabolic gene-gene interactions and risk of neural tube defects
    Philip J Lupo
    Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA
    Mol Genet Metab 111:46-51. 2014
    ..00004). Our findings suggest that maternal metabolic genes associated with hyperglycemia and insulin resistance and fetal metabolic genes involved in glucose homeostasis may interact to increase the risk of NTDs. ..
  15. doi request reprint Differences in folic acid use, prenatal care, smoking, and drinking in early pregnancy by occupation
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Prev Med 55:341-5. 2012
    ..To describe differences in four high risk periconceptional behaviors (lack of folic acid supplementation, lack of early prenatal care, smoking, and drinking) by maternal occupation...
  16. doi request reprint Predictors of trisomy 21 in the offspring of older and younger women
    A J Agopian
    Center for Human Genetics, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 94:31-5. 2012
    ..To identify factors associated with the risk of trisomy 21 in the offspring of younger and older women, we analyzed data for cases with trisomy 21 from the Texas Birth Defects Registry for 1999 to 2007...
  17. doi request reprint NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA
    Birth Defects Res A Clin Mol Teratol 91:61-5. 2011
    ..Although several folate-related genes have been studied as they relate to CHDs and CTRDs (e.g., MTHFR), others have not been adequately assessed...
  18. pmc Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects
    Jin Long
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, USA
    Birth Defects Res A Clin Mol Teratol 91:879-84. 2011
    ....
  19. doi request reprint Association between thyroxine levels at birth and choanal atresia or stenosis among infants in Texas, 2004-2007
    Laura J Lee
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 94:951-4. 2012
    ..Therefore, we conducted a case-control study to examine the association between newborn T(4) levels and CA...
  20. pmc Maternal occupational exposure to polycyclic aromatic hydrocarbons: effects on gastroschisis among offspring in the National Birth Defects Prevention Study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030, USA
    Environ Health Perspect 120:910-5. 2012
    ..There is evidence in animal models that maternal exposure to PAHs during pregnancy is associated with gastroschisis in offspring; however, to our knowledge, no human studies examining this association have been conducted...
  21. doi request reprint Hispanic ethnicity and acculturation, maternal age and the risk of gastroschisis in the National Birth Defects Prevention Study
    Zeina G Khodr
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030 3900, USA
    Birth Defects Res A Clin Mol Teratol 97:538-45. 2013
    ..This analysis was conducted to further define the associations between gastroschisis and parental Hispanic ethnicity and acculturation, and to determine whether such associations vary by maternal age...
  22. pmc Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology and Disease Control, The University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030, USA
    J Biomed Biotechnol 2010:630940. 2010
    ..02). This association is consistent with the effects of this genotype combination on folate-homocysteine biochemistry but remains to be confirmed in independent study populations...
  23. pmc Planar cell polarity pathway genes and risk for spina bifida
    Shu Wen
    Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 152:299-304. 2010
    ..01. In conclusion, our results, though largely negative, suggest that the PRICKLE2 gene may potentially modify the risk of spina bifida and deserves further investigation...
  24. doi request reprint Epidemiology of Ebstein anomaly: prevalence and patterns in Texas, 1999-2005
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, USA
    Am J Med Genet A 155:1007-14. 2011
    ..These findings help to define subgroups of women at increased risk of having offspring affected by Ebstein anomaly. Furthermore, our findings add to the limited body of literature on this rare but serious malformation...
  25. doi request reprint A case-control study of maternal bathing habits and risk for birth defects in offspring
    Aj Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Environ Health 12:88. 2013
    ..Thus, we assessed the relationships between bathing habits during pregnancy and the risk for several nonsyndromic birth defects in offspring...
  26. pmc Variants of folate metabolism genes and risk of left-sided cardiac defects
    Laura E Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 88:48-53. 2010
    ..Efforts to establish the relationships between these factors and CHD risk have, however, been hampered by a number of factors, including small study sample sizes and phenotypic heterogeneity...
  27. doi request reprint Differences in exposure assignment between conception and delivery: the impact of maternal mobility
    Philip J Lupo
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030, USA
    Paediatr Perinat Epidemiol 24:200-8. 2010
    ....
  28. doi request reprint Epidemiology of nonsyndromic conotruncal heart defects in Texas, 1999-2004
    Jin Long
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77382, USA
    Birth Defects Res A Clin Mol Teratol 88:971-9. 2010
    ..The aim of the present study was to identify and compare maternal and infant characteristics associated with three CTDs: truncus arteriosus (TA), dextro-transposition of the great arteries (d-TGA), and tetralogy of Fallot (TOF)...
  29. ncbi request reprint Evaluation of two methods for assessing gene-environment interactions using data from the Danish case-control study of facial clefts
    Analee J Etheredge
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Birth Defects Res A Clin Mol Teratol 73:541-6. 2005
    ....
  30. pmc MI-GWAS: a SAS platform for the analysis of inherited and maternal genetic effects in genome-wide association studies using log-linear models
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, 77030, USA
    BMC Bioinformatics 12:117. 2011
    ..However, available software packages for log-linear analyses are not well suited to the analysis of typical genome-wide association data (e.g. including missing data)...
  31. pmc Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot
    Katelyn S Weymouth
    University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Am J Med Genet A 155:2170-9. 2011
    ..Collectively, our results suggest that variation in genes that encode contractile proteins of skeletal myofibers may play a role in the etiology of clubfoot...
  32. doi request reprint Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model
    Denise S Hill
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Toxicol Appl Pharmacol 239:29-36. 2009
    ..Periconceptional hyperglycemia is a significant risk factor for neural tube defects (NTDs), the second most common structural birth defect. A suspected teratogen, arsenic (As) induces NTDs in laboratory animals...
  33. doi request reprint Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data
    Laura E Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, USA
    Clin Biochem 42:1275-81. 2009
    ..This study was designed to evaluate a method based on stable isotope dilution liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS)...
  34. ncbi request reprint Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994
    Laura E Mitchell
    Department of Biomedical Sciences, Baylor College of Dentistry, The Texas A and M University System Health Science Center, Houston, TX, USA
    Am J Epidemiol 158:69-76. 2003
    ....
  35. ncbi request reprint The human T locus and spina bifida risk
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Hum Genet 115:475-82. 2004
    ..The TIVS7 polymorphism or a variant that is in linkage disequilibrium with the TIVS7 polymorphism may, therefore, play a role in T gene expression and influence the risk of spina bifida...
  36. ncbi request reprint The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 174:315-22. 2004
    ..We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low...
  37. ncbi request reprint Loss of function polymorphisms in NAT1 protect against spina bifida
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Hum Genet 120:52-7. 2006
    ....
  38. pmc Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor
    Zhi Yong Lu
    Centers for Cancer Pharmacology, Pharmacogenetics, and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Birth Defects Res A Clin Mol Teratol 82:736-41. 2008
    ..The present study was undertaken to identify potential determinants of MCP-1 levels in women of reproductive age...
  39. pmc Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida
    Marie Therese Doolin
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Hum Genet 71:1222-6. 2002
    ..87-49.67) and MTRR (R1=2.05, 95% CI 1.05-3.99; R2=3.15, 95% CI 0.92-10.85). These findings highlight the importance of considering both the maternal and embryonic genotype when evaluating putative spina bifida susceptibility loci...
  40. ncbi request reprint Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Arterioscler Thromb Vasc Biol 23:1014-20. 2003
    ..Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism...
  41. doi request reprint An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104 6084, USA
    Hum Genet 123:289-95. 2008
    ....
  42. ncbi request reprint The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 114:182-5. 2004
    ..Our findings indicate that the TYMS 3R3R genotype is not a determinant of homocysteine in this sample of healthy young Caucasian adults from Northern Ireland...
  43. ncbi request reprint Guidelines for the design and analysis of studies on nonsyndromic cleft lip and cleft palate in humans: summary report from a Workshop of the International Consortium for Oral Clefts Genetics
    Laura E Mitchell
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cleft Palate Craniofac J 39:93-100. 2002
    ..This report presents summary statements of the four subcommittees...
  44. ncbi request reprint Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Birth Defects Res A Clin Mol Teratol 70:101-6. 2004
    ....
  45. ncbi request reprint A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 70:396-9. 2004
    ..k.a. canalicular multispecific organic anion transporter [cMOAT], multidrug resistance related protein 2 [MRP2]), a member of the ABC transporter family that effluxes natural folates and anti-folate drugs such as methotrexate...
  46. doi request reprint Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations
    Carolyn M Summers
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Hum Genet 16:1010-3. 2008
    ..66 vs 8.77 micromol/l, P=0.045), and serum folate levels were 27.7% higher (11.16 vs 8.74 nmol/l, P=0.034). These findings suggest that the CBS 844ins68 allele 'normalizes' homocysteine and folate levels in MTHFR 677TT individuals...
  47. ncbi request reprint Discordant MZ twins with cleft lip and palate: a model for identifying genes in complex traits
    Maria Adela Mansilla
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Twin Res Hum Genet 8:39-46. 2005
    ..While no etiologic variants were identified in this study, sequence comparisons of discordant MZ twins can serve as a tool for identifying etiologic mutations in clefting and other complex traits...
  48. ncbi request reprint The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Birth Defects Res A Clin Mol Teratol 73:512-6. 2005
    ..Such variants could exert an influence on the risk of NTDs via their role in acetylation or folate catabolism and could act through the maternal or the embryonic genotype...
  49. doi request reprint Evidence for sex differences in the determinants of homocysteine concentrations
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Genet Metab 93:355-62. 2008
    ..Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects...
  50. ncbi request reprint Maternal genotype for the monocyte chemoattractant protein 1 A(-2518)G promoter polymorphism is associated with the risk of spina bifida in offspring
    Liselotte E Jensen
    Am J Med Genet A 140:1114-8. 2006