David W Mercer

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Presidential address: academic surgery: can we adapt?
    David W Mercer
    Department of Surgery, University of Texas Medical School at Houston LBJ General Hospital, 77026, USA
    Surgery 138:115-24. 2005
  2. ncbi request reprint Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2
    James W Suliburk
    Department of Surgery, The University of Texas Medical School at Houston, 77030, USA
    Surgery 138:134-40. 2005
  3. ncbi request reprint Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthase
    Emily K Robinson
    Department of Surgery, University of Texas Health Science Center, Houston, TX 77026, USA
    Surgery 138:523-9. 2005
  4. ncbi request reprint Salicylate enhances rat gastric gelatinase activity
    Emily K Robinson
    Department of Surgery at the University of Texas Health Science Center Houston, USA
    J Surg Res 133:69-75. 2006
  5. ncbi request reprint Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis
    Ernest A Gonzalez
    Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Trauma 59:1092-8. 2005
  6. ncbi request reprint The impact of diabetes in patients with necrotizing soft tissue infections
    Lillian S Kao
    Department of General Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Surg Infect (Larchmt) 6:427-38. 2005
  7. ncbi request reprint Rat gastric gelatinase induction during endotoxemia
    Emily K Robinson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Dig Dis Sci 51:548-59. 2006
  8. ncbi request reprint Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenase
    Sonlee D West
    Department of Surgery, University of Texas Medical School, Houston, Texas, 77030, USA
    Dig Dis Sci 51:754-65. 2006
  9. ncbi request reprint Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia
    Emily K Robinson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Shock 25:507-14. 2006
  10. ncbi request reprint Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion
    Ernest A Gonzalez
    Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Trauma 61:66-73; discussion 73-4. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Presidential address: academic surgery: can we adapt?
    David W Mercer
    Department of Surgery, University of Texas Medical School at Houston LBJ General Hospital, 77026, USA
    Surgery 138:115-24. 2005
  2. ncbi request reprint Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2
    James W Suliburk
    Department of Surgery, The University of Texas Medical School at Houston, 77030, USA
    Surgery 138:134-40. 2005
    ..Because ketamine anesthesia has anti-inflammatory effects in some tissues, we hypothesized that it would attenuate lipopolysaccharide (LPS)-induced liver injury...
  3. ncbi request reprint Rat gastric injury after lipopolysaccharide: role of inducible nitric oxide synthase
    Emily K Robinson
    Department of Surgery, University of Texas Health Science Center, Houston, TX 77026, USA
    Surgery 138:523-9. 2005
    ..The effects of long-term treatment with LPS on gastric injury are unknown as is the role of iNOS. We hypothesized that LPS would cause macroscopic gastric injury at later time points through an iNOS-dependent pathway...
  4. ncbi request reprint Salicylate enhances rat gastric gelatinase activity
    Emily K Robinson
    Department of Surgery at the University of Texas Health Science Center Houston, USA
    J Surg Res 133:69-75. 2006
    ..We recently demonstrated that increased MMP-2 activity participated in lipopolysaccharide (LPS)-induced gastric injury. Thus we hypothesized that MMPs may play a role in other models of gastric injury...
  5. ncbi request reprint Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis
    Ernest A Gonzalez
    Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Trauma 59:1092-8. 2005
    ..In contrast to I/R cell necrosis, apoptosis provides controlled cell death that minimizes inflammation. We therefore hypothesized that HS resuscitation after mesenteric I/R would induce apoptosis and decrease mucosal injury...
  6. ncbi request reprint The impact of diabetes in patients with necrotizing soft tissue infections
    Lillian S Kao
    Department of General Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Surg Infect (Larchmt) 6:427-38. 2005
    ..Given the association of diabetes with necrotizing soft tissue infections (NSTIs) and hyperglycemia with mortality in critically ill patients, this study investigates the impact of diabetes and hyperglycemia in NSTI patients...
  7. ncbi request reprint Rat gastric gelatinase induction during endotoxemia
    Emily K Robinson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Dig Dis Sci 51:548-59. 2006
    ..Furthermore, selective metalloproteinase inhibition ameliorated gastric injury in this model. These data suggest that lipopolysaccharide-induced gastric injury is mediated, at least in part, by increased MMP-2 production...
  8. ncbi request reprint Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenase
    Sonlee D West
    Department of Surgery, University of Texas Medical School, Houston, Texas, 77030, USA
    Dig Dis Sci 51:754-65. 2006
    ..However, the ability of LPS to cause gastric stasis and increase gastric luminal fluid accumulation involves COX-2...
  9. ncbi request reprint Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia
    Emily K Robinson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Shock 25:507-14. 2006
    ..Therefore, the purpose of these studies was to compare the effects of selective and nonselective NOS inhibition on LPS-induced gastric MMP production...
  10. ncbi request reprint Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion
    Ernest A Gonzalez
    Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Trauma 61:66-73; discussion 73-4. 2006
    ..We hypothesized that a dose dependent effect exists related to increasing tonicity and that the optimal gut protective dose would provide better protection against remote organ injury than large volume isotonic crystalloids...
  11. ncbi request reprint Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1
    Kenneth S Helmer
    Department of Surgery, University of Texas Medical School, Houston, Texas 77026, USA
    Dig Dis Sci 51:1571-81. 2006
    ..Ketamine diminishes the susceptibility of gastric mucosa to damage from luminal irritants during endotoxemia, which is mediated in part by down-regulation of iNOS and up-regulation of HO-1...
  12. ncbi request reprint Ketamine attenuates early lipopolysaccharide-induced gastric dysfunction: role of stress-inducible phosphoproteins
    James W Suliburk
    Department of General Surgery, The University of Texas Medical School at Houston, Houston, Texas, USA
    J Trauma 62:316-9. 2007
    ....
  13. doi request reprint Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase
    Sonlee D West
    Department of Surgery at the University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Crit Care Med 36:572-9. 2008
    ..However, the interaction between these enzymes is not clearly understood. The objective was to clarify the interactions between NOS and COX in the rat gastric mucosa in the presence and absence of lipopolysaccharide...
  14. doi request reprint Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokines
    Sasha D Adams
    Department of Surgery, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 65:170-4. 2008
    ..The effect of these anesthetics on the systemic inflammatory response and other organs remains to be fully elucidated. We hypothesized that ketamine, but not isoflurane, would blunt the cytokine response to LPS administration...
  15. pmc Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut
    Emily K Robinson
    Department of Surgery, University of Texas Houston Health Science Center, Houston, TX 77030, USA
    JPEN J Parenter Enteral Nutr 32:433-8. 2008
    ..We therefore hypothesized that arginine would enhance expression of MMP-2 in the postischemic gut...
  16. ncbi request reprint Time-dependent aggravation or attenuation of lipopolysaccharide-induced gastric injury by nitric oxide synthase inhibition
    James W Suliburk
    Department of Surgery, University of Texas Medical School at Houston, Houston, Texas 77026, USA
    J Surg Res 129:265-71. 2005
    ....
  17. ncbi request reprint Induction of NF-kappaB, IkappaB-alpha, and iNOS in rat gastric mucosa during endotoxemia
    Kenneth S Helmer
    Department of Surgery, University of Texas Medical School, Houston, Texas 77030, USA
    J Surg Res 104:46-52. 2002
    ....
  18. ncbi request reprint Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats
    Kenneth S Helmer
    Department of Surgery, University of Texas Medical School, Houston, Texas 77026, USA
    Gastroenterology 123:173-86. 2002
    ..This study was performed to examine expression of gastric nitric oxide synthase (NOS) isoforms during endotoxemia in rats and to assess their role(s) in gastric injury from bile and ethanol...
  19. ncbi request reprint Cholecystokinin secretagogue-induced gastroprotection: role of nitric oxide and blood flow
    Sonlee D West
    Department of Surgery, University of Texas Medical School, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 284:G399-410. 2003
    ..The protective mechanism appears to involve increased production of nitric oxide from primarily the constitutive isoforms of NOS and a resultant increase in blood flow...
  20. ncbi request reprint Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?
    Terrence H Liu
    Shock 18:549-54. 2002
    ..The data also suggest that the constitutive isoforms of NOS play a hepatoprotective role in both models of hepatic injury...
  21. ncbi request reprint Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemia
    Kenneth S Helmer
    Department of Surgery, University of Texas Medical School, LBJ General Hospital, 5656 Kelley Street, Houston, TX 77026, USA
    Shock 20:63-9. 2003
    ..Furthermore, in rat models of endotoxemia, especially those evaluating the stomach, careful consideration needs to be given if anesthetic combinations with ketamine and/or xylazine are used, as they alter LPS-induced responses...
  22. ncbi request reprint Ketamine/xylazine attenuates LPS-induced iNOS expression in various rat tissues
    Kenneth S Helmer
    Department of Surgery at the University of Texas Medical School, Houston, Texas 77030, USA
    J Surg Res 112:70-8. 2003
    ....
  23. pmc Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression
    Kenneth S Helmer
    Department of Surgery, Trauma Research Center University of Texas Medical School, Houston, Texas 77026, USA
    Ann Surg 239:501-9. 2004
    ..To evaluate lipopolysaccharide (LPS)-induced inhibition of gastric acid secretion...
  24. ncbi request reprint Cholecystokinin-induced gastroprotection: a review of current protective mechanisms
    Sonlee D West
    Department of Surgery, University of Texas Medical School, Houston, Texas 77030, USA
    Dig Dis Sci 49:361-9. 2004
    ..This review focuses on the ability of CCK to render the stomach more resistant to injury from luminal insults and will summarize recent studies that examine the possible mechanisms involved...
  25. ncbi request reprint Differential effects of anesthetics on endotoxin-induced liver injury
    James W Suliburk
    Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas, USA
    J Trauma 58:711-6; discussion 716-7. 2005
    ..We hypothesized that ketamine, but not isoflurane, would attenuate lipopolysaccharide (LPS)-induced liver injury through differential modulation of iNOS and HO-1...
  26. ncbi request reprint Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation
    James W Suliburk
    Department of General Surgery, The University of Texas Medical School at Houston, Houston, Texas 77026, USA
    J Surg Res 127:203-7. 2005
    ..The purpose of this study was to determine if the anti-inflammatory properties of ketamine improve impaired gastric emptying and gastrointestinal transit because of LPS...
  27. ncbi request reprint Acute pancreatitis in intensive care unit patients: value of clinical and radiologic prognosticators at predicting clinical course and outcome
    Terrence H Liu
    Departments of Surgery, The University of Texas Houston Medical School and Lyndon B Johnson General Hospital, Houston, TX, USA
    Crit Care Med 31:1026-30. 2003
    ..To assess the value of clinical and/or radiographic prognostic indices in predicting the clinical course and outcome of patients with acute pancreatitis, in the intensive care unit...
  28. pmc Bombesin-induced gastroprotection
    Sonlee D West
    Department of Surgery, University of Texas Medical School, Houston, TX 77026, USA
    Ann Surg 241:227-31. 2005
    ....
  29. doi request reprint Gastric alkalinization after major trauma
    Christine S Cocanour
    Department of Surgery, UC Davis Medical Center, Sacramento, California, USA
    J Trauma 64:681-7. 2008
    ..Therefore, we hypothesized that trauma patients have an alkaline gastric environment that may be because of bile reflux...
  30. ncbi request reprint Lipopolysaccharide-induced gastrointestinal injury in rats: role of surface hydrophobicity and bile salts
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston Medical School, 77225, USA
    Shock 17:77-80. 2002
    ..We conclude that LPS disrupts gastrointestinal barrier integrity, in part by mechanisms involving bile constituents and an attenuation in the mucosa's hydrophobic characteristics...