Reza Mehvar

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint High-performance liquid chromatographic analysis of cyclosporin A in rat blood and liver using a commercially available internal standard
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:107-14. 2002
  2. ncbi request reprint Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: local immunosuppressive effects in liver after systemic administration to rats
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    Pharm Res 20:198-204. 2003
  3. ncbi request reprint Attenuation of Kupffer cell activation in cold-preserved livers after pretreatment of rats with methylprednisolone or its macromolecular prodrug
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Pharm Res 20:1001-8. 2003
  4. ncbi request reprint Effects of duration of ischemia and donor pretreatment with methylprednisolone or its macromolecular prodrug on the disposition of indocyanine green in cold-preserved rat livers
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Pharm Res 21:1000-8. 2004
  5. pmc Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Transplantation 81:678-85. 2006
  6. pmc The importance of active learning and practice on the students' mastery of pharmacokinetic calculations for the intermittent intravenous infusion dosing of antibiotics
    Reza Mehvar
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S, Coulter, Amarillo, TX 79106, USA
    BMC Med Educ 12:116. 2012
  7. ncbi request reprint Confounding issues in estimation of patient-specific pharmacokinetic parameters and dosage individualization of aminoglycosides
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Curr Clin Pharmacol 7:28-35. 2012
  8. pmc Estimation of pharmacokinetic parameters based on the patient-adjusted population data
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA
    Am J Pharm Educ 70:96. 2006
  9. ncbi request reprint Interdependency of pharmacokinetic parameters: a chicken-and-egg problem? Not!
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    J Pharm Pharm Sci 9:113-8. 2006
  10. ncbi request reprint Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, USA
    J Pharm Sci 95:1414-24. 2006

Research Grants

Collaborators

Detail Information

Publications50

  1. ncbi request reprint High-performance liquid chromatographic analysis of cyclosporin A in rat blood and liver using a commercially available internal standard
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:107-14. 2002
    ..2 or 0.1 microg/ml based on 250 microl of blood or 1 ml of liver homogenate, respectively. The assay was capable of measuring blood and liver concentrations of CyA in a rat injected intravenously with a single 5-mg/kg dose of the drug...
  2. ncbi request reprint Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: local immunosuppressive effects in liver after systemic administration to rats
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    Pharm Res 20:198-204. 2003
    ..The purpose of this work was to study the local immunosuppressive effects of systemically administered methylprednisolone (MP) and its prodrug, dextran-methylprednisolone (DMP), in rat livers...
  3. ncbi request reprint Attenuation of Kupffer cell activation in cold-preserved livers after pretreatment of rats with methylprednisolone or its macromolecular prodrug
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Pharm Res 20:1001-8. 2003
    ..Our hypothesis was that donor pretreatment, before liver harvest, with methylprednisolone (MP) or its dextran prodrug (DMP) would reduce KC activation...
  4. ncbi request reprint Effects of duration of ischemia and donor pretreatment with methylprednisolone or its macromolecular prodrug on the disposition of indocyanine green in cold-preserved rat livers
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Pharm Res 21:1000-8. 2004
    ..We hypothesized that an increase in the duration of preservation would result in a progressive decrease in the hepatic uptake and/or biliary excretion of indocyanine green (ICG), which would be attenuated by pharmacologic interventions...
  5. pmc Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Transplantation 81:678-85. 2006
    ..We investigated the effects of a novel liver-targeted dextran prodrug of MP (DMP) in an orthotopic rat liver transplantation (OLT) model...
  6. pmc The importance of active learning and practice on the students' mastery of pharmacokinetic calculations for the intermittent intravenous infusion dosing of antibiotics
    Reza Mehvar
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S, Coulter, Amarillo, TX 79106, USA
    BMC Med Educ 12:116. 2012
    ....
  7. ncbi request reprint Confounding issues in estimation of patient-specific pharmacokinetic parameters and dosage individualization of aminoglycosides
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Curr Clin Pharmacol 7:28-35. 2012
    ..Therefore, it is recommended that exact equations developed specifically for multiple intravenous infusions be used without any modification, particularly in settings where clinicians are being trained...
  8. pmc Estimation of pharmacokinetic parameters based on the patient-adjusted population data
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA
    Am J Pharm Educ 70:96. 2006
    ..Additionally, some numerical examples are provided to assist the reader in understanding the material. The author uses these tools in a pharmacokinetics course taught to PharmD students...
  9. ncbi request reprint Interdependency of pharmacokinetic parameters: a chicken-and-egg problem? Not!
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    J Pharm Pharm Sci 9:113-8. 2006
    ..It is concluded that there is no dilemma in interdependency of the PK parameters, and the relationships among the PK parameters and between PK and physiological parameters are clear...
  10. ncbi request reprint Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, USA
    J Pharm Sci 95:1414-24. 2006
    ....
  11. ncbi request reprint Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:152-9. 2007
    ..The application of the assay was demonstrated by simultaneous measurement of plasma concentrations of T, M1, and M5 enantiomers in a healthy volunteer after the administration of 50 mg oral doses of racemic T...
  12. ncbi request reprint Hepatic disposition of cyclosporine A in isolated perfused rat livers
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Pharm Pharm Sci 7:47-54. 2004
    ..To develop an isolated perfused rat liver model to study the hepatic disposition of cyclosporine A (CyA) in both sexes...
  13. ncbi request reprint Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Curr Pharm Biotechnol 4:283-302. 2003
    ..Collectively, these data suggest that macromolecular polysaccharides are promising agents for improving drug delivery...
  14. pmc A participation requirement to engage students in a pharmacokinetics course synchronously taught at a local and distant campus
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Am J Pharm Educ 74:118. 2010
    ..To design, implement, and evaluate a strategy to actively engage doctor of pharmacy (PharmD) students at local and distant sites in a pharmacokinetics course...
  15. ncbi request reprint Effects of in vivo hepatic ischemia-reperfusion injury on the hepatobiliary disposition of rhodamine 123 and its metabolites in isolated perfused rat livers
    Ridhi Parasrampuria
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
    J Pharm Pharm Sci 15:318-28. 2012
    ..Therefore, the purpose of this study was to investigate the effects of warm hepatic IR on the hepatobiliary disposition of rhodamine 123 (RH-123), a P-gp substrate, and its glucuronidated metabolite (RH-Glu), an Mrp2 substrate, in rats...
  16. doi request reprint Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers
    Imam H Shaik
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Free Radic Res 44:441-53. 2010
    ..It is concluded that the induction of P450 by phenobarbital significantly increases hepatic production of ROS, leading to significantly higher hepatic IR injury...
  17. doi request reprint Effects of cytochrome p450 inhibition by cimetidine on the warm hepatic ischemia-reperfusion injury in rats
    Imam H Shaik
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Surg Res 159:680-8. 2010
    ..Here, we studied the effects of cimetidine on the warm IR injury in the liver...
  18. ncbi request reprint Divergent effects of nitric oxide donors on the biliary efflux transporters in isolated perfused rat livers: nitric oxide-independent inhibition of ABC transporters by sodium nitroprusside
    Ridhi Parasrampuria
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Drug Metab Lett 5:64-72. 2011
    ..The observed inhibitory effects of SNP on the functions of both P-gp and Mrp2 are via an NO-independent mechanism...
  19. doi request reprint Protective effects of diallyl sulfide, a garlic constituent, on the warm hepatic ischemia-reperfusion injury in a rat model
    Imam H Shaik
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, Texas 79106, USA
    Pharm Res 25:2231-42. 2008
    ..The aim of this study is to evaluate the effects of diallyl sulfide (DAS) on the warm hepatic ischemia-reperfusion (IR) injury in a rat model...
  20. doi request reprint Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency
    Vivek Gupta
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, Texas 79106, United States
    Mol Pharm 10:1655-67. 2013
    ..Overall, our study suggests that PGE1 loaded inhalable particulate formulations improve PH symptoms and arrest the progression of disease at a reduced dosing frequency compared to plain PGE1...
  21. pmc Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats
    Imam H Shaik
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Pharm Sci 101:4003-12. 2012
    ..These data suggest that a single intravenous dose of DMP1 produces an intense and sustained immunosuppression in the liver for a relatively long time, which may be useful in liver transplantation...
  22. pmc Effects of methylprednisolone and its liver-targeted dextran prodrug on ischemia-reperfusion injury in a rat liver transplantation model
    Anjaneya P Chimalakonda
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, Texas 79106, USA
    Pharm Res 24:2231-8. 2007
    ..To evaluate the effectiveness of a liver-targeted dextran prodrug (DMP) of methylprednisolone (MP) in cold preservation-warm reperfusion injury associated with liver transplantation...
  23. pmc Plasma pharmacokinetics and tissue disposition of novel dextran-methylprednisolone conjugates with peptide linkers in rats
    Suman Penugonda
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
    J Pharm Sci 99:1626-37. 2010
    ..In contrast, in the kidneys, the AUC of MP regenerated from DMP-5 was higher than that after DMP-1 administration. These data suggest that DMP-1 may be more suitable than DMP-5 for targeting immunosuppression to the liver and spleen...
  24. doi request reprint Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers
    Ridhi Parasrampuria
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    J Pharm Sci 99:455-66. 2010
    ..It is concluded that the use of RH-123 in an IPRL model may serve as a dual marker for the determination of the altered functions of P-gp and/or Mrp2...
  25. ncbi request reprint Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Drug Metab Dispos 34:1160-6. 2006
    ....
  26. ncbi request reprint Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver
    Krishna C Chimalakonda
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Bioconjug Chem 18:2097-108. 2007
    ..These studies indicate the feasibility of the synthesis of 3TCS-dextran and its potential use for the selective delivery of 3TC to the liver...
  27. ncbi request reprint Route-dependent stereoselective pharmacokinetics of tramadol and its active O-demethylated metabolite in rats
    Ridhi Parasrampuria
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Chirality 19:190-6. 2007
    ....
  28. pmc Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates
    Suman Penugonda
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    J Pharm Sci 97:2649-64. 2008
    ..These newly developed dextran conjugates of MP show promise for controlled delivery of MP in lysosomes...
  29. ncbi request reprint Short-term inhibitory effects of nitric oxide on cytochrome P450-mediated drug metabolism: time dependency and reversibility profiles in isolated perfused rat livers
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA
    Drug Metab Dispos 32:1446-54. 2004
    ..The short-term effects of NO on P450 are time-dependent and enzyme-selective, with both reversible and irreversible mechanisms...
  30. ncbi request reprint Microsomal cytochrome P450 levels and activities of isolated rat livers perfused with albumin
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Pharm Res 20:81-8. 2003
    ..Here, we hypothesize that BSA-induced increase in the release of TNF-alpha, and possibly other cytokines, would affect cytochrome P450 (CYP)-mediated drug metabolism...
  31. doi request reprint Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach
    Venkateswaran C Pillai
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    Bioconjug Chem 21:203-7. 2010
    ..Additionally, the avidin-biotin approach may be of potential value for in vivo gene knockdown...
  32. ncbi request reprint Enzyme-selective effects of nitric oxide on affinity and maximum velocity of various rat cytochromes P450
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA
    Drug Metab Dispos 33:829-36. 2005
    ..These results indicate that NO can potentially change both the Vmax and Km of various substrates selectively and confirm our previous findings that the activity of CYP2D1 is not affected by NO donors...
  33. pmc Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug
    Shuang Qing Zhang
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:927-32. 2009
    ..The method was successfully applied to the measurement of low concentrations of regenerated MP in plasma and liver after intravenous administration of a single dose (5mg/kg) of a liver-targeted dextran prodrug of MP to rats...
  34. doi request reprint Effects of transient overexpression or knockdown of cytochrome P450 reductase on reactive oxygen species generation and hypoxia reoxygenation injury in liver cells
    Venkateswaran C Pillai
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Clin Exp Pharmacol Physiol 38:846-53. 2011
    ..4. Our data suggest that CPR plays a major role in the ROS generation by liver cells under the basal conditions. However, the role of CPR in the ROS generation during simulated in vitro IR injury in these cells is minimal, if any...
  35. pmc Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples
    Imam H Shaik
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    Anal Bioanal Chem 385:105-13. 2006
    ..The developed assay is rapid, sensitive, accurate, and precise and is suitable for studies of the redox status of liver under physiologic and pathophysiologic conditions...
  36. doi request reprint Dose-dependent inhibition of transporter-mediated hepatic uptake and biliary excretion of methotrexate by cyclosporine A in an isolated perfused rat liver model
    Ridhi Parasrampuria
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, Texas 79106, USA
    J Pharm Sci 99:5060-9. 2010
    ..It is concluded that CyA significantly alters the hepatobiliary disposition of MTX by inhibiting its sinusoidal uptake and/or biliary transport, potentially reducing enterohepatic recirculation of the drug in vivo...
  37. doi request reprint Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats
    Imam H Shaik
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Pharm Sci 100:5281-92. 2011
    ....
  38. ncbi request reprint Hepatic disposition and effects of nitric oxide donors: rapid and concentration-dependent reduction in the cytochrome P450-mediated drug metabolism in isolated perfused rat livers
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter, Amarillo, TX 79106, USA
    J Pharmacol Exp Ther 310:718-27. 2004
    ..These studies indicate that the effects of NO on the down-regulation of cytochrome 450 catalytic activity are rapid, concentration-dependent, and isoenzyme-selective...
  39. doi request reprint Effects of hepatic ischemia-reperfusion injury on the P-glycoprotein activity at the liver canalicular membrane and blood-brain barrier determined by in vivo administration of rhodamine 123 in rats
    Mohammad K Miah
    Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
    Pharm Res 31:861-73. 2014
    ..To investigate the effects of normothermic hepatic ischemia-reperfusion (IR) injury on the activity of P-glycoprotein (P-gp) in the liver and at the blood-brain barrier (BBB) of rats using rhodamine 123 (RH-123) as an in vivo marker...
  40. pmc Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension
    Vivek Gupta
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300S Coulter, Amarillo, TX 79106, USA
    J Control Release 167:189-99. 2013
    ..Overall, this study established the proof-of-principle that aerosolized liposomal fasudil is a feasible option for a non-invasive, controlled release and pulmonary preferential treatment of PAH...
  41. doi request reprint Inhibition of NADPH-cytochrome P450 reductase by tannic acid in rat liver microsomes and primary hepatocytes: methodological artifacts and application to ischemia-reperfusion injury
    Venkateswaran C Pillai
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106
    J Pharm Sci 100:3495-505. 2011
    ..These data may be useful in future studies using TA as an inhibitor of CPR in microsomes and primary hepatocytes...
  42. ncbi request reprint Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats
    Imam H Shaik
    Department of Pharmaceutical Sciences and Center for Blood Brain Barrier Research, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    Brain Res 1531:84-93. 2013
    ..265±0.034) and PCA (0.228±0.038) rats were not significantly different. It is concluded that whereas 10-day PCA alters the peripheral pharmacokinetics of FL, it does not significantly affect the BBB permeability to the marker. ..
  43. ncbi request reprint Development and application of an isolated perfused rat liver model to study the stimulation and inhibition of tumor necrosis factor-alpha production ex vivo
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo 79106, USA
    Pharm Res 19:47-53. 2002
    ....
  44. ncbi request reprint Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells
    Nikhil M Vad
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Pharm Sci 97:1934-45. 2008
    ..Our findings suggest that the mechanisms of 4-HEB toxicity in SK-MEL-28 were o-quinone formation, intracellular GSH depletion, ROS formation and mitochondrial toxicity...
  45. ncbi request reprint Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    Clin Pharmacokinet 41:533-58. 2002
    ..Because the effects of these drugs are related to their plasma concentrations, this information is of special clinical relevance...
  46. ncbi request reprint Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin
    Anthony J Busti
    School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX 75216, USA
    J Cardiovasc Pharmacol 51:605-10. 2008
    ..The objective is to study the pharmacokinetic interaction of RSV with atazanavir/ritonavir (ATV/RTV) or fosamprenavir/ritonavir (FPV/RTV)...
  47. doi request reprint Enantioselective determination of tramadol and its main phase I metabolites in human plasma by high-performance liquid chromatography
    Yalda H Ardakani
    Biopharmaceutics and Pharmacokinetics Division, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155 6451, Iran
    J Chromatogr B Analyt Technol Biomed Life Sci 864:109-15. 2008
    ..The procedure was applied to assess the pharmacokinetics of the enantiomers of tramadol and its two main metabolites following oral administration of single 100-mg doses to healthy volunteers...
  48. ncbi request reprint Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Clin Pharmacokinet 42:1359-82. 2003
    ..It is concluded that knowledge of the stereoselective aspects of these agents may be helpful in better understanding their mechanisms of action and possibly optimising their clinical safety and/or effectiveness...
  49. ncbi request reprint Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents
    Majid Vakily
    Department of Drug Metabolism and Pharmacology, TAP Pharmaceutical Product Inc, Lake Forest, IL 60045 4832, USA
    Ann Pharmacother 36:693-701. 2002
    ..To review the previously published studies on pharmacokinetics and pharmacodynamics of chiral drugs used in the treatment of asthma...
  50. doi request reprint Dependence of time to reach steady-state on the length of dosage interval
    Reza Mehvar
    Ann Pharmacother 42:1518-9. 2008

Research Grants4

  1. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2007
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
  2. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2005
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
  3. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2006
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..