DANIEL M MEDINA

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Chemical carcinogenesis of rat and mouse mammary glands
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Dis 28:63-8. 2007
  2. pmc Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage
    Min Zhu
    Transgenic Oncogenesis and Genomics Section, Laboratory of Cell Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Genome Biol 12:R77. 2011
  3. pmc Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA
    Karen M Bussard
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res 12:R86. 2010
  4. pmc Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis
    Benny Abraham Kaipparettu
    Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Mol Cancer 8:15. 2009
  5. pmc Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer
    Sangjun Lee
    Breast Center, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 8:R6. 2006
  6. pmc Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models
    Lakshmanaswamy Rajkumar
    Department of Pathology, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, El Paso, TX 79905, USA
    Breast Cancer Res 9:R12. 2007
  7. pmc Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors
    Brigitte Blackman
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Breast Cancer Res 7:R248-55. 2005
  8. doi request reprint Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mammary Gland Biol Neoplasia 13:271-7. 2008
  9. ncbi request reprint Mammary developmental fate and breast cancer risk
    Daniel Medina
    Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Relat Cancer 12:483-95. 2005
  10. ncbi request reprint Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis
    Daniel Medina
    Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:3493-6. 2005

Research Grants

  1. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2000
  2. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2001
  3. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2002
  4. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2003
  5. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
  6. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS.
    Daniel Medina; Fiscal Year: 1999
  7. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1992
  8. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Daniel Medina; Fiscal Year: 1990
  9. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Daniel Medina; Fiscal Year: 1991
  10. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1993

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Chemical carcinogenesis of rat and mouse mammary glands
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Dis 28:63-8. 2007
    ..Thus, many different models will be needed to fully enable an understanding of the cellular and molecular basis for human breast cancer and eventually provide the critical preventive and therapeutic approaches to conquer this cancer...
  2. pmc Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage
    Min Zhu
    Transgenic Oncogenesis and Genomics Section, Laboratory of Cell Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Genome Biol 12:R77. 2011
    ....
  3. pmc Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA
    Karen M Bussard
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res 12:R86. 2010
    ..We hypothesized that long-lived epithelial cells are present in immortal, premalignant cell populations, undergo asymmetric division, retain their template DNA strands, and cycle both during allometric growth and during pregnancy...
  4. pmc Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis
    Benny Abraham Kaipparettu
    Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Mol Cancer 8:15. 2009
    ..Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele...
  5. pmc Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer
    Sangjun Lee
    Breast Center, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 8:R6. 2006
    ....
  6. pmc Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models
    Lakshmanaswamy Rajkumar
    Department of Pathology, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, El Paso, TX 79905, USA
    Breast Cancer Res 9:R12. 2007
    ..The experiments reported here address the question of whether a short-term hormone treatment can prevent mammary tumorigenesis in two different genetically engineered mouse models...
  7. pmc Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors
    Brigitte Blackman
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Breast Cancer Res 7:R248-55. 2005
    ..To set the stage for functional experiments on this molecule, we examined the developmental expression and localization of claudin 7 in the murine mammary epithelium and in a selection of murine mammary tumors...
  8. doi request reprint Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mammary Gland Biol Neoplasia 13:271-7. 2008
    ..Newer transgenic mouse models provide a renewed opportunity to engage in the study of the mechanisms and processes underlying mammary metastasis...
  9. ncbi request reprint Mammary developmental fate and breast cancer risk
    Daniel Medina
    Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Relat Cancer 12:483-95. 2005
    ..The current studies have moved this research area from the biological to the molecular realm and offer the potential for directing prevention efforts at specific molecular targets...
  10. ncbi request reprint Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis
    Daniel Medina
    Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:3493-6. 2005
    ..These results show that tamoxifen delays the emergence of ER-alpha-negative tumors if given early in premalignant progression...
  11. ncbi request reprint Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 118:123-7. 2005
    ..The results demonstrate that the chemical-carcinogen treated stroma did not enhance mammary tumorigenesis in this model and that carcinogen treatment of the mammary epithelium was essential for tumorigenesis...
  12. pmc Stromal fibroblasts influence human mammary epithelial cell morphogenesis
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4723-4. 2004
  13. ncbi request reprint The preneoplastic phenotype in murine mammary tumorigenesis
    D Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 5:393-407. 2000
    ..Analogous hyperplasias from several defined genetic models, adequately characterized at the biological and molecular levels, would provide appropriate models for testing chemopreventive agents...
  14. ncbi request reprint Breast cancer: the protective effect of pregnancy
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Clin Cancer Res 10:380S-4S. 2004
    ..These results demonstrate that p53 plays a pivotal role in hormone-induced protection and raises the question of the mechanisms by which the steroid hormones, estrogen and progesterone, functionally activate p53...
  15. ncbi request reprint Se-methylselenocysteine: a new compound for chemoprevention of breast cancer
    D Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Nutr Cancer 40:12-7. 2001
    ....
  16. ncbi request reprint Biological and genetic properties of the p53 null preneoplastic mammary epithelium
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 16:881-3. 2002
    ....
  17. ncbi request reprint Mechanisms of hormonal prevention of breast cancer
    D Medina
    Department of Molecularand Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 952:23-35. 2001
    ....
  18. ncbi request reprint Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis
    Christian R Loehberg
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:12026-33. 2007
    ..Our results indicate that a short prior exposure to chloroquine may have a preventative application for mammary carcinogenesis...
  19. ncbi request reprint Hormone-induced chromosomal instability in p53-null mammary epithelium
    Debananda Pati
    Department of Pediatrics, Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:5608-16. 2004
    ....
  20. ncbi request reprint Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis
    Lakshmi Sivaraman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Breast Cancer Res Treat 73:75-83. 2002
    ..Several possible explanations of the puzzling relationship between elimination of cycling cells and increased tumor incidence are discussed and alternative strategies for the prevention of breast cancer are proposed...
  21. ncbi request reprint Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development
    Gu Kong
    Breast Center, Baylor College of Medicine, Houston, Texas, TX 77030, USA
    Oncogene 21:7214-25. 2002
    ..Collectively, the effects of cyclin D2 overexpression on mammary gland development during pregnancy and involution are attributed to two major factors, altered p27(kip1) protein level and inhibition of cyclin D1 phosphorylation...
  22. ncbi request reprint Hormone dependence in premalignant mammary progression
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:1067-72. 2003
    ..This model would appear an excellent one to test the effects of chemopreventive agents on the development of both ER-negative and ER-positive mammary tumors...
  23. ncbi request reprint Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Environ Mol Mutagen 39:178-83. 2002
    ..These results demonstrate that, on a background of underlying genetic instability, very low doses of environmental mutagens and mitogens can produce strong cocarcinogenic effects...
  24. pmc Overexpression of Separase induces aneuploidy and mammary tumorigenesis
    Nenggang Zhang
    Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:13033-8. 2008
    ..These results collectively suggest that Separase is an oncogene, whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 mutant background...
  25. pmc Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:168-74. 2009
    ....
  26. ncbi request reprint p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis
    Daniel Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cancer Res 63:6140-3. 2003
    ..Additionally, the experiments highlight the usefulness of transgenic mouse models in the testing of hypotheses derived from the classic rat mammary models...
  27. ncbi request reprint Cell cycle genes in a mouse mammary hyperplasia model
    Thenaa K Said
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 9:81-93. 2004
    ..This review provides an overview of gene alterations in the cell cycle components in mouse mammary hyperplasia...
  28. ncbi request reprint Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis
    Thea M Goepfert
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 62:4115-22. 2002
    ..Cumulatively, these results suggest that ratAurA overexpression and centrosome amplification were linked to tumor development and progression and may serve as early markers in tumorigenesis...
  29. pmc The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
    D Craig Allred
    Breast Center Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 6:240-5. 2004
    ....
  30. pmc p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development
    Yijun Yi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 15:2302-11. 2004
    ....
  31. ncbi request reprint Loss of chromosomal integrity drives rat mammary tumorigenesis
    Thea M Goepfert
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Cancer 120:985-94. 2007
    ..Collectively, these data suggest that the carcinogen MNU induces changes resulting in genetic instability detectable before hyperplasia and tumors develop in the rat mammary gland...
  32. ncbi request reprint Biological and molecular characteristics of the premalignant mouse mammary gland
    Daniel Medina
    Department of Molecular and Cellular Biology, One Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA
    Biochim Biophys Acta 1603:1-9. 2002
    ....
  33. ncbi request reprint Serial analysis of gene expression in normal p53 null mammary epithelium
    C Marcelo Aldaz
    The University of Texas M D Anderson Cancer Center, Department of Carcinogenesis, Smithville, Texas, TX 78957, USA
    Oncogene 21:6366-76. 2002
    ..This is the first study to examine the transcriptome of very early stages of preneoplastic progression in an in vivo model that mimics human breast cancer...
  34. ncbi request reprint Mammary tumor modifiers in BALB/cJ mice heterozygous for p53
    Joanna G Koch
    The University of Texas Graduate School of Biomedical Sciences and the Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mamm Genome 18:300-9. 2007
    ..The second modifier mapped is Mtsm2, a recessive-acting modifier. Mtsm2 is located on chromosome X and is significantly linked to mammary tumorigenesis (p = 1.03 x 10(-7))...
  35. pmc Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    Mei Zhang
    Department of Molecular and Cellular Biology, Graduate program in Translational Biology and Molecular Medicine, and Lester and Sue Smith Breast Center of Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:4674-82. 2008
    ..Furthermore, this p53-null mouse mammary tumor model may allow us to identify new CSC markers and to test the functional importance of these markers...
  36. ncbi request reprint Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7993-8002. 2005
    ..Our results suggest that AIB1 may serve as a potential target for prevention of carcinogen-induced breast cancer initiation and for treatment of breast cancer progression...
  37. ncbi request reprint Hormone-induced protection against breast cancer
    Lakshmi Sivaraman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 7:77-92. 2002
    ..One central question that is still unresolved is whether the refractoriness is intrinsic to the mammary epithelial cells and/or mediated by persistent alterations in the host environment...
  38. pmc Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
    Catherine E Gatza
    Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 313:130-41. 2008
    ..These data indicate that appropriate levels of p53 activity are important in regulating mammary gland ductal morphogenesis, in part through regulation of the IGF-1 pathway...
  39. ncbi request reprint Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis
    Zhigang Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Clin Exp Metastasis 25:389-400. 2008
    ..Further functional studies of metastasis signature genes should help to develop means to curb the metastasis process...

Research Grants30

  1. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2000
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  2. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2001
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  3. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2002
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  4. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2003
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  5. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  6. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS.
    Daniel Medina; Fiscal Year: 1999
    ..These experiments will increase the understanding of regulation of the growth and tumorigenic progression of mammary preneoplasias and provide a model system for understanding regulation of growth in early stage breast cancer. ..
  7. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1992
    ....
  8. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Daniel Medina; Fiscal Year: 1990
    ..The hypothesis that the chemopreventive effects of selenium on cell growth are mediated by modification of protein function will be pursued by examining protein phosphorylation and protein synthesis...
  9. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Daniel Medina; Fiscal Year: 1991
    ..The hypothesis that the chemopreventive effects of selenium on cell growth are mediated by modification of protein function will be pursued by examining protein phosphorylation and protein synthesis...
  10. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1993
    ....
  11. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..