Steve A Maxwell

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis
    S A Maxwell
    Department of Pathology, Texas A and M Health Science Center, College Station 77843 1114, USA
    Electrophoresis 17:1772-5. 1996
  2. ncbi Telomerase activity in immortalized endothelial cells undergoing p53-mediated apoptosis
    S A Maxwell
    Department of Pathology and Laboratory Medicine, Texas A and M Health Science Center, College Station, USA
    Biochem Biophys Res Commun 241:642-5. 1997
  3. ncbi Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines
    S A Maxwell
    Department of Pathology and Laboratory Medicine, Texas A and M University Health Science Center, College Station, TX 77843 1114, USA
    Proc Natl Acad Sci U S A 97:13009-14. 2000
  4. ncbi Biological and molecular characterization of an ECV-304-derived cell line resistant to p53-mediated apoptosis
    S A Maxwell
    Department of Pathology and Laboratory Medicine, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    Apoptosis 5:277-90. 2000
  5. ncbi Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas
    Steve A Maxwell
    Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, Texas 77843 1114, USA
    J Biol Chem 278:9784-9. 2003
  6. ncbi Gene expression profiling of p53-sensitive and -resistant tumor cells using DNA microarray
    S A Maxwell
    Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, TX 77843 1114, USA
    Apoptosis 9:171-9. 2004
  7. ncbi The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    Armando Rivera
    Department of Pathology and Laboratory Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    J Biol Chem 280:29346-54. 2005
  8. ncbi Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation
    Hyeong Il Kwak
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Angiogenesis 15:287-303. 2012
  9. ncbi Akt, 14-3-3ζ, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Leuk Lymphoma 52:849-64. 2011
  10. ncbi 14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, The Texas A and M Health Science Center, College Station, Texas 77840 1114, USA
    J Biol Chem 284:22379-89. 2009

Collaborators

  • Kayla J Bayless
  • Shih Chi Su
  • Hyeong Il Kwak
  • Armando Rivera
  • Hojin Kang
  • E Adriana Mendoza
  • Jui M Dave

Detail Information

Publications12

  1. ncbi Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis
    S A Maxwell
    Department of Pathology, Texas A and M Health Science Center, College Station 77843 1114, USA
    Electrophoresis 17:1772-5. 1996
    ..The differential expression of isoforms 1, 4, and 7 in apoptotic cells suggests that one or more specific phosphorylation events generating these forms of p53 could play a role in regulating the function of p53 in apoptosis...
  2. ncbi Telomerase activity in immortalized endothelial cells undergoing p53-mediated apoptosis
    S A Maxwell
    Department of Pathology and Laboratory Medicine, Texas A and M Health Science Center, College Station, USA
    Biochem Biophys Res Commun 241:642-5. 1997
    ..Telomerase activity was measured by a PCR-based telomeric repeat amplification protocol (TRAP). Telomerase activity was found to be unaffected by overexpression of p53 and apoptosis in immortalized endothelial cells...
  3. ncbi Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines
    S A Maxwell
    Department of Pathology and Laboratory Medicine, Texas A and M University Health Science Center, College Station, TX 77843 1114, USA
    Proc Natl Acad Sci U S A 97:13009-14. 2000
    ..The results directly implicate proline oxidase and the proline/P5C pathway in p53-induced growth suppression and apoptosis...
  4. ncbi Biological and molecular characterization of an ECV-304-derived cell line resistant to p53-mediated apoptosis
    S A Maxwell
    Department of Pathology and Laboratory Medicine, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    Apoptosis 5:277-90. 2000
    ..DECV cells should prove to be a useful tool in future studies to elucidate mechanisms of p53-mediated apoptosis and differentiation...
  5. ncbi Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas
    Steve A Maxwell
    Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, Texas 77843 1114, USA
    J Biol Chem 278:9784-9. 2003
    ..The presence of proline oxidase in mitochondria, a primary organelle that regulates apoptosis, places this molecule in a subcellular localization that can directly influence the apoptotic pathway and thus tumorigenesis...
  6. ncbi Gene expression profiling of p53-sensitive and -resistant tumor cells using DNA microarray
    S A Maxwell
    Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, TX 77843 1114, USA
    Apoptosis 9:171-9. 2004
    ..Our analysis identifies many new potential targets for p53 that play roles in cell cycle regulation, DNA repair, redox control, cell adhesion, apoptosis, and differentiation...
  7. ncbi The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    Armando Rivera
    Department of Pathology and Laboratory Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    J Biol Chem 280:29346-54. 2005
    ..The activation of calcineurin-regulated transcription factor pathways by proline oxidase might affect gene expression events important to p53 regulation of cell growth and apoptosis...
  8. ncbi Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation
    Hyeong Il Kwak
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Angiogenesis 15:287-303. 2012
    ..These findings help explain why S1P and GF synergize to stimulate robust sprouting in 3D collagen matrices...
  9. ncbi Akt, 14-3-3ζ, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Leuk Lymphoma 52:849-64. 2011
    ..The data implicate activation of an Akt-14-3-3ζ signaling pathway in promoting a multidrug-resistant phenotype associated with a vimentin-dependent invasive behavior in DLBCL cells...
  10. ncbi 14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, The Texas A and M Health Science Center, College Station, Texas 77840 1114, USA
    J Biol Chem 284:22379-89. 2009
    ..Our study implicates 14-3-3zeta in the pathogenesis of DLBCL and suggests a promising combination strategy with a 14-3-3 inhibitor for the treatment of refractory DLBCL...
  11. ncbi Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity
    Shih Chi Su
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, Texas 77843 1114, USA
    J Biol Chem 285:40624-34. 2010
    ..Collectively, we report that annexin 2 regulates endothelial morphogenesis through an adherens junction-mediated pathway upstream of Akt...
  12. ncbi Identification of a p53-response element in the promoter of the proline oxidase gene
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, Room 252, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Biochem Biophys Res Commun 369:308-13. 2008
    ..We concluded from these experiments that a p53-binding site is positioned at -1161 to -1188bp upstream of the POX transcriptional start site...