Susan J Marriott

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated
    Marie Hélène Cavanagh
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, G1V 4G2, Canada
    Retrovirology 3:15. 2006
  2. pmc Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 6:9. 2009
  3. ncbi request reprint Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein
    S J Marriott
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    Virology 224:206-13. 1996
  4. ncbi request reprint Augmentation of human T cell leukaemia virus type I Tax transactivation by octamer binding sites
    S J Marriott
    Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
    J Gen Virol 78:2259-67. 1997
  5. ncbi request reprint Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells
    Susan J Marriott
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Biomed Sci 9:292-8. 2002
  6. ncbi request reprint Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response
    Susan J Marriott
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 24:5986-95. 2005
  7. pmc Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response
    Chandtip Chandhasin
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:6952-61. 2008
  8. pmc Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage
    Tajhal Dayaram
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e55989. 2013
  9. doi request reprint Effect of transforming viruses on molecular mechanisms associated with cancer
    Tajhal Dayaram
    Interdepartmental Program in Cell and Molecular Biology, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Cell Physiol 216:309-14. 2008
  10. ncbi request reprint Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation
    Michael L Gatza
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Environ Mol Mutagen 45:304-25. 2005

Collaborators

Detail Information

Publications24

  1. pmc HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated
    Marie Hélène Cavanagh
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, G1V 4G2, Canada
    Retrovirology 3:15. 2006
    ..Thorough characterization is required to demonstrate the existence of these transcripts and gain insight into their role in retrovirus biology...
  2. pmc Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 6:9. 2009
    ..Analysis of full-length genomes can provide basic information on the evolutionary history and replication and pathogenic potential of new viruses...
  3. ncbi request reprint Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein
    S J Marriott
    Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
    Virology 224:206-13. 1996
    ..These results raise the possibility that the HBV X protein may affect the level of HTLV-I gene expression in co-infected individuals...
  4. ncbi request reprint Augmentation of human T cell leukaemia virus type I Tax transactivation by octamer binding sites
    S J Marriott
    Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
    J Gen Virol 78:2259-67. 1997
    ..Taken together, these results demonstrate that the degree of Tax transactivation can be influenced by the elemental composition of the target promoter...
  5. ncbi request reprint Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells
    Susan J Marriott
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Biomed Sci 9:292-8. 2002
    ..The consequences of these effects as well as the evolutionary advantage this may provide to HTLV-I are discussed...
  6. ncbi request reprint Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response
    Susan J Marriott
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 24:5986-95. 2005
    ..The contribution of these activities to genome instability and cellular transformation will be discussed...
  7. pmc Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response
    Chandtip Chandhasin
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:6952-61. 2008
    ..Attempts to replicate in the presence of these lesions would result in gradual accumulation of mutations, leading to genome instability and cellular transformation...
  8. pmc Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage
    Tajhal Dayaram
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e55989. 2013
    ..Premature G(1) exit of Tax-expressing cells in the presence of DNA lesions creates an environment that tolerates incorporation of random mutations into the host genome...
  9. doi request reprint Effect of transforming viruses on molecular mechanisms associated with cancer
    Tajhal Dayaram
    Interdepartmental Program in Cell and Molecular Biology, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Cell Physiol 216:309-14. 2008
    ..While the transforming properties of these viruses are probably unintended consequences of replication strategies, they provide excellent systems in which to study cancer development...
  10. ncbi request reprint Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation
    Michael L Gatza
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Environ Mol Mutagen 45:304-25. 2005
    ..This review discusses mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to mediate genomic instability and cellular transformation...
  11. pmc Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export
    Michael L Gatza
    Department of Molecular Virology and Microbiology, Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 4:95. 2007
    ..Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins...
  12. pmc Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1
    Heather Y Winter
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, Texas 77030, USA
    J Virol 81:13075-81. 2007
    ..These results identify a functional SRE within the HTLV-1 LTR and suggest that both Elk-1 and SRF play important roles in regulating basal HTLV-1 gene expression...
  13. pmc Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection
    Heather Y Winter
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 81:6089-98. 2007
    ..These results suggest that Tax activates SRF-responsive transcription by enhancing its binding affinity to multiple different SRE sequences...
  14. ncbi request reprint Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades
    Michael L Gatza
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 22:5141-9. 2003
    ..This review will concentrate on the effects of Tax on the dysregulation of the G(1)/S and G(2)/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation...
  15. ncbi request reprint The HTLV-I Tax oncoprotein: hyper-tasking at the molecular level
    Diane R Wycuff
    Dept Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Front Biosci 10:620-42. 2005
    ..Whereas for the virus these functions of Tax provide a means for successful completion of its life cycle, for the cell, they result at best in anarchy, and at worst in death of both the cell and the organism of which that cell is a part...
  16. pmc Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism
    Michael L Gatza
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza MS 385, Houston, TX 77030, USA
    J Virol 80:6657-68. 2006
    ..Changes in Tax distribution and interacting partners are likely to affect cellular processes that regulate cellular transformation...
  17. pmc The HTLV-1 Tax oncoprotein represses Ku80 gene expression
    Razvan I Ducu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 416:1-8. 2011
    ..The reduction of Ku80 transcription by Tax may deplete the cell of an essential DNA break binding protein, resulting in reduced repair of DNA double strand breaks and accumulation genomic mutations...
  18. pmc Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression
    Dustin C Edwards
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 82:11714-22. 2008
    ....
  19. ncbi request reprint Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax
    Francene J Lemoine
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, TX 77030, USA
    Oncogene 21:7230-4. 2002
    ..These data suggest that HTLV-I Tax alters the genomic stability of cells, an effect that may play an important role in Tax-mediated, HTLV-I associated cellular transformation...
  20. ncbi request reprint Identification of a functional serum response element in the HTLV-I LTR
    Diane R Wycuff
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 324:540-53. 2004
    ..These data identify a functional serum response element in the HTLV-I LTR and suggest that SRF may play an important role in regulating basal HTLV-I gene expression in early infection and reactivation from latency...
  21. pmc High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells
    Charletha V Irvin-Wilson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Viruses 3:2396-411. 2011
    ..This general approach represents a significant advancement over manual cell polarity scoring, which is subject to experimenter bias and requires more time and effort to evaluate large numbers of cells...
  22. ncbi request reprint Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemia
    Masao Matsuoka
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Cancer Res 67:10638-41. 2007
  23. ncbi request reprint A new sensitive and quantitative HTLV-I-mediated cell fusion assay in T cells
    Marie Ève Paré
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Canada
    Virology 338:309-22. 2005
    ....
  24. ncbi request reprint Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitors
    Mélanie Langlois
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Ste Foy Québec, Canada G1V 4G2
    Virology 329:395-411. 2004
    ..These results demonstrate for the first time a powerful effect of PTP inhibitors on HTLV-I LTR activity and suggest participation of both CREB-dependent and -independent pathways in this activation...