ALI MARIAN

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Utilities and limitations of genetic testing for hypertropic cardiomyopathy
    Aj Marian
    The University of Texas Health Science Center, The Brown Foundation Institute of Molecular Medicine, Center for Cardiovascular Genetic Research, Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner Street, DAC 900A, Houston, TX 77030, USA 1 713 500 2350 1 713 500 2320
    Expert Opin Med Diagn 2:539-46. 2008
  2. pmc Challenges in medical applications of whole exome/genome sequencing discoveries
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX 77030, USA
    Trends Cardiovasc Med 22:219-23. 2012
  3. pmc Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy
    Suet Nee Chen
    Institute of Molecular Medicine, University of Texas Health Sciences Center, Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner St, Suite C900A, Houston, TX 77030, USA
    Circ Res 111:907-19. 2012
  4. pmc The enigma of genetics etiology of atherosclerosis in the post-GWAS era
    A J Marian
    Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 77030, USA
    Curr Atheroscler Rep 14:295-9. 2012
  5. doi request reprint Elements of 'missing heritability'
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, Texas 77030, USA
    Curr Opin Cardiol 27:197-201. 2012
  6. pmc Molecular genetic studies of complex phenotypes
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX 77030, USA
    Transl Res 159:64-79. 2012
  7. pmc Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis
    Suet Nee Chen
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX, USA
    BMC Med Genet 10:111. 2009
  8. pmc The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis
    Suet Nee Chen
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, and Texas Heart Institute, Houston, TX 77030, USA
    BMC Cardiovasc Disord 9:3. 2009
  9. ncbi request reprint Clinical implications of the "personal" genome
    Ali J Marian
    Center for Cardiovascular Genetic Research, Brown Foundation Institute of Molecular Medicine, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Curr Atheroscler Rep 10:361-3. 2008
  10. pmc Hypertrophic cardiomyopathy: from genetics to treatment
    Ali J Marian
    Center for Cardiovascular Genetics, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner Street, Suite C900A, Houston, TX 77030, USA
    Eur J Clin Invest 40:360-9. 2010

Collaborators

Detail Information

Publications35

  1. doi request reprint Utilities and limitations of genetic testing for hypertropic cardiomyopathy
    Aj Marian
    The University of Texas Health Science Center, The Brown Foundation Institute of Molecular Medicine, Center for Cardiovascular Genetic Research, Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner Street, DAC 900A, Houston, TX 77030, USA 1 713 500 2350 1 713 500 2320
    Expert Opin Med Diagn 2:539-46. 2008
    ..A comprehensive approach that includes the information content of the causal mutations, the modifier genes and the non-genetic factors will be necessary for accurate risk stratification and genetic-based interventions...
  2. pmc Challenges in medical applications of whole exome/genome sequencing discoveries
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX 77030, USA
    Trends Cardiovasc Med 22:219-23. 2012
    ..The most important contribution of WES or WGS is in delineation of the novel molecular pathways involved in the pathogenesis of the phenotype, which would be expected to provide for preventive and therapeutic opportunities...
  3. pmc Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy
    Suet Nee Chen
    Institute of Molecular Medicine, University of Texas Health Sciences Center, Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner St, Suite C900A, Houston, TX 77030, USA
    Circ Res 111:907-19. 2012
    ..TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for subsequent degradation by the ubiquitin-proteasome system (UPS)...
  4. pmc The enigma of genetics etiology of atherosclerosis in the post-GWAS era
    A J Marian
    Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 77030, USA
    Curr Atheroscler Rep 14:295-9. 2012
    ..Collectively, the recent findings are indicative of the etiological complexity of coronary atherosclerosis. Hence, it is expected that genetic etiology of coronary atherosclerosis will remain enigmatic in the foreseeable future...
  5. doi request reprint Elements of 'missing heritability'
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, Texas 77030, USA
    Curr Opin Cardiol 27:197-201. 2012
    ..To discuss the basis of 'missing heritability', which has emerged as an enigma in the post-genome-wide association studies (GWAS) era...
  6. pmc Molecular genetic studies of complex phenotypes
    Ali J Marian
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX 77030, USA
    Transl Res 159:64-79. 2012
    ..This review provides an update on the current progress and limitations in identifying DSVs that are associated with phenotypic effects...
  7. pmc Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis
    Suet Nee Chen
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute, Houston, TX, USA
    BMC Med Genet 10:111. 2009
    ....
  8. pmc The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis
    Suet Nee Chen
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, and Texas Heart Institute, Houston, TX 77030, USA
    BMC Cardiovasc Disord 9:3. 2009
    ..The LCAS is a randomized placebo-control longitudinal follow-up study in patients with CAD conducted to test the effects of fluvastatin on progression or regression of coronary atherosclerosis...
  9. ncbi request reprint Clinical implications of the "personal" genome
    Ali J Marian
    Center for Cardiovascular Genetic Research, Brown Foundation Institute of Molecular Medicine, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, TX 77030, USA
    Curr Atheroscler Rep 10:361-3. 2008
  10. pmc Hypertrophic cardiomyopathy: from genetics to treatment
    Ali J Marian
    Center for Cardiovascular Genetics, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center and Texas Heart Institute at St Luke s Episcopal Hospital, 6770 Bertner Street, Suite C900A, Houston, TX 77030, USA
    Eur J Clin Invest 40:360-9. 2010
    ..Hypertrophic cardiomyopathy (HCM) is the prototypic form of pathological cardiac hypertrophy. HCM is an important cause of sudden cardiac death in the young and a major cause of morbidity in the elderly...
  11. pmc Experimental therapies in hypertrophic cardiomyopathy
    Ali J Marian
    Center for Cardiovascular Genetics, St Luke s Episcopal Hospital and Texas Heart Institute, Brown Foundation Institute of Molecular Medicine, The Unversity of Texas Health Science Center, Houston, TX 77030, USA
    J Cardiovasc Transl Res 2:483-92. 2009
    ....
  12. pmc Medical DNA sequencing
    Ali J Marian
    The Brown Foundation Institute of Molecular Medicine, Texas Heart Institute at St Luke s Episcopal Hospital, University of Texas Health Science Center, Houston, TX 77030, USA
    Curr Opin Cardiol 26:175-80. 2011
    ..To discuss implications of information garnered through whole-genome and exome sequencing in the practice of cardiovascular medicine...
  13. pmc Strategic approaches to unraveling genetic causes of cardiovascular diseases
    A J Marian
    Center for Cardiovascular Genetics, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center, 6770 Bertner Street, Suite C900A, Houston, TX 77030, USA
    Circ Res 108:1252-69. 2011
    ..In this review, we discuss various strategies that are used to delineate the genetic contribution to medically important cardiovascular phenotypes, emphasizing the utility of the new deep sequencing approaches...
  14. pmc Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy
    Raffaella Lombardi
    Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Circ Res 109:1342-53. 2011
    ..We have implicated signaling properties of junction protein plakoglobin (PG) in the pathogenesis of ARVC...
  15. pmc Genetic determinants of cardiac hypertrophy
    Ali J Marian
    The Brown Foundation Institute of Molecular Medicine, Center for Cardiovascular Genetic Research, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Curr Opin Cardiol 23:199-205. 2008
    ..We focus on the molecular genetics of cardiac hypertrophy in various conditions with an emphasis on hypertrophic cardiomyopathy, a genetic paradigm of cardiac hypertrophic response...
  16. pmc Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation
    Ali J Marian
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Am Coll Cardiol 47:827-34. 2006
    ....
  17. pmc Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy
    Raffaella Lombardi
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center, 6770 Bertner Street, Houston, TX 77030, USA
    Circ Res 104:1076-84. 2009
    ..We conclude adipocytes in arrhythmogenic right ventricular cardiomyopathy originate from the second heart field cardiac progenitors, which switch to an adipogenic fate because of suppressed canonical Wnt signaling by nuclear plakoglobin...
  18. pmc A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
    Suet N Chen
    Section of Cardiology, Center for Preventive Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 45:1611-9. 2005
    ....
  19. pmc On predictors of sudden cardiac death in hypertrophic cardiomyopathy
    Ali J Marian
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza 519D, Houston, Texas 77030, USA
    J Am Coll Cardiol 41:994-6. 2003
  20. pmc Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms
    Raffaella Lombardi
    Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, and Texas Heart Institute, Houston, TX, USA
    Circulation 119:1398-407. 2009
    ..We posit that treatment with N-acetylcysteine, a precursor of glutathione, the largest intracellular thiol pool against oxidative stress, could reverse cardiac hypertrophy and fibrosis in HCM...
  21. pmc Differential interactions of thin filament proteins in two cardiac troponin T mouse models of hypertrophic and dilated cardiomyopathies
    Raffaella Lombardi
    Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX 77030, USA
    Cardiovasc Res 79:109-17. 2008
    ..To test the hypothesis, we generated transgenic mice expressing either cardiac troponin T (cTnT)-Q92 or cTnT-W141, known to cause HCM and DCM, respectively, in the heart...
  22. pmc Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy
    Adriana Osio
    Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Circ Res 100:766-8. 2007
    ..It was absent in 2 normal family members and 517 controls. Both mutations affect highly conserved amino acids. We conclude MYOZ2 is a novel causal gene for human HCM...
  23. pmc Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy
    E Warwick Daw
    Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 16:2463-71. 2007
    ....
  24. pmc Regulatable atrial natriuretic peptide gene therapy for hypertension
    Kurt J Schillinger
    Department of Molecular and Cellular Biology, Section of Cardiovascular Sciences and Cardiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:13789-94. 2005
    ..Given these capabilities, this vector represents a paradigm for the gene therapy of HTN...
  25. pmc Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    Ke Ma
    Section of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:2748-53. 2003
    ..We conclude that EL is a major determinant of HDL concentration, structure, and metabolism in mice, and a major determinant of HDL concentration in humans...
  26. pmc Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease
    Dong Chuan Guo
    The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Hum Genet 84:617-27. 2009
    ....
  27. pmc Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
    Eduardo Garcia-Gras
    Section of Cardiology and Center for Cardiac Development, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 116:2012-21. 2006
    ..These findings could provide for the opportunity to identify new diagnostic markers and therapeutic targets in patients with ARVC...
  28. ncbi request reprint Matrix metalloproteinase-I gene variants and risk of myocardial infarction
    Ali J Marian
    Curr Atheroscler Rep 8:174-6. 2006
  29. pmc Phenotypic plasticity of sarcomeric protein mutations
    Ali J Marian
    J Am Coll Cardiol 49:2427-9. 2007
  30. pmc Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy
    Crystal M Ripplinger
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Circ Res 101:1049-57. 2007
    ....
  31. ncbi request reprint Interleukin-18 and cardiovascular events
    Ali J Marian
    Curr Atheroscler Rep 8:173-4. 2006
  32. ncbi request reprint Cholesteryl ester transfer protein TaqIB polymorphism in the cholesterol and recurrent events study
    Ali J Marian
    Curr Atheroscler Rep 7:178-9. 2005
  33. ncbi request reprint Pharmacogenetic study of statin therapy and cholesterol reduction
    Ali J Marian
    Curr Atheroscler Rep 7:177-8. 2005
  34. pmc Can an energy-deficient heart grow bigger and stronger?
    Robert Roberts
    J Am Coll Cardiol 41:1783-5. 2003
  35. pmc Surprises of the genome and "personalized" medicine
    Ali J Marian
    J Am Coll Cardiol 51:456-8. 2008

Research Grants8

  1. Modifier Genes of Familial Hypertrophic Cardiomyopathy
    ALI MARIAN; Fiscal Year: 2005
    ..Treatment found to induce regression of hypertrophy in the rabbit with FHCM will most likely also induce regression of hypertrophy in human FHCM and hypertrophy due to other cardiac causes. ..
  2. Canonical Wnt Signaling in Pathogenesis and Rescue of ARVC Phenotype
    ALI MARIAN; Fiscal Year: 2009
    ..ARVC is an important cause of sudden death in the young. Currently, there is no specific treatment or prevention for ARVC. ..
  3. Canonical Wnt Signaling in Pathogenesis and Rescue of ARVC Phenotype
    Ali J Marian; Fiscal Year: 2010
    ..ARVC is an important cause of sudden death in the young. Currently, there is no specific treatment or prevention for ARVC. ..