L B Marangell

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Neurostimulation therapies in depression: a review of new modalities
    L B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Acta Psychiatr Scand 116:174-81. 2007
  2. ncbi request reprint Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
    Bipolar Disord 8:566-75. 2006
  3. ncbi request reprint Omega-3 fatty acids in bipolar disorder: clinical and research considerations
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 75:315-21. 2006
  4. ncbi request reprint Switching antidepressants for treatment-resistant major depression
    L B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA
    J Clin Psychiatry 62:12-7. 2001
  5. ncbi request reprint Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA
    J Clin Psychiatry 63:391-5. 2002
  6. ncbi request reprint Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
    Lauren B Marangell
    Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Bipolar Disord 6:139-43. 2004
  7. ncbi request reprint Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA
    Depress Anxiety 19:20-3. 2004
  8. ncbi request reprint A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Suite 560, 6655 Travis Road, Houston, TX 77030, USA
    Am J Psychiatry 160:996-8. 2003
  9. ncbi request reprint Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial
    A L Stoll
    Brigham and Women s Hospital, Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 56:407-12. 1999
  10. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005

Research Grants

  1. Acute Pharmacotherapy of Late-Life Mania
    Mark Kunik; Fiscal Year: 2007

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Neurostimulation therapies in depression: a review of new modalities
    L B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Acta Psychiatr Scand 116:174-81. 2007
    ..In response to an increased understanding of the neurobiology of severe psychiatric disorders, new therapeutic modalities are entering clinical practice that involve the direct stimulation of the brain...
  2. ncbi request reprint Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
    Bipolar Disord 8:566-75. 2006
    ....
  3. ncbi request reprint Omega-3 fatty acids in bipolar disorder: clinical and research considerations
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 75:315-21. 2006
    ..Our pilot trial of DHA in women who plan to stop conventional psychotropics in order to conceive suggests that such trials are feasible...
  4. ncbi request reprint Switching antidepressants for treatment-resistant major depression
    L B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA
    J Clin Psychiatry 62:12-7. 2001
    ..Practical issues, such as when to consider switching and how to switch from one medication to another, are addressed...
  5. ncbi request reprint Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA
    J Clin Psychiatry 63:391-5. 2002
    ..We report a clinical trial of olanzapine in the treatment of prominent apathy in the absence of depression in patients on long-term treatment with selective serotonin reuptake inhibitors (SSRIs) for nonpsychotic major depression...
  6. ncbi request reprint Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
    Lauren B Marangell
    Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Bipolar Disord 6:139-43. 2004
    ..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study...
  7. ncbi request reprint Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA
    Depress Anxiety 19:20-3. 2004
    ..Controlled studies are lacking...
  8. ncbi request reprint A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Suite 560, 6655 Travis Road, Houston, TX 77030, USA
    Am J Psychiatry 160:996-8. 2003
    ..This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression...
  9. ncbi request reprint Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial
    A L Stoll
    Brigham and Women s Hospital, Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 56:407-12. 1999
    ..The present study was performed to examine whether omega3 fatty acids also exhibit mood-stabilizing properties in bipolar disorder...
  10. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  11. ncbi request reprint Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:355-63. 2005
    ..The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established...
  12. ncbi request reprint Brief report: paroxetine in younger and adult individuals at high risk for suicide
    Mark S Bauer
    Department of Psychiatry, Brown University, USA
    Psychopharmacol Bull 39:31-7. 2006
    ..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals...
  13. ncbi request reprint A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, and Department of Veterans Affairs, Houston, Texas, USA
    J Clin Psychiatry 69:183-9. 2008
    ..The aim of the present study was to investigate the efficacy of VNS in a group of patients with treatment-resistant rapid-cycling bipolar disorder (RCBD) who were excluded from previous trials...
  14. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  15. ncbi request reprint Protein kinase inhibition by omega-3 fatty acids
    B Mirnikjoo
    Division of Neuroscience, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 276:10888-96. 2001
    ..Overall, our results from both in vitro and live cell preparations suggest that inhibition of second messenger-regulated protein kinases is one locus of action of omega-3 fatty acids...
  16. ncbi request reprint Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and South Central Mental Illness Research and Education Core, Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 69:916-22. 2008
    ....
  17. ncbi request reprint Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD
    James M Martinez
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Ben Taub Hospital, Houston, TX 77030, USA
    Psychiatr Serv 56:1541-8. 2005
    ..Little is known about serious adverse events that occur in the context of clinical care for bipolar disorder. This study examined predictors of serious adverse events in a large cohort of patients with bipolar disorder...
  18. pmc Prescription patterns of psychotropic medications in elderly compared with younger participants who achieved a "recovered" status in the systematic treatment enhancement program for bipolar disorder
    Rayan K Al Jurdi
    Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA
    Am J Geriatr Psychiatry 16:922-33. 2008
    ..This study compares prescription patterns between young adults and elderly with bipolar disorder who achieved a recovery status during the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
  19. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  20. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  21. ncbi request reprint Vagus nerve stimulation: current use and potential applications in child and adolescent psychiatry
    James M Martinez
    Menninger Department of Psychiatry, Baylor College of Medicine, 6655 Travis Road, Suite 560, Houston, TX 77030, USA
    Child Adolesc Psychiatr Clin N Am 14:177-91, viii. 2005
    ..This intervention also holds promise as a potential treatment in children and adolescents, although research is currently lacking...
  22. pmc Current issues: women and bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine Houston, Texas, USA
    Dialogues Clin Neurosci 10:229-38. 2008
    ..In order to best address these issues, clinicians must be familiar with the data and collaborate with the patient to assess risks and benefits for the individual women and her family...
  23. ncbi request reprint Use of treatment algorithms for depression
    Madhukar H Trivedi
    Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychiatry 67:1458-65. 2006
  24. ncbi request reprint Current suicide ideation and prior suicide attempts of bipolar patients as influences on caregiver burden
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    Suicide Life Threat Behav 37:482-91. 2007
    ..Levels of depression in caregivers varied with whether the caregiver was a spouse or a parent, and whether patients had a history of suicide attempts, current suicidal ideation, or both...
  25. ncbi request reprint The importance of subsyndromal symptoms in bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Baylor College of Medicine, and the South Central Mental Illness Research, Education, and Clinical Center of the Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 65:24-7. 2004
    ..In addition, the use of subsyndromal symptoms to broaden the diagnostic criteria for bipolar disorder is receiving increased attention. This article reviews and discusses these important issues...
  26. doi request reprint Predictors of remission with placebo using an integrated study database from patients with major depressive disorder
    J C Nelson
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Curr Med Res Opin 28:325-34. 2012
    ..To identify predictors of remission with placebo treatment in double-blind randomized controlled trials (RCTs) in major depressive disorder (MDD)...
  27. ncbi request reprint Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro
    H F Seung Kim
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Psychiatry 6:246-8. 2001
    ..In contrast, arachidonic acid had no effect on PKC activity. Thus, PKC represents a potential site of action of omega-3 fatty acids in their effects on the treatment of bipolar disorder...
  28. pmc The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States
    J Affect Disord 114:58-67. 2009
    ..This report describes baseline characteristics and functional outcomes of subjects who have prospectively observed subsyndromal symptoms after a major depressive episode (MDE)...
  29. pmc Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregivers
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Bipolar Disord 11:876-84. 2009
    ..This study examined whether caregivers' health is associated with changes in suicidal ideation and depressive symptoms among bipolar patients observed over one year...
  30. ncbi request reprint The efficacy and tolerability of duloxetine in the treatment of anxious versus non-anxious depression: a post-hoc analysis of an open-label outpatient study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, and Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Ann Clin Psychiatry 19:187-95. 2007
    ..This study compares the efficacy and tolerability of 12 weeks of open-label duloxetine in adult outpatients with anxious versus non-anxious depression...
  31. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  32. doi request reprint Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 34:522-34. 2009
    ..Shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS...
  33. ncbi request reprint Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  34. ncbi request reprint Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
    ..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders...
  35. ncbi request reprint Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Mark S Bauer
    Providence Veterans Affairs Medical Center and the Department of Psychiatry and Human Behavior, Brown University, VAMC 116R, 830 Chalkstone Avenue, Providence, R I 02908 4799, USA
    J Clin Psychiatry 67:48-55. 2006
    ..However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder...
  36. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  37. ncbi request reprint How blind is double-blind? A study of fish oil versus placebo
    Karen E Damico
    Psychopharmacology Research Laboratory, Center for the Development of Novel and Natural Treatments for Mood Disorders, McLean Hospital, Belmont, MA 02478, USA
    Prostaglandins Leukot Essent Fatty Acids 66:393-5. 2002
    ..The results suggest that altering subjects' expectations could further improve the validity of the double-blind...
  38. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  39. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  40. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
    ..Yet patients who showed substantial clinical benefit maintained the improvement at remarkably high rates. This durability of benefit was not attributable to alterations in other treatments...
  41. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  42. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  43. ncbi request reprint A cross-national relationship between sugar consumption and major depression?
    Arthur N Westover
    Mood Disorders Center MDOC, Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA
    Depress Anxiety 16:118-20. 2002
    ..Possible relationships between sugar consumption, beta-endorphins, and oxidative stress are discussed...
  44. ncbi request reprint Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporter
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
    Ann Med 37:590-602. 2005
    ..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile...
  45. pmc Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  46. pmc Increased rate of non-right-handedness in patients with bipolar disorder
    Cecylia Nowakowska
    J Clin Psychiatry 69:866-7. 2008
  47. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  48. ncbi request reprint Overweight and obesity in bipolar disorders
    Po W Wang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Room 2117, CA 94305 5723, USA
    J Psychiatr Res 40:762-4. 2006
  49. ncbi request reprint Thyroid hormones and mood: are population data applicable to clinical cohorts?
    Lauren B Marangell
    Acta Psychiatr Scand 106:1-2. 2002

Research Grants1

  1. Acute Pharmacotherapy of Late-Life Mania
    Mark Kunik; Fiscal Year: 2007
    ..The sites have a history of successful collaborative research, including demanding geriatric studies. ..