CLINTON MACDONALD

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. ncbi Differences in polyadenylation site choice between somatic and male germ cells
    K Wyatt McMahon
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430 6540 USA
    BMC Mol Biol 7:35. 2006
  2. ncbi A family of splice variants of CstF-64 expressed in vertebrate nervous systems
    Ganesh S Shankarling
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430 6540, USA
    BMC Mol Biol 10:22. 2009
  3. ncbi Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430 6540, USA
    Wiley Interdiscip Rev RNA 1:494-501. 2010
  4. ncbi Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64
    Steve Tardif
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 83:464-72. 2010
  5. ncbi Reexamining the polyadenylation signal: were we wrong about AAUAAA?
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry and Southwest Cancer Center at University Medical Center, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock 79430, USA
    Mol Cell Endocrinol 190:1-8. 2002
  6. ncbi Alternative mRNA polyadenylation can potentially affect detection of gene expression by affymetrix genechip arrays
    Ju Y Lee
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    Appl Bioinformatics 5:249-53. 2006
  7. ncbi Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility
    Brinda Dass
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Proc Natl Acad Sci U S A 104:20374-9. 2007
  8. ncbi Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers
    Roberto R Monarez
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Biochem J 401:651-8. 2007
  9. ncbi The flowers that bloom in the spring: RNA processing and seasonal flowering
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Cell 113:671-2. 2003
  10. ncbi Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis
    Donglin Liu
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 35:234-46. 2007

Research Grants

  1. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2006
  2. MRNA PROCESSING IN REPRODUCTION & FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2001
  3. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. ncbi Differences in polyadenylation site choice between somatic and male germ cells
    K Wyatt McMahon
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430 6540 USA
    BMC Mol Biol 7:35. 2006
    ..We therefore hypothesized that male germ cell-specific polyadenylation sites would be inefficiently used in somatic cells...
  2. ncbi A family of splice variants of CstF-64 expressed in vertebrate nervous systems
    Ganesh S Shankarling
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430 6540, USA
    BMC Mol Biol 10:22. 2009
    ..Since the CstF-64 polyadenylation protein is known to be an important regulator of tissue-specific polyadenylation, we examined its expression in brain and other organs...
  3. ncbi Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430 6540, USA
    Wiley Interdiscip Rev RNA 1:494-501. 2010
    ..Given the profound effect alternative polyadenylation can have on gene expression and human health, improved understanding of alternative polyadenylation could lead to numerous advances in control of gene activity...
  4. ncbi Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64
    Steve Tardif
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 83:464-72. 2010
    ..To our knowledge, this is the first demonstration that a gene involved in polyadenylation has a negative consequence on sperm-ZP adhesion...
  5. ncbi Reexamining the polyadenylation signal: were we wrong about AAUAAA?
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry and Southwest Cancer Center at University Medical Center, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock 79430, USA
    Mol Cell Endocrinol 190:1-8. 2002
    ....
  6. ncbi Alternative mRNA polyadenylation can potentially affect detection of gene expression by affymetrix genechip arrays
    Ju Y Lee
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    Appl Bioinformatics 5:249-53. 2006
    ..This could lead to inaccurate interpretation of GeneChip data when the changes of expression values actually result from alternative use of polyadenylation sites...
  7. ncbi Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility
    Brinda Dass
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Proc Natl Acad Sci U S A 104:20374-9. 2007
    ..Finally, these transgenic mice provide a model for the study of polyadenylation in an isolated in vivo system and highlight the role of a growing family of testis-expressed autosomal retroposed variants of X-linked genes...
  8. ncbi Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers
    Roberto R Monarez
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Biochem J 401:651-8. 2007
    ..This supports the hypothesis that tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements...
  9. ncbi The flowers that bloom in the spring: RNA processing and seasonal flowering
    Clinton C MacDonald
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Cell 113:671-2. 2003
    ..A new paper in this issue of Cell describes how one regulatory gene controls its own expression at the level of mRNA polyadenylation, adding an exciting new model for both the RNA processing and plant gene expression fields...
  10. ncbi Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis
    Donglin Liu
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 35:234-46. 2007
    ..Our results highlight developmental differences in polyadenylation site choice and in the elements that likely control them during spermatogenesis...

Research Grants10

  1. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2006
    ..Finally, we will begin to examine tauCstF-64 function in human germ cells by examining its distribution in human testis and other tissues. ..
  2. MRNA PROCESSING IN REPRODUCTION & FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2001
    ..The experiments proposed here should allow us to begin to understand how this fundamental process operates in male germ cells. ..
  3. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    CLINTON MACDONALD; Fiscal Year: 2006
    ..This environment, supplemented with trips to meetings and visits to collaborators, will provide excellent support for my endeavors. ..