Research Topics
Genomes and GenesSpecies | Lan H LySummaryAffiliation: Texas A and M Health Science Center Country: USA Publications
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Publications
Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in miceKhairul Bariah Abdul-Majid
Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21231 1001, USA
BMC Microbiol 8:151. 2008..The antigenic properties of these strains may alter the progression of disease due to a reduction in host immune cell recruitment to the lungs resulting in disease attenuation and prolonged host survival...
Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivoLan H Ly
Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
J Infect Dis 198:768-71. 2008..Furthermore, significant increases in interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and interleukin-12p40 cytokine mRNA were seen in the pleural cells of the BCG-vaccinated guinea pigs...- Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritisLan H Ly
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, 463 Reynolds Medical Building, College Station, TX, USA
Microbes Infect 11:680-8. 2009..Neutralization of TNFalpha hastened the transition to an anti-inflammatory cytokine response in guinea pig pleural granulomas and exudate cells... - Tuberculosis: vaccines in the pipelineLan H Ly
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
Expert Rev Vaccines 7:635-50. 2008..Some of these new vaccines may eventually be recommended for travelers to TB high-burden countries. This paper summarizes the progress of vaccine candidates in animal models to improve, replace or augment BCG vaccination... - Cytokine profiles in primary and secondary pulmonary granulomas of Guinea pigs with tuberculosisLan H Ly
Texas A and M Health Science Center, Microbial and Molecular Pathogenesis, 463 Reynolds Medical Building, College Station, TX 77843, USA
Am J Respir Cell Mol Biol 38:455-62. 2008.... 
Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigsLan H Ly
Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843, USA
Cell Microbiol 9:1127-36. 2007..Moreover, analysis of the individual lung lobes at 6 weeks post infection suggests that heterogeneity exists in the cytokine profile between the lobes of the lung...- Cloning of guinea pig IL-4: reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infectionAmminikutty Jeevan
Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843 1114, United States
Tuberculosis (Edinb) 91:47-56. 2011..tuberculosis infection modulates IL-4 mRNA expression in the guinea pig. Cloning of guinea pig IL-4 will allow us to address the role of IL-4 in vaccine-induced resistance to pulmonary TB in a highly relevant animal model... - Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cellsLan H Ly
Department of Nutrition and Food Science, Texas A and M University System Health Science Center, College Station, TX, USA
Prostaglandins Leukot Essent Fatty Acids 74:29-37. 2006..01). Therefore, we conclude that dietary EPA may suppress CD4(+) T-cell activation by enhancing the downregulatory co-receptor CTLA-4, while not altering the levels of CD28... - Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosisDiana L Bonilla
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
PLoS ONE 5:e10878. 2010..We hypothesized that incorporation of n-3 PUFA suppresses activation of macrophage antimycobacterial responses and favors bacterial growth, in part, by modulating the IFNgamma-mediated signaling pathway... - Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansionPing Zhang
Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX, USA
J Nutr 136:2391-8. 2006..05) the number of cell divisions in vivo. These studies suggest that the attenuated inflammatory response which accompanies FO feeding may be explained, at least in part, by suppression of Th1 clonal expansion... - Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 productionYang-Yi Fan
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843-2471, USA
J Immunol 173:6151-60. 2004..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis... - The Yin-Yang of TNFalpha in the guinea pig model of tuberculosisLan H Ly
Department of Microbial and Molecular Pathogenesis, Texas A and M System Health Science Center, College Station, Texas, 77843 1114, USA
Indian J Exp Biol 47:432-9. 2009..Furthermore, BCG vaccination modulates TNFalpha responses directly in the pulmonary granulomas to reduce tissue damage. The bipolar nature of TNFalpha should be considered as knowledge of this critical molecule continues to grow... - Guinea pig neutrophil-macrophage interactions during infection with Mycobacterium tuberculosisKirti V Sawant
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, 463 Reynolds Medical Building, College Station, TX 77843 1114, USA
Microbes Infect 12:828-37. 2010..tuberculosis H37Rv alone. Taken together, these data suggest that neutrophil-macrophage interactions may contribute to host defense against M. tuberculosis infection... - Prokaryotic Expression and In Vitro Functional Analysis of IL-1β and MCP-1 from Guinea PigVijaya R Dirisala
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, 407 Reynolds Medical Building, College Station, TX, 77843 1114, USA
Mol Biotechnol 54:312-9. 2013..These biologically active recombinant guinea pig proteins will facilitate an in-depth understanding of the role they play in the immune responses of the guinea pig to TB and other diseases... - Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid raftsYang-Yi Fan
Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University System, Health Science Center, College Station, TX, USA
J Nutr 133:1913-20. 2003..These data indicate for the first time that dietary (n-3) PUFA differentially modulate T-cell raft and soluble membrane phospholipid and fatty acyl composition... - Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with miceSanjay K Jain
Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Infect Dis 195:1634-42. 2007..However, unlike mice, M. tuberculosis-infected guinea pigs form caseating granulomas, which may simulate human disease more closely...