Lan H Ly

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. pmc Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice
    Khairul Bariah Abdul-Majid
    Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21231 1001, USA
    BMC Microbiol 8:151. 2008
  2. doi request reprint Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    J Infect Dis 198:768-71. 2008
  3. pmc Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritis
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, 463 Reynolds Medical Building, College Station, TX, USA
    Microbes Infect 11:680-8. 2009
  4. pmc Cytokine profiles in primary and secondary pulmonary granulomas of Guinea pigs with tuberculosis
    Lan H Ly
    Texas A and M Health Science Center, Microbial and Molecular Pathogenesis, 463 Reynolds Medical Building, College Station, TX 77843, USA
    Am J Respir Cell Mol Biol 38:455-62. 2008
  5. doi request reprint Tuberculosis: vaccines in the pipeline
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Expert Rev Vaccines 7:635-50. 2008
  6. ncbi request reprint Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigs
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843, USA
    Cell Microbiol 9:1127-36. 2007
  7. pmc Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis
    Diana L Bonilla
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
    PLoS ONE 5:e10878. 2010
  8. doi request reprint Cloning of guinea pig IL-4: reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infection
    Amminikutty Jeevan
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843 1114, United States
    Tuberculosis (Edinb) 91:47-56. 2011
  9. ncbi request reprint Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells
    Lan H Ly
    Department of Nutrition and Food Science, Texas A and M University System Health Science Center, College Station, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 74:29-37. 2006
  10. pmc Prokaryotic expression and in vitro functional analysis of IL-1β and MCP-1 from guinea pig
    Vijaya R Dirisala
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX, USA
    Mol Biotechnol 54:312-9. 2013

Detail Information

Publications16

  1. pmc Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice
    Khairul Bariah Abdul-Majid
    Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21231 1001, USA
    BMC Microbiol 8:151. 2008
    ..The antigenic properties of these strains may alter the progression of disease due to a reduction in host immune cell recruitment to the lungs resulting in disease attenuation and prolonged host survival...
  2. doi request reprint Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    J Infect Dis 198:768-71. 2008
    ..Furthermore, significant increases in interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and interleukin-12p40 cytokine mRNA were seen in the pleural cells of the BCG-vaccinated guinea pigs...
  3. pmc Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritis
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, 463 Reynolds Medical Building, College Station, TX, USA
    Microbes Infect 11:680-8. 2009
    ..Neutralization of TNFalpha hastened the transition to an anti-inflammatory cytokine response in guinea pig pleural granulomas and exudate cells...
  4. pmc Cytokine profiles in primary and secondary pulmonary granulomas of Guinea pigs with tuberculosis
    Lan H Ly
    Texas A and M Health Science Center, Microbial and Molecular Pathogenesis, 463 Reynolds Medical Building, College Station, TX 77843, USA
    Am J Respir Cell Mol Biol 38:455-62. 2008
    ....
  5. doi request reprint Tuberculosis: vaccines in the pipeline
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Expert Rev Vaccines 7:635-50. 2008
    ..Some of these new vaccines may eventually be recommended for travelers to TB high-burden countries. This paper summarizes the progress of vaccine candidates in animal models to improve, replace or augment BCG vaccination...
  6. ncbi request reprint Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigs
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843, USA
    Cell Microbiol 9:1127-36. 2007
    ..Moreover, analysis of the individual lung lobes at 6 weeks post infection suggests that heterogeneity exists in the cytokine profile between the lobes of the lung...
  7. pmc Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis
    Diana L Bonilla
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
    PLoS ONE 5:e10878. 2010
    ..We hypothesized that incorporation of n-3 PUFA suppresses activation of macrophage antimycobacterial responses and favors bacterial growth, in part, by modulating the IFNgamma-mediated signaling pathway...
  8. doi request reprint Cloning of guinea pig IL-4: reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infection
    Amminikutty Jeevan
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843 1114, United States
    Tuberculosis (Edinb) 91:47-56. 2011
    ..tuberculosis infection modulates IL-4 mRNA expression in the guinea pig. Cloning of guinea pig IL-4 will allow us to address the role of IL-4 in vaccine-induced resistance to pulmonary TB in a highly relevant animal model...
  9. ncbi request reprint Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells
    Lan H Ly
    Department of Nutrition and Food Science, Texas A and M University System Health Science Center, College Station, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 74:29-37. 2006
    ..01). Therefore, we conclude that dietary EPA may suppress CD4(+) T-cell activation by enhancing the downregulatory co-receptor CTLA-4, while not altering the levels of CD28...
  10. pmc Prokaryotic expression and in vitro functional analysis of IL-1β and MCP-1 from guinea pig
    Vijaya R Dirisala
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, College Station, TX, USA
    Mol Biotechnol 54:312-9. 2013
    ..These biologically active recombinant guinea pig proteins will facilitate an in-depth understanding of the role they play in the immune responses of the guinea pig to TB and other diseases...
  11. ncbi request reprint The Yin-Yang of TNFalpha in the guinea pig model of tuberculosis
    Lan H Ly
    Department of Microbial and Molecular Pathogenesis, Texas A and M System Health Science Center, College Station, Texas, 77843 1114, USA
    Indian J Exp Biol 47:432-9. 2009
    ..Furthermore, BCG vaccination modulates TNFalpha responses directly in the pulmonary granulomas to reduce tissue damage. The bipolar nature of TNFalpha should be considered as knowledge of this critical molecule continues to grow...
  12. ncbi request reprint Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion
    Ping Zhang
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX, USA
    J Nutr 136:2391-8. 2006
    ..05) the number of cell divisions in vivo. These studies suggest that the attenuated inflammatory response which accompanies FO feeding may be explained, at least in part, by suppression of Th1 clonal expansion...
  13. ncbi request reprint Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production
    Yang Yi Fan
    Molecular and Cell Biology Section, Faculty of Nutrition, Texas A and M University Health Science Center, College Station, TX 77843 2471, USA
    J Immunol 173:6151-60. 2004
    ..Similar results were obtained when purified DHA was fed. These data demonstrate for the first time that dietary DHA alters T cell membrane microdomain composition and suppresses the PKCtheta; signaling axis...
  14. pmc Guinea pig neutrophil-macrophage interactions during infection with Mycobacterium tuberculosis
    Kirti V Sawant
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, 463 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Microbes Infect 12:828-37. 2010
    ..tuberculosis H37Rv alone. Taken together, these data suggest that neutrophil-macrophage interactions may contribute to host defense against M. tuberculosis infection...
  15. ncbi request reprint Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts
    Yang Yi Fan
    Faculty of Nutrition, Center for Environmental and Rural Health, Texas A and M University System, Health Science Center, College Station, TX, USA
    J Nutr 133:1913-20. 2003
    ..These data indicate for the first time that dietary (n-3) PUFA differentially modulate T-cell raft and soluble membrane phospholipid and fatty acyl composition...
  16. ncbi request reprint Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice
    Sanjay K Jain
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Infect Dis 195:1634-42. 2007
    ..However, unlike mice, M. tuberculosis-infected guinea pigs form caseating granulomas, which may simulate human disease more closely...