Philip J Lupo

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi request reprint Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:875-81. 2012
  2. pmc Maternal occupational exposure to polycyclic aromatic hydrocarbons: effects on gastroschisis among offspring in the National Birth Defects Prevention Study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030, USA
    Environ Health Perspect 120:910-5. 2012
  3. ncbi request reprint Cryptosporidium muris in a Texas canine population
    Philip J Lupo
    Center for Infectious Disease, The University of Texas School of Public Health, Houston, Texas 77030, USA
    Am J Trop Med Hyg 78:917-21. 2008
  4. doi request reprint Epidemiology of Ebstein anomaly: prevalence and patterns in Texas, 1999-2005
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, USA
    Am J Med Genet A 155:1007-14. 2011
  5. pmc Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston 77030, USA
    Environ Health Perspect 119:397-402. 2011
  6. ncbi request reprint Proportion of neural tube defects attributable to known risk factors
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 97:42-6. 2013
  7. pmc Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas, Houston, TX, USA
    Am J Epidemiol 176:1101-9. 2012
  8. doi request reprint The association between neonatal thyroxine and craniosynostosis, Texas, 2004-2007
    Syed Shahrukh Hashmi
    The University of Texas Medical School, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 94:1004-9. 2012
  9. doi request reprint Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study
    A J Agopian
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Am J Med Genet A 158:109-15. 2012
  10. doi request reprint Case-control study of maternal residential atrazine exposure and male genital malformations
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Am J Med Genet A 161:977-82. 2013

Collaborators

Detail Information

Publications33

  1. doi request reprint Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:875-81. 2012
    ..Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring...
  2. pmc Maternal occupational exposure to polycyclic aromatic hydrocarbons: effects on gastroschisis among offspring in the National Birth Defects Prevention Study
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030, USA
    Environ Health Perspect 120:910-5. 2012
    ..There is evidence in animal models that maternal exposure to PAHs during pregnancy is associated with gastroschisis in offspring; however, to our knowledge, no human studies examining this association have been conducted...
  3. ncbi request reprint Cryptosporidium muris in a Texas canine population
    Philip J Lupo
    Center for Infectious Disease, The University of Texas School of Public Health, Houston, Texas 77030, USA
    Am J Trop Med Hyg 78:917-21. 2008
    ..To our knowledge, this is the first report of a naturally occurring C. muris infection in a canine host. The finding of C. muris in asymptomatic canines supports the notion of dogs as potential sources of human infection...
  4. doi request reprint Epidemiology of Ebstein anomaly: prevalence and patterns in Texas, 1999-2005
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, USA
    Am J Med Genet A 155:1007-14. 2011
    ..These findings help to define subgroups of women at increased risk of having offspring affected by Ebstein anomaly. Furthermore, our findings add to the limited body of literature on this rare but serious malformation...
  5. pmc Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston 77030, USA
    Environ Health Perspect 119:397-402. 2011
    ..However, there have been no studies assessing the association between environmental levels of hazardous air pollutants, such as benzene, and neural tube defects (NTDs), a common and serious group of congenital malformations...
  6. ncbi request reprint Proportion of neural tube defects attributable to known risk factors
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Birth Defects Res A Clin Mol Teratol 97:42-6. 2013
    ..Recognized risk factors for neural tube defects (NTDs) poorly predict population-level NTD risk. However, the proportion of NTDs that can be attributed to these risk factors is uncertain...
  7. pmc Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas, Houston, TX, USA
    Am J Epidemiol 176:1101-9. 2012
    ..These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy...
  8. doi request reprint The association between neonatal thyroxine and craniosynostosis, Texas, 2004-2007
    Syed Shahrukh Hashmi
    The University of Texas Medical School, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 94:1004-9. 2012
    ..Neonatal thyroid hormone (T4) is evaluated nationally at birth by the Newborn Screening Program (NBS). This study evaluated the relationship between NBS T4 levels and craniosynostosis...
  9. doi request reprint Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study
    A J Agopian
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Am J Med Genet A 158:109-15. 2012
    ..55, 95% confidence interval: 1.23-1.95]. These findings provide evidence that certain spina bifida subtypes and sub-phenotypes may be etiologically distinct...
  10. doi request reprint Case-control study of maternal residential atrazine exposure and male genital malformations
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
    Am J Med Genet A 161:977-82. 2013
    ..2, 95% confidence interval: 1.1-1.3). Previous literature from animal and epidemiological studies supports our findings. Our results provide further evidence of a suspected teratogenic role of atrazine...
  11. doi request reprint Swimming pool use and birth defect risk
    A J Agopian
    Division of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA
    Am J Obstet Gynecol 209:219.e1-9. 2013
    ..Thus, we evaluated the relationship between maternal swimming pool use during early pregnancy and risk for select birth defects in offspring...
  12. doi request reprint Polytomous logistic regression as a tool for exploring heterogeneity across birth defect subtypes: an example using anencephaly and spina bifida
    Philip J Lupo
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 88:701-5. 2010
    ..Although the validity of using composite phenotypes has been questioned, formal evaluations of the underlying assumption of effect homogeneity across component phenotypes have not been conducted...
  13. doi request reprint Working towards a risk prediction model for neural tube defects
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 94:141-6. 2012
    ..Several risk factors have been consistently associated with neural tube defects (NTDs). However, the predictive ability of these risk factors in combination has not been evaluated...
  14. doi request reprint Differences in folic acid use, prenatal care, smoking, and drinking in early pregnancy by occupation
    A J Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Prev Med 55:341-5. 2012
    ..To describe differences in four high risk periconceptional behaviors (lack of folic acid supplementation, lack of early prenatal care, smoking, and drinking) by maternal occupation...
  15. doi request reprint Differences in exposure assignment between conception and delivery: the impact of maternal mobility
    Philip J Lupo
    Division of Epidemiology and Disease Control, University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030, USA
    Paediatr Perinat Epidemiol 24:200-8. 2010
    ....
  16. pmc Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer
    Michael D Swartz
    Division of Biostatistics, University of Texas School of Public Health, Houston, Texas, United States of America
    PLoS ONE 8:e53475. 2013
    ..This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients (B vitamins, methionine, choline, and betaine) and their gene-nutrient interactions...
  17. doi request reprint Hispanic ethnicity and acculturation, maternal age and the risk of gastroschisis in the National Birth Defects Prevention Study
    Zeina G Khodr
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas 77030 3900, USA
    Birth Defects Res A Clin Mol Teratol 97:538-45. 2013
    ..This analysis was conducted to further define the associations between gastroschisis and parental Hispanic ethnicity and acculturation, and to determine whether such associations vary by maternal age...
  18. doi request reprint Association between thyroxine levels at birth and choanal atresia or stenosis among infants in Texas, 2004-2007
    Laura J Lee
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 94:951-4. 2012
    ..Therefore, we conducted a case-control study to examine the association between newborn T(4) levels and CA...
  19. doi request reprint Maternal residential atrazine exposure and risk for choanal atresia and stenosis in offspring
    A Jack Agopian
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX77030, USA
    J Pediatr 162:581-6. 2013
    ..To assess the relationship between estimated residential maternal exposure to atrazine during pregnancy and the risk for choanal atresia or stenosis in offspring...
  20. pmc Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia
    Darryl Nousome
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA
    Leuk Res 37:531-5. 2013
    ..02). The EPHX1 haplotype was marginally associated with risk (P=0.05), whereas haplotypes in CYP1B1 and GSTA4 were not. Our results suggest genetic variation in xenobiotic metabolism is important in childhood ALL etiology...
  21. pmc A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA
    Cancer Causes Control 23:1797-803. 2012
    ..We conducted a case-parent triad study evaluating the role of maternal and offspring genotypes in the folate metabolic pathway on childhood acute lymphoblastic leukemia (ALL) risk...
  22. pmc Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study
    Philip J Lupo
    Department of Pediatrics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Hematol Oncol 29:679-85. 2012
    ..26, P = .01) was associated with medulloblastoma risk. This exploratory study highlights the utility of the case-parent triad design, but these results should be interpreted cautiously due to the limited sample size...
  23. pmc Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects
    Jin Long
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, USA
    Birth Defects Res A Clin Mol Teratol 91:879-84. 2011
    ....
  24. doi request reprint Maternal residential atrazine exposure and gastroschisis by maternal age
    A J Agopian
    Division of Epidemiology, Human Genetics and Environmental Sciences, Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA
    Matern Child Health J 17:1768-75. 2013
    ..This relationship appears to be different in older versus younger mothers, providing further evidence that the etiology of gastroschisis may vary based on maternal age...
  25. doi request reprint Maternal smoking during pregnancy and the risk of congenital heart defects in offspring: a systematic review and metaanalysis
    Laura J Lee
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA
    Pediatr Cardiol 34:398-407. 2013
    ..This systematic review and metaanalysis suggests that maternal smoking is modestly associated with an increased risk of CHDs and some CHD subtypes...
  26. pmc A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Mol Genet Metab 107:592-5. 2012
    ..46, 95% CI: 1.05-11.00), after adjusting for the effect of the offspring haplotype. These results suggest offspring and maternal variation in the GCH1 gene and altered BH(4) biosynthesis may contribute to NTD risk...
  27. pmc Using a bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads
    Ying Cao
    Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America
    PLoS ONE 8:e84658. 2013
    ....
  28. pmc An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA
    Pediatr Blood Cancer 59:605-10. 2012
    ....
  29. pmc Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999-2008
    Anushuya Ramakrishnan
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas, School of Public Health, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 97:532-7. 2013
    ..Therefore, our goal was to conduct a case-control study examining the association between estimated maternal residential exposure to benzene, toluene, ethyl benzene, and xylene (BTEX) and the risk of oral clefts among offspring...
  30. doi request reprint NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects
    Philip J Lupo
    Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX, USA
    Birth Defects Res A Clin Mol Teratol 91:61-5. 2011
    ..Although several folate-related genes have been studied as they relate to CHDs and CTRDs (e.g., MTHFR), others have not been adequately assessed...
  31. ncbi request reprint A comparative analysis of modeled and monitored ambient hazardous air pollutants in Texas: a novel approach using concordance correlation
    Philip J Lupo
    Division of Epidemiology and Disease Control, The University of Texas School of Public Health, Houston, TX 77030, USA
    J Air Waste Manag Assoc 59:1278-86. 2009
    ..5. On the basis of concordance correlation analysis, the findings indicate there is poorer agreement when compared with the previously applied ad hoc methods to assess comparability between modeled and monitored levels of ambient HAPs...
  32. pmc Comparative assessment of air pollution-related health risks in Houston
    Ken Sexton
    The University of Texas School of Public Health, Brownsville, Texas 78520 4956, USA
    Environ Health Perspect 115:1388-93. 2007
    ..To address this problem, decision makers must set priorities among thousands of individual air pollutants as they formulate effective and efficient mitigation strategies...
  33. pmc Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study
    Sid E O'Bryant
    Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th St, STOP 8321, Lubbock, TX 79430, USA
    Arch Neurol 65:1091-5. 2008
    ..The Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) score is commonly used, although the utility regarding this score in staging dementia severity is not well established...