Hui Chen Lu

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Role of efficient neurotransmitter release in barrel map development
    Hui Chen Lu
    Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:2692-703. 2006
  2. ncbi request reprint Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development
    Hui Chen Lu
    Division of Neuroscience and Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza S 603, Houston, Texas 77030, USA
    Nat Neurosci 6:939-47. 2003
  3. pmc Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway
    Wei Chi She
    Department of Pediatrics, The Cain Foundation Laboratories, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Neurosci 29:1379-96. 2009
  4. pmc Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons
    Yan Gang Sun
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurosci 33:2048-59. 2013
  5. pmc mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation
    Carlos J Ballester-Rosado
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:16896-909. 2010
  6. pmc GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination
    Chia Shan Wu
    The Cain Foundation Laboratories, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e60314. 2013
  7. ncbi request reprint Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling
    Melis Inan
    Division of Neurology Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:4338-49. 2006
  8. pmc GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons
    Yan Gang Sun
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurosci 32:7782-90. 2012
  9. pmc What can we get from 'barrels': the rodent barrel cortex as a model for studying the establishment of neural circuits
    Chia Shan Wu
    The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Houston, TX, USA
    Eur J Neurosci 34:1663-76. 2011
  10. pmc mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion
    Chris P Jew
    The Cain Foundation Laboratories, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e70415. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Role of efficient neurotransmitter release in barrel map development
    Hui Chen Lu
    Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:2692-703. 2006
    ..These results demonstrate how efficient synaptic transmission mediated by AC1 function contributes to the development of cortical barrel maps...
  2. ncbi request reprint Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development
    Hui Chen Lu
    Division of Neuroscience and Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza S 603, Houston, Texas 77030, USA
    Nat Neurosci 6:939-47. 2003
    ..These results suggest that activity-dependent mechanisms operate through an AC1/PKA signaling pathway to target some synapses for consolidation and others for elimination during barrel map formation...
  3. pmc Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway
    Wei Chi She
    Department of Pediatrics, The Cain Foundation Laboratories, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Neurosci 29:1379-96. 2009
    ....
  4. pmc Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons
    Yan Gang Sun
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurosci 33:2048-59. 2013
    ..Our study demonstrates fast and precise synaptic E-I signaling mediated by ACh, suggesting novel computational mechanisms for the cholinergic control of neuronal activity in thalamic circuits...
  5. pmc mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation
    Carlos J Ballester-Rosado
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:16896-909. 2010
    ..Together, our data provide strong evidence that mGluR5 signaling in cortical principal neurons exerts both cell-autonomous and -nonautonomous influences to modulate the formation of cortical sensory circuits...
  6. pmc GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination
    Chia Shan Wu
    The Cain Foundation Laboratories, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e60314. 2013
    ..Taken together, these results suggest that GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior...
  7. ncbi request reprint Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling
    Melis Inan
    Division of Neurology Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:4338-49. 2006
    ....
  8. pmc GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons
    Yan Gang Sun
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurosci 32:7782-90. 2012
    ..Our results show that GABA-evoked depolarizations can interact with T-type Ca(2+) channels to powerfully control spike generation in TRN neurons...
  9. pmc What can we get from 'barrels': the rodent barrel cortex as a model for studying the establishment of neural circuits
    Chia Shan Wu
    The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Houston, TX, USA
    Eur J Neurosci 34:1663-76. 2011
    ..We will specifically focus on the anatomical and functional establishment of the somatosensory thalamocortical circuits...
  10. pmc mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion
    Chris P Jew
    The Cain Foundation Laboratories, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e70415. 2013
    ....
  11. doi request reprint Transient cerebral ischemia increases CA1 pyramidal neuron excitability
    Yuan Fan
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, NB204, Houston, TX 77030, USA
    Exp Neurol 212:415-21. 2008
    ..These data suggest that an increase in CA1 pyramidal neuron excitability after ischemia may exacerbate cell loss. Moreover, this dendritic channelopathy may be amenable to treatment...
  12. pmc Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    Hsiao Tuan Chao
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 468:263-9. 2010
    ..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
  13. pmc Target-dependent control of synaptic inhibition by endocannabinoids in the thalamus
    Yan Gang Sun
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Neurosci 31:9222-30. 2011
    ..Together, our results show that endocannabinoids control transmitter release at specific thalamic synapses, and could dynamically regulate sensory information processing and thalamus-mediated synchronous oscillations...
  14. pmc CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
    M Cecilia Ljungberg
    The Cain Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 21:251-67. 2012
    ..Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies...
  15. pmc LMO4 functions as a co-activator of neurogenin 2 in the developing cortex
    Joanna S T Asprer
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:2823-32. 2011
    ..Our results indicate that LMO4 promotes the acquisition of cortical neuronal identities by forming a complex with NGN2 and subsequently activating NGN2-dependent gene expression...
  16. pmc A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins
    Keiko Sakai
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res 1276:11-21. 2009
    ..These results suggest that a VLDLR variant lacking the third complement-type repeat is generated by neuron-specific alternative splicing. Such differential splicing may result in different lipid uptake in neurons and astrocytes...
  17. pmc NMNATs, evolutionarily conserved neuronal maintenance factors
    Yousuf O Ali
    The Cain Foundation Laboratories, Texas Children s Hospital, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Houston, TX 77030, USA Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA Electronic address
    Trends Neurosci 36:632-40. 2013
    ..We then summarize data supporting a role for NMNATs in neuronal maintenance and raise intriguing questions on how NMNATs preserve neuronal integrity and facilitate proper neural function throughout life. ..
  18. pmc SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
    Kihoon Han
    1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA 2 Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA 3 Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Houston, Texas 77030, USA
    Nature 503:72-7. 2013
    ..The mood-stabilizing drug valproate, but not lithium, rescues the manic-like behaviour of Shank3 transgenic mice raising the possibility that this hyperkinetic disorder has a unique pharmacogenetic profile. ..
  19. pmc Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Chia Shan Wu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 32:693-706. 2010
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use...
  20. pmc A digital atlas to characterize the mouse brain transcriptome
    James P Carson
    Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Comput Biol 1:e41. 2005
    ..The semi-automated annotation method developed here is applicable to a broad spectrum of complex tissues and data modalities...
  21. ncbi request reprint Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h)
    Yuan Fan
    Center for Learning and Memory, University of Texas at Austin, 1 University Station, C7000, Austin, Texas 78712, USA
    Nat Neurosci 8:1542-51. 2005
    ..The occurrence of such a reduction in cellular excitability in parallel with synaptic potentiation would be a negative feedback mechanism to normalize neuronal output firing and thus promote network stability...
  22. pmc GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    Jane E Lauckner
    Departments of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2699-704. 2008
    ..GPR55 activation also inhibits M current. These results establish GPR55 as a cannabinoid receptor with signaling distinct from CB(1) and CB(2)...