Dan Liu

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment
    Dan Liu
    Laboratory of Cellular Dynamics, University of Science and Technology of China and the National Laboratory for Physical Sciences, Hefei 230027, China
    J Biol Chem 282:21415-24. 2007
  2. ncbi request reprint Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:51338-42. 2004
  3. ncbi request reprint The human Rap1 protein complex and modulation of telomere length
    Matthew S O'Connor
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 279:28585-91. 2004
  4. pmc A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
    Matthew S O'Connor
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11874-9. 2006
  5. ncbi request reprint PTOP interacts with POT1 and regulates its localization to telomeres
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 6:673-80. 2004
  6. doi request reprint TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs
    Hyeung Kim
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 16:372-9. 2009
  7. pmc OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation
    Ma Wan
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:26725-31. 2009
  8. ncbi request reprint TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
  9. pmc Telomere maintenance through spatial control of telomeric proteins
    Liuh Yow Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:5898-909. 2007
  10. doi request reprint Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
    Jiancong Liang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Cell Biol 10:731-9. 2008

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment
    Dan Liu
    Laboratory of Cellular Dynamics, University of Science and Technology of China and the National Laboratory for Physical Sciences, Hefei 230027, China
    J Biol Chem 282:21415-24. 2007
    ..Our results indicate that HsNUF2 and CENP-E are required for organization of stable microtubule-kinetochore attachment that is essential for faithful chromosome segregation in mitosis...
  2. ncbi request reprint Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:51338-42. 2004
    ..These results help to unify previous observations and suggest that telomere maintenance depends on the multi-subunit telosome...
  3. ncbi request reprint The human Rap1 protein complex and modulation of telomere length
    Matthew S O'Connor
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 279:28585-91. 2004
    ..These results indicate that hRap1 negatively regulates telomere length in vivo and suggest that the linker region of hRap1 may modulate the recruitment of negative regulators of telomere length...
  4. pmc A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
    Matthew S O'Connor
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11874-9. 2006
    ..Our results suggest that coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance...
  5. ncbi request reprint PTOP interacts with POT1 and regulates its localization to telomeres
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 6:673-80. 2004
    ..Furthermore, expression of the respective interaction domains on PTOP and POT1 alone extended telomere length in human cells. Therefore, PTOP heterodimerizes with POT1 and regulates POT1 telomeric recruitment and telomere length...
  6. doi request reprint TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs
    Hyeung Kim
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 16:372-9. 2009
    ..Our findings indicate that an array of TRF2 molecules functions as a protein hub and regulates telomeres by recruiting different signaling molecules via a linear sequence code...
  7. pmc OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation
    Ma Wan
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:26725-31. 2009
    ..Taken together, our studies suggest that OBFC1/AAF44 represents a new player in the telomere interactome for telomere maintenance...
  8. ncbi request reprint TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
    ....
  9. pmc Telomere maintenance through spatial control of telomeric proteins
    Liuh Yow Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:5898-909. 2007
    ....
  10. doi request reprint Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
    Jiancong Liang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Cell Biol 10:731-9. 2008
    ..Our data collectively suggest that Nanog and Oct4 associate with unique repressor complexes on their target genes to control ES cell fate...
  11. pmc Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK
    Jun Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Biol Chem 284:14377-85. 2009
    ..These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3-kinase and CISK...
  12. ncbi request reprint Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres
    Zhou Songyang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Crit Rev Eukaryot Gene Expr 16:103-18. 2006
    ..The establishment of the Telomere Interactome will also enable the integration of the intricate circuitries that regulate telomeres with other cellular interactomes in vertebrates...
  13. pmc MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis
    Ka Wing Fong
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Cell Sci 126:825-37. 2013
    ..Together, these data suggest that MTR120 is a novel MT-associated protein that directly stabilizes MTs and hence ensures the fidelity of cell division...
  14. pmc NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
    Jun Cui
    The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Nat Immunol 13:387-95. 2012
    ..Our results identify a previously unrecognized role for NLRP4 in the regulation of type I interferon signaling and provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation...
  15. pmc SGK3 is associated with estrogen receptor expression in breast cancer
    Jun Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res Treat 134:531-41. 2012
    ..These findings implicate SGK3 as an additional component to a complex and heterogeneous disease, and point to the potential benefits of incorporating SGK3 into the process of breast cancer diagnosis and treatment...
  16. pmc Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling
    Katherine Y King
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Blood 118:1525-33. 2011
    ..The deleterious effects of excessive IFN signaling may explain how hematologic abnormalities arise in patients with inflammatory conditions...
  17. pmc The telosome/shelterin complex and its functions
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
    Genome Biol 9:232. 2008
    ..A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions...
  18. doi request reprint ERM-mediated genetic screens in mammalian cells
    Dan Liu
    Cell based Assay Screening Service Core, Baylor College of Medicine, Houston, Texas, USA
    Methods Enzymol 446:409-19. 2008
    ..This chapter will discuss general design, procedures, and applications of the ERM strategy...
  19. doi request reprint Analysis of average telomere length in cultured human cells
    Dan Liu
    Department of Biochemistry and Molecular Biology, Cell based Assay Screening Service Core, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 735:13-9. 2011
    ..Tremendous heterogeneity can be observed both between species and within a single cell line population. Here, we describe the assay that analyzes the average length of telomeres in cultured cells (TRF analysis)...
  20. pmc Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes
    Konrad Gabrusiewicz
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Oncotarget 5:2208-20. 2014
    ....
  21. pmc Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression
    Yuhui Yuan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:8032-42. 2007
    ..These findings suggest that p27 plays an essential role in restriction of breast cancer progression...
  22. doi request reprint Genetic mapping of anti-apoptosis pathways in myeloid progenitor cells
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 559:283-91. 2009
    ..The advantages of the ERM method include regulatable expression, flexible design, and efficiency...
  23. pmc Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype
    Dan Liu
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Oncotarget 1:700-9. 2010
    ....
  24. ncbi request reprint Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)
    Yi Xing
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Biol Chem 279:30662-9. 2004
    ..Furthermore, biochemical studies reveal that CISK-PX dimerizes in the presence of the linker between the PX domain and kinase domain, suggesting a multivalent mechanism in membrane localization of CISK...
  25. ncbi request reprint Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA
    Baoshan Xu
    State Key Laboratories for AgroBiotechnology and Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, P R China
    Biol Pharm Bull 31:1182-91. 2008
    ..It indicated that there was a cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through LDLR in vivo...
  26. ncbi request reprint A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing hindbrain
    Amata Hornbruch
    Genes and Development Research Group, Department of Cell Biology and Anatomy, Institute of Maternal and Child Health, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
    Mech Dev 122:900-13. 2005
    ....
  27. doi request reprint The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle
    Aaron J Oakley
    Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 283:22031-42. 2008
    ..Mutation of Glu(98) to Ala or Gln completely inactivates the enzyme without altering the overall fold...
  28. ncbi request reprint E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain
    Dan Liu
    Key Laboratory of Glycoconjugates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Dongan Road 130, Shanghai 200032, People s Republic of China
    Arch Biochem Biophys 477:20-6. 2008
    ..Taken together, E1AF increases mithramycin A-induced Huh-7 cells apoptosis and Bax expression depending on its DNA-binding domain, indicating that E1AF might contribute to the therapeutic efficiency of mithramycin A for hepatoma...
  29. ncbi request reprint Inhibition of human telomerase reverse transcriptase in hep-2 cells using short hairpin RNA expression vectors
    Shi ming Chen
    Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Arch Otolaryngol Head Neck Surg 132:200-5. 2006
    ..Our objective was to investigate the effect of short hairpin RNA (shRNA) on hTERT expression and telomerase activity in laryngeal cancer cells...
  30. ncbi request reprint Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharide
    Ming He
    Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Department of Pharmacology, Nanchang University School of Medicine, Nanchang, PR China
    Clin Exp Pharmacol Physiol 33:374-80. 2006
    ..In contrast, 14-3-3eta mRNA had a slight increase without significance. 4. Our results suggest that 14-3-3 may play a role in both acute and subacute (postburn infectious) phases of severe burn...
  31. ncbi request reprint Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis
    Dan Liu
    Division of Cellular Dynamics, Hefei National Laboratory and University of Science and Technology of China, Hefei, China 230027
    Biochem Biophys Res Commun 345:394-402. 2006
    ..We hypothesize that CENP-E degradation is essential for faithful mitotic exit and the proteolysis of CENP-E is mediated by SCF via a direct Skp1 link...
  32. pmc Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    Dan Liu
    Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:15160-5. 2003
    ..TRPM5 channels are nonselective among monovalent cations and not detectably permeable to divalent cations. We propose that the regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system...
  33. ncbi request reprint Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
    Dan Liu
    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Bioorg Med Chem Lett 16:5032-5. 2006
    ....
  34. ncbi request reprint beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization
    Jianhai Jiang
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Biochem Biophys Res Commun 358:41-6. 2007
    ....
  35. ncbi request reprint Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2
    He Ping Chen
    Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Nanchang University, Nanchang 330006, PR China
    Life Sci 81:372-9. 2007
    ..Furthermore, inhibition of the ERK1/2 with PD98059 abolished the 14-3-3 protein up-regulation in cardiomyocytes induced by APC. The results indicate that APC up-regulates 14-3-3 protein expression through the ERK1/2 signaling pathways...
  36. ncbi request reprint Construction of HA-1-DC nucleic-acid vaccine and induction of specific cytotoxic T lymphocytes
    Yaya Wang
    Tumor Blood Center, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510230, China
    J Huazhong Univ Sci Technolog Med Sci 27:261-4. 2007
    ..The cytotoxicty of inducing CTLs was higher than the control group. It was suggested that minor histocompatibility antigen HA-1 could be considered as a target of immunotherapy against leukemia after HSCT...
  37. pmc Functional interaction of E1AF and Sp1 in glioma invasion
    Jianhai Jiang
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Gene Research Center, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, People s Republic of China
    Mol Cell Biol 27:8770-82. 2007
    ..This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors...
  38. ncbi request reprint [A study on the apoptosis of gastric carcinoma cells induced by arsenic trioxide combined with Ad-IkappaBalphaM]
    Bing Rong Liu
    Department of Digestive Diseases, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China
    Zhonghua Nei Ke Za Zhi 46:569-72. 2007
    ..To study the activation of nuclear factor-kappaB (NF-kappaB) in gastric carcinoma SGC-7901 cells after treating with As(2)O(3) and the enhancement of the therapeutic effect of As(2)O(3) with recombinant adenovirus IkappaBalphaM...
  39. doi request reprint Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis
    Jin Zhou
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    J Biochem 143:547-54. 2008
    ..Collectively, these results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis...
  40. doi request reprint Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity
    Lan Wei
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT 2601, Australia
    Int J Biochem Cell Biol 40:1616-28. 2008
    ..The results indicate that GSTM2-2 is a novel luminal regulator of the RyR channels in the heart...
  41. doi request reprint Cdc34-mediated degradation of ATF5 is blocked by cisplatin
    Yuanyan Wei
    Gene Research Center, Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Ministry of Public Health, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai, China
    J Biol Chem 283:18773-81. 2008
    ..In summary, a down-regulation of proteasome-mediated degradation of ATF5 might contribute to cisplatin-induced apoptosis, providing a new mechanism of cisplatin-induced apoptosis...
  42. ncbi request reprint Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats
    Qiren Huang
    Department of Pharmacology, Jiangxi Medical College, Ba Yi Road 603, Nanchang 330006, PR China
    Burns 31:637-42. 2005
    ..These results suggest that SQS, developed from Chinese traditional herbs, might be effective in decreasing inflammation induced by burns...