Xia Lin

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
    Tamara Alliston
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    J Biol Chem 280:24227-37. 2005
  2. ncbi request reprint Specificity and versatility in tgf-beta signaling through Smads
    Xin Hua Feng
    Department of Molecular and Cellular Biology, Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Cell Dev Biol 21:659-93. 2005
  3. pmc C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation
    Lisa L Maduzia
    Waksman Institute, Department of Molecular Biology and Biochemistry, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
    BMC Dev Biol 5:8. 2005
  4. pmc Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0640, USA
    EMBO J 19:5178-93. 2000
  5. ncbi request reprint SUMO-1 modification activated GATA4-dependent cardiogenic gene activity
    Jun Wang
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:49091-8. 2004
  6. ncbi request reprint SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31043-8. 2003
  7. ncbi request reprint The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
    Carl O Brown
    Department of Molecular and Cellular Biology, The Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:10659-69. 2004
  8. pmc Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2
    Min Liang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA
    Mol Cell Biol 24:7524-37. 2004
  9. pmc Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Room 131D, Houston, TX 77030, USA
    Mol Cell Biol 23:9081-93. 2003
  10. pmc Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:345-57. 2009

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1
    Tamara Alliston
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California 94143 0512, USA
    J Biol Chem 280:24227-37. 2005
    ..In this way, Evi-1 acts as a general Smad corepressor to inhibit TGF-beta-, activin-, and BMP-inducible transcription...
  2. ncbi request reprint Specificity and versatility in tgf-beta signaling through Smads
    Xin Hua Feng
    Department of Molecular and Cellular Biology, Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Cell Dev Biol 21:659-93. 2005
    ..We review the molecular basis for the specificity and versatility of signaling by the many ligands through this conceptually simple signal transduction mechanism...
  3. pmc C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation
    Lisa L Maduzia
    Waksman Institute, Department of Molecular Biology and Biochemistry, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
    BMC Dev Biol 5:8. 2005
    ..To identify additional factors that modulate TGFbeta signaling in the Sma/Mab pathway, we have undertaken a genetic screen for small animals and have identified kin-29...
  4. pmc Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0640, USA
    EMBO J 19:5178-93. 2000
    ..These findings explain the tumor suppressor roles of Smad2 and Smad4 in growth arrest signaling by TGF-beta...
  5. ncbi request reprint SUMO-1 modification activated GATA4-dependent cardiogenic gene activity
    Jun Wang
    Center for Cardiovascular Development, Division of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:49091-8. 2004
    ..GATA4 was identified as a SUMO-1-targeted transcription factor and together with PIAS1 was shown to be a potent regulator of cardiac gene activity...
  6. ncbi request reprint SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31043-8. 2003
    ....
  7. ncbi request reprint The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
    Carl O Brown
    Department of Molecular and Cellular Biology, The Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:10659-69. 2004
    ....
  8. pmc Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2
    Min Liang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA
    Mol Cell Biol 24:7524-37. 2004
    ..These results suggest an important role for the SCFSkp2 complex in switching cancer mutants of Smad4 to undergo polyubiquitination-dependent degradation...
  9. pmc Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Room 131D, Houston, TX 77030, USA
    Mol Cell Biol 23:9081-93. 2003
    ..We conclude that the nuclear functions and physical interaction of Smad6 and CtBP provide a novel mechanism for the transcriptional regulation by inhibitory Smads...
  10. pmc Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:345-57. 2009
    ..In conclusion, our study supports a definitive role for RanBP3 in mediating Smad2/3 nuclear export and terminating TGF-beta signaling...
  11. pmc Smad2 positively regulates the generation of Th17 cells
    Gustavo J Martinez
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:29039-43. 2010
    ..These results demonstrate that Smad2 positively regulates the generation of inflammatory Th17 cells...
  12. pmc Critical regulation of TGFbeta signaling by Hsp90
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:9244-9. 2008
    ..Our data reveal an essential level of TGFbeta signaling regulation mediated by Hsp90 by its ability to chaperone TbetaRs and also implicate the use of Hsp90 inhibitors in blocking undesired activation of TGFbeta signaling in diseases...
  13. pmc PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3
    Fangyan Dai
    Department of Molecular and Cellular Biology, Texas A and M Health Sciences Center, Houston, Texas 77030, USA
    EMBO Rep 12:1175-81. 2011
    ..Our findings indicate the critical role of PPM1A in maximizing exporter activity of RanBP3 for efficient termination of canonical TGF-β signalling...
  14. pmc Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover
    Chao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 31:835-49. 2008
    ..These two sites are located within a degron of SRC-3 and are primary determinants of SRC-3 turnover. Moreover, PP1 regulates the oncogenic cell proliferation and invasion functions of SRC-3 in breast cancer cells...
  15. ncbi request reprint Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 281:38365-75. 2006
    ..Taken together, this work identifies the first example of a Smad2/3 linker phosphatase(s) and reveals an important new substrate for SCPs...
  16. ncbi request reprint Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
    Xueyan Duan
    Department of Molecular and Cellular Biology, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:36526-32. 2006
    ..Collectively, our study suggests that PPM1A plays an important role in controlling BMP signaling through catalyzing Smad dephosphorylation...
  17. ncbi request reprint Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 11:1389-96. 2003
    ..This study identifies SUMOylation as a regulatory mechanism underlying CtBP1-dependent transcriptional repression...
  18. pmc Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA
    Mol Cell Biol 27:6183-94. 2007
    ..Therefore, these results define Erbin as a novel negative modulator of Smad2/Smad3 functions and expand the physiological role of Erbin to the regulation of TGFbeta signaling...
  19. ncbi request reprint Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:18714-9. 2003
    ..2 promoter. Importantly, SUMO-1 overexpression enhanced TGF-beta-induced transcriptional responses. These findings identify sumoylation as a unique mechanism to modulate Smad4-dependent cellular responses...
  20. doi request reprint BCL6 represses Smad signaling in transforming growth factor-beta resistance
    Degang Wang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:783-9. 2008
    ..This study provides strong evidence that overexpression of BCL6 contributes to TGF-beta resistance in B-cell lymphoma...
  21. ncbi request reprint PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 125:915-28. 2006
    ..This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling...
  22. pmc Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:9755-63. 2009
    ..Thus, TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner...
  23. pmc Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 647:125-37. 2010
    ..The second step involves nuclear export of dephosphorylated Smad2/3 with the aid of nuclear protein RanBP3 to terminate Smad signaling. This chapter introduces methods for examining nuclear export of Smad2/3 in TGF-beta signaling...
  24. ncbi request reprint Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1
    Min Liang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:22857-65. 2004
    ..These data demonstrate that PIAS1 protein positively modulates TGF-beta responses as a SUMO E3 ligase for Smad4...
  25. ncbi request reprint Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)
    Xin Hua Feng
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 9:133-43. 2002
    ..These results suggest that oncogenic c-Myc promotes cell growth and cancer development partly by inhibiting the growth inhibitory functions of Smads...
  26. ncbi request reprint Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth
    Brad Bryan
    Alkek Institute of Biosciences and Technology, Department of Medical Biochemistry and Genetics, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    FEBS Lett 579:1015-9. 2005
    ..Together, our data suggest that localized regulation of different subsets of Rho GTPases by specific guidance signals results in an intracellular asymmetry of RhoA activity, which could regulate neurite outgrowth and guidance...
  27. ncbi request reprint Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:6517-24. 2007
    ..Our study suggests a novel role for SUMO modification in the regulation of myogenic differentiation...
  28. ncbi request reprint dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development
    Yao Yun Liang
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Ophthalmology, Program of Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:26307-10. 2003
    ..We conclude that dSmurf specifically targets phosphorylated MAD to proteasome-dependent degradation and regulates DPP signaling during development...
  29. pmc Phospho-control of TGF-beta superfamily signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 19:8-20. 2009
    ..This article illustrates the essential roles of reversible phosphorylation in controlling the strength and duration of TGF-beta signaling and the ensuing physiological responses...
  30. pmc COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 493:236-40. 2013
    ....
  31. pmc Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop
    Yan Wang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:33578-84. 2008
    ..PPM1B only efficiently dephosphorylated Cdk9 Thr-186 in vitro when 7SK RNA was depleted from P-TEFb. Taken together, our data indicate that PPM1A and to some extent PPM1B are important negative regulators of P-TEFb function...
  32. ncbi request reprint Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation
    David H Berger
    Department of Surgery, The Baylor College of Medicine, Houston, Tex, USA
    Surgery 132:310-6. 2002
    ..In this study we hypothesized that decreased TGF-beta receptor expression leads to reduced Smad signaling and overexpression of c-Myc in intestinal epithelial (RIE) and transformed intestinal epithelial cells (RIE-Tr) cells...
  33. doi request reprint A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 15:8-10. 2008
    ..in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation...
  34. pmc Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H
    Tao Shen
    1 Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA 2 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA 3 Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, TX 77030, USA
    Cell Res 24:727-41. 2014
    ..In conclusion, this study suggests that PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. ..
  35. ncbi request reprint Abrogation of transforming growth factor-beta signaling in pancreatic cancer
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Room 131D, Houston, Texas 77030, USA
    World J Surg 29:312-6. 2005
    ..In this review, we summarize recent research progress on TGFbeta signaling and pancreatic cancer...
  36. doi request reprint Smad3 mediates immediate early induction of Id1 by TGF-beta
    Yao Yun Liang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, BCM 390, Research Tower, Room R711, One Baylor Plaza, Houston, TX 77030, USA
    Cell Res 19:140-8. 2009
    ..Chromatin immunoprecipitation assay confirms that Smad3 and Smad4 bind to the upstream region of the Id1 gene. Our results demonstrate that Smad3, but not Smad2, mediates TGF-beta1-dependent early transcriptional induction of Id1...
  37. pmc Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway
    Xi Lin
    Texas A and M Health Science Center, Institute of Biosciences and Technology, Houston, Texas, USA
    Mol Cell Biol 32:297-308. 2012
    ..Skeletal- and cardiac-muscle-specific SRF knockouts resulted in significant decreases in PTPLa expression, suggesting a conserved transcriptional regulation of the PTPLa gene in mice...
  38. ncbi request reprint Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston TX 77030, USA
    J Genet Genomics 34:1-9. 2007
    ..This article briefly reviews how dynamic phosphorylation and dephosphorylation of SMADs control or fine-tune the signaling strength and duration and ultimately the physiological consequences in TGF-beta signaling...
  39. pmc PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
    Wenjing Sun
    Texas Children s Cancer Center, Department of Pediatrics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, United States
    Cell Signal 21:95-102. 2009
    ..These data suggest that PPM1A and PPM1B play an important role in the termination of TNFalpha-mediated NF-kappaB activation through dephosphorylating and inactivating IKKbeta...
  40. pmc Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
    Gustavo J Martinez
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77054, USA
    J Biol Chem 284:35283-6. 2009
    ..These results demonstrate that Smad3 is differentially involved in the reciprocal regulatory and inflammatory T cell generation...
  41. pmc TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections
    Sakiko Inamoto
    Department of Internal Medicine and Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, MSB 6 100, 6431, Fannin St, Houston, TX 77030, USA
    Cardiovasc Res 88:520-9. 2010
    ..The aim of this study is to determine the molecular mechanism by which TGFBR2 mutations cause TAADs...
  42. pmc To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Signal 20:1579-91. 2008
    ..Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling...
  43. pmc Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier
    Jun Wang
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 283:23235-43. 2008
    ..SUMO conjugation stabilized the formation of Nkx2.5-containing complexes that led to robust transcriptional activation. Thus, SUMO modification serves as a positive regulator for Nkx2.5 transcriptional activity...
  44. pmc Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis
    Jiyuan Chen
    Division of Nephrology, Department of Medicine Nephrology, Baylor College of Medicine, Houston, TX, USA
    Lab Invest 94:545-56. 2014
    ..Taken together, our results demonstrate that Smad3 signaling has an essential role in the activation of bone marrow-derived fibroblasts in the kidney during the pathogenesis of renal fibrosis. ..
  45. ncbi request reprint Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK
    Hirofumi Jono
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 278:27811-9. 2003
    ....
  46. pmc Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    Suping Zhang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Mol Cell Biol 27:4488-99. 2007
    ..Finally, we provide evidence that Smad7 disrupts the formation of the TGF-beta-induced functional Smad-DNA complex. Our findings suggest that Smad7 inhibits TGF-beta signaling in the nucleus by a novel mechanism...
  47. ncbi request reprint Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription
    Hirofumi Jono
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:45547-57. 2002
    ....
  48. pmc A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
    J Clin Invest 114:1704-13. 2004
    ..This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-beta/Smad2 pathway and cell cycle progression...
  49. pmc TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation
    Hajime Ishinaga
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    EMBO J 26:1150-62. 2007
    ..These studies provide new insights into the novel regulation of NF-kappaB by TGF-beta signaling...
  50. ncbi request reprint Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunity 27:349-60. 2007
    ..Thus, CYLD is detrimental for host survival, thereby indicating a mechanism underlying the high early mortality of pneumococcal pneumonia...
  51. ncbi request reprint Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues
    Shu Kun Wu
    Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefangdadao, Wuhan, Hubei Province, China
    World J Gastroenterol 13:4554-9. 2007
    ..To investigate the expressions of PTEN, PPM1A and P-Smad2 in hepatocellular carcinoma (HCC) and their significance...
  52. pmc Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder
    Allen G Li
    Department of Otolaryngology, Oregon Health and Science University, Portland, OR, USA
    EMBO J 23:1770-81. 2004
    ..Our study suggests that certain pathological condition-induced TGFbeta1 overexpression in the skin may synergize with or induce molecules required for the development of Th1 inflammatory skin disorders...