Jianrong Li

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    J Neuroinflammation 8:89. 2011
  2. pmc Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    Jianrong Li
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5321-30. 2008
  3. pmc Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes
    Jianrong Li
    The F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Neurosci Res 87:1997-2005. 2009
  4. ncbi request reprint Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Biol Chem 281:9460-70. 2006
  5. pmc Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:10616-27. 2004
  6. ncbi request reprint Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury
    Olivier Baud
    Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Eur J Neurosci 20:29-40. 2004
  7. pmc Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
    Jianrong Li
    Department of Neurology, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9936-41. 2005
  8. ncbi request reprint 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes
    Hong Wang
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:2049-58. 2004
  9. pmc Microfluidic compartmentalized co-culture platform for CNS axon myelination research
    Jaewon Park
    Department of Electrical and Computer Engineering, College of Engineering, Texas A and M University, College Station, TX 77843 3128, USA
    Biomed Microdevices 11:1145-53. 2009
  10. ncbi request reprint Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation
    Olivier Baud
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:1713-26. 2004

Collaborators

Detail Information

Publications18

  1. pmc Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    J Neuroinflammation 8:89. 2011
    ..However, the effects of virus-induced glial activation on oligodendrocytes are not fully understood...
  2. pmc Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    Jianrong Li
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5321-30. 2008
    ....
  3. pmc Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes
    Jianrong Li
    The F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Neurosci Res 87:1997-2005. 2009
    ..In summary, our data indicate that vitamin K prevents oxidative cell death by blocking activation of 12-LOX and ROS generation...
  4. ncbi request reprint Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Biol Chem 281:9460-70. 2006
    ....
  5. pmc Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation
    Yumin Zhang
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:10616-27. 2004
    ....
  6. ncbi request reprint Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury
    Olivier Baud
    Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Eur J Neurosci 20:29-40. 2004
    ..These data suggest a primary involvement of superoxide in glutathione depletion toxicity in developing OLs, and suggest an important role for MnSOD in the resistance observed in mature OLs...
  7. pmc Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
    Jianrong Li
    Department of Neurology, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9936-41. 2005
    ..Our results reveal a role for NADPH oxidase in LPS-induced OL death and suggest that peroxynitrite produced by iNOS and NADPH oxidase in activated microglia may play an important role in the pathogenesis of white matter disorders...
  8. ncbi request reprint 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes
    Hong Wang
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:2049-58. 2004
    ..These results suggest that 12-LOX activation plays a key role in oxidative stress-induced OL death...
  9. pmc Microfluidic compartmentalized co-culture platform for CNS axon myelination research
    Jaewon Park
    Department of Electrical and Computer Engineering, College of Engineering, Texas A and M University, College Station, TX 77843 3128, USA
    Biomed Microdevices 11:1145-53. 2009
    ..These results indicate that this device can be used as an excellent in vitro co-culture platform for studying localized axon-glia interaction and signalling...
  10. ncbi request reprint Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation
    Olivier Baud
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 20:1713-26. 2004
    ..In conclusion, we suggest that the vulnerability of developing OLs to NO involves mitochondrial dysfunction and translocation of AIF from mitochondria to nuclei...
  11. ncbi request reprint Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes
    Olivier Baud
    Department of Neurology, Division of Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:1531-40. 2004
    ..These data provide evidence for a key role for GPx-catalase cooperativity in the resistance of mature OLs to H2O2-induced cell death...
  12. doi request reprint Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury
    Sunja Kim
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Brain Pathol 22:41-57. 2012
    ..Taken together, our findings implicate that disturbed sphingolipid pathways in reactive astrocytes may indirectly contribute to oligodendroglial injury in cerebral white matter disorders...
  13. ncbi request reprint Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons
    Jianrong Li
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    J Neurosci 23:5816-26. 2003
    ....
  14. pmc Micro-macro hybrid soft-lithography master (MMHSM) fabrication for lab-on-a-chip applications
    Jaewon Park
    Department of Electrical and Computer Engineering, College of Engineering, Texas A and M University, College Station, TX 77843 3128, USA
    Biomed Microdevices 12:345-51. 2010
    ..The resulting structures were characterized for the integrity of the transferred pattern sizes and the surface roughness using scanning electron microscopy and optical profilometry...
  15. pmc Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors
    Sunja Kim
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, USA
    J Neurochem 116:53-66. 2011
    ..Collectively, our results demonstrate oligodendroglial TNFR1 in mediating inflammatory destruction of preOLs and suggest a previously unrecognized role for astrocytes in promoting TNF toxicity to preOLs...
  16. pmc Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication
    Andrew J Steelman
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Neurosci Res 72:32-42. 2012
    ..Our data show anatomical differences of cuprizone-induced demyelination and remyelination in the corpus callosum and the importance of examining specific callosal regions in myelin repair studies using this model...
  17. pmc The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination
    Ying Chen
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 12:1398-406. 2009
    ....
  18. ncbi request reprint Isolation and culture of rat and mouse oligodendrocyte precursor cells
    Ying Chen
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Protoc 2:1044-51. 2007
    ..Isolation and culture of a large, homogenous population of rodent OPCs should significantly facilitate studies on OPC lineage progression and their utility in myelin repair after injury...

Research Grants4

  1. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2007
    ..Such fundamental insights into the cellular and molecular mechanisms of neonatal white matter injury will provide new avenues for developing novel strategies for the prevention and treatment of this devastating disorder. ..
  2. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2009
    ..Such fundamental insights into the cellular and molecular mechanisms of neonatal white matter injury will provide new avenues for developing novel strategies for the prevention and treatment of this devastating disorder. ..
  3. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2010
    ..Such fundamental insights into the cellular and molecular mechanisms of neonatal white matter injury will provide new avenues for developing novel strategies for the prevention and treatment of this devastating disorder. ..