V Lefebvre

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 11, Houston, TX 77030, USA
    EMBO J 17:5718-33. 1998
  2. ncbi request reprint The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
  3. ncbi request reprint Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo
    G Zhou
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:14989-97. 1998
  4. ncbi request reprint Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer
    L C Bridgewater
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:14998-5006. 1998
  5. pmc An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 16:4512-23. 1996
  6. pmc Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    W Huang
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 20:4149-58. 2000
  7. ncbi request reprint L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
    V Lefebvre
    Department of Molecular Genetics, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA
    Osteoarthritis Cartilage 9:S69-75. 2001
  8. ncbi request reprint Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis
    Q Zhao
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Dev Dyn 209:377-86. 1997
  9. ncbi request reprint Toward understanding SOX9 function in chondrocyte differentiation
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, USA
    Matrix Biol 16:529-40. 1998
  10. ncbi request reprint Transcriptional mechanisms of chondrocyte differentiation
    B de Crombrugghe
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Matrix Biol 19:389-94. 2000

Collaborators

Detail Information

Publications16

  1. pmc A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 11, Houston, TX 77030, USA
    EMBO J 17:5718-33. 1998
    ..Our data suggest that L-Sox5/Sox6 and Sox9, which belong to two different classes of Sox transcription factors, cooperate with each other in expression of Col2a1 and possibly other genes of the chondrocytic program...
  2. ncbi request reprint The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  3. ncbi request reprint Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo
    G Zhou
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:14989-97. 1998
    ..Overall our results suggest a model whereby both Sox9 and these other proteins bind to several HMG-like sites in the Col2a1 gene to cooperatively control its expression in cartilage...
  4. ncbi request reprint Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer
    L C Bridgewater
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:14998-5006. 1998
    ..These similarities suggest the existence of a genetic program designed to coordinately regulate the expression of these and perhaps other genes involved in the chondrocyte differentiation pathway...
  5. pmc An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 16:4512-23. 1996
    ..Together, our results indicate that an 18-bp sequence in Col2a1 intron 1 controls chondrocyte expression and suggest that RCS cells and chondrocytes contain specific POU domain proteins involved in enhancer activity...
  6. pmc Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    W Huang
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 20:4149-58. 2000
    ....
  7. ncbi request reprint L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
    V Lefebvre
    Department of Molecular Genetics, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA
    Osteoarthritis Cartilage 9:S69-75. 2001
    ..This work was carried out to identify transcription factors controlling the differentiation of mesenchymal cells into chondrocytes...
  8. ncbi request reprint Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis
    Q Zhao
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Dev Dyn 209:377-86. 1997
    ....
  9. ncbi request reprint Toward understanding SOX9 function in chondrocyte differentiation
    V Lefebvre
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, USA
    Matrix Biol 16:529-40. 1998
    ..Defining SOX9 function and the mechanisms that regulate SOX9 gene expression should contribute to a better understanding of chondrocyte differentiation...
  10. ncbi request reprint Transcriptional mechanisms of chondrocyte differentiation
    B de Crombrugghe
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Matrix Biol 19:389-94. 2000
    ..These results favor the hypothesis that in achondroplasia, a disease caused by activating mutations in FGF receptor 3, there might also be an abnormally high Sox9 expression...
  11. ncbi request reprint Regulatory mechanisms in the pathways of cartilage and bone formation
    B de Crombrugghe
    The University of Texas M D Anderson Cancer Center, Department of Molecular Genetics, 1515 Holcombe Boulevard, Box 11, Houston, Texas 77030, USA
    Curr Opin Cell Biol 13:721-7. 2001
    ....
  12. ncbi request reprint Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha
    S Murakami
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 275:3687-92. 2000
    ..The down-regulation of Sox9 may have a crucial role in inhibiting expression of the cartilage phenotype in inflammatory joint diseases...
  13. ncbi request reprint A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice
    G Zhou
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Cell Sci 108:3677-84. 1995
    ....
  14. ncbi request reprint Analysis of the promoter region of human cartilage oligomeric matrix protein (COMP)
    M Deere
    Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Matrix Biol 19:783-92. 2001
    ..These results indicate that COMP expression within these cells is regulated in a unique manner that differs from the expression of other extracellular matrix genes...
  15. ncbi request reprint Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing
    H Uusitalo
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    J Bone Miner Res 16:1837-45. 2001
    ....
  16. ncbi request reprint The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells
    D K Panda
    Department of Medicine, McGill University, Montreal, Quebec H3A1A1, Canada
    J Biol Chem 276:41229-36. 2001
    ....