Cheng C Lee

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism
    Isadora Susan Daniels
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 8:e75418. 2013
  2. pmc p53 regulates Period2 expression and the circadian clock
    Takao Miki
    1 Department of Biochemistry and Molecular Biology, Medical School, University of Texas Health Science Center Houston, Houston, Texas 77030, USA 2
    Nat Commun 4:2444. 2013
  3. doi request reprint Is human hibernation possible?
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Annu Rev Med 59:177-86. 2008
  4. ncbi request reprint Tumor suppression by the mammalian Period genes
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    Cancer Causes Control 17:525-30. 2006
  5. ncbi request reprint The circadian clock and tumor suppression by mammalian period genes
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Methods Enzymol 393:852-61. 2005
  6. ncbi request reprint Tumor suppression and circadian function
    Misty Chen-Goodspeed
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Biol Rhythms 22:291-8. 2007
  7. ncbi request reprint Constant darkness is a circadian metabolic signal in mammals
    Jianfa Zhang
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Nature 439:340-3. 2006
  8. ncbi request reprint Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
    Krista Kaasik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 430:467-71. 2004
  9. ncbi request reprint The circadian clock: pacemaker and tumour suppressor
    Loning Fu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Cancer 3:350-61. 2003
  10. pmc Fragile X-related proteins regulate mammalian circadian behavioral rhythms
    Jing Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Hum Genet 83:43-52. 2008

Collaborators

  • Michael R Blackburn
  • Urs Albrecht
  • J H Meijer
  • Isadora Susan Daniels
  • Zhaoyang Zhao
  • Krista Kaasik
  • Jianfa Zhang
  • Takao Miki
  • Jing Zhang
  • Misty Chen-Goodspeed
  • Loning Fu
  • Vinay Nath
  • Tomoko Matsumoto
  • William G O Brien
  • Zhenyin Tao
  • William G O'Brien
  • Tomoko Miki
  • Corinne Jud
  • Ben A Oostra
  • Filippo Tamanini
  • Mariska J Vansteensel
  • David L Nelson
  • Zhe Fang

Detail Information

Publications11

  1. pmc AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism
    Isadora Susan Daniels
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 8:e75418. 2013
    ..Together, these findings demonstrate a central role of AMPD3 in the regulation of 5'-AMP mediated hypometabolism and further implicate erythrocytes in this behavioral response. ..
  2. pmc p53 regulates Period2 expression and the circadian clock
    Takao Miki
    1 Department of Biochemistry and Molecular Biology, Medical School, University of Texas Health Science Center Houston, Houston, Texas 77030, USA 2
    Nat Commun 4:2444. 2013
    ..Our studies demonstrate that p53 modulates mouse circadian behaviour...
  3. doi request reprint Is human hibernation possible?
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Annu Rev Med 59:177-86. 2008
    ..The recent discovery of a biomolecule, 5'-AMP, which allows nonhibernating mammals to rapidly and safely enter severe hypothermia could remove this impediment and enable the wide adoption of hypothermia as a routine clinical tool...
  4. ncbi request reprint Tumor suppression by the mammalian Period genes
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    Cancer Causes Control 17:525-30. 2006
    ..Recently studies of human breast and endometrial cancers revealed that the loss and deregulation of PERIOD proteins is common in the tumor cells...
  5. ncbi request reprint The circadian clock and tumor suppression by mammalian period genes
    Cheng Chi Lee
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Methods Enzymol 393:852-61. 2005
    ..Genetic studies have demonstrated that many key regulators of cell cycle and growth control are also important circadian clock regulators, confirming the critical role of circadian function in organismal homeostasis...
  6. ncbi request reprint Tumor suppression and circadian function
    Misty Chen-Goodspeed
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Biol Rhythms 22:291-8. 2007
    ..Recent studies demonstrate that both PER1 and PER2 are involved in ATM-Chk1/Chk2 DNA damage response pathways and implicate normal circadian function as a factor in tumor suppression...
  7. ncbi request reprint Constant darkness is a circadian metabolic signal in mammals
    Jianfa Zhang
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA
    Nature 439:340-3. 2006
    ..Induction of mClps expression by 5'-AMP in LD mice was reciprocally linked to blood glucose levels. Our findings uncover a circadian metabolic rhythm in mammals...
  8. ncbi request reprint Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
    Krista Kaasik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 430:467-71. 2004
    ..Our data show that the circadian clock and haem biosynthesis are reciprocally regulated and suggest that porphyrin-containing molecules are potential targets for therapy of circadian disorders...
  9. ncbi request reprint The circadian clock: pacemaker and tumour suppressor
    Loning Fu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Cancer 3:350-61. 2003
    ..Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets...
  10. pmc Fragile X-related proteins regulate mammalian circadian behavioral rhythms
    Jing Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Hum Genet 83:43-52. 2008
    ....
  11. pmc A role of erythrocytes in adenosine monophosphate initiation of hypometabolism in mammals
    Isadora Susan Daniels
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    J Biol Chem 285:20716-23. 2010
    ..In summary, our investigations reveal that 5'-AMP mediated hypometabolism is probably triggered by reduced oxygen transport by erythrocytes initiated by uptake of 5'-AMP...

Research Grants13

  1. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2006
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  2. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2004
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  3. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2003
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  4. MOLECULAR ROLE OF RIGUI IN MAMMALIAN CIRCADIAN PATHWAY
    Cheng Lee; Fiscal Year: 2001
    ..Understanding genetics and molecular basis of RIGUI function could lead to new paradigms on how genes control mammalian behavior. ..
  5. PATHOGENESIS STUDIES OF SPINOCEREBELLAR ATAXIA TYPE 6
    Cheng Lee; Fiscal Year: 2001
    ..The results obtained from the proposed studies will provide answers to the role of polyglutamine expansion in neuronal cell death leading to SCA6. ..
  6. MOLECULAR ROLE OF RIGUI IN MAMMALIAN CIRCADIAN PATHWAY
    Cheng Lee; Fiscal Year: 2000
    ..Understanding genetics and molecular basis of RIGUI function could lead to new paradigms on how genes control mammalian behavior. ..
  7. MOLECULAR ROLE OF RIGUI IN MAMMALIAN CIRCADIAN PATHWAY
    Cheng Lee; Fiscal Year: 2000
    ..Understanding genetics and molecular basis of RIGUI function could lead to new paradigms on how genes control mammalian behavior. ..
  8. PATHOGENESIS STUDIES OF SPINOCEREBELLAR ATAXIA TYPE 6
    Cheng Lee; Fiscal Year: 2000
    ..The results obtained from the proposed studies will provide answers to the role of polyglutamine expansion in neuronal cell death leading to SCA6. ..
  9. MOLECULAR ROLE OF RIGUI IN MAMMALIAN CIRCADIAN PATHWAY
    Cheng Lee; Fiscal Year: 1999
    ..Understanding genetics and molecular basis of RIGUI function could lead to new paradigms on how genes control mammalian behavior. ..
  10. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2007
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  11. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2005
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  12. PATHOGENESIS STUDIES OF SPINOCEREBELLAR ATAXIA TYPE 6
    Cheng Lee; Fiscal Year: 1999
    ..The results obtained from the proposed studies will provide answers to the role of polyglutamine expansion in neuronal cell death leading to SCA6. ..