Adrian V Lee

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation
    Adrian V Lee
    Department of Medicine, Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 9:516S-23S. 2003
  2. doi request reprint Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2
    Yasir H Ibrahim
    Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Cancer Res 6:1491-8. 2008
  3. doi request reprint Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth
    Angelo J Casa
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 132:61-73. 2012
  4. pmc Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
    Robert K Dearth
    Breast Cancer, Baylor College of Medicine and Methodist Hospital, Department of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 26:9302-14. 2006
  5. pmc BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells
    Beate C Litzenburger
    Lester and Sue Smith Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:226-37. 2009
  6. ncbi request reprint Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 23:7721-35. 2005
  7. ncbi request reprint Estrogen-mediated down-regulation of E-cadherin in breast cancer cells
    Steffi Oesterreich
    The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:5203-8. 2003
  8. pmc Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 12:R40. 2010
  9. ncbi request reprint Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2
    Robert K Dearth
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cell Cycle 6:705-13. 2007
  10. pmc Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM
    Simeen Malik
    Department of Molecular and Cellular Biology, 3 Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 30:399-412. 2010

Collaborators

Detail Information

Publications61

  1. ncbi request reprint New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation
    Adrian V Lee
    Department of Medicine, Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 9:516S-23S. 2003
    ..This review will highlight how recent studies using these STIs have elucidated novel mechanisms of STI action that may be used in the development of new therapeutic strategies for the treatment of cancer...
  2. doi request reprint Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2
    Yasir H Ibrahim
    Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Cancer Res 6:1491-8. 2008
    ....
  3. doi request reprint Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth
    Angelo J Casa
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 132:61-73. 2012
    ..This may be important clinically, as tumors with active ERα and IGF-IR signaling may require co-targeting of both pathways...
  4. pmc Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
    Robert K Dearth
    Breast Cancer, Baylor College of Medicine and Methodist Hospital, Department of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 26:9302-14. 2006
    ..This study defines IRSs as oncogene proteins in vivo and provides new models to develop inhibitors against IRSs for anticancer therapy...
  5. pmc BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells
    Beate C Litzenburger
    Lester and Sue Smith Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:226-37. 2009
    ....
  6. ncbi request reprint Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 23:7721-35. 2005
    ..Finally, we will consider the clinical implications of these observations...
  7. ncbi request reprint Estrogen-mediated down-regulation of E-cadherin in breast cancer cells
    Steffi Oesterreich
    The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:5203-8. 2003
    ..We propose that estrogen-mediated down-regulation of E-cadherin is a novel way of reducing E-cadherin levels in estrogen receptor-positive breast cancer...
  8. pmc Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    Chad J Creighton
    Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 12:R40. 2010
    ..We thus examined whether deregulated PI3K signaling in luminal ER+ breast tumors is associated with ER level and activity and intrinsic molecular subtype...
  9. ncbi request reprint Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2
    Robert K Dearth
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cell Cycle 6:705-13. 2007
    ..In this review we will discuss the role of IRSs in both transformation and cancer progression...
  10. pmc Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM
    Simeen Malik
    Department of Molecular and Cellular Biology, 3 Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 30:399-412. 2010
    ....
  11. ncbi request reprint The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth
    Jana Divisova
    Department of Medicine, Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 98:315-27. 2006
    ..This data supports previous studies indicating a role for GH/IGF in mammary gland development, and suggests that pegvisomant maybe useful for the prevention and/or treatment of estrogen receptor positive breast cancer...
  12. pmc High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy
    Beate C Litzenburger
    Lester and Sue Smith Breast Center and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
    Clin Cancer Res 17:2314-27. 2011
    ..We tested whether the IGF signature was affected by anti-IGF-I receptor (IGF-IR) inhibitors and whether the IGF signature correlated with response to a dual anti-IGF-IR/insulin receptor (InsR) inhibitor, BMS-754807...
  13. ncbi request reprint Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalization
    Klaudia M Dobrzycka
    Department of Medicine, The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:7859-63. 2006
    ..SAFB1 loss also caused lack of contact inhibition, increased foci formation, and increased oncogene-induced anchorage-independent growth. These findings suggest that SAFB1 is a novel player in cellular immortalization and transformation...
  14. pmc Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    Chad J Creighton
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 26:4078-85. 2008
    ..To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells...
  15. ncbi request reprint Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration
    Xiaojiang Cui
    Breast Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 66:5304-13. 2006
    ..Because AP-1 activity is involved in breast cancer progression, our work may also suggest IRS-2 as a useful marker for aggressive breast cancer...
  16. pmc Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis
    Benny Abraham Kaipparettu
    Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Mol Cancer 8:15. 2009
    ..Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele...
  17. ncbi request reprint Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth
    David G DeNardo
    Department of Molecular and Cellular Biology, and Breast Center, Baylor College of Medicine, Houston, TX, USA
    Mol Cell Endocrinol 277:13-25. 2007
    ..These results demonstrate that ER DNA binding is not absolutely required for estrogen to induce breast cancer cell growth...
  18. ncbi request reprint Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development
    Brandy M Heckman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 309:137-49. 2007
    ..These results indicate that IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis...
  19. ncbi request reprint Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain
    Steven M Townson
    Departments of Medicine, The Breast Center, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
    J Biol Chem 279:26074-81. 2004
    ..We propose a model in which SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery...
  20. pmc Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer
    Ilenia Migliaccio
    Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM 600, Room N1110, Houston, TX 77030, USA
    Breast Cancer Res Treat 123:651-60. 2010
    ..0001) when compared with patients with PR-/IRS-1- tumors. In conclusion, nuclear IRS-1 may be a useful marker to predict tamoxifen response in patients with early breast cancer, particularly when assessed in combination with PR...
  21. pmc Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer
    Robert K Dearth
    Breast Center, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:312-21. 2010
    ..Therefore, although the parity reduction in circulating GH does not affect circulating IGF-I levels, it is possible that reduced GH acts directly at the mammary gland and may play a role in pregnancy protection from breast cancer...
  22. pmc Scaffold attachment factor B1 functions in development, growth, and reproduction
    Margarita Ivanova
    Department of Medicine, Baylor College of Medicine, Breast Center, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:2995-3006. 2005
    ..Together, these in vivo findings establish a critical role for SAFB1 in development, growth regulation, and reproduction...
  23. ncbi request reprint The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance
    Angelo J Casa
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Front Biosci 13:3273-87. 2008
    ..It concludes with a description of approaches to target IGF-IR and argues that inhibition of IGF signaling, in conjunction with standard therapies, may enhance the response of cancer cells to multiple modalities...
  24. ncbi request reprint Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt
    Darryl L Hadsell
    Department of Pediatrics, The Breast Center, Baylor College of Medicine, USDAS ARS Chiuldren s Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA
    J Endocrinol 194:327-36. 2007
    ....
  25. ncbi request reprint Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 147:3877-88. 2006
    ..Higher circulating levels of IGF-I can stimulate somatic growth and lean mass and improve glucose tolerance...
  26. pmc A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis
    Robert K Dearth
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 11:377. 2011
    ..The purpose of this study was to assess the ability of circulating IGF-I to independently initiate mammary tumorigenesis and/or accelerate the progression of ErbB2 mediated mammary tumor growth...
  27. pmc Molecular profiles of progesterone receptor loss in human breast tumors
    Chad J Creighton
    Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:287-99. 2009
    ..Patient prognosis and response to endocrine therapy in breast cancer correlate with protein expression of both estrogen receptor (ER) and progesterone receptor (PR), with poorer outcome in patients with ER+/PR- compared to ER+/PR+ tumors...
  28. pmc Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
    Hyun Jung Kim
    Baylor College of Medicine, Breast Center MS 600, One Baylor Plaza, Room N1110, Houston, TX 77030, USA
    Mol Cell Biol 27:3165-75. 2007
    ..This study places IGF-IR among a small group of oncogenes that, when overexpressed alone, can confer in vivo tumorigenic growth of MCF10A cells and indicates the hierarchy in the mechanism of IGF-IR-induced EMT...
  29. ncbi request reprint Progesterone receptor loss correlates with human epidermal growth factor receptor 2 overexpression in estrogen receptor-positive breast cancer
    Hyun Jung Kim
    Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Clin Cancer Res 12:1013s-1018s. 2006
    ....
  30. ncbi request reprint Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance
    Grazia Arpino
    Breast Center, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA
    J Natl Cancer Inst 97:1254-61. 2005
    ..We hypothesized that ER+/PR- breast tumors are more likely than ER+/PR+ breast tumors to have an aggressive phenotype, to express HER-1 and overexpress HER-2, and are less likely to benefit from tamoxifen adjuvant therapy...
  31. doi request reprint Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
    David L Kleinberg
    Neuroendocrine Unit, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Endocr Rev 30:51-74. 2009
    ....
  32. doi request reprint Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    Shuying Liu
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 15:539-50. 2009
    ..Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer...
  33. doi request reprint Novel egg white-based 3-D cell culture system
    Benny Abraham Kaipparettu
    Department of Medicine, Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Biotechniques 45:165-8, 170-1. 2008
    ..Thus, this finding lays the foundation for significantly increased, cost-effective use of 3-D cultures in cell biology...
  34. doi request reprint Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity
    Adam S Potter
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Biochem 113:110-21. 2012
    ..Together, these results demonstrate that IGF-I can increase the stability of FOXA1 protein expression and place it as a critical mediator of IGF-I regulation of gene expression and IGF-I-mediated biological responses...
  35. pmc Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
    Catherine E Gatza
    Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 313:130-41. 2008
    ..These data indicate that appropriate levels of p53 activity are important in regulating mammary gland ductal morphogenesis, in part through regulation of the IGF-1 pathway...
  36. ncbi request reprint AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:1875-85. 2004
    ..These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways...
  37. ncbi request reprint Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapy
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, Houston, Texas, USA
    Clin Cancer Res 10:396S-401S. 2004
    ....
  38. pmc Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell lines
    Oliver A Hampton
    Graduate Program in Structural and Computational Biology and Molecular Biophysics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Cancer Genet 204:447-57. 2011
    ....
  39. ncbi request reprint Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Endocrinol 16:2675-91. 2002
    ..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation...
  40. pmc 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational research
    Adrian V Lee
    Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
    Breast Cancer Res 6:E10. 2004
    ..This report will summarize preclinical and translational highlights from the meeting...
  41. ncbi request reprint Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 22:6937-41. 2003
    ..Taken together, our data suggest that IRS-2 may play an important role in crosstalk between progesterone and the IGFs in breast cancer cells...
  42. ncbi request reprint Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation
    Darryl L Hadsell
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 73:1116-25. 2005
    ....
  43. pmc A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome
    Oliver A Hampton
    Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 19:167-77. 2009
    ..We show that knock-down of SULF2 in cell lines causes tumorigenic phenotypes, including increased proliferation, enhanced survival, and increased anchorage-independent growth...
  44. pmc Insulin receptor substrates (IRSs) and breast tumorigenesis
    Bonita Tak Yee Chan
    Lester and Sue Smith Breast Center, Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    J Mammary Gland Biol Neoplasia 13:415-22. 2008
    ..In this review we will discuss the roles of IRSs in mammary gland development and breast cancer...
  45. ncbi request reprint SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor
    Steven M Townson
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:20059-68. 2003
    ..Our findings suggest that evolutionary duplication of the SAFB gene has allowed it to retain crucial functions, but also to gain novel functions in the cytoplasm and/or nucleus...
  46. ncbi request reprint Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in brea
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 17:575-88. 2003
    ....
  47. doi request reprint Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labeling
    Amy A Hassan
    Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Contrast Media Mol Imaging 5:34-8. 2010
    ..Cell pellets derived from the ser-GNT labeled cells give bright T(1)-weighted MR images, confirming that the ser-GNTs are a promising new nanoprobe technology for magnetic cell labeling and possibly for in vivo cellular trafficking...
  48. pmc Location, location, location: regulation of breast cancer progression by the microenvironment
    Adrian V Lee
    Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
    Breast Cancer Res 6:279-80. 2004
  49. ncbi request reprint A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells
    Deepali Sachdev
    Department of Medicine and Cancer Center, University of Minnesota, Minnesota 55455, USA
    J Biol Chem 279:5017-24. 2004
    ..Our data show that IGF1R can regulate several aspects of the malignant phenotype. In these cells, metastasis but not proliferation requires IGF1R function...
  50. ncbi request reprint Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen
    Amy M Fowler
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin, USA
    FASEB J 18:81-93. 2004
    ..Further, they describe a potential mechanism whereby increases in ERalpha concentration may provide a proliferative advantage by augmenting ERalpha function regardless of ligand status...
  51. ncbi request reprint Local insulin-like growth factor-II mediates prolactin-induced mammary gland development
    Russell C Hovey
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1402, USA
    Mol Endocrinol 17:460-71. 2003
    ..Together, these data demonstrate a role for IGF-II as a mediator of PRL action in the mouse mammary gland during ductal branching and alveolar development...
  52. ncbi request reprint Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement
    Steven E Come
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 10:327S-330S. 2004
  53. ncbi request reprint Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells
    David W Singleton
    Department of Cell Biology, Neurobiology and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Mol Cell Endocrinol 221:47-55. 2004
    ..Taken together these data illustrate novel gene regulation by BPA and E2, which has implications for in vivo actions and previous reports of additive and synergistic effects on breast cancer cell growth...
  54. ncbi request reprint Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor
    Joan M Carboni
    Oncology Drug Discovery and Discovery Toxicology, Bristol Myers Squibb Research Institute, Princeton, New Jersey 08534, USA
    Cancer Res 65:3781-7. 2005
    ..This new model should provide new opportunities for further understanding how aberrant IGF-IR signaling leads to tumorigenesis and for optimizing novel antagonists of the receptor kinase...
  55. ncbi request reprint The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells
    Naama Reizner
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Endocrinol 35:135-44. 2005
    ....
  56. pmc Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells
    Steven M Townson
    Department of Human Genetics, Virginia Commonwealth University and Massey Cancer Center, Sanger Hall, Richmond, VA 23219, USA
    Biochem Biophys Res Commun 349:540-8. 2006
    ..Taken together, our study provides further evidence that coactivation and corepression are integrally linked processes and that RFP is a component of an ESR1 regulatory complex...
  57. ncbi request reprint Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1
    Sharon Maor
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Endocrinol 191:605-12. 2006
    ..Dysregulated expression of the IGF-IR gene may have pathologic consequences with relevance in breast cancer etiology...
  58. ncbi request reprint Insights into the role of progesterone receptors in breast cancer
    Suzanne A W Fuqua
    J Clin Oncol 23:931-2; author reply 932-3. 2005
  59. ncbi request reprint Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells
    David W Singleton
    Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Environ Res 100:86-92. 2006
    ..5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development...
  60. ncbi request reprint Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statement
    Steven E Come
    Breast Cancer Program, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Cancer Res 12:997s-1000s. 2006
  61. ncbi request reprint Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statement
    Steven E Come
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 9:443S-6S. 2003