Wei Dong LE

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Are heat shock proteins therapeutic target for Parkinson's disease?
    Guang Rui Luo
    Institute of Health Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Int J Biol Sci 3:20-6. 2007
  2. ncbi request reprint Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury
    W D Le
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 56:652-8. 1999
  3. ncbi request reprint Minocycline: neuroprotective mechanisms in Parkinson's disease
    M Thomas
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Pharm Des 10:679-86. 2004
  4. ncbi request reprint Mutations in NR4A2 associated with familial Parkinson disease
    Wei Dong LE
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:85-9. 2003
  5. ncbi request reprint Heterogeneous phenotype in a family with compound heterozygous parkin gene mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Neurol 63:273-7. 2006
  6. ncbi request reprint Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Neurol 176:322-7. 2002
  7. pmc Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration
    Yuen Sum Lau
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Eur J Neurosci 33:1264-74. 2011
  8. doi request reprint A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
    Xu Ping Li
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosignals 20:223-36. 2012
  9. ncbi request reprint Genetic analysis of the GABRA1 gene in patients with essential tremor
    Hao Deng
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Neurosci Lett 401:16-9. 2006
  10. ncbi request reprint Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism
    Hao Deng
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Neurosci Lett 382:297-9. 2005

Collaborators

Detail Information

Publications29

  1. pmc Are heat shock proteins therapeutic target for Parkinson's disease?
    Guang Rui Luo
    Institute of Health Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Int J Biol Sci 3:20-6. 2007
    ..The critical role of HSPs and recent discovery of some novel HSPs inducers suggest that HSPs may be potential therapeutic targets for PD and other neurodegenerative disorders...
  2. ncbi request reprint Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury
    W D Le
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 56:652-8. 1999
    ..These findings support the importance of HO-1 in protecting neurons against oxidative stress-induced injury...
  3. ncbi request reprint Minocycline: neuroprotective mechanisms in Parkinson's disease
    M Thomas
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Pharm Des 10:679-86. 2004
    ..In this review, we present the current experimental evidence for the potential use of tetracycline derivative, minocycline, as a neuroprotective agent in PD...
  4. ncbi request reprint Mutations in NR4A2 associated with familial Parkinson disease
    Wei Dong LE
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:85-9. 2003
    ..Additionally, mutations in NR4A2 affect transcription of the gene encoding tyrosine hydroxylase. These data suggest that mutations in NR4A2 can cause dopaminergic dysfunction, associated with Parkinson disease...
  5. ncbi request reprint Heterogeneous phenotype in a family with compound heterozygous parkin gene mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Neurol 63:273-7. 2006
    ..Mutations in the parkin gene (PRKN) cause autosomal recessive early-onset Parkinson disease (EOPD)...
  6. ncbi request reprint Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Neurol 176:322-7. 2002
    ....
  7. pmc Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration
    Yuen Sum Lau
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Eur J Neurosci 33:1264-74. 2011
    ..Therefore, modifying lifestyle with increased exercise activity would be a non-pharmacological neuroprotective approach for averting neurodegenerative processes, as demonstrated in experimental chronic parkinsonism...
  8. doi request reprint A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
    Xu Ping Li
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosignals 20:223-36. 2012
    ..These findings provide insight into the mechanistic interplay between UPS impairment and iron misregulation and suggest that the disturbances in IRP2, TfR1 and H-Frt may contribute to DA neuron degeneration...
  9. ncbi request reprint Genetic analysis of the GABRA1 gene in patients with essential tremor
    Hao Deng
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Neurosci Lett 401:16-9. 2006
    ..Since the 156T>C variant appears to be not pathogenically relevant, our results suggest that missense, nonsense or splice site mutation in the coding region of the GABRA1 gene is not a major genetic cause of ET in Caucasian subjects...
  10. ncbi request reprint Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism
    Hao Deng
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Neurosci Lett 382:297-9. 2005
    ..Since none of these variations appear to be pathogenically relevant, our results suggest that mutation of PACRG plays little or no role in the development of EOP...
  11. pmc Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis
    Jia Li
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    Acta Pharmacol Sin 34:644-50. 2013
    ..To develop a C. elegans model of amyotrophic lateral sclerosis (ALS) and to evaluate the role of autophagy in the disease...
  12. ncbi request reprint Epigallocatechin gallate protects dopaminergic neurons against 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by inhibiting microglial cell activation
    Rui Li
    Department of Neurology, People s Hospital of Shaanxi Province, Xi an 710068, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:376-80. 2006
    ..To observe whether the dopaminergic neuroprotective effect of (-)-epigallocatechin gallate (EGCG) is associated with its inhibition of microglial cell activation in vivo...
  13. ncbi request reprint Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease
    Wei Wang
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Gerontol A Biol Sci Med Sci 63:127-34. 2008
    ..The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene...
  14. ncbi request reprint A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Neurol 64:421-4. 2007
    ..Mutations in the parkin gene cause autosomal recessive early-onset Parkinson disease (EOPD). The A265G variant in the HS1 binding protein 3 gene (HS1BP3) is common in essential tremor (ET)...
  15. ncbi request reprint Collective roles of molecular chaperones in protein degradation pathways associated with neurodegenerative diseases
    Guang Rui Luo
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China
    Curr Pharm Biotechnol 11:180-7. 2010
    ..Therefore, the study of HSPs might shed new light on not only the mechanisms of protein synthesis and degradation, but also the possible therapeutic targets of fibril formation associating diseases...
  16. doi request reprint Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis
    Guang Rui Luo
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mol Cell Neurosci 39:202-10. 2008
    ..6 fold. These results suggest that Nr4a2 may play an important role in the differentiation and maturation rather than the survival of DA progenitors in the PT area during zebrafish early embryogenesis...
  17. doi request reprint Genetic study of an American family with DYT3 dystonia (lubag)
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosci Lett 448:180-3. 2008
    ..In contrast, TAF1 and CXCR3 gene expression in peripheral blood lymphocytes is not a suitable surrogate disease marker for DYT3...
  18. ncbi request reprint Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons
    Habib A Mohamed
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 69:110-6. 2002
    ..These data suggest that FcgammaRs appear to participate in IgG uptake into motor neurons as well as IgG-mediated increases in intracellular calcium and acetylcholine release from motor axon terminals...
  19. ncbi request reprint Novel splicing variant of the human orphan nuclear receptor Nurr1 gene
    Ping Yi Xu
    Department of Neurology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, China
    Chin Med J (Engl) 117:899-902. 2004
    ..Nurr1 is a member of the nuclear receptor superfamily of transcription factors. The objective of the present study was to identify novel splicing variants of the gene in neuronal and non-neuronal tissues and determine their functions...
  20. ncbi request reprint ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in alpha-synuclein transgenic C. elegans
    Yi Min Wang
    Neural Genomics Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Bull 23:329-35. 2007
    ..To investigate the toxic effect of environmental neurotoxin MPP+ to C. elegans and identify the mechanisms that cause the toxicity...
  21. ncbi request reprint Minocycline and other tetracycline derivatives: a neuroprotective strategy in Parkinson's disease and Huntington's disease
    Madhavi Thomas
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Neuropharmacol 26:18-23. 2003
  22. ncbi request reprint Stem cell transplantation: a promising therapy for Parkinson's disease
    Yi Wang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai 200025, China
    J Neuroimmune Pharmacol 2:243-50. 2007
    ..Future stem cell research should focus not only on ameliorating the symptoms of Parkinson's disease but also on neuroprotection or neurorescue that can favorably modify the natural course and slow the progression of the disease...
  23. ncbi request reprint Retinal pigment epithelial cells: biological property and application in Parkinson's disease
    Ming Ming
    Laboratory of Neurogenomics, Institute of Health Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Chin Med J (Engl) 120:416-20. 2007
  24. ncbi request reprint Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-alpha in conditions of heavy metal ion deficiency
    Jun Hai Yang
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Invest Ophthalmol Vis Sci 46:1039-46. 2005
    ..To investigate the mechanism underlying apoptosis in retinal pigment epithelium (RPE) induced by TNF-alpha in conditions of heavy metal ion deficiency...
  25. ncbi request reprint Biomarkers of neurodegenerative disorders: how good are they?
    Varun Rachakonda
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Cell Res 14:347-58. 2004
    ..This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases...
  26. ncbi request reprint Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients
    Cong Cong Sun
    Department of Neurology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 125:583-7. 2012
    ..This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a relatively large population of Chinese patients...
  27. ncbi request reprint (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury
    Rui Li
    Health Science Center, Shanghai Institute for Biological Science, Chinese Academy of Science, Shanghai Second Medical University, Shanghai, Peoples Republic of China
    J Neurosci Res 78:723-31. 2004
    ..Our study demonstrates that EGCG is a potent inhibitor of microglial activation and thus is a useful candidate for a therapeutic approach to alleviating microglia-mediated dopaminergic neuronal injury in PD...
  28. ncbi request reprint Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice
    Syed Z Imam
    South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA
    FASEB J 19:1441-50. 2005
    ....
  29. ncbi request reprint Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia
    Xuan Liu
    Joint Laboratory of Institute of Biomedical Sciences, Ruijin Hospital, Shanghai Second Medical University, Shanghai, People s Republic of China
    J Neurosci Res 81:653-65. 2005
    ..The cytoplasm location of microglial ERbeta suggests the possible involvement of nonclassical effects of estrogen on microglia. Changes in microglial ERbeta expression levels may modulate such effects of estrogen...

Research Grants9

  1. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2002
    ....
  2. NURR1 Gene Mutations in Parkinson's Disease
    Weidong Le; Fiscal Year: 2006
    ....
  3. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2000
    ....
  4. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2002
    ....
  5. NURR1 Gene Mutations in Parkinson's Disease
    Wei Dong LE; Fiscal Year: 2004
    ....
  6. NURR1 Gene Mutations in Parkinson's Disease
    Wei Dong LE; Fiscal Year: 2005
    ....
  7. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2001
    ....
  8. NURR1 Gene Mutations in Parkinson's Disease
    Wei Dong LE; Fiscal Year: 2003
    ....
  9. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2003
    ....