J M Lawler

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat
    Jong Hee Kim
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    Exp Gerontol 43:317-29. 2008
  2. doi request reprint Biphasic stress response in the soleus during reloading after hind limb unloading
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Med Sci Sports Exerc 44:600-9. 2012
  3. pmc Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels
    John M Lawler
    Department of Health and Kinesiology, Interdisciplinary Faculty of Nutrition, Texas A and M University, College Station, TX 77843 4243, USA
    Free Radic Biol Med 49:1969-77. 2010
  4. ncbi request reprint Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1756-63. 2006
  5. pmc Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy
    John M Lawler
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    J Physiol 589:2161-70. 2011
  6. pmc Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, 77843 4243, USA
    Antioxid Redox Signal 15:2529-41. 2011
  7. ncbi request reprint Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women
    J M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, 77843 4243, USA
    Int J Sports Med 23:477-83. 2002
  8. ncbi request reprint Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors
    John M Lawler
    Department of Health and Kinesiology, Redox Biology and Cell Signaling Laboratory, Texas A and M University, College Station, TX 77843 4243, USA
    Biochem Biophys Res Commun 294:1093-100. 2002
  9. ncbi request reprint Direct antioxidant properties of creatine
    John M Lawler
    276 B Read Building, Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Biochem Biophys Res Commun 290:47-52. 2002
  10. pmc Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1496-502. 2009

Research Grants

Detail Information

Publications18

  1. pmc Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat
    Jong Hee Kim
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    Exp Gerontol 43:317-29. 2008
    ..Total hydroperoxides were higher in OAL than YAL, but were not elevated in OExCR, with out a change in MnSOD. IGF-1 levels were lower in OAL (-57%) than YAL, but partially protected in the OExCR group (+51%)...
  2. doi request reprint Biphasic stress response in the soleus during reloading after hind limb unloading
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Med Sci Sports Exerc 44:600-9. 2012
    ..We postulated that proinflammatory signaling and stress response alterations would characterize early and late phases of signaling during reloading...
  3. pmc Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels
    John M Lawler
    Department of Health and Kinesiology, Interdisciplinary Faculty of Nutrition, Texas A and M University, College Station, TX 77843 4243, USA
    Free Radic Biol Med 49:1969-77. 2010
    ..These results are consistent with the hypothesis that DHPR redox state and RyR function are modulated in an interactive manner, affecting contractility in intact diaphragm fiber bundles...
  4. ncbi request reprint Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1756-63. 2006
    ..CAT trended higher (P = 0.059) in ECO compared with SCO. These data indicate that exercise training following onset of coronary artery occlusion results in recovery of critical stress proteins and reduces oxidative stress...
  5. pmc Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy
    John M Lawler
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    J Physiol 589:2161-70. 2011
    ..Oxidative stress may act as an amplifier, exacerbating disruption of the dystroglycan complex, upregulation of the inflammatory transcription factor NF-B, and thus functional impairment of force-generating capacity...
  6. pmc Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, 77843 4243, USA
    Antioxid Redox Signal 15:2529-41. 2011
    ..Emerging thought suggests that pro-inflammatory signaling and oxidative stress may contribute to sarcopenia...
  7. ncbi request reprint Combination of estrogen replacement and exercise protects against HDL oxidation in post-menopausal women
    J M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, 77843 4243, USA
    Int J Sports Med 23:477-83. 2002
    ..07). These data indicate that the combination of estrogen replacement and regular exercise in post-menopausal women may be most effective in reducing oxidation of HDL in vivo...
  8. ncbi request reprint Specificity of antioxidant enzyme inhibition in skeletal muscle to reactive nitrogen species donors
    John M Lawler
    Department of Health and Kinesiology, Redox Biology and Cell Signaling Laboratory, Texas A and M University, College Station, TX 77843 4243, USA
    Biochem Biophys Res Commun 294:1093-100. 2002
    ....
  9. ncbi request reprint Direct antioxidant properties of creatine
    John M Lawler
    276 B Read Building, Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Biochem Biophys Res Commun 290:47-52. 2002
    ..375 mM). To our knowledge, this is the first evidence that creatine has the potential to act as a direct antioxidant against aqueous radical and reactive species ions...
  10. pmc Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1496-502. 2009
    ..Moreover, upregulation of MnSOD in the aging heart was directly associated with attenuated levels of oxidative stress, including iNOS...
  11. ncbi request reprint Differential response of heat shock proteins to hindlimb unloading and reloading in the soleus
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, 276B Read Building, Department of Health and Kinesiology, Texas A and M University, College Station, 77843 4243, USA
    Muscle Nerve 33:200-7. 2006
    ..Thus dysregulation and uncoupling of the Hsp70 and Hsp25 pathways may lead not only to muscle atrophy with prolonged unloading, but also impaired recovery of muscle mass during early reloading...
  12. ncbi request reprint Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle
    John M Lawler
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Free Radic Biol Med 35:9-16. 2003
    ..6% and hindlimb muscle DCFH-DA oxidation by 162.1%. These results indicate that hindlimb unloading results in a disruption of antioxidant status, elevation of hydroperoxides, and an increase in oxidative stress...
  13. ncbi request reprint Relationship between NADP-specific isocitrate dehydrogenase and glutathione peroxidase in aging rat skeletal muscle
    J M Lawler
    276 B Read Building, Redox Biology Laboratory, Eloise Beard Smith Human Performance Laboratories, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Mech Ageing Dev 122:291-304. 2001
    ..In summary, these data are consistent with the hypotheses that ICDP is higher in more oxidative fibers, inducible with aging, and most closely associated with the glutathione peroxidase system in skeletal muscle...
  14. ncbi request reprint Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle
    Wook Song
    Texas A and M University, Redox Biology and Cell Signaling Laboratory, College Station, Texas 77843 4243, USA
    Antioxid Redox Signal 8:517-28. 2006
    ..These results indicate that treadmill exercise training attenuates fiber atrophy and pro-apoptotic signaling in aging skeletal muscle...
  15. ncbi request reprint Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart
    Hyo Bum Kwak
    Redox Biology and Cell Signaling Laboratory, Texas A and M University, College Station, Texas 77843 4243, USA
    FASEB J 20:791-3. 2006
    ..These are the first data to demonstrate protective effects of endurance exercise training against elevated apoptosis and remodeling in the aging heart...
  16. pmc Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats
    Wook Song
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, and Intercollegiate Faculty of Nutrition, Texas A and M University, College Station, TX 77843 4243, USA
    J Gerontol A Biol Sci Med Sci 64:540-9. 2009
    ..eNOS was unaffected by aging or exercise in the SOL. Our results indicate that endurance exercise training attenuates age-induced alterations of NOS isoforms with a greater response in fast-twitch compared with slow-twitch muscle...
  17. pmc Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart
    Hyo Bum Kwak
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    FASEB J 25:1106-17. 2011
    ..Therefore, exercise training could protect the aging heart against dysregulation of MMPs and fibrosis by suppressing elevation of TIMP-1 and TGF-β...
  18. doi request reprint Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
    Emanuele Marzetti
    Department of Aging and Geriatric Research, University of Florida Institute on Aging, College of Medicine, Gainesville, FL 32610, USA
    Free Radic Biol Med 44:160-8. 2008
    ..The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed...

Research Grants2

  1. Regulation of Oxidative Stress in the mdx Diaphragm
    JOHN LAWLER; Fiscal Year: 2007
    ..We anticipate that our results will have important clinical significance, as we expect to elucidate mechanisms by which oxidative stress contributes to damage, cell loss, and weakness in the dystrophic diaphragm. ..