Hui Lan

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
    Hui Y Lan
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Nephrol Hypertens 12:25-9. 2003
  2. ncbi request reprint Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    Hui Y Lan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 14:1535-48. 2003
  3. ncbi request reprint Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes
    Arup Chakraborty
    Renal Section, Dept of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Renal Physiol 292:F895-904. 2007
  4. ncbi request reprint Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
  5. ncbi request reprint Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7
    Wansheng Wang
    Dept of Medicine Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 293:F1123-30. 2007
  6. ncbi request reprint Transforming growth factor-beta and Smad signalling in kidney diseases
    Wansheng Wang
    Department of Medicine Nephrology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nephrology (Carlton) 10:48-56. 2005
  7. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
  8. pmc Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney
    Chun Cheng Hou
    Department of Medicine, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Am J Pathol 166:761-71. 2005
  9. ncbi request reprint Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7
    Wansheng Wang
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Alkek N520, Houston, Texas 77030, USA
    J Am Soc Nephrol 16:1371-83. 2005
  10. pmc Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications
    Vijay Koka
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 113:1353-60. 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
    Hui Y Lan
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Nephrol Hypertens 12:25-9. 2003
    ..This review describes the recent findings in the context of the tubular epithelial-myofibroblast transdifferentiation process and discusses the possible mechanisms involved...
  2. ncbi request reprint Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    Hui Y Lan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 14:1535-48. 2003
    ..TGF-beta-mediated renal fibrosis is regulated positively by Smad2/3, but negatively by Smad7. Target blockade of TGF-beta/Smad signaling by expression of Smad7 may provide a new therapeutic potential for renal fibrosis...
  3. ncbi request reprint Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes
    Arup Chakraborty
    Renal Section, Dept of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Renal Physiol 292:F895-904. 2007
    ..The data suggest that STC1 plays a critical role in transendothelial migration of inflammatory cells and is involved in the regulation of numerous aspects of endothelial function...
  4. ncbi request reprint Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
    ..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic...
  5. ncbi request reprint Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7
    Wansheng Wang
    Dept of Medicine Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 293:F1123-30. 2007
    ..Our results show that potassium supplementation can reduce renal inflammation and hence, could modulate the progression of kidney injury in CKD...
  6. ncbi request reprint Transforming growth factor-beta and Smad signalling in kidney diseases
    Wansheng Wang
    Department of Medicine Nephrology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nephrology (Carlton) 10:48-56. 2005
    ..Thus, targeting Smad signalling by overexpression of Smad7 may have great therapeutic potential for kidney diseases...
  7. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  8. pmc Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney
    Chun Cheng Hou
    Department of Medicine, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Am J Pathol 166:761-71. 2005
    ....
  9. ncbi request reprint Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7
    Wansheng Wang
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Alkek N520, Houston, Texas 77030, USA
    J Am Soc Nephrol 16:1371-83. 2005
    ..Smad7-mediated inhibition of NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation...
  10. pmc Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications
    Vijay Koka
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 113:1353-60. 2006
    ..However, the mechanism of induction of chymase in diabetes remains unknown...
  11. ncbi request reprint Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
    Ping Fu
    Department of Medicine Nephrology, West China Hospital of Sichuan University, Chengdu, China
    J Am Soc Nephrol 17:3105-14. 2006
    ..The interplay between the Rho/Rho kinase pathway and the Smad signaling pathway may be a key mechanism by which loss of ROCK1 does not prevent renal fibrosis in the UUO model...
  12. pmc Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease
    Xiao R Huang
    Department of Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong, China
    Am J Physiol Renal Physiol 295:F118-27. 2008
    ..Inhibition of renal TGF-beta1 expression and activation, thereby blocking the downstream TGF-beta signaling pathway, may be a critical mechanism by which latent TGF-beta1 protects against renal fibrosis...
  13. ncbi request reprint TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
    Takahiko Nakagawa
    Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:605-13. 2004
    ..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear...
  14. ncbi request reprint Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F658-64. 2004
    ..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease...
  15. ncbi request reprint Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation
    Jin H Li
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 13:1464-72. 2002
    ....
  16. ncbi request reprint Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease
    Jin H Li
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:176-8. 2004
    ..Thus, AGEs act by activating Smad signaling to mediate diabetic complications via both TGF-beta-dependent and -independent pathways, shedding new light on the pathogenesis of diabetic organ injury...
  17. ncbi request reprint Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
    Hypertension 41:1287-93. 2003
    ..Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease...
  18. ncbi request reprint Role of TGF-beta signaling in extracellular matrix production under high glucose conditions
    Jin H Li
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Kidney Int 63:2010-9. 2003
    ..We hypothesize that this may be mediated by activating transforming growth factor-beta (TGF-beta)/Smads signaling...
  19. ncbi request reprint Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease
    Xiao R Huang
    Departments of Medicine Nephrology and Pathology, Baylor College of Medicine, One Baylor Plaza, Alkek N520, Houston, TX 77030, USA
    J Am Soc Nephrol 14:1738-47. 2003
    ..Results from this study suggest that blockade of both AngII-generating pathways may provide additional beneficial effect on diabetic nephropathy...
  20. pmc Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway
    Jin H Li
    Departments of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 164:1389-97. 2004
    ..The findings from this study suggest that targeting the RAGE or the ERK MAP kinase pathway may provide new therapeutic strategies for diabetic nephropathy and shed new light on the pathogenesis of diabetic nephropathy...
  21. ncbi request reprint Effects of Smad7 overexpression on peritoneal inflammation in a rat peritoneal dialysis model
    Jing Nie
    Department of Nephrology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Perit Dial Int 27:580-8. 2007
    ..In this study, we examined the effects of the TGF-beta signaling pathway on peritoneal inflammation associated with PD in rats by over-expressing Smad7, an inhibitor of TGF-beta/Smad signaling...
  22. doi request reprint XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells
    Liang Qiao
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Tumour Biol 29:122-9. 2008
    ..XIAP-associated factor 1 (XAF1) is a tumor suppressor gene, but its role in angiogenesis is unknown. We investigated whether XAF1 has any antiangiogenesis effect...
  23. pmc Latent TGF-beta1 protects against crescentic glomerulonephritis
    Xiao R Huang
    Department of Medicine, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, China
    J Am Soc Nephrol 19:233-42. 2008
    ....
  24. ncbi request reprint Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 282:F991-7. 2002
    ..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system...
  25. ncbi request reprint Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection
    Hai Ying Zhang
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Liver Int 25:571-9. 2005
    ..Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases...
  26. ncbi request reprint Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques
    Yao zhong Kong
    Department of Medicine, The First People s Foshan Hospital, Foshan, Guangdong, China
    Atherosclerosis 178:207-15. 2005
    ..The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques...
  27. ncbi request reprint Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells
    Susumu Watanabe
    Baylor College of Medicine, Houston, Tex, USA
    Am J Nephrol 24:387-92. 2004
    ..We hypothesized that this stimulation occurs via the JAK (janus-activated kinase)/STAT (signal and transducers and activators of transcription) signaling pathway...
  28. ncbi request reprint Effects of cyclosporine in osteopontin null mice
    Marilda Mazzali
    Division of Nephrology, Department of Pathology, University of Washington, Seattle, Washington, USA
    Kidney Int 62:78-85. 2002
    ..This study tested the hypothesis that the absence of OPN would ameliorate CsA nephropathy...
  29. doi request reprint Role of macrophage migration inhibition factor in kidney disease
    Hui Y Lan
    Department of Medicine and Center for Inflammatory Diseases and Molecular Therapies, The University of Hong Kong, Hong Kong, SAR, China
    Nephron Exp Nephrol 109:e79-83. 2008
    ..MIF plays a critical role in kidney diseases and further studies of the functional role and signaling mechanisms of MIF in human kidney diseases are needed...

Research Grants2

  1. ANGIOTENSIN II-SMAD SIGNALING IN CARDIAC FIBROSIS
    Hui Lan; Fiscal Year: 2005
    ..We expect that the outcomes obtained will support the central hypothesis, providing new insights into the pathogenesis of Ang ll-mediated cardiac fibrosis and information for the development of new therapeutic strategies. ..
  2. SMAD SIGNALING IN ANGIOTENSIN II-MEDIATED RENAL FIBROSIS
    Hui Lan; Fiscal Year: 2005
    ....