Rajesh Kumar

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. doi Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors
    Qian Chen Yong
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine Scott and White Central Texas Veterans Health Care System, 1901 South First Street, Building 205, Temple, Texas 76504, USA
    Cardiovasc Diabetol 12:169. 2013
  2. doi The intracrine renin-angiotensin system
    Rajesh Kumar
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Clin Sci (Lond) 123:273-84. 2012
  3. doi Diversity of pathways for intracellular angiotensin II synthesis
    Rajesh Kumar
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Temple, Texas, USA
    Curr Opin Nephrol Hypertens 18:33-9. 2009
  4. doi Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
    Vivek P Singh
    Cardiovascular Research Institute, Texas A and M HSC, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 294:H1675-84. 2008
  5. doi Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor
    CANDICE M THOMAS
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine Scott and White Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Clin Sci (Lond) 124:529-41. 2013
  6. pmc Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
    Vivek P Singh
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX, USA
    Diabetes 57:3297-306. 2008
  7. ncbi High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes
    Vivek P Singh
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 293:H939-48. 2007
  8. doi Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline
    Sandeep Kumar
    Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A and M Health Science Center, Scott and White Hospital, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Am J Physiol Heart Circ Physiol 302:H1655-66. 2012
  9. ncbi Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system
    Sandhya Sanghi
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, TX, USA
    Regul Pept 132:1-8. 2005
  10. ncbi The intracellular renin-angiotensin system: a new paradigm
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
    Trends Endocrinol Metab 18:208-14. 2007

Collaborators

Detail Information

Publications19

  1. doi Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors
    Qian Chen Yong
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine Scott and White Central Texas Veterans Health Care System, 1901 South First Street, Building 205, Temple, Texas 76504, USA
    Cardiovasc Diabetol 12:169. 2013
    ..In cardiac myocytes, intracellular angiotensin (ANG) II synthesis and actions are ACE and AT1 independent, respectively. However, a role of this system in diabetes-induced organ damage is not clear...
  2. doi The intracrine renin-angiotensin system
    Rajesh Kumar
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Clin Sci (Lond) 123:273-84. 2012
    ..The intracellular RAS is a relatively new concept for the RAS. The present review provides a synopsis of the literature on this system in different tissues...
  3. doi Diversity of pathways for intracellular angiotensin II synthesis
    Rajesh Kumar
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Temple, Texas, USA
    Curr Opin Nephrol Hypertens 18:33-9. 2009
    ..In this review, evidence of the intracellular RAS and the mechanism of Ang II synthesis in various cell types will be discussed...
  4. doi Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
    Vivek P Singh
    Cardiovascular Research Institute, Texas A and M HSC, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 294:H1675-84. 2008
    ....
  5. doi Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor
    CANDICE M THOMAS
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine Scott and White Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Clin Sci (Lond) 124:529-41. 2013
    ..Activation of PLZF by PRR represented a novel mechanism in diabetic cardiomyopathy. Differential effects of the three agents on oxidative stress, cytokines and PRR expression suggested subtle differences in their mechanisms of action...
  6. pmc Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
    Vivek P Singh
    Division of Molecular Cardiology, Department of Medicine, Texas A and M Health Science Center, College of Medicine, Scott and White, Central Texas Veterans Health Care System, Temple, TX, USA
    Diabetes 57:3297-306. 2008
    ..In the present study, we determined whether hyperglycemia activates the cardiac intracellular renin-Ang system (RAS) in vivo and whether ARBs, ACE, or renin inhibitors block synthesis and effects of intracellular Ang II (iAng II)...
  7. ncbi High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes
    Vivek P Singh
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 293:H939-48. 2007
    ..Significantly, NRVM synthesized and retained ANG II intracellularly, which redistributed to the nucleus under high-glucose conditions, suggesting a role for an intracrine mechanism in diabetic conditions...
  8. doi Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline
    Sandeep Kumar
    Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A and M Health Science Center, Scott and White Hospital, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Am J Physiol Heart Circ Physiol 302:H1655-66. 2012
    ..Eur Respir J 22: 358-363, 2003)...
  9. ncbi Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system
    Sandhya Sanghi
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, TX, USA
    Regul Pept 132:1-8. 2005
    ..These findings suggest that unlike in plasma, ANP positively regulates the RAS in cardiac fibroblasts, which may have a significant role in development of the fetal heart...
  10. ncbi The intracellular renin-angiotensin system: a new paradigm
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
    Trends Endocrinol Metab 18:208-14. 2007
    ..A more comprehensive understanding of the intracellular RAS provides for new strategies in system regulation and a more efficacious approach to the management of RAS-related diseases...
  11. pmc Intracardiac intracellular angiotensin system in diabetes
    Rajesh Kumar
    Division of Molecular Cardiology, Texas A and M Health Science Center, College of Medicine, Temple, TX 76504, USA
    Am J Physiol Regul Integr Comp Physiol 302:R510-7. 2012
    ..We have discussed the significance of an intracellular RAS in cardiac pathophysiology and implications for potential therapies...
  12. doi The intracellular renin-angiotensin system: implications in cardiovascular remodeling
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, Texas, USA
    Curr Opin Nephrol Hypertens 17:168-73. 2008
    ..Here, we address the cardiovascular effects of angiotensin II and the role an intracellular renin-angiotensin system might play...
  13. doi Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules
    Sandeep Kumar
    Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A and M Health Science Center, College Station, TX 77840, USA
    Free Radic Biol Med 50:206-15. 2011
    ..The study highlights the importance of the NF-κB signaling pathway and therapeutic benefits of PDTC treatment in cardiac remodeling...
  14. ncbi The intracellular renin-angiotensin system in the heart
    Rajesh Kumar
    Curr Hypertens Rep 11:104-10. 2009
    ..We describe the physiology of the intracellular RAS, potential pathologic roles of intracellular Ang II, and the relevance of the intracellular system in view of recent clinical trials involving various RAS inhibitors...
  15. pmc Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance
    Yajuan Qi
    Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A and M University Health Science Center, and Scott and White, Central Texas Veterans Health Care System, Temple, Texas
    Diabetes 62:3887-900. 2013
    ....
  16. pmc Do multiple nuclear factor kappa B activation mechanisms explain its varied effects in the heart?
    Rajesh Kumar
    Division of Molecular Cardiology, College of Medicine, Texas A and M Health Science Center, Scott and White Healthcare, and Central Texas Veterans Health Care System, Temple, TX
    Ochsner J 13:157-65. 2013
    ..Furthermore, NF-κB is a pleiotropic transcription factor that receives signals from multiple pathways, including the renin-angiotensin system (RAS) and cytokines, 2 important modulators of cardiac remodeling...
  17. ncbi Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy
    Kenneth M Baker
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, College of Medicine, 1901 S 1st Street, Building 205, Temple 76504, USA
    Regul Pept 120:5-13. 2004
    ..These data demonstrate a previously unknown growth mechanism of Ang II in the heart, which should be considered when designing therapeutic strategies to block Ang II actions...
  18. ncbi Intracellular angiotensin II induces cell proliferation independent of AT1 receptor
    Kenneth M Baker
    Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Am J Physiol Cell Physiol 291:C995-1001. 2006
    ..These data demonstrate that intracrine ANG II can act independent of AT(1) receptors and suggest novel intracellular mechanisms of action for ANG II...
  19. ncbi Kinase inhibitors for cardiovascular disease
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    J Mol Cell Cardiol 42:1-11. 2007
    ..We review potential protein kinase targets and recent evidence supporting therapeutic interventional value in CVDs...