Russell D Klein
Affiliation: Texas Medical Center
- Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cellsRussell D Klein
The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
Carcinogenesis 23:217-21. 2002....
- Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variantsBobby Bhatia
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
J Biol Chem 278:25091-100. 2003..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization...
- Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cellsShaohua Tang
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
J Biol Chem 277:16189-201. 2002..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
- Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpressionJennifer Kl Colby
Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
Neoplasia 10:782-96. 2008..The progressive nature of the metaplastic/dysplastic changes observed in this model make it a valuable tool for examining the transition from chronic inflammation to neoplasia...
- SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effectsJoyce E Rundhaug
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 42:40-52. 2005....
- Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancerAaron M Sargeant
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1291, USA
Toxicol Pathol 35:549-61. 2007..We conclude that targeting of the PDK1/Akt pathway has chemopreventive relevance in prostate cancer and causes other in vivo effects mediated in part by an alteration of bioenergetic signaling...
- Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinomaViola C Ruddat
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Prostate 64:128-38. 2005..Gleason grading is currently the predominant method for prediction, with only few biomarkers available. More biomarkers, especially as they relate to cancer progression are desirable...
- Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cellsPeiying Yang
Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
J Lipid Res 45:1030-9. 2004..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation...
- A role for the WWOX gene in prostate cancerHaiyan R Qin
Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Cancer Res 66:6477-81. 2006..The data are consistent with a role for WWOX as a prostate cancer tumor suppressor and suggest that WWOX signal pathways should be further investigated in normal and cancerous prostate cells and tissues...
- Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathwayXingya Wang
The Ohio State University, Department of Human Nutrition and the Ohio State University Comprehensive Cancer Center, Cancer Chemoprevention Program, Campbell Hall, Columbus, Ohio 43210, USA
Mol Carcinog 46:912-23. 2007..We conclude that PGE2-induced VEGF secretion in prostate cancer cells is mediated through EP2-, and possibly EP4-, dependent cAMP signaling pathways...
- The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissueXingya Wang
Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
Carcinogenesis 29:120-8. 2008..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
- OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate modelAaron M Sargeant
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA
Cancer Res 68:3999-4009. 2008..These results suggest that OSU-HDAC42 has value in prostate cancer prevention. [Cancer Res 2008;68(10):3999-4009]...
- The use of genetically engineered mouse models of prostate cancer for nutrition and cancer chemoprevention researchRussell D Klein
Department of Human Nutrition and Cancer Chemoprevention and Support Program, Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, Columbus, 43210, USA
Mutat Res 576:111-9. 2005....