Russell D Klein

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells
    Russell D Klein
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 23:217-21. 2002
  2. ncbi request reprint Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
    Bobby Bhatia
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    J Biol Chem 278:25091-100. 2003
  3. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
  4. pmc Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression
    Jennifer Kl Colby
    Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Neoplasia 10:782-96. 2008
  5. ncbi request reprint SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 42:40-52. 2005
  6. ncbi request reprint Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer
    Aaron M Sargeant
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1291, USA
    Toxicol Pathol 35:549-61. 2007
  7. ncbi request reprint Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma
    Viola C Ruddat
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Prostate 64:128-38. 2005
  8. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004
  9. ncbi request reprint A role for the WWOX gene in prostate cancer
    Haiyan R Qin
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 66:6477-81. 2006
  10. ncbi request reprint Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway
    Xingya Wang
    The Ohio State University, Department of Human Nutrition and the Ohio State University Comprehensive Cancer Center, Cancer Chemoprevention Program, Campbell Hall, Columbus, Ohio 43210, USA
    Mol Carcinog 46:912-23. 2007

Collaborators

  • Haiyen Zhau
  • Robert A Newman
  • Ronald A Lubet
  • David G Johnson
  • Claudio J Conti
  • Janet Sawicki
  • Scott B Shappell
  • S M Fischer
  • Leland W Chung
  • DEAN TANG
  • Shuho Semba
  • Xingya Wang
  • Peiying Yang
  • Aaron M Sargeant
  • Bobby Bhatia
  • Shaohua Tang
  • Jennifer Kl Colby
  • Steven K Clinton
  • Ching Shih Chen
  • Robert C Rengel
  • Samuel K Kulp
  • Haiyan R Qin
  • Joyce E Rundhaug
  • Viola C Ruddat
  • Dharam Chopra
  • Carlos J Maldonado
  • Dhyan Chandra
  • Mark J McArthur
  • Toru Kawamoto
  • Yu Chieh Wang
  • Amy I Pavone
  • Kaoru Kiguchi
  • Penny K Riggs
  • Jennifer K L Colby
  • Mamoru Yamaguchi
  • Yoko Kashida
  • Carl D Morrison
  • Dimitrios Iliopoulos
  • Teresa Druck
  • Kay Huebner
  • Muller Fabbri
  • Carlo M Croce
  • Stefano Volinia
  • Stephanie Whitman
  • Amy Pavone
  • Sally Gaddis
  • Hyunsuk Kil
  • Theodore R Holman
  • Thomas R Berton
  • Kathleen A Hawkins
  • Elisabeth McCauley
  • C Marcelo Aldaz
  • Diana Chan
  • David G Menter
  • Edward Felix
  • Carrie Cartwright
  • Timothy Madden
  • Jeanine Traag
  • Jianjun Shen
  • Junwei Liu

Detail Information

Publications13

  1. ncbi request reprint Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells
    Russell D Klein
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 23:217-21. 2002
    ....
  2. ncbi request reprint Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
    Bobby Bhatia
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    J Biol Chem 278:25091-100. 2003
    ..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization...
  3. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  4. pmc Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression
    Jennifer Kl Colby
    Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Neoplasia 10:782-96. 2008
    ..The progressive nature of the metaplastic/dysplastic changes observed in this model make it a valuable tool for examining the transition from chronic inflammation to neoplasia...
  5. ncbi request reprint SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 42:40-52. 2005
    ....
  6. ncbi request reprint Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer
    Aaron M Sargeant
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1291, USA
    Toxicol Pathol 35:549-61. 2007
    ..We conclude that targeting of the PDK1/Akt pathway has chemopreventive relevance in prostate cancer and causes other in vivo effects mediated in part by an alteration of bioenergetic signaling...
  7. ncbi request reprint Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma
    Viola C Ruddat
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Prostate 64:128-38. 2005
    ..Gleason grading is currently the predominant method for prediction, with only few biomarkers available. More biomarkers, especially as they relate to cancer progression are desirable...
  8. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004
    ..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation...
  9. ncbi request reprint A role for the WWOX gene in prostate cancer
    Haiyan R Qin
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 66:6477-81. 2006
    ..The data are consistent with a role for WWOX as a prostate cancer tumor suppressor and suggest that WWOX signal pathways should be further investigated in normal and cancerous prostate cells and tissues...
  10. ncbi request reprint Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway
    Xingya Wang
    The Ohio State University, Department of Human Nutrition and the Ohio State University Comprehensive Cancer Center, Cancer Chemoprevention Program, Campbell Hall, Columbus, Ohio 43210, USA
    Mol Carcinog 46:912-23. 2007
    ..We conclude that PGE2-induced VEGF secretion in prostate cancer cells is mediated through EP2-, and possibly EP4-, dependent cAMP signaling pathways...
  11. ncbi request reprint The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue
    Xingya Wang
    Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
    Carcinogenesis 29:120-8. 2008
    ..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
  12. doi request reprint OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model
    Aaron M Sargeant
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 68:3999-4009. 2008
    ..These results suggest that OSU-HDAC42 has value in prostate cancer prevention. [Cancer Res 2008;68(10):3999-4009]...
  13. ncbi request reprint The use of genetically engineered mouse models of prostate cancer for nutrition and cancer chemoprevention research
    Russell D Klein
    Department of Human Nutrition and Cancer Chemoprevention and Support Program, Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, Columbus, 43210, USA
    Mutat Res 576:111-9. 2005
    ....