John Klein

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Small intestine inflammation in Roquin-mutant and Roquin-deficient mice
    Jeremy S Schaefer
    Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center School of Dentistry, Houston, Texas, United States of America
    PLoS ONE 8:e56436. 2013
  2. ncbi request reprint T-cell activation in the curious world of the intestinal intraepithelial lymphocyte
    John R Klein
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Immunol Res 30:327-37. 2004
  3. ncbi request reprint Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid
    John R Klein
    Dental Branch, Department of Diagnostic Sciences, The University of Texas Health Science Center at Houston, Room 4 133, 6516 M D Anderson Blvd, Houston, TX 77030, USA
    Autoimmunity 36:417-21. 2003
  4. ncbi request reprint Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis
    John R Klein
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Exp Biol 207:55-65. 2004
  5. pmc The immune system as a regulator of thyroid hormone activity
    John R Klein
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Room 3 094F, Dental Branch, 6516 MD Anderson Boulevard, 77030, USA
    Exp Biol Med (Maywood) 231:229-36. 2006
  6. ncbi request reprint Maximum immunobioactivity of murine small intestinal intraepithelial lymphocytes resides in a subpopulation of CD43+ T cells
    Heuy Ching Wang
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, 6516 M D Anderson Boulevard, Houston, TX 77030, USA
    J Immunol 173:6294-302. 2004
  7. pmc T-cell activation in the intestinal mucosa
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX, USA
    Immunol Rev 215:189-201. 2007
  8. pmc Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biochem Biophys Res Commun 342:782-90. 2006
  9. pmc Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets
    Dina Montufar-Solis
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Dental Branch, Houston, TX 77030, USA
    J Leukoc Biol 82:1166-73. 2007
  10. pmc Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells
    Shaun Varghese
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Cell Biochem 105:271-6. 2008

Research Grants

  1. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2003
  2. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2009
  3. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John R Klein; Fiscal Year: 2010
  4. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2001
  5. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2009
  6. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2007
  7. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2006
  8. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2005
  9. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2002
  10. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2002

Collaborators

  • Nadarajah Vigneswaran
  • P R Wyde
  • C M Flaitz
  • Dina Montufar-Solis
  • Jeremy S Schaefer
  • Heuy Ching Wang
  • Tomas Garza
  • Kevin Otten
  • Qin Zhou
  • Jolene Dragoo
  • Shaun Varghese
  • Ba Bie Teng
  • Virginia L Scofield
  • Kevin McGrory
  • Niyati Nakra
  • M John Hicks
  • Bryce H Vincent
  • Jeremy Schaefer
  • Mary K Estes
  • Elly Cheng

Detail Information

Publications24

  1. pmc Small intestine inflammation in Roquin-mutant and Roquin-deficient mice
    Jeremy S Schaefer
    Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center School of Dentistry, Houston, Texas, United States of America
    PLoS ONE 8:e56436. 2013
    ....
  2. ncbi request reprint T-cell activation in the curious world of the intestinal intraepithelial lymphocyte
    John R Klein
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Immunol Res 30:327-37. 2004
    ..These and other issues central to the operational workings of the intestinal immune system are elaborated in this article, and a model is presented in which IEL activation can be viewed as a layered, three-stage activational process...
  3. ncbi request reprint Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid
    John R Klein
    Dental Branch, Department of Diagnostic Sciences, The University of Texas Health Science Center at Houston, Room 4 133, 6516 M D Anderson Blvd, Houston, TX 77030, USA
    Autoimmunity 36:417-21. 2003
    ....
  4. ncbi request reprint Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis
    John R Klein
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Exp Biol 207:55-65. 2004
    ..These findings define a novel bone marrow-derived hematopoietic cell population that resides in the thyroid of normal mice, which may have a unique role in the microregulation of thyroid physiology and homeostasis...
  5. pmc The immune system as a regulator of thyroid hormone activity
    John R Klein
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Room 3 094F, Dental Branch, 6516 MD Anderson Boulevard, 77030, USA
    Exp Biol Med (Maywood) 231:229-36. 2006
    ..In this article, the basic underpinnings of the hematopoietic-thyroid connection are described, and a model is presented in which the immune system participates in the regulation of thyroid hormone activity during acute infection...
  6. ncbi request reprint Maximum immunobioactivity of murine small intestinal intraepithelial lymphocytes resides in a subpopulation of CD43+ T cells
    Heuy Ching Wang
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, 6516 M D Anderson Boulevard, Houston, TX 77030, USA
    J Immunol 173:6294-302. 2004
    ..These findings define two functionally distinct populations of IELs based on CD43 expression independent of TCR class, and they identify a subset of IELs that may serve as a target to better control intestinal inflammation...
  7. pmc T-cell activation in the intestinal mucosa
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX, USA
    Immunol Rev 215:189-201. 2007
    ..We discuss how costimulatory molecules may hold the key to controlling IEL activation through a multiphase process beginning with cells that have already entered into the early stage of activation...
  8. pmc Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biochem Biophys Res Commun 342:782-90. 2006
    ....
  9. pmc Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets
    Dina Montufar-Solis
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Dental Branch, Houston, TX 77030, USA
    J Leukoc Biol 82:1166-73. 2007
    ..These findings point to distinctly different activational effects of IL-18 on IELs, both with regard to the type of functional responses elicited and with respect to the IEL subsets affected...
  10. pmc Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells
    Shaun Varghese
    Department of Diagnostic Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Cell Biochem 105:271-6. 2008
    ..These findings have direct functional implications for understanding a TSH immune-endocrine circuit in the small intestine...
  11. ncbi request reprint An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Rm 3 094F, University of Texas Health Science Center at Houston, Dental Branch, 6516 MD Anderson Blvd, Houston, TX 77030, USA
    J Immunol Methods 308:251-4. 2006
    ..It is expected that this procedure will have practical benefit as a means of isolating IELs with high purity on a routine basis that can be used for in vivo or in vitro studies of IEL function...
  12. ncbi request reprint An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells
    Heuy Ching Wang
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center at Houston, 77030, USA
    Blood 101:119-23. 2003
    ....
  13. ncbi request reprint Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells
    Heuy Ching Wang
    Dental Branch, Department of Basic Sciences, University of Texas Health Science Center, Houston 77030, USA
    J Immunol 169:4717-22. 2002
    ..These data also imply that under appropriate conditions it is possible for T cells to be sustained in a state of partial activation...
  14. pmc Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX, USA
    Biochem Biophys Res Commun 338:1158-63. 2005
    ..These findings open the way to a better understanding of the process by which T cells are activated in the intestinal epithelium...
  15. pmc ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice
    Jeremy S Schaefer
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Leukoc Biol 87:301-8. 2010
    ..These findings implicate ICOS as an activational signal of Th17 cells during chronic intestinal inflammation, and they suggest that under some conditions, control of ICOS expression may help to suppress chronic intestinal inflammation...
  16. pmc A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid
    Jeremy S Schaefer
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Gen Comp Endocrinol 162:241-4. 2009
    ..These findings identify an unknown splice variant of human TSHbeta. They also have implications for immune-endocrine interactions in the thyroid and for understanding autoimmune thyroid disease from a new perspective...
  17. pmc Massive but selective cytokine dysregulation in the colon of IL-10-/- mice revealed by multiplex analysis
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, 6516 MD Anderson Boulevard, Houston, TX, USA
    Int Immunol 20:141-54. 2008
    ..These findings emphasize the need to better understand cytokine networks in chronic inflammation and they provide a rationale for combining immunotherapies in the treatment of intestinal inflammation...
  18. ncbi request reprint Chemokine changes during oral wound healing
    Kevin McGrory
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biochem Biophys Res Commun 324:317-20. 2004
    ..These findings have implications for developing therapeutic strategies aimed at promoting more effective tissue healing at oral surfaces...
  19. ncbi request reprint Characterization of novel anti-mouse thyrotropin monoclonal antibodies
    Qin Zhou
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center, 6516 MD Anderson Blvd, Houston, TX 77030, USA
    Hybrid Hybridomics 21:75-9. 2002
    ....
  20. pmc Immunological regulation of metabolism--a novel quintessential role for the immune system in health and disease
    Jeremy S Schaefer
    Department of Diagnostic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77054, USA
    FASEB J 25:29-34. 2011
    ..This hypothesis, which is amenable to empirical analysis, defines a previously unknown role for the immune system in health and disease, and it provides a dynamic connection between immune-endocrine interactions at the organismic level...
  21. ncbi request reprint Antigen-induced chemokine activation in mouse buccal epithelium
    Kevin Otten
    Department of Basic Sciences, University of Texas Health Science Center, Dental Branch, Rm 4 133, 6516 M D Anderson Blvd, Houston, TX 77030, USA
    Biochem Biophys Res Commun 304:36-40. 2003
    ....
  22. ncbi request reprint Modulation of gamma delta T cells in mouse buccal epithelium following antigen priming
    Kevin Otten
    Department of Basic Sciences, University of Texas Health Science Center Houston, Dental Branch, Houston, TX 77030, USA
    Biochem Biophys Res Commun 294:626-9. 2002
    ....
  23. pmc Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection
    Dina Montufar-Solis
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Centre at Houston, Houston, TX 77030, USA
    Int J Exp Pathol 91:276-80. 2010
    ..These findings suggest that sgp130 may have a beneficial effect during intestinal virus infection by disrupting interleukin-6 trans-signalling, thereby reducing the local inflammatory response...
  24. pmc Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection
    Virginia L Scofield
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
    Immunol Lett 99:36-44. 2005
    ..These findings lend credence to the notion that TSH plays a role both in the development of intestinal T cells, and in the process of local immunity during enteric virus infection...

Research Grants11

  1. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2003
    ..Phenotypic analyses will be done using lymphocytes from gastrointestinal inflammatory sites, and characterization of hormone-activated regulatory and effector cells will be identified through adoptive transfer experiments. ..
  2. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2009
    ..abstract_text> ..
  3. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John R Klein; Fiscal Year: 2010
    ..These studies will use in vitro approaches and in vivo gene therapy strategies to explore the involvement of Roquin, under the influence of IL-10, in the control of colonic IL-17 expression. ..
  4. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2001
    ..Phenotypic analyses will be done using lymphocytes from gastrointestinal inflammatory sites, and characterization of hormone-activated regulatory and effector cells will be identified through adoptive transfer experiments. ..
  5. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2009
    ..abstract_text> ..
  6. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2007
    ..abstract_text> ..
  7. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2006
    ..abstract_text> ..
  8. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2005
    ..abstract_text> ..
  9. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2002
    ..Phenotypic analyses will be done using lymphocytes from gastrointestinal inflammatory sites, and characterization of hormone-activated regulatory and effector cells will be identified through adoptive transfer experiments. ..
  10. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2002
    ..Phenotypic analyses will be done using lymphocytes from gastrointestinal inflammatory sites, and characterization of hormone-activated regulatory and effector cells will be identified through adoptive transfer experiments. ..