Eric Klann

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  2. ncbi request reprint Biochemical mechanisms for translational regulation in synaptic plasticity
    Eric Klann
    Departments of Molecular Physiology and Biophysics and Neuroscience, Baylor College of Medicine, One Baylor Plaza BCM 335, Houston, TX 77030, USA
    Nat Rev Neurosci 5:931-42. 2004
  3. ncbi request reprint Synaptic plasticity and translation initiation
    Eric Klann
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 11:365-72. 2004
  4. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008
  5. pmc Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
    Jing Zhang
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    J Neurophysiol 101:2572-80. 2009
  6. pmc Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease
    Kenneth T Kishida
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza BCM 335, Houston, TX 77030, USA
    Mol Cell Biol 26:5908-20. 2006
  7. ncbi request reprint Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 51:441-54. 2006
  8. doi request reprint Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK
    A Tara Huddleston
    Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    J Neurophysiol 99:1565-71. 2008
  9. ncbi request reprint The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:13161-72. 2007
  10. pmc Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity
    Marcia D Antion
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 15:29-38. 2008

Collaborators

Detail Information

Publications49

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  2. ncbi request reprint Biochemical mechanisms for translational regulation in synaptic plasticity
    Eric Klann
    Departments of Molecular Physiology and Biophysics and Neuroscience, Baylor College of Medicine, One Baylor Plaza BCM 335, Houston, TX 77030, USA
    Nat Rev Neurosci 5:931-42. 2004
    ..In this review, we highlight these translational regulatory mechanisms and the signalling pathways that govern the expression of synaptic plasticity in response to specific types of neuronal stimulation...
  3. ncbi request reprint Synaptic plasticity and translation initiation
    Eric Klann
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 11:365-72. 2004
    ....
  4. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008
    ..Our results indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors...
  5. pmc Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
    Jing Zhang
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    J Neurophysiol 101:2572-80. 2009
    ..These results indicated that both FMRP and FXR2P function in synaptic plasticity and that they likely operate in related but independent pathways...
  6. pmc Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease
    Kenneth T Kishida
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza BCM 335, Houston, TX 77030, USA
    Mol Cell Biol 26:5908-20. 2006
    ..Taken together, our results are consistent with NADPH oxidase being required for hippocampal synaptic plasticity and memory and are consistent with reports of cognitive dysfunction in patients with CGD...
  7. ncbi request reprint Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 51:441-54. 2006
    ..These findings indicate that the translation, ubiquitination, and proteolysis of FMRP functions as a dynamic regulatory system for controlling synaptic plasticity...
  8. doi request reprint Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK
    A Tara Huddleston
    Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    J Neurophysiol 99:1565-71. 2008
    ..Thus superoxide-induced potentiation requires the redox targeting of RyR3 and the subsequent activation of ERK...
  9. ncbi request reprint The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:13161-72. 2007
    ..We propose a model in which RCAN1 plays a positive role in L-LTP and memory by constraining phosphatase signaling...
  10. pmc Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity
    Marcia D Antion
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 15:29-38. 2008
    ..Our observations suggest that neither gene by itself is required for L-LTP but instead may be required for other types of synaptic plasticity required for cognitive processing...
  11. pmc NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1
    Kenneth T Kishida
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 94:299-306. 2005
    ..Taken together, our results suggest that ROS production, especially superoxide production via NADPH oxidase, is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1...
  12. ncbi request reprint Superoxide dismutase and hippocampal function: age and isozyme matter
    Daoying Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Antioxid Redox Signal 9:201-10. 2007
    ..The work discussed in this review has important implications for the use of antioxidant treatments and for our understanding of the role of superoxide in physiological and pathological processes...
  13. ncbi request reprint NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1
    Jessica L Banko
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 91:462-70. 2004
    ....
  14. pmc Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
    Daoying Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Learn Mem 87:372-84. 2007
    ..These findings increase our knowledge of the role of mitochondrial superoxide in physiological and pathological processes in the brain...
  15. pmc Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease
    Cynthia A Massaad
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e10561. 2010
    ..In addition, a general state of oxidation has long been known to be a major hallmark of the disease. What is not known however, are the mechanisms by which oxidative stress contributes to the pathology of AD...
  16. pmc Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
    Cynthia A Massaad
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:13576-81. 2009
    ..These findings directly link mitochondrial superoxide to AD pathology and demonstrate the beneficial effects of a mitochondrial anti-oxidant enzyme, hence offering significant therapeutic implications for AD...
  17. ncbi request reprint Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression
    Jessica L Banko
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:2167-73. 2006
    ..Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD...
  18. ncbi request reprint Translocation and activation of Rac in the hippocampus during associative contextual fear learning
    Luis A Martinez
    Department of Molecular Physiology, Baylor College of Medicine, One Bayor Plaza, Houston, TX 77030, USA
    Neurobiol Learn Mem 88:104-13. 2007
    ..Our data indicate that NMDA receptor-dependent associative fear learning alters Rac localization and function in the mouse hippocampus...
  19. ncbi request reprint Behavioral alterations in mice lacking the translation repressor 4E-BP2
    Jessica L Banko
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Neurobiol Learn Mem 87:248-56. 2007
    ....
  20. pmc NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1
    Maria V Tejada-Simon
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Biochem Biophys Res Commun 343:504-12. 2006
    ..Taken together, our data are consistent with the idea that Rac could be participating in NMDA receptor-dependent changes in morphology that occur during synaptic plasticity and memory formation in the adult mouse hippocampus...
  21. pmc Sources and targets of reactive oxygen species in synaptic plasticity and memory
    Kenneth T Kishida
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    Antioxid Redox Signal 9:233-44. 2007
    ....
  22. ncbi request reprint Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase
    Daoying Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:3933-41. 2006
    ..We conclude that there is an age-dependent alteration in the role of superoxide in modulating synaptic plasticity and learning and memory...
  23. ncbi request reprint The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus
    Jessica L Banko
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:9581-90. 2005
    ..These results suggest a crucial role for proper regulation of the eIF4F complex by 4E-BP2 during LTP and learning and memory in the mouse hippocampus...
  24. pmc Synaptic localization of a functional NADPH oxidase in the mouse hippocampus
    Maria V Tejada-Simon
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Neurosci 29:97-106. 2005
    ..Taken together, our data suggest that NADPH oxidase is present in mouse hippocampus and might be the source of superoxide production required for LTP and memory function...
  25. pmc Rapid isolation of synaptoneurosomes and postsynaptic densities from adult mouse hippocampus
    Laura Elena Villasana
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    J Neurosci Methods 158:30-6. 2006
    ..Moreover, two different protocols using swing and fixed bucket rotors were used for this small-scale PSD isolation and both resulted in a very pure partition, supporting the idea that this procedure is reliable and consistent...
  26. pmc NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures
    Faridis Serrano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
    Mol Brain 2:31. 2009
    ..In this study we sought to characterize the cellular localization of phosphorylated, active ERK in organotypic hippocampal cultures after acute exposure to either Abeta (1-42) or nicotine...
  27. ncbi request reprint Reactive oxygen species and synaptic plasticity in the aging hippocampus
    Faridis Serrano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Ageing Res Rev 3:431-43. 2004
    ....
  28. pmc Early changes in the apparent diffusion coefficient (ADC) in a mouse model of Sandhoff's disease occur prior to disease symptoms and behavioral deficits
    Lingyun Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Magn Reson Med 62:1175-84. 2009
    ..5 to 4 months of age) and behavioral deficits (3 months of age). The magnitude of the decrease ranged from 4-18%...
  29. pmc Reactive oxygen species in the regulation of synaptic plasticity and memory
    Cynthia A Massaad
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Antioxid Redox Signal 14:2013-54. 2011
    ..The review also shows that the inability to restrain either age- or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function...
  30. ncbi request reprint Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:6352-61. 2004
    ..Together, our findings indicate that activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-LTD and suggest that this pathway may couple group I mGluRs to translation initiation in hippocampal area CA1...
  31. pmc Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome
    Hanoch Kaphzan
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 31:17637-48. 2011
    ..These findings are the first evidence for pathology of intrinsic membrane properties and AIS-specific changes in AS, a neurodevelopmental disorder associated with autism...
  32. ncbi request reprint Role of reactive oxygen species in hippocampal long-term potentiation: contributory or inhibitory?
    Lauren T Knapp
    Department of Molecular Physiology and Biophysics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 70:1-7. 2002
    ..We also discuss possible sources that might be responsible for the production of ROS after the induction of LTP. Finally, we propose a functional ROS continuum to help explain this dichotomy of ROS function in hippocampal LTP...
  33. pmc The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory
    Min Li
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 10:1083-9. 2008
    ..Further, Cdh1 heterozygous mice show defects in late-phase long-term potentiation (L-LTP) in the hippocampus and are deficient in contextual fear-conditioning, suggesting that Cdh1 has a role in learning and memory...
  34. ncbi request reprint NADPH oxidase immunoreactivity in the mouse brain
    Faridis Serrano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Brain Res 988:193-8. 2003
    ..The expression of NADPH oxidase proteins in neurons suggests the possibility that enzymatic production of superoxide by a NADPH oxidase may play a role in both normal neuronal function as well as neurodegeneration in the brain...
  35. ncbi request reprint Metaplastic protein phosphatases
    Eric Klann
    Department of Molecular Physiology and Biophysics and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 9:153-5. 2002
  36. ncbi request reprint Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome
    Richard J Siarey
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, F Edward Hérbert School, Bethesda, Maryland 20814, USA
    J Neurochem 98:1266-77. 2006
    ..16...
  37. ncbi request reprint Long-term depression in the adult hippocampus in vivo involves activation of extracellular signal-regulated kinase and phosphorylation of Elk-1
    Edda Thiels
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 22:2054-62. 2002
    ....
  38. ncbi request reprint Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
    Ulrike Kemmerling
    Centro FONDAP de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Cell Calcium 41:491-502. 2007
    ....
  39. ncbi request reprint Early maintenance of hippocampal mossy fiber--long-term potentiation depends on protein and RNA synthesis and presynaptic granule cell integrity
    Eduardo Calixto
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 23:4842-9. 2003
    ..These results indicate that the mechanisms that underlie MF LTP maintenance differ from those involved in LTP maintenance at other glutamatergic synapses...
  40. ncbi request reprint Switching gears: translational mastery of transcription during memory formation
    Charles A Hoeffer
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 54:186-9. 2007
    ..present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2alpha...
  41. pmc Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus
    Jennifer N Gelinas
    Department of Physiology, University of Alberta School of Medicine, Edmonton, Alberta T6G 2H7, Canada
    Learn Mem 15:403-11. 2008
    ..Activation of Epac represents a novel signaling pathway for rapid regulation of the stability of enduring forms of LTP and, perhaps, of hippocampus- dependent long-term memories...
  42. pmc mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice
    Marcia D Antion
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA
    Mol Cell Biol 28:2996-3007. 2008
    ..Our data also suggest that S6Ks are not required for the expression of mGluR-LTD and that the synthesis of 5'TOP-encoded proteins is independent of S6Ks during mGluR-LTD...
  43. ncbi request reprint Hippocampal memory and plasticity in superoxide dismutase mutant mice
    Edda Thiels
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, 446 Crawford Hall, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:601-5. 2002
    ..These findings have implications for the use of antioxidant treatments as well as for our understanding of the signaling events involved in cognition...
  44. ncbi request reprint Potentiation of hippocampal synaptic transmission by superoxide requires the oxidative activation of protein kinase C
    Lauren T Knapp
    Department of Neuroscience and the Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 22:674-83. 2002
    ..Finally, our findings suggest that superoxide, in addition to its well known role as a neurotoxin, also can be considered a small messenger molecule critical for normal neuronal signaling...
  45. doi request reprint Cap-dependent translation initiation and memory
    Jessica L Banko
    Department of Molecular Medicine, University of South Florida Health, 12901 Bruce B Downs Boulevard, MDC 61, Tampa, FL, USA
    Prog Brain Res 169:59-80. 2008
    ....
  46. pmc NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea
    Guanxia Zhan
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 172:921-9. 2005
    ..We hypothesized that long-term intermittent hypoxia activates brain NADPH oxidase and that this enzyme serves as a critical source of superoxide in the oxidation injury and in hypersomnolence...
  47. pmc Altered protein synthesis is a trigger for long-term memory formation
    Eric Klann
    Center for Neural Science, New York University, New York, NY, USA
    Neurobiol Learn Mem 89:247-59. 2008
    ..We feel that a clear delineation of these three principles will assist in interpreting the available experimental data, and propose that the available data are consistent with a role for protein synthesis in memory...
  48. ncbi request reprint ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation
    Jennifer N Gelinas
    Departments of Physiology and Psychiatry, and Centre for Neuroscience, University of Alberta School of Medicine, Edmonton, Alberta, Canada
    J Biol Chem 282:27527-35. 2007
    ....
  49. ncbi request reprint Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK
    Susana D Ugarte
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci Res 73:105-12. 2003
    ..These studies suggest that GDNF can protect dopaminergic cells against some but not all aspects of 6-OHDA-induced toxicity by acting through both PI3K and MAPK signaling pathways...